Claims
- 1. A compound of the formula ##STR9## wherein X represents an oxygen or sulfur atom;
- R.sup.1 represents Br, Cl, F, phenoxy, alkylthio, alkylsulfinyl, alkylsulfonyl, alkylaminosulfonyl, dialkylaminosulfonyl, benzoyl, alkoxy, alkyl, halogenated alkyl or acetyl;
- R.sup.2 represents H, Br, Cl, F or CF.sub.3 ; and
- n represents the integer 1, 2, 3 or 4 provided that, when n is the integer 1;
- (a) R.sup.1 is other than phenoxy, alkylthio, alkylsulfinyl, alkylsulfonyl, alkylaminosulfonyl, dialkylaminosulfonyl or benzoyl when R.sup.2 is H; and
- (b) R.sup.1 is other than Br, Cl, or F when R.sup.2 is H, Br, Cl or F.
- 2. The compound of claim 1 wherein
- X represents an oxygen atom;
- R.sup.1 represents alkyl, halogenated alkyl or alkoxy;
- R.sup.2 represents H, Br, Cl, F or CF.sub.3 ; and
- n represents the integer 1 or 2.
- 3. The compound of claim 2 wherein
- R.sup.1 represents halogenated alkyl; and
- R.sup.2 represents H, Br, Cl or CF.sub.3.
- 4. The compound of claim 1 which is 2-(3-methoxyphenoxy)-5-nitrobenzonitrile.
- 5. The compound of claim 1 which is 2-((4-trifluoromethyl)phenoxy)-5-nitrobenzonitrile.
- 6. The compound of claim 1 which is 2-(4-acetylphenoxy)-5-nitrobenzonitrile.
- 7. The compound of claim 1 which is 2-(4-chloro-2-methylphenoxy)-5-nitrobenzonitrile.
- 8. The compound of claim 1 which is 2-(3,4,5-trichlorophenoxy)-5-nitrobenzonitrile.
- 9. The compound of claim 1 which is 2-(2,3,5,6-tetrafluorophenoxy)-5-nitrobenzonitrile.
- 10. The compound of claim 1 which is 2-(2,3,4,5,6-pentafluorophenoxy)-5-nitrobenzonitrile.
- 11. The compound of claim 1 which is 2-((2-trifluoromethyl)phenoxy)-5-nitrobenzonitrile.
- 12. The compound of claim 1 which is 2-((3-trifluoromethyl)phenoxy)-5-nitrobenzonitrile.
- 13. The compound of claim 1 which is 2-(3,5-bis(trifluoromethyl)phenoxy)-5-nitrobenzonitrile.
- 14. The compound of claim 1 which is 2-(2,3,4-trichlorophenoxy)-5-nitrobenzonitrile.
- 15. The compound of claim 1 which is 2-(2,3,5-trichlorophenoxy)-5-nitrobenzonitrile.
- 16. The compound of claim 1 which is 2-(2,3,6-trichlorophenoxy)-5-nitrobenzonitrile.
- 17. A method for inhibiting viruses which comprises contacting viruses or virus host cells with an effective virus inhibiting amount of a compound corresponding to the formula ##STR10## wherein X represents an oxygen or sulfur atom;
- R.sup.1 represents Br, Cl, F, phenoxy, alkylthio, alkylsulfinyl, alkylsulfonyl, alkylaminosulfonyl, dialkylaminosulfonyl, benzoyl, alkoxy, alkyl, halogenated alkyl or acetyl;
- R.sup.2 represents H, Br, Cl, F or CF.sub.3 ; and
- n represents the integer 1, 2, 3 or 4 provided that, when n is the integer 1;
- (a) R.sup.1 is other than phenoxy, alkylthio, alkylsulfinyl, alkylsulfonyl, alkylaminosulfonyl, dialkylaminosulfonyl or benzoyl when R.sup.2 is H; and
- (b) R.sup.1 is other than Br, Cl or F when R.sup.2 is H, Br, Cl or F.
- 18. The method of claim 17 wherein the compound is contacted with a virus host cell.
- 19. The method of claim 17 wherein the compound is contacted with virus and mammalian cells.
- 20. The method of claim 17 wherein the viruses are picornaviruses.
- 21. The method of claim 17 wherein
- X represents an oxygen atom;
- R.sup.1 represents alkyl, halogenated alkyl or alkoxy;
- R.sup.2 represents H, Br, Cl, F or CF.sub.3 ; and
- n represents the integer 1 or 2.
- 22. The method of claim 21 wherein R.sup.1 represents halogenated alkyl; and
- R.sup.2 represents H, Br, Cl or CF.sub.3.
- 23. The method of claim 22 wherein the compound is 2-((4-trifluoromethyl)phenoxy)-5-nitrobenzonitrile.
- 24. A method for inhibiting viruses which comprises administering to an animal an effective virus inhibiting amount of a compound corresponding to the formula ##STR11## wherein X represents an oxygen or sulfur atom;
- R.sup.1 represents Br, Cl, F, phenoxy, alkylthio, alkylsulfinyl, alkylsulfonyl, alkylaminosulfonyl, dialkylaminosulfonyl, benzoyl, alkoxy, alkyl, halogenated alkyl or acetyl;
- R.sup.2 represents H, Br, Cl, F or CF.sub.3 ; and
- n represents the integer 1, 2, 3 or 4 provided that, when n is the integer 1;
- (a) R.sup.1 is other than phenoxy, alkylthio, alkylsulfinyl, alkylsulfonyl, alkylaminosulfonyl, dialkylaminosulfonyl or benzoyl when R.sup.2 is H; and
- (b) R.sup.1 is other than Br, Cl or F when R.sup.2 is H, Br, Cl or F.
- 25. The method of claim 24 wherein the animal is a mammal.
- 26. The method of claim 24 wherein the animal is an animal infected with picornavirus.
- 27. The method of claim 26 wherein the picornavirus is a Rhinovirus.
- 28. The method of claim 26 wherein the picornavirus is a Coxsackievirus.
- 29. A composition for inhibiting viruses comprising an inert carrier in combination with an effective virus inhibiting amount of a compound corresponding to the formula ##STR12## wherein X represents an oxygen or sulfur atom;
- R.sup.1 represents Br, Cl, F, phenoxy, alkylthio, alkylsulfinyl, alkylsulfonyl, alkylaminosulfonyl, dialkylaminosulfonyl, benozyl, alkoxy, alkyl, halogenated alkyl or acetyl;
- R.sup.2 represents H, Br, Cl, F or CF.sub.3 ; and
- n represents the integer 1, 2, 3 or 4 provided that, when n is the integer 1;
- (a) R.sup.1 is other than phenoxy, alkylthio, alkylsulfinyl, alkylsulfonyl, alkylaminosulfonyl, dialkylaminosulfonyl or benzoyl when R.sup.2 is H; and
- (b) R.sup.1 is other than Br, Cl or F when R.sup.2 is H, Br, Cl or F.
- 30. The composition of claim 29 wherein the inert carrier is a non-toxic carrier.
- 31. The composition of claim 30 wherein the non-toxic carrier is a pharmaceutically-acceptable carrier.
CROSS-REFERENCE TO RELATED U.S. APPLICATION
This application is a continuation-in-part of copending U.S. application Ser. No. 115,480 filed Jan. 25, 1980, now U.S. Pat. No. 4,254,144.
US Referenced Citations (2)
Continuation in Parts (1)
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Number |
Date |
Country |
Parent |
115480 |
Jan 1980 |
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