Claims
- 1. A substituted basic 2-aminotetralin of the formula ##STR124## in which R' and R.sup.2 each independently is lower alkyl, and X is F of CH.sub.3.
- 2. A compound according to claim 1, wherein such compound is 2-{N-[3-(4-fluorophenylsulfonamido)ethyl]-N-propyl}amino-8-methoxy-1,2,3,4-tetrahydronaphthalene of the formula ##STR125## or its salt.
- 3. A compound according to claim 1, wherein such compound is 8-methoxy-2-{N-[2-(4-toluene-sulphonamido)ethyl]-N-propyl}amino-1,2,3,4-tetrahydronaphthalene of the formula ##STR126## or its salt.
- 4. A composition for treatment of a disorder of the central nervous system, the cardiovascular system or the intestinal tract comprising an amount effective therefor of a compound of salt according to claim 1 and a physiologically acceptable diluent.
- 5. A unit dose of a composition according to claim 4 in the form of a tablet, ampule or capsule.
- 6. A method of treating a patient suffering from a disorder of the central nervous system calling for administration of a material having a high affinity for 5-HT.sub.1 receptors, comprising administering to such patient an amount effective therefor of a compound or salt according to claim 1.
- 7. The method according to claim 1, wherein such compound is
- 2-{N-[3-(4-fluorophenylsulfonamido)ethyl]-N-propyl}amino-8-methoxy-1,2,3,4-tetrahydronaphthalene
- 8-methoxy-2-{N-[2-(4-toluene-sulphonamido)ethyl]-N-propyl}amino-1,2,3,4-tetrahydronaphthalene,
- or its salt.
Priority Claims (2)
Number |
Date |
Country |
Kind |
3642192 |
Dec 1986 |
DEX |
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3718317 |
Jun 1987 |
DEX |
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Parent Case Info
This is a division of application Ser. No. 378,733, filed Jul. 12, 1989, now U.S. Pat. No. 5,026,857, which is a division of application Ser. No. 130,373, filed Dec. 8, 1987, now U.S. Pat. No. 4,880,802.
US Referenced Citations (1)
Number |
Name |
Date |
Kind |
4707497 |
Cecchi et al. |
Nov 1987 |
|
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Non-Patent Literature Citations (3)
Entry |
Chemical Abstracts, vol. 106, Feb. 2, 1987, No. 5, p. 94 106:28103s, Emerit et al, "Irreversible blockade of central 5-HT1A receptor . . . ". |
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Divisions (2)
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Number |
Date |
Country |
Parent |
378733 |
Jul 1989 |
|
Parent |
130373 |
Dec 1987 |
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