Claims
- 1. A compound of the formula ##STR253## wherein n is zero or one;
- R.sub.5 is hydrogen, lower alkyl, halo substituted lower alkyl, benzyl, or phenethyl;
- R.sub.3 is hydrogen, lower alkyl, benzyl, or benzhydryl;
- R.sub.4 is hydrogen, lower alkyl, halo substituted lower alkyl, ##STR254## R.sub.1 and R.sub.2 are independently selected from the group consisting of hydrogen, lower alkyl, halo substituted lower alkyl, ##STR255## R.sub.13 is hydrogen, lower alkyl of 1 to 4 carbons, lower alkoxy of 1 to 4 carbons, lower alkylthio of 1 to 4 carbons, chloro, bromo, fluoro, trifluoromethyl, hydroxy, phenyl, phenoxy, phenylthio, or phenylmethyl;
- q is zero or an integer from 1 to 7;
- m is zero, one, two or three; and
- p is one, two or three provided that p is more than one only if R.sub.13 is hydrogen, methyl, methoxy, chloro, or fluoro.
- 2. A compound of claim 1 wherein
- n is zero;
- R.sub.2 is hydrogen; and
- R.sub.5 is hydrogen.
- 3. A compound of claim 2 wherein
- R.sub.4 is lower alkyl of 1 to 7 carbons, trifluoromethyl, ##STR256## cyclopentyl, cyclohexyl, ##STR257## R.sub.3 is hydrogen, lower alkyl, or benzyl; R.sub.1 is lower alkyl of 1 to 7 carbons, or ##STR258## q is zero or an integer from 1 to 4; and R.sub.13 is hydrogen, methyl, methoxy, methylthio, chloro, bromo, fluoro, or hydroxy.
- 4. The compound of claim 3 wherein R.sub.4 is phenyl; R.sub.1 is ##STR259## and R.sub.3 is --C.sub.2 H.sub.5.
- 5. The compound of claim 3 wherein R.sub.4 is phenyl; R.sub.1 is --(CH.sub.2).sub.5 --CH.sub.3 ; and R.sub.3 is --C.sub.2 H.sub.5.
- 6. The compound of claim 3 wherein R.sub.4 is --(CH.sub.2).sub.4 --CH.sub.3 ; R.sub.1 is ##STR260## and R.sub.3 is --C.sub.2 H.sub.5.
Parent Case Info
This is a division of application Ser. No. 260,659 filed May 4, 1981 now U.S. Pat. No. 4,381,297.
US Referenced Citations (11)
Foreign Referenced Citations (4)
Number |
Date |
Country |
868532 |
Oct 1978 |
BEX |
2027025 |
Feb 1980 |
GBX |
2028327 |
Mar 1980 |
GBX |
2039478 |
Aug 1980 |
GBX |
Non-Patent Literature Citations (1)
Entry |
Mauger et al., "Analogs and Homologs of Proline and Hydroxyproline" Chem. Review, vol. 66, pp. 47-86 (1966). |
Divisions (1)
|
Number |
Date |
Country |
Parent |
260659 |
May 1981 |
|