Claims
- 1. A substituted benzenesulfonylurea or-thiourea of the formula I ##STR38## in which R(1) is hydrogen or methyl,
- R(2) is hydrogen, F, Cl, Br, I, (C.sub.1 -C.sub.6)-alkoxy,
- E is oxygen or sulfur,
- Y is a hydrocarbon chain of the formula:
- --{CR(3).sub.2 }.sub.n --
- where R(3)=H or (C.sub.1 -C.sub.2)-alkyl and n=1, 2, 3 or 4,
- X is hydrogen, F, Cl, Br, I or (C.sub.1 -C.sub.6)-alkyl and
- Z is F, Cl, Br, I, NO.sub.2, (C.sub.1 -C.sub.4)-alkoxy or (C.sub.1 -C.sub.4)-alkyl.
- 2. A compound of the formula I as claimed in claim 1, in which:
- R(1) is hydrogen or methyl,
- R(2) is hydrogen, C.sub.1 -C.sub.6)-alkyl, (C.sub.1 -C.sub.6)-alkoxy, or F, Cl, Br or I,
- E is oxygen or sulfur,
- Y is a hydrocarbon chain of the formula
- --{CR(3).sub.2 }.sub.n --
- where R(3)=H or (C.sub.1 -C.sub.2)-alkyl and n=1, 2, 3 or 4,
- X is hydrogen, F, Cl or (C.sub.1 -C.sub.4)-alkyl and
- Z is nitro, F, Cl, (C.sub.1 -C.sub.4)-alkyl or (C.sub.1 -C.sub.4)-alkoxy.
- 3. A compound of the formula I as claimed in claim 1 in which:
- R(1) is hydrogen or methyl, and
- R(2) is hydrogen, fluorine or chlorine,
- E is oxygen or sulfur,
- Y is a hydrocarbon chain of the formula
- --{CR(3).sub.2 }.sub.n --
- where R(3)=H or (C.sub.1 -C.sub.2)-alkyl and n=1, 2, 3 or 4,
- X is hydrogen, F, Cl, or (C.sub.1 -C.sub.4)-alkyl, and
- Z is chlorine, fluorine, (C.sub.1 -C.sub.4)-alkyl or (C.sub.1 -C.sub.4)-alkoxy.
- 4. A compound of the formula I as claimed in claim 1, in which:
- R(1) is hydrogen or methyl,
- R(2) is methoxy or methyl,
- E is oxygen or sulfur,
- Y is a substituted or unsubstituted hydrocarbon radical having two to three carbon atoms of the formula
- --{CR(3).sub.2 }.sub.n --
- where R(3)=H or methyl and n=2 or 3,
- X is hydrogen, F, Cl or (C.sub.1 -C.sub.3)-alkyl and
- Z is chlorine or fluorine, (C.sub.1 -C.sub.3)-alkyl or (C.sub.1 -C.sub.3)-alkoxy.
- 5. A pharmaceutical composition comprising an active amount of a compound of the formula I as claimed in claim 1 and a suitable pharmaceutical carrier therefor.
- 6. A method of treating disturbances in cardiac rhythm comprising administering to a host suffering from cardiac disturbances, an effective amount of a compound as claimed in claim 1.
- 7. A method of preventing sudden cardiac death comprising administering to a host suffering from cardiac disturbances, an effective amount of a compound as claimed in claim 1.
- 8. A method of treating ischemic conditions of the heart comprising administering to a host having ischemic conditions an effective amount of a compound as claimed in claim 1.
- 9. A method of inhibiting ATP-sensitive potassium channels comprising utilizing a compound as claimed in claim 1.
- 10. A method of treating weakened cardiac force comprising administering to a host suffering from weakened cardiac force, an effective amount of a compound as claimed in claim 1.
- 11. A method of improving cardiac function following a heart transplant comprising administering to a host who has undergone a heart transplant, an effective amount of a compound as claimed in claim 1.
Priority Claims (1)
Number |
Date |
Country |
Kind |
43 05 450.1 |
Feb 1993 |
DEX |
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Parent Case Info
This application is a continuation, of application Ser. No. 08/198,048 filed Feb. 18, 1994, now abandoned.
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Entry |
Cardiovascular Effects of the Novel Potassium Channel Opener (3S,4R)--3 --Hydroxy--2, 2--dimethyl--4--(2--oxo--1--pyrrolidinyl)--6--phenylsulfonylchromane Hemihydrate, Arzneimittel-Dorschung/Drug Research, W. Linz et al., 1992. |
Continuations (1)
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Number |
Date |
Country |
Parent |
198048 |
Feb 1994 |
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