Substituted cyclohexane derivatives

Abstract

The present invention relates to substituted cyclohexane derivatives having the structure: ##STR1## wherein the dotted line may be a carbon-carbon double bond or a carbon-carbon single bond; wherein R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.5, R.sub.6, R.sub.7 and R.sub.8 may be hydrogen or lower alkyl; wherein Z may be any of the following: ##STR2## wherein R.sub.9 may be hydrogen or lower alkyl; and wherein R.sub.10 and R.sub.11 are lower alkyl. This invention also provides methods of preparing and using the compounds as odor-modifying ingredients in perfumes and perfumed products, and as flavor-modifying ingredients in foodstuffs and tobacco products.

Description

BACKGROUND OF THE INVENTION

There is an increased demand for materials which can be utilized to impart, alter or enhance the flavor and/or fragrance of consumable items. The natural oils which have traditionally been used for this purpose often suffer the disadvantages of limited supply, high cost, and variable quality.

Accordingly, the search for synthetic materials which can function as partial or total replacements for essentials oils, or which can find used in the creation of new and unique flavor and fragrance materials has intensified in recent years.

Various substituted cyclohexane derivatives have been disclosed in the prior art. For example, Arctander, Perfume and Flavor Chemicals, Vols. 1 & 2, (1969) provides the following illustrative examples of such compounds which have use in perfume and flavor compositions: ##STR3##

Extremely dry, woody-camphoraceous, almost "tarry" odor with leather-like undertone.

Used in perfume compositions to lend power and diffusiveness to soap fragrances, along with woody notes, Ionones, Cedarwood oil derivatives, etc. and with the acetate of this alcohol. It is stable in soap and does not discolor in mixtures with any common perfume chemical." ##STR4##

Warm-herbaceous, breadlike, penetrating and diffusive odor, somewhat spicy, in extreme dilution also floral, overall reminiscent of Spearmint Oil (rectified).

Warm and sweet, spicy, refreshing minty taste.

Occasionally used in perfume compositions, particularly in floral bases, where it introduces enormous power and often lends pleasing natural notes to the fragrance. However, it demands great skill and experience in application. It seems to constitute a very good and compatible companion to Rose Oxide and the Jasmone chemicals.

Extensively used in flavor compositions, mainly as a powerful spearmint note, to fortify Spearmint oil, etc. in hard candy, chewing gum, toothpaste and many kinds of candy. Furthermore, in Mint flavor blends, spice blends, liquor flavors, etc." ##STR5##

Powerful green-orrisy, slightly woody odor. Rather dry without being pronounced "camphoraceous." ##STR6##

Woody-rootlike, dry-sweet and very tenacious odor with resemblance to Vetiver, Cedar and Amyris.

This material has been suggested for use in perfume compositions, where it may introduce a supporting note to Vetiver and precious wood notes, furthermore give "lift" and stable power particularly in soap perfumes. It blends excellently with the Ionones and Methylionones, with Cedarwood derivatives and musks, and with Oakmoss products." ##STR7##

Powerful and rather pungent, but in dilution pleasant, warm-herbaceous and minty-camphoraceous odor, reminiscent of Tansy oil or Dalmation Sage oil.

The title ketone has been suggested for use in perfume compositions, and if it became available in a state of higher olfactory purity and quality, it could well be used in modern soap and detergent fragrances, perfumes for household products, etc."

Chemical Abstracts, Vol. 68, 39828e (abstract of L. M. Shulov, et al., Zh. Org. Khim. 1967, 3, 1819) discloses the preparation of the compound: ##STR8## having the fragrance of fresh greens.

U.S. Pat. No. 3,211,157 discloses the preparation of compounds having the following structure: ##STR9## wherein the wavy lines represent "cis" or "trans" isomers which upon addition to tobacco impart "a pleasing flavor."

German Pat. Nos. 2,216,974 and 2,256,347 disclose a compound having the structure ##STR10## which is prepared by a process unrelated to that of the instant invention.

U.S. Pat. No. 3,268,589 discloses compounds having the structures: ##STR11## which impart a peppery, spicy odor to tobacco.

Although the compounds disclosed in U.S. Pat. Nos. 3,211,157 and 3,268,589 and German Pat. Nos. 2,216,974 and 2,256,347 have functional groups which are similar to the compounds of our invention, the structures and organoleptic profiles are different in kind from the compounds of the instant invention.

Schulte-Elte, et al. Justus Liebigs Ann. Chem., 1975, 484 discloses the compound having the structure: ##STR12## which was isolated from a reaction mixture as an unexpected minor by-product. No indication of utility or discussion of the organoleptic properties of the compound is given.

No prediction of the organoleptic properties of the compounds of the instant invention can be made by a study of the above-mentioned disclosures.

DETAILED DESCRIPTION OF THE INVENTION

It has been found that new and novel flavors and flavoring compositions, perfumes and perfumed articles, as well as tobacco products, can be successfully produced by adding effective amounts of one or more of the substituted cyclohexane and cyclohexene derivatives having the structural formula: ##STR13## wherein the dotted line may be a carbon-carbon double bond or a carbon-carbon single bond; wherein R.sub.1,R.sub.2,R.sub.3,R.sub.4,R.sub.5,R.sub.6,R.sub.7 and R.sub.8 may be hydrogen or lower alkyl; wherein Z may be any of the following: ##STR14## wherein R.sub.9 may be hydrogen or lower alkyl; and wherein R.sub.10 and R.sub.11 may be lower alkyl.

The substituted cyclohexane and cyclohexene derivatives of the present invention have been found to possess distinctive balsamic, amber-like, woody, sweet, rooty, musty, earthy, leathery, green, citrus, herbaceous, floral odors which are useful in fine fragrances as well as perfumed products such as soaps, detergents, deodorants, cosmetic preparations and the like.

One or more of the substituted cyclohexanes and cyclohexenes of this invention and auxiliary perfume ingredients, for example, alcohols, aldehydes, ketones, nitriles, esters and essential oils, may be admixed so that the combined odors of the individual components produce a desired fragrance. Such perfume compositions are carefully balanced harmonious blends of essential oils, aroma chemicals, resinoids and other extracts of natural odorous materials. Each ingredient imparts its own characteristic effect in the composition. Thus, one or more of the substituted cyclohexanes and cyclohexenes of this invention can be employed to impart novel characteristics in fragrance compositions.

Such compositions may contain up to about 80 weight percent of any one or more of the substituted cyclohexanes and cyclohexenes of this invention. Ordinarily, at least about 0.001 weight percent of the substituted cyclohexane or cyclohexene is required to impart significant odor characteristics. Amounts in the range from about 1 to about 60 weight percent are preferred. The substituted cyclohexanes and cyclohexenes of this invention may be formulated into concentrates containing from about 1 to about 60 weight percent in an appropriate solvent. Such concentrates are then employed to formulate products such as colognes, soaps, etc., wherein the concentration of the compounds of this invention can be in the range of from about 0.001 to about 7 weight percent, depending upon the final product. For example, the concentration of the chemicals of this invention will be from about 0.001 to about 0.1 weight percent in detergents, and from about 0.01 to about 7 weight percent in perfumes and colognes.

The substituted cyclohexanes and cyclohexenes of this invention are useful as olfactory components of perfume compositions for detergents and soaps; space odorants and deodorants; perfumes, colognes; toilet water; bath preparations such as bath oils and bath solids; hair preparations such as lacquers, brilliantines, pomades and shampoos; cosmetic preparations such as creams, deodorants, hand lotions and sunscreens; powders such as talcs, dusting powders and face powders; and the like.

Because of their unique organoleptic properties, the substituted cyclohexanes and cyclohexenes of this invention have also been found to have utility in the alteration of the flavor component or components of flavor compositions. They can be used effectively to impart a certain natural character to artificial flavors. They can also be employed successfully to modify the organoleptic properties of such consumables as chewing gums, beverages, pharmaceutical preparations, fruit juices and the like.

The flavoring properties of the substituted cyclohexanes and cyclohexenes of this invention depend upon the type of products to which they are added. They develop woody, earthy, minty, fruity, citrusy flavor notes or combinations thereof. They can be employed advantageously in certain citrus products such as orange oil to round off the taste and in grape flavors where the taste and aroma are markedly enhanced.

Again, the proportions of the substituted cyclohexanes and cyclohexenes of this invention can vary within a wide range of concentrations depending upon the organoleptic properties desired. Typically, particularly interesting flavor effects can be obtained with concentrations of about 0.001 to about 1 weight percent of the compound in the final flavor composition. In some situations higher concentrations of the substituted cyclohexanes and cyclohexenes are required to produce special flavoring effects. For example, when used in artificial flavor compositions they may be incorporated at levels of 20 weight percent or more.

When one or more of the substituted cyclohexanes or cyclohexenes of this invention is added to smoking tobacco or synthetic tobacco, they impart woody, amber-like, and cedarwood notes to the tobacco aroma. The proportions are preferably between 1 to 100 ppm, but in certain situations higher levels may be usefully employed.

The description of the practice of the instant invention set forth above is meant to illustrate its usefulness and is in no way intended to limit the scope of the invention.

In accordance with one of the embodiments of the present invention, the compounds of the invention can be prepared by one of several processes. In some of the processes outlined hereinbelow the starting material is an appropriately substituted 2,4-dioxocyclohexane carboxylate having the structural formula: ##STR15## wherein R.sub.1,R.sub.2, and R.sub.3 are as defined hereinabove; and R is methyl or ethyl, preferably, methyl. Specific examples of carboxylates (I) falling within the scope of the foregoing structural formula include the following:

Methyl 2,4-dioxo-3-methylcyclohexane carboxylate Methyl 2,4-dioxo-5-methylcyclohexane carboxylate Methyl 2,4-dioxo-6-methylcyclohexane carboxylate Methyl 2,4-dioxo-3,5-dimethylcyclohexane carboxylate Methyl 2,4-dioxo-3,6-dimethylcyclohexane carboxylate Methyl 2,4-dioxo-5,6-dimethylcyclohexane carboxylate Methyl 2,4-dioxo-3,5,6-trimethylcyclohexane carboxylate Methyl 2,4-dioxo-3-methyl-5-ethylcyclohexane carboxylate Methyl 2,4-dioxo-3-methyl-6-ethylcyclohexane carboxylate Methyl 2,4-dioxo-3-methyl-5,6-diethylcyclohexane carboxylate Methyl 2,4-dioxo-5-methyl-3-ethylcyclohexane carboxylate Methyl 2,4-dioxo-5-methyl-6-ethylcyclohexane carboxylate Methyl 2,4-dioxo-5-methyl-3,6-diethylcyclohexane carboxylate Methyl 2,4-dioxo-6-methyl-3-ethylcyclohexane carboxylate Methyl 2,4-dioxo-6-methyl-5-ethylcyclohexane carboxylate Methyl 2,4-dioxo-6-methyl-3,5-diethylcyclohexane carboxylate Methyl 2,4-dioxo-3,5,6-triethylcyclohexane carboxylate Methyl 2,4-dioxo-3-methyl-5-propylcyclohexane carboxylate Methyl 2,4-dioxo-3-methyl-6-propylcyclohexane carboxylate Methyl 2,4-dioxo-3-methyl-5,6-dipropylcyclohexane carboxylate Methyl 2,4-dioxo-5-methyl-3-propylcyclohexane carboxylate Methyl 2,4-dioxo-5-methyl-6-propylcyclohexane carboxylate Methyl 2,4-dioxo-5-methyl-3,6-dipropylcyclohexane carboxylate Methyl 2,4-dioxo-6-methyl-3-propylcyclohexane carboxylate Methyl 2,4-dioxo-6-methyl-5-propylcyclohexane carboxylate Methyl 2,4-dioxo-6-methyl-3,5-dipropylcyclohexane carboxylate Methyl 2,4-dioxo-3,5,6-tripropylcyclohexane carboxylate Methyl 2,4-dioxo-3-methyl-5-isopropylcyclohexane carboxylate Methyl 2,4-dioxo-3-methyl-6-isopropylcyclohexane carboxylate Methyl 2,4-dioxo-3-methyl-5,6-diisopropylcyclohexane carboxylate Methyl 2,4-dioxo-5-methyl-3-isopropylcyclohexane carboxylate Methyl 2,4-dioxo-5-methyl-6-isopropylcyclohexane carboxylate Methyl 2,4-dioxo-5-methyl-3,6-diisopropylcyclohexane carboxylate Methyl 2,4-dioxo-6-methyl-3-isopropylcyclohexane carboxylate Methyl 2,4-dioxo-6-methyl-5-isopropylcyclohexane carboxylate Methyl 2,4-dioxo-6-methyl-3,5-diisopropylcyclohexane carboxylate Methyl 2,4-dioxo-3,5,6-triisopropylcyclohexane carboxylate Methyl 2,4-dioxo-3-ethylcyclohexane carboxylate Methyl 2,4-dioxo-5-ethylcyclohexane carboxylate Methyl 2,4-dioxo-6-ethylcyclohexane carboxylate Methyl 2,4-dioxo-3-ethyl-5-propylcyclohexane carboxylate Methyl 2,4-dioxo-3-ethyl-6-propylcyclohexane carboxylate Methyl 2,4-dioxo-3-ethyl-5,6-dipropylcyclohexane carboxylate Methyl 2,4-dioxo-5-ethyl-3-propylcyclohexane carboxylate Methyl 2,4-dioxo-5-ethyl-6-propylcyclohexane carboxylate Methyl 2,4-dioxo-5-ethyl-3,6-dipropylcyclohexane carboxylate Methyl 2,4-dioxo-6-ethyl-3-propylcyclohexane carboxylate Methyl 2,4-dioxo-6-ethyl-5-propylcyclohexane carboxylate Methyl 2,4-dioxo-6-ethyl-3,5-dipropylcyclohexane carboxylate Methyl 2,4-dioxo-3-propylcyclohexane carboxylate Methyl 2,4-dioxo-5-propylcyclohexane carboxylate Methyl 2,4-dioxo-6-propylcyclohexane carboxylate Methyl 2,4-dioxo-3-propyl-5-isopropylcyclohexane carboxylate Methyl 2,4-dioxo-3-propyl-6-isopropylcyclohexane carboxylate Methyl 2,4-dioxo-3-propyl-5,6-diisopropylcyclohexane carboxylate Methyl 2,4-dioxo-5-propyl-3-isopropylcyclohexane carboxylate Methyl 2,4-dioxo-5-propyl-6-isopropylcyclohexane carboxylate Methyl 2,4-dioxo-5-propyl-3,6-diisopropylcyclohexane carboxylate Methyl 2,4-dioxo-6-propyl-3-isopropylcyclohexane carboxylate Methyl 2,4-dioxo-6-propyl-5-isopropylcyclohexane carboxylate Methyl 2,4-dioxo-6-propyl-3,5-diisopropylcyclohexane carboxylate

Some of these are known compounds and to the extent that they are new, known methods such as those diagrammed in Scheme A can be employed for their production.

SCHEME A ##STR16##

Process 1

The appropriate 2,4-dioxocyclohexane carboxylate (I) is subjected to enol ether formation by treatment with a lower alkanol, preferably isopropanol in the presence of an acidic catalyst such as a mineral acid or p-toluenesulfonic acid and a hydrocarbon solvent such as benzene, toluene, xylene and the like with azeotropic removal of water (as disclosed in German Pat. No. 2,335,080) resulting in a compound with the structure: ##STR17## wherein R.sub.12 is lower alkyl, preferably, isopropyl or isobutyl.

The carboxylate II is reacted with an olefin compound having the structure: ##STR18## wherein X is a halogen selected from the group consisting of chloro, bromo, and iodo thereby forming an alkylated carboxylate having the structure: ##STR19##

The above transformation may be accomplished, for example, by first forming the enolate of the carboxylate (II) with an alkali metal hydride such as sodium hydride or potassium hydride in an inert solvent such as benzene, toluene, xylene, tetrahydrofuran, dimethoxyethane, dimethylformamide, hexamethylphosphoric triamide, or dimethyl sulfoxide. The enolate is then treated with the olefinic halide at temperatures in the range from about 0.degree. to 120.degree. C., the temperature range from about 20.degree. to 40.degree. C. being preferred. Although either compound may be used in excess, the preferred molar ratio of olefinic halide to carboxylate is from about 1:1 to about 1.2:1. Reaction times of from about 1 to 15 hours are required depending upon the temperature and solvent utilized, with higher temperatures resulting in decreased reactions times.

Alternatively, the reaction may be carried out in the presence of a phase transfer catalyst. Specific examples of phase transfer catalysts useful in the present invention include benzyltriethylammonium chloride, cetyltrimethylammonium chloride, and tricaprylmethylammonium chloride. The alkylation of carboxylate II with the olefinic halide is carried out in the presence of approximately one equivalent of a base such as an alkali metal hydride, alkoxide, or hydroxide in an inert solvent such as benzene, toluene, xylene, hexane, or methylene chloride. Temperatures in the range from about 20.degree. to 150.degree. C. may be employed, the temperature range from about 30.degree. to 100.degree. C. being preferred. The amount of phase transfer catalyst based on carboxylate II may vary from about 0.1 to 10 mole percent, the preferred amount being in the range from about 0.5 to 5 mole percent.

The alkylated carboxylate III is then decarboxylated by heating it in the presence of an alkali metal salt in a polar, aprotic solvent such as dimethylsulfoxide, hexamethylphosphoric triamide, 1-methyl-2-pyrrolidone, or dimethylformamide resulting in production of a cyclic ketone having the structure: ##STR20## wherein the substituents are as set forth hereinabove. Preferred metal salts include lithium chloride, lithium bromide, lithium iodide, sodium chloride, sodium iodide, and sodium cyanide. The reaction is desirably carried out at temperatures from about 80.degree. to 160.degree. C., with temperatures in the range from about 100.degree. to 140.degree. C. being preferred.

It is desirable that the mole ratio of carboxylate:alkali metal salt be from about 1:1 to 1:10, preferably from about 1:1.5 up to about 1:2.

The cyclic ketone IV may then be further transformed by any one or a combination of the steps outlined in Scheme B to obtain the compounds of the instant invention.

SCHEME B ##STR21##

In accordance with the transformation illustrated by Scheme B hereinabove, the ketone IV may be reacted with an organometallic derivative such as a Grignard reagent (e.g. R.sub.4 MgX) or an organolithium compound (e.g., R.sub.4 Li) wherein R.sub.4 is lower alkyl. The reaction with the organometallic is desirably carried out with a stoichiometric quantity of the reagent when the lithium derivative is utilized or with excess organometalic (2 to 3 equivalents) when a Grignard reagent is employed. The reaction is preferably carried out in inert solvents such as diethyl ether, tetrahydrofuran, or mixtures of diethyl ether or tetrahydrofuran in benzene, toluene, or hexane. It is preferred to carry out the reaction in an inert atmosphere such as nitrogen or argon at temperatures in the range from about 0.degree. C. to 50.degree. C. The resulting organometallic adduct is then hydrolyzed with a dilute aqueous acid such as hydrochloric acid. The hydrolyzed product may be isolated by solvent extraction and purified by fractional distillation to give the substituted 2-cyclohexene-1-one, V. This ketone may be utilized in perfume or flavor compositions or further modified.

The ketone V may be treated with a Grignard reagent R.sub.9 MgX such as CH.sub.3 MgI or an organolithium R.sub.9 Ki wherein R.sub.9 is lower alkyl under reaction conditions essentially the same as those stated hereinabove. In this instance, the hydrolysis is accomplished with either ice-cold aqueous mineral acid or preferably with a saturated ammonium chloride solution.

Reduction of the ketone group in V with an alkali metal aluminum hydride such as diisobutylaluminum hydride at about 0.degree. C. in an inert solvent such as hexane or toluene followed by hydrolysis under neutral conditions gives the corresponding alcohol VI which may be utilized in perfume or flavor compositions.

The hydrogenation of ketone V is carried out in the presence of a metal catalyst such as palladium on carbon, copper chromite, or Raney nickel in an inert solvent such as a lower alcohol. Dilute solutions (e.g. 0.1 to 0.5 molar) of an alkali metal hydroxide in a lower alkanol such as ethanol at temperatures from about 20.degree. C. to 50.degree. C. are particularly desirable for the conversion to the cyclohexanone VII. Purification by fractional distillation results in a compound which may be utilized in perfume or flavor compositions or further modified.

The reduction of compound VII may be performed using standard methodology, for example, by means of an alkali metal aluminum hydride such as lithium aluminum hydride in an inert solvent such as diethyl ether or tetrahydrofuran at temperatures from about 0.degree. C. to 30.degree. C. Alternatively, a boron hydride such as sodium borohydride in a lower alkanol may be employed resulting in the preparation of compound VIII. This material may be utilized in perfume or flavor compositions or reacted with an organometallic compound such as a Grignard reagent (e.g., R.sub.9 MgX) or an organolithium R.sub.9 Li wherein R.sub.9 is lower alkyl under conditions similar to those described for ketone V thus leading to formation of the alcohol X which itself may be utilized in perfume or flavor compositions.

In accordance with another embodiment of the present invention, the ketone group in IV may be reduced with an alkali aluminum hydride such as lithium aluminum hydride in an inert solvent such as tetrahydrofuran or diethyl ether at temperatures from about 0.degree. to 40.degree. C. which, after hydrolytic work-up employing a dilute mineral acid such as HCl, results in the formation of the ketone having the structure: ##STR22## wherein R.sub.1, R.sub.2, R.sub.3, R.sub.5, R.sub.6, and R.sub.7 have the meaning defined above. This ketone may be utilized in perfume and flavor compositions or further modified.

The reaction conditions for the transformatins of XI illustrated in Scheme C are essentially the same as those described in detail hereinabove for the corresponding reaction in Scheme B.

SCHEME C ##STR23##

In addition, the cyclohexenone XI may be reacted with an organometallic reagent such as (R.sub.4).sub.2 Cu or a Grignard reagent R.sub.4 MgX in the presence of a catalytic amount of a copper salt, i.e. cuprous iodide, wherein R.sub.4 is lower alkyl according to known methods (see, for example, Posner, Organic Reactions, Vol. 19, p 1, (1972). Temperatures in the range from about -30.degree. to 10.degree. C. are typically employed and the solvent may be either diethyl ether or tetrahydrofuran. Reaction times from about 1 to 10 hours are required and hydrolysis using an aqueous mineral acid results in a compound having the structural formula: ##STR24##

The alcohols VI, VIII, XIII and XV may, in addition, be subjected to esterification in accordance with standard techniques (see, L. F. Fieser and M. Fieser, Reagents for Organic Synthesis, Vol. I, p 958 (1967). For example, esterification with an alkanoic acid anhydride such as acetic anhydride or propionic anhydride or treatment with an acyl halide, preferably an acyl chloride in the presence of an organic base such as N,N-dimethylaniline to form compounds having the structure: ##STR25## wherein R.sub.4 is hydrogen or lower alkyl; wherein R.sub.11 is lower alkyl; and wherein the dotted line represents a carbon-carbon double bond or a carbon-carbon single bond.

In accordance with a further embodiment of the present invention, the alcohol group in compounds VI, VIII, XIII and XV may be transformed by etherification to compounds having the structure: ##STR26## wherein R.sub.4 is hydrogen or lower alkyl; wherein R.sub.8 is lower alkyl; and wherein the dotted line represents a carbon-carbon double bond or a carbon-carbon single bond. The transformation may be effected by known techniques (see J. March, Advanced Organic Chemistry, 2nd ed., p. 357, (1977). For example, the alcohol may be treated with an alkali metal hydride such as sodium hydride in an inert solvent followed by alkylation of the resulting alkoxide with either an alkyl halide R.sub.8 X (e.g. CH.sub.3 I) or an alkyl sulfate (R.sub.8).sub.2 SO.sub.4 (e.g. (CH.sub.3).sub.2 SO.sub.4) to generate the compounds of formula XVIII.

Process 2

The appropriately substituted 1,3-cyclohexanedione enol ether having the structure: ##STR27## wherein R.sub.1, R.sub.2, R.sub.3, and R.sub.12 have the meaning set forth hereinabove may likewise be reacted with an olefinic compound having the structure: ##STR28## wherein X is a halogen chosen from chloro, bromo, or iodo and each of R.sub.5, R.sub.6, and R.sub.7 are hydrogen or lower alkyl.

Alkylation, following a known procedure (J. Org. Chem., 38, 1775 (1973)) may be accomplished by first forming the kinetic enolate with an alkali metal salt of a secondary amine such as lithium diisopropylamide or lithium isopropylcyclohexylamide in an inert solvent such as diethyl ether, tetrahydrofuran, or mixtures of tetrahydrofuran or diethyl ether with hexamethylphosphoric triamide. The alkylation is carried out at temperatures from about -70.degree. to -50.degree. C. after which the reaction mixture is allowed to warm to 20.degree.-25.degree. C. Reaction times can range from 2 to 15 h. depending upon the solvent and olefinic halide employed. The compound thus formed having the structure: ##STR29## may be treated in the same manner as the identical compound described in Process 1 and illustrated in Schemes B and C.

In accordance with a further embodiment of the present invention, the ketone IV may be treated with an alkali metal salt of a secondary amine such as lithium diisopropylamide or lithium isopropylcyclohexylamide as described hereinabove for compound XIX. Alkylation of the resulting enolate may be accomplished with an alkyl halide R.sub.8 X wherein X may be chloro, bromo, or iodo at temperatures from about -60.degree. C. to -40.degree. C. after which the reaction mixture is allowed to warm to about 20.degree. C. to 25.degree. C. Reaction times can range from about 10 to 25 hours depending upon the solvent and halide employed. The compound thus formed having the structure: ##STR30## may be further transformed as described for the similar compound of Process 1 and illustrated in Schemes B and C.

Isolation and purification of the final products of the present invention is achieved by conventional techniques which include extraction, distillation, crystallization, preparative chromatographic separation and the like.

It will be recognized that the compounds of the present invention can exist in several stereoisomeric forms, including the "R" and "S", as well as the "cis" and "trans" isomers. The foregoing structural formulae are intended to embrace the individual stereoisomers as well mixtures of the various stereoisomers of the substituted cyclohexanes and cyclohexenes of this invention.

The following examples are set forth to more fully illustrate the practices of this invention, but are in no way meant to limit the scope thereof.

EXAMPLE 1

Methyl 2-oxo-4-isopropoxy-6-methyl 3-cyclohexene carboxylate

A mixture of methyl 2,4-dioxo-6-methylcyclohexane carboxylate (184 g, 1 mol), isopropanol (96 g, 1.6 mol) and p-toluenesulfonic acid (2 g) in benzene (600 mL) was heated at reflux for 6 hours with azeotropic removal of water. After cooling, the solution was washed several times with 5% sodium carbonate solution and the benzene then removed on a rotary evaporator. Short path distillation gave 171.6 g of the carboxylate, bp 110.degree.-112.degree. C./0.05 mm.

IR (film): 1750, 1665, 1610 cm.sup.-1 NMR (CDCl.sub.3): 1.08(3H, d, J=5.5 Hz), 1.32 (6H, d, J=6 Hz), 2.0-2.9(3H,m), 3.1(1H,dd), 3.8(3H,s), 4.5(1H, h, J=6 Hz), 5.42(1H,bs) .delta..

EXAMPLE 2

Methyl 1-(3-methyl-2-butenyl)-2-oxo-4-isopropoxy-6-methyl-3-cyclohexene carboxylate

Method A

To a stirred suspension of sodium hydride (50% dispersion, 0.15 mol) in anhydrous dimethylformamide (120 mL) under a nitrogen atmosphere was added methyl 2-oxo-4-isopropoxy-6-methyl-3-cyclohexene carboxylate (29.4 g, 0.13 mol; produced according to Example 1), dropwise over 30 minutes while maintaining the temperature between 30.degree. and 35.degree. C. After addition was complete, the temperature was held at 40.degree. C. for 1 hour and then prenyl bromide (22.3 g, 0.15 mol; prepared by the method of Tetrahedron, 33, 580 (1977) in dimethylformamide (20 mL) was added followed by stirring for 16 hours at room temperature. The reaction mixture was poured into water (300 mL) and extracted with ether. The ether extracts were washed with water, brine, and dried (Na.sub.2 SO.sub.4). Removal of the solvent gave 34.5 g of methyl carboxylate which was used without further purification. Kugelrohr distillation (bath temperature 125.degree. C./0.05 mm) of a small sample gave material with the following spectral data:

IR (film): 1745, 1660, 1610 cm.sup.-1 NMR (CDCl.sub.3): 0.95(3H,2d), 1.25(6H,d), 1.62(6H,2s), 2-2.9(5H,complex), 3.62(3H,s), 4.4(1H,h), 4.8(1H,m), 5.4(1H,bs) .delta.. MS: 294(M+), 193, 151, 69, 169, 177.

Method B

Sodium hydride (50% dispersion, 0.06 mol) was freed of mineral oil and suspended in toluene (20 mL) under a nitrogen atmosphere. The suspension was heated to 75.degree. C. and methyl 2-oxo-4-isopropoxy-6-methyl-3-cyclohexene carboxylate (11.3 g, 0.05 mol) in an equal volume of toluene was added. Heating was continued for 1 hour and then Aliquat 336.RTM. (0.2 g, previously dried by azeotropic removal of water) was added along with prenyl bromide (8.2 g, 0.055 mol). The mixture was heated at 75.degree.-80.degree. C. for 4 hours and then cooled to room temperature. Several milliliters of methanol were added and the reaction mixture poured into 100 mL of water. The toluene layer was washed with water and the solvent removed on a rotary evaporator to give 13 g of a crude amber colored oil. Short path distillation gave 7.1 g of alkylated carboxylate, bp 111.degree.-118.degree. C./0.05 mm.

EXAMPLE 3

3-Isopropoxy-5-methyl-6-(3-methyl-2-butenyl)-2-cyclohexen-1-one

Reaction: ##STR31## To a solution of methyl 1-(3-methyl-2-butenyl)-2-oxo-4-isopropoxy-6-methyl-3-cyclohexene carboxylate (29.4 g, 0.1 mol) in anhydrous hexamethylphosphoric triamide (220 mL) was added anhydrous lithium chloride (6.4 g, 0.15 mol). The mixture was stirred at 130.degree. C. in a nitrogen atmosphere for 1.5 hours and then added to water (800 mL). The aqueous solution was extracted with ether. The combined ether extracts were washed with water and dried (Na.sub.2 SO.sub.4). The ether was removed on a rotary evaporator and the residue vacuum distilled, yielding 20.1 g of 3-isopropoxy-5-methyl-6-(3-methyl-2-butenyl)-2-cyclohexen-1-one, bp 104.degree.-108.degree. C./0.05 mm. The product was shown by glc/ms to be a mixture of "cis" and "trans" isomers in a ratio of 76:24.

IR (film): 1660, 1610 cm.sup.-1 NMR (CDCl.sub.3): 1.0(3H,2d), 1.28(6H,d,J=6 Hz), 1.65(6H,bs), 1.9-2.7(6H,m), 4.45(1H,h,J=6 Hz), 5.1(1H,m),5,35(1H,s) .delta.. MS: 236(M+), 69, 111, 126, 84, 168.

EXAMPLE 4

3,5-Dimethyl-4-(3-methyl-2-butenyl)-2-cyclohexen-1-one

Reaction: ##STR32##

To a solution of 3-isopropoxy-5-methyl-6-(3-methyl-2-butenyl)-2-cyclohexen-1-one (11.8 g, 0.05 mol) in ether (150 mL) at 0.degree. C. was added ethereal methyllithium (28 mL, 0.06 mol) over a period of 15 minutes. The mixture was allowed to warm to room temperature and stirred for 2 hours. 2 N aqueous hydrochloric acid solution (400 mL) was added and stirring continued at room temperature for 1 hour. The organic layer was separated, washed with aqueous sodium bicarbonate and dried (Na.sub.2 SO.sub.4). Removal of the solvent and distillation of the residue gave 7.8 g of enone, bp 65.degree.-68.degree. C./0.01 mm as a mixture of two isomers by glc/ms (74% and 23%).

IR (film): 1670, 1628 cm.sup.-1 NMR (CCl.sub.4): 1.0(3H,2d), 1.65(6H,2bs), 1.92(3H,d), 1.8-2.6 (6H,m), 5.05(1H,m), 5.7(1H,bs) .delta.. MS: 192(M+), 109, 69, 124,110,77

EXAMPLE 5

A perfume composition was prepared by mixing the following:

______________________________________ %______________________________________Vanillin 0.5Coumarin 3.0Musk ketone 4.5Geraniol 3.0Oil Geranium 1.5Benzyl acetate 7.5Oil Cedarwood 3.0Cedryl acetate 9.0Hydroxycitronellal 12.0Benzyl salicylate 4.5Isoamyl salicylate 4.5Oil Ylang extra 3.0Oil Clary Sage 1.5Oil Orange Sweet Flor. 1.5Oil Lavender Barreme 1.5Oil Bergamot rect. 4.5Linalool synthetic 3.0Linalyl acetate synthetic 1.5Methyl dihydrojasmonate 3.0Oil Sandalwood, East Indian 3.0Cinnamic alcohol ex Styrax 0.5Phenylethyl acetate 0.5Phenylethyl alcohol 2.0Ionone alpha 0.5Gamma undecalactone 10% 0.5Rose oxide 10% 0.5Oil Nutmeg 10% 0.5Oil Patchouly 0.5Jasmin Absolute, Italian 3.0Oil Neroli 0.5laevo Carvone 10% 0.5Diethyl phthalate 9.03,5-Dimethyl-4-(3-methyl-2-butenyl)-2- 6.0cyclohexen-1-one 100.0______________________________________

EXAMPLE 6

3-Ethyl-4-(3-methyl-2-butenyl)-5-methyl-2-cyclohexen-1-one

Reaction: ##STR33## Ethyl bromide (14.1 g, 0.13 mol) in absolute diethyl ether (20 mL) was added under nitrogen to magnesium turnings (3.1 g, 0.13 g-atom) at a rate sufficient to maintain gentle reflux. To this solution was added 3-iso-propoxy-5-methyl-6-(3p-methyl-2-butenyl)-2-cyclohexen-1-one (10 g, 0.042 mol) in absolute diethyl ether (15 mL) dropwise over 40 minutes. The reaction mixture was refluxed for an additional 3 hours. The cooled mass was cautiously added to 2 N hydrochloric acid (250 mL) and stirred at toom temperature for 1 hour. The organic layer was separated and the aqueous extracted with two 50 mL portions of diethyl ether. The extracts were combined, washed with saturated sodium bicarbonate, and dried (Na.sub.2 SO.sub.4). Solvent removal and distillation gave 5.6 g of enone, bp 99.degree.-107.degree. C./0.5 mm. The product is a mixture of two isomers (ca. 70:30) as indicated by glc/ms.

IR (film): 1670, 1630 cm.sup.-1 NMR (CDCl.sub.3): 1.05 (6H,t superimposed on broad d), 1.65 (6H,2bs), 1.8-2.6(8H,m), 5.1(1H,m), 5.85(1H,bs) .delta.. MS: 206(M+), 109, 138, 69, 123, 95

EXAMPLE 7

4-(3-Methyl-2-butenyl)-5-methyl-2-cyclohexen-1-one

Reaction: ##STR34## To a stirred suspension of lithium aluminum hydride (1.9 g, 0.05 mol) in anhydrous diethyl ether (250 mL) at 0.degree. C. was added 3-isopropoxy-5-methyl-6-(3-methyl-2-butenyl)-2-cyclohexen-1-one (11.8 g, 0.05 mol) in diethyl ether (20 mL). The mixture was stirred for 1.5 hour and then ethyl acetate (22 g) was added slowly to destroy excess hydride. Water (10 ml) was added and the mixture warmed to room temperature. The solution was filtered and added with stirring to 2 N hydrochloric acid (200 mL). After 1 hour the organic layer was separated and the aqueous extracted once with diethyl ether. The combined ether layers were washed with saturated sodium bicarbonate solution and dried (Na.sub.2 SO.sub.4). Solvent removal and distillation through an 8 cm micro Vigreaux column gave 8.4 g of enone, bp 99.degree.-101.degree. C./1 mm (2 isomers by glc/ms analysis).

IR (film): 1675, 1630 cm.sup.-1 NMR (CCl.sub.4): 1.05(3H.bd), 1.62(6H,2s), 1.8-2.6(6H,m), 5.15(1H,m), 5.9(1H,broadened d,J=10.5 Hz), 6.78(1H, broadened d,J=10.5 Hz) .delta.. MS: 178(M+), 69, 110, 95, 41.

EXAMPLE 8

3,5-Dimethyl-4-allyl-2-cyclohexen-1-one

Reaction A: ##STR35## Reaction B: ##STR36##

Procedure A

To a solution of dry diisopropylamine (15 g, 0.145 mol) in anhydrous tetrahydrofuran (100 mL) under a nitrogen atmosphere was added a 2.5 M hexane solution of n-butyllithium (58 mL), with stirring at -20.degree. C. The solution was cooled to -70.degree. C. and hexamethylphosphoric triamide (27 g) was added, followed after 30 minutes by dropwise addition of 3-isopropoxy-5-methyl-2-cyclohexen-1-one (23.5 g, 0.14 mol) in tetrahydrofuran (30 mL). After 40 minutes allylbromide (18.1 g, 0.15 mol) in an equal volume of tetrahydrofuran was added dropwise over 20 minutes. The cooling bath was removed and the temperature allowed to rise to 25.degree. C. Stirring was continued for 2 hours followed by addition of water (5 mL) and removal of the solvent on a rotary evaporator. The residue was dissolved in diethyl ether, washed with water and brine, and dried (Na.sub.2 SO.sub.4). Solvent removal and fractional distillation afforded 24.1 g of alkylated ketone, bp 125.degree.-130.degree. C./1 mm. the glc/ms analysis demonstrated the presence of two isomers (ratio of 84:16).

IR (film): 1655, 1620 cm.sup.-1 NMR (CDCl.sub.3): 1.1(3H,2d), 1.3(6H,d,J=6 Hz), 1.8-2.7(6H,m), 4.45(1H,h,J=6 Hz), 5.05(2H,m), 5.32(1H,bs), 5.8(1H,m) .delta.. MS: 208(M+), 84, 82, 69, 151, 85.

Procedure B

A solution of 3-isopropoxy-5-methyl-6-allyl-2-cyclohexen-1-one (16.6 g, 0.08 mol) in anhydrous diethyl ether (300 mL) was cooled to 0.degree. C. under nitrogen and 1.6 M ethereal methyllithium (56 mL, 0.09 mol) added. The mixture was stirred for 2 hours and methanol added to destroy any excess methyllithium. The reaction mixture was mixed with 2 N aqueous hydrochloric acid (400 mL) and stirred for 1 hour. The reaction mixture was then extracted with diethyl ether and the ether extracts washed with saturated sodium bicarbonate solution. The extracts were dried (Na.sub.2 SO.sub.4) and concentrated on a rotary evaporator. The crude oil was fractionally distilled to give 11.4 g of enone, bp 88.degree.-90.degree. C./1.5 mm, as a mixture of 2 isomers (glc/ms analysis).

IR (film): 1670, 1630, 915 cm.sup.-1 NMR (CDCL.sub.3): 1.05(3H,2d), 2.0(3H,d), 2.1-2.75 (6H,m), 5.1(2H,m), 5.75(1H,m), 5.85(1H,bs) .delta.. MS: 164(M+), 95, 79, 67, 93, 77

EXAMPLE 9

3,5-Dimethyl-4-(2-methyl-2-propenyl)-2-cyclohexen-1-one

Essentially the same process as Example 8 was employed.

Procedure A

The alkylation with methallyl chloride required overnight reaction at room temperature for completion. Purification was accomplished by initial short path distillation, followed by chromatography on 500 g of silica gel, eluting with hexaneethyl acetate 85:15. In this manner 12.5 g of 3-isopropoxy-5-methyl-6-(2-methyl-2-propenyl)-2-cyclohexen-1-one was obtained having the structure: ##STR37##

IR (film): 1660, 1620 cm.sup.-1 NMR (CDCl.sub.3): 1.05 (3H,2d), 1.3(6H,d,J=6 Hz), 1.75(3H,bs), 1.9-2.6(6H,m), 4.45(1H,h,J=6 Hz), 4.78(2H,m) 5.3(1H,s) .delta.. MS: 222(M+), 96, 84, 85, 165, 69

Procedure B

Treatment of 3-isopropoxy-5-methyl-6-(2-methyl-2-propenyl)-2-cyclohexen-1-one (5.6 g, 0.025 mol) with 1.6 M methyllithium (0.03 mol) in diethyl ether gave, after hydrolysis, 4.4 g of 3,5-dimethyl-4-(2-methyl-2-propenyl)-2-cyclohexen-1-one, bp 120.degree.-125.degree. C./1 mm, having the structure: ##STR38##

Again two isomers were present, as determined by glc/ms analysis.

IR (Film); 1670, 1620 cm.sup.-1 NMR (CDCl.sub.3): 1.02(3H,bd), 1.78(3H,bs), 2.0(3H,d), 2.1-2.8 (6H,m), 4.8(2H,m), 5.85(1H,bs) .delta.. MS: 178(M+), 95, 94, 122, 93, 79

EXAMPLE 10

3,5-Diemthyl-4-(2-butenyl)-2-cyclohexen-1-one

Prepared by the same process as Example 8.

Procedure A

Alkylation was accomplished with commercial crotyl chloride (contains 20% 3-chloro-1-butene) overnight at room temperature. Isolation and short path distillation afforded 14.1 g of a product which was 81% pure. Chromatography on 500 g of silica gel, eluting with hexane-ethyl acetate 80:20, gave 9.2 g of 3-isopropoxy-5-methyl-6-(2-butenyl)-2-cyclohexen-1-one having the structure: ##STR39##

IR: 1660, 1615 cm.sup.-1 NMR: 1.08(3H,bd), 1.3(6H,d,J=6 Hz), 1.65(3H,m), 1.8-2.7 (6H,m), 4.45 (1H,h,J=6 Hz), 5.35(1H,s), 5.45(2H,m) .delta.. MS: 222(M+), 84, 165, 111, 125, 69)

Procedure B

Treatment of the 3-isopropoxy-5-methyl-6-(2-butenyl)-2-cyclohexen-1-one (5.6 g, 0.025 mol) with 1.6 M methyllithium (0.03 mol) in diethyl ether gave after acid hydrolysis, 3.3 g of 3,5-dimethyl-4-(2-butenyl)-2-cyclohexen-1-one, bp 125.degree.-130.degree. C./1 mm, having the structure: ##STR40## Glc/ms analysis indicated the presence of four isomers (ratio 57:17:20:6).

IR (film): 1670, 1625, 970 cm.sup.-1 NMR (CDCl.sub.3): 1.05(3H,bd), 1.65(3H,m), 2.0(3H,d,J=1.5 Hz), 2.35(6H,m), 5.46(2H,m), 5.85(1H,bs) .delta.. MS (major isomer): 178(M+), 109, 124, 95, 79, 55

EXAMPLE 11

3,5-Dimethyl-4(3-methyl-2-butenyl)cyclohexanone

Reaction: ##STR41##

A solution of 3,5-dimethyl-4-(3-methyl-2-butenyl)-2-cyclohexen-1-one (8.2 g, 0.043 mol) in 0.3 M ethanolic KOH (16 mL) was hydrogenated at room temperature and 1 atmosphere over 5% palladium on carbon (0.8 g). After uptake of 1 equivalent of hydrogen, the solution was filtered through Celite and concentrated. The residue was partitioned between hexane and water; then the hexane layer was dried (Na.sub.2 SO.sub.4) and the solvent removed on a rotary evaporator. Kugelrohr distillation gave 7.3 g of 3,5-dimethyl-4-(3-methyl-2-butenyl) cyclohexanone, bp 115.degree. C./0.5 mm.

IR(film): 1720 cm.sup.-1 NMR(CDCl.sub.3): 1.0(6H, two overlapping d), 1.7(6H,2bs), 1.8-2.6(9H,m), 5.18(1H,m).delta.. MS: 194(M+), 69, 124, 55, 83, 82

EXAMPLE 12

3,5-Dimethyl-4-(3-methyl-2-butenyl)-cyclohexanol

Reaction: ##STR42##

A suspension of lithium aluminum hydride (0.68 g, 0.018 mol) is anhydrous diethyl ether (50 mL) was stirred under nitrogen at 10.degree. C. while 3,5-dimethyl-4-(3-methyl-2-butenyl) cyclohexanone (6.8 g, 0.035 mol) in anhydrous ether (15 mL) was added over a period of 30 minutes. The mixture was stirred at room temperature for 2 hours; then it was treated successively with H.sub.2 O (0.7 mL), 15% NaOH (0.7 mL), and H.sub.2 O (2.1 mL). The solution was filtered, dried (NaSO.sub.4), and concentrated to give the crude alcohol as a colorless oil. Kugelrohr distillation afforded 6.2 g of 3,5-dimethyl-4-(3-methyl-2-butenyl) cyclohexanol, bp 130.degree. C./0.3 mm.

IR(film): 3350 cm.sup.-1 NMR (CDCl.sub.3): 0.95 (6H, overlapping doublets), 1.3-2.4(16H, m with superimposed broadened absorptions at 1.65 and 1.7), 3.6(1H, m), 5.08(1H,M).delta.. MS: 196(M+), 109, 67, 69, 107, 83

EXAMPLE 13

3,5-Dimethyl-4-(3-methyl-2-butenyl)-2-cyclohexen-1-ol

Reaction: ##STR43##

A solution of 3,5-dimethyl-4-(3methyl-2-butenyl)-2-cyclohexen-1-one (4 g, 0.02 mol) in hexane (25 mL) was stirred under nitrogen at 0.degree. C. and 1 M diisobutylaluminum hydride (25 mL) was added dropwise over 30 minutes. The mixture was stirred for 2 hours and methanol (60 mL) added to precipitate the salts. The solution was filtered and washed with 15% hydrochloric acid, saturated sodium bicarbonate and brine. Drying (Na.sub.2 SO.sub.4), and solvent removal, followed by Kugelrohr distillation gave 3.8 g of 3,5-dimethyl-4-(3-methyl-2-butenyl)-2-cyclohexen-1-ol, bp 135.degree. -140.degree. C./0.5 mm.

IR(film): 3320, 1650 cm.sup.-1 NMR(CDCl.sub.3): 0.95(3H,2d), 1.65(6H,2bd), 1.7-2.6(7H,m), 4.1(1H,m), 5.0(1H,m), 5.5(1H,m).delta.. MS: (major isomer): 194(M+), 107, 133, 91, 109, 69.

EXAMPLE 14

A fougere type perfume composition was prepared by mixing the following:

______________________________________ %______________________________________Coumarin 5.0Musk Ambrette 5.0Musk aldehyde FDO 5.0Methylionone gamma 4.0Isoamyl salicylate 4.0Oil Galbanum 0.5Delta decalactone (1% in diethyl phthalate) 0.5Santol FDO 4.0Oil Patchouly 6.0Oakmoss absolute incolore 4.0Oil Neroli - Base 7.0Oil Geranium Maroc 10.0Phenylethyl alcohol 3.0Oil Bergamot 7.0Linalool synthetic 6.0Oil Lavender 50- 52% 10.0Eugenol extra 2.0Isoeugenol 1.0Benzyl benzoate 4.03,5-Dimethyl-4-(3-methyl-2-butenyl)-2- 12.0cyclohexen-1-ol 100.0______________________________________

EXAMPLE 15

A wood base was prepared by mixing the following:

______________________________________Coumarin 4.0Olibanum resinoid 2.0Oil Guaiacwood 4.0Methylionone gamma 8.0Santol FDO 2.0Para-tertiarybutylcyclohexyl acetate 2.0Isopropyl quinoline 10% 4.0Oil Patchouly 2.0Linalool synthetic 2.0Oil Bergamot terpeneless 4.0Oil Cedarwood 12.0Cedryl acetate 22.0Acetyl cedrene 24.03,5-Dimethyl-4-(3-methyl-2-butenyl)- 8.0cyclohexanone 100.0______________________________________

EXAMPLE 16

A floral bouquet was prepared by mixing the following:

______________________________________ %______________________________________Musk ketone 1.0Coumarin 1.0Methyl everninate 0.5Oakmoss absolute 0.5Geraniol 10.0Phenylethyl alcohol 16.0Citronellol 2.0Geranyl acetate 1.0Indole 10% 1.0Rose otto 3.0Rose oxide 10% 1.0Hydroxycitronellal 14.0Pentadecanolide 1.0Methyl dihydrojasmonate 10.0Hexyl cinnamic alcohol 10.0Benzyl acetate 1.0Oil Ylang extra 0.5Cinnamic alcohol 0.5Phenylethyl acetate 0.5Gamma undecalactone 10% 0.5Cyclamen aldehyde 0.5Ionone alpha 0.5Methylionone gamma 4.0Cedroxyde 4.0Acetyl cedrene 8.0Oil Bergamot rect. 3.03,5-Dimethyl-4-(3-methyl-2-butenyl) 5.0cyclohexanone 100.0______________________________________

EXAMPLE 17

A perfume composition was prepared by mixing the following:

______________________________________ %______________________________________Oakmoss absolute Yugoslav 4.0Coumarin 3.0Musk ketone 6.0Musk ambrette 2.0Ionone alpha 2.0Methylionone gamma 2.5Cinnamic alcohol 2.5Oil Sandalwood, East Indian 5.0Acetyl cedrene 7.5Oil Patchouly 1.0Amylcinnamic aldehyde 1.0Benzyl acetate 2.5Oil Olibanum 10% 1.0Heliotropin 1.0Oil Styrax 1.0Isoeugenol 0.5Hydroxycitronellal 0.5Ethyl vanillin 0.5Labdanum absolute 0.5Oil Lemon 1.0Oil Orange sweet Flor. 4.0Benzyl alcohol 2.0Phenylethyl alcohol 2.5Phenyl acetaldehyde 10% 1.0Rose absolute 2.5Oil Geranium 2.5Jasmin absolute, Italian 5.0Oil Neroli, Moroccan 0.5Aldehyde C 10 10% 1.0Aldehyde C 11 undecylenic 10% 4.0Aldehyde C 12 MNA 10% 2.0Oil Bergamot rect. 20.04-(3-Methyl-2-butenyl)-5-methyl-2- 8.0cyclohexen-1-one 100.0______________________________________

EXAMPLE 18

The following raspberry flavor was prepared

______________________________________Acetic acid 0.1Gamma undecalactone 0.1Benzyl acetate 0.1Oil Buchu 0.1Maltol 0.24-(p-Hydroxyphenyl)-2-butanone 1.0Ethyl acetate 3.0Ethyl butyrate 1.0Hexyl acetate 1.5Ionone beta 0.5Irone alpha, 1% in alcohol 0.7Hexanal 0.8Ethyl alcohol 90.9 100.0______________________________________

This formulation was added to water, sugar and acid at the level of 10 ppm, and 3,5-dimethyl-4-(3-methyl-2-butenyl)cyclohexanol was added at a concentration of 1 ppm. The flavor which contained the substituted cyclohexanol was much preferred over a control. It added a smooth, woody character to the formulation and produced a more natural raspberry flavor.

EXAMPLE 19

3,5-Dimethyl-4-(3-methyl-2-butenyl)cyclohexanone (alternate method)

Reaction: ##STR44##

Cuprous iodide (0.52 g, 0.003 mol) was added at -5.degree. C. to a Grignard solution prepared from magnesium (1.45 g, 0.06 mol) and methyl iodide (8.5 g, 0.06 mol) in anhydrous ether (30 mL) under nitrogen. The reaction mixture was stirred for 20 minutes and then 4-(3-methyl-2-butenyl)-5-methyl-2-cyclohexen-1-one (5.3 g, 0.03 mol, prepared according to Example 7) in ether (10 mL) was added dropwise. The mixture was stirred at 0.degree. C. for 2 hours and then quenched into saturated NH.sub.4 Cl solution (300 mL) which was made slightly basic by the addition of NH.sub.4 OH. The aqueous solution was extracted with ether, and the combined extracts washed with water and dried (Na.sub.2 SO.sub.4). Solvent removal and Kugelrohr distillation gave 4.7 g of ketone, bp 115.degree. C./0.5 mm.

Spectral data agreed with that reported for Example 7.

EXAMPLE 20

1,3,5-Trimethyl-4-(3-methyl-2-butenyl)-2-cyclohexen-1-ol

Reaction: ##STR45##

A solution of 3,5-dimethyl-4-(3-methyl-2-butenyl)-2-cyclohexen-1-one (2.9 g, 0.015 mol), prepared according to Example 4, in anhydrous tetrahydrofuran (20 mL), was cooled to 0.degree. C. under nitrogen and 1.6 M ethereal methyllithium (10 mL) added dropwise. The solution was allowed to warm to room temperature and stirred for 4 hours. The reaction mixture was poured into ammonium chloride solution and extracted with ether. The ether extracts were washed with water, brine and dried (Na.sub.2 SO.sub.4). Solvent removal and kugelrohr distillation (bath temperature 95.degree.-100.degree. C./0.1 mm) gave 2.8 g of the alcohol.

IR(film): 3400, 1665 cm.sup.-1. NMR(CDCl.sub.3): 1.05(3H,m), 1.25(3H,s), 1.55-2.65 (16H,m), 5.0(1H,m), 5.4(1H,m).delta.. MS: 190(M-18), 121, 105, 93, 147, 69.

EXAMPLE 21

A chypre type perfume composition was prepared by mixing the following:

______________________________________ %______________________________________Oil Angelica Root 0.5Castoreum absolute 0.5Oil Rose 1.0Civet absolute 1.0Oakmoss absolute 1.0Musk Ambretee 2.0Labdanum resinoid 3.0Oil Ylang extra 5.0Benzyl acetate 6.0Oil Sandalwood 7.0Vanillin 6.0Benzyl alcohol 9.0Jasmin extract 12.0Coumarin 12.0Phenylethyl alcohol 12.0Oil Bergamot 20.04-(3-Methyl-2-butenyl)-5-methyl-2- 2.0cyclohexen-1-one 100.0______________________________________

EXAMPLE 22

A lavender fragrance was prepared by mixing the following:

______________________________________ %______________________________________Oakmoss absolute 1.0Musk xylene 4.0Oil Rosemary 5.0Oil Petitgrain Paraguay 3.0Benzyl acetate 5.0Oil Bois de Rose 7.0Coumarin 10.0Terpinyl acetate 10.0Oil Spike Lavender 20.0Oil Lavandin 30.03-Ethyl-4-(3-methyl-2-butenyl)-5-methyl- 5.02-cyclohexen-1-one 100.0______________________________________

EXAMPLE 23

A jasmin fragrance was prepared by mixing the following:

______________________________________ %______________________________________Gamma undecalactone 0.5p-Cresyl phenylacetate 0.5Ethyl cinnamate 0.9Oil Ylang 7.0Geranyl acetate 6.0Amylcinnamic aldehyde 5.0Linalool synthetic 10.0Benzyl acetate 20.0Phenylethyl alcohol 20.0Hydroxycitronellal 30.03,5-Dimethyl-4-(2-butenyl)-2- 0.1cyclohexen-1-one 100.0______________________________________

EXAMPLE 24

An oil vetiver substitute was prepared by mixing the following:

______________________________________ %______________________________________Oil Patchouly 1.0Geraniol ex Palmarosa 1.0Ionone residue 3.0Oil Copaiba 12.0Cedryl acetate 13.0Oil Guaicwood 16.0Oil Cedarwood 15.0Terpineol 5.0Oil Bois de Rose 9.03,5-Dimethyl-4-(3-methyl-2-butenyl)- 25.0cyclohexanol 100.0______________________________________

EXAMPLE 25

Modification of an orange flavor:

______________________________________ %______________________________________Orange Oil Florida 96.73,5-Dimethyl-4-(3-methyl-2-butenyl)-2- 3.3cyclohexen-1-one 100.0______________________________________

This modified orange flavor was tested at the level of 30 ppm in a standard beverage medium consisting of sugar, acid and water. Whereas the straight orange oil at 30 ppm had the expected orange flavor, the modified flavor containing 3,5-dimethyl-4-(3-methyl-2-butenyl)-2-cyclohexen-1-one at the level of 1 ppm in the formulation was decidedly grapefruit in character.

EXAMPLE 26

The following cinnamon flavor compositions were prepared:

______________________________________ A(%) B(%)______________________________________Salicylic aldehyde 0.1 0.1Oil Ginger 0.3 0.3o-Methoxycinnamic aldehyde 0.1 0.1o-Methoxybenzaldehyde 0.1 0.1Methyl salicylate 0.5 0.5Terpineol alpha 2.0 2.0Eugenol 2.0 2.0Ionone beta 0.5 0.5Cinnamic aldehyde 91.1 94.43,5-Dimethyl-4-(3-methyl-2-butenyl) 3.3 0.0cyclohexanone 100.0 100.0______________________________________

The above cinnamon flavor formulations were tasted at a level of 30 ppm. Composition A which contained 3,5-dimethyl-4-(3-methyl-2-butenyl)cyclohexanone successfully reduced the harshness of the cinnamic aldehyde. It resulted in a softer, more natural flavor.

EXAMPLE 27

The following grape base was prepared:

______________________________________ %______________________________________Gamma undecalactone 0.2Ionone beta 0.8Ethyl oenanthate 1.0Ethyl methylphenylglycidate 1.0Cinnamic alcohol 3.0Methylnaphthyl ketone 3.0Methyl anthranilate 35.0Ethyl acetate 56.0 100.0______________________________________

The above grape flavor was tasted at 30 ppm in a beverage base (sugar, water and acid). Then 3,5-dimethyl-4-(3-methyl-2-butenyl)-2-cyclohexen-1-one was added at the level of 1 ppm. The flavor developed by the grape base containing the added ketone was much preferred. The harsh acidic taste of the base was subdued and overall resulted in a better Concord flavor.

EXAMPLE 28

A fougere type perfume composition was prepared by mixing the following:

______________________________________ %______________________________________Coumarin 3.0Musk ketone 4.0Musk ambrette 6.0Isoamyl salicylate 8.0Vanillin from lignin 2.0Oil Geranium Maroc 3.0Oil Patchouly 3.0Phenylethyl alcohol 3.0Geraniol 6.0Oil Bergamot 10.0Heliotropin 3.0Oakmoss absolute incolore 2.0Anisic aldehyde 1.0Santol FDO 2.0Oil Lavender 50- 52% 8.0Linalool synthetic 7.0Eugenol extra 2.0Oil Lemon Italian 10.0Lilial 6.0Benzyl benzoate 8.03,5-Dimethyl-4-(3-methyl-2-butenyl)-2- 3.0cyclohexen-1-one 100.0______________________________________

EXAMPLE 29

A violet perfume composition was prepared by mixing the following:

______________________________________ %______________________________________Musk ambrette 0.6Jasmine absolute 0.3Violet leaves absolute 0.1Heliotropin 1.0Methylionone 3.0Benzoin Siam 2.0Oil Cedarwood 20.0Oil Sandalwood 30.0Oil Orris Root 40.03,5-Dimethyl-4-(3-methyl-2-butenyl) 3.0cyclohexanol 100.0______________________________________

EXAMPLE 30

A fougere type perfume composition was prepared by mixing the following:

______________________________________ %______________________________________Undecyclenic aldehyde 0.2Civet absolute 0.3Vanillin 0.5Rose Otto 0.5Acetophenone 0.5Anisic aldehyde 1.0Oil Clary Sage 1.0Isoamyl salicylate 2.0Oil Patchouly 2.0Jasmin absolute 3.0Oil Sandalwood 3.0Linalool synthetic 4.0Courmarin 7.0Benzyl acetate 10.0Oil Bois de Rose 10.0Oil Lavender 20.0Oil Bergamot rectified 30.01,3,5-Trimethyl-4-(3-methyl-2-butenyl)- 5.02-cyclohexen-1-ol 100.0______________________________________

EXAMPLE 31

Tobacco flavor composition

A 1% ethanol solution of 3,5-dimethyl-4-(3-methyl-2-butenyl)-2-cyclohexen-1-one was sprayed on smoking tobacco in an amount sufficient to provide a tobacco composition containing 70 ppm of the flavor additive on a dry basis.

To provide a flavored tobacco which also contained synthetic tobacco, the procedure for the production of a tobacco flavor composition heretofore described in this Example was repeated, except that a synthetic tobacco such as cellulose fibers, for example "CYTREL" (a trademark of the Celenese Chemical Corporation) or "POLYSTREP" (a trademark of Imperial Chemical Corporation) was mixed with the tobacco in a ratio of approximately 1 to 1 by weight.

In a third procedure, a 1% ethanol solution of 3,5-dimethyl-4-(3-methyl-2-butenyl)-2-cyclohexen-1-one was sprayed on synthetic tobacco at the level of 70 ppm on a dry weight basis.

Tobacco flavor compositions prepared by any of the above methods may then be used in the manufacture of cigarettes.

In a panel evaluation against control cigarettes the taste of the flavored cigarettes was described as "light" and woody in character.

EXAMPLE 32

Tobacco flavor composition

A 1% ethanol solution of 3,5-dimethyl-4-(3-methyl-2-butenyl) cyclohexanone was employed at the level of 60 ppm in a similar manner to that described in Example 31.

The taste, as evaluated in cigarettes, was described as possessing a floral and woody character.

EXAMPLE 33

Tobacco flavor composition

By replacing the ketone in Example 31 with 4-(3-methyl-2-butenyl)-5-methyl-2-cyclohexen-1-one at the level of 30 ppm, the taste had a strong cedar character.

Claims

1. A smoking composition comprising a smoking material and at least 0.0001% by weight of one or more of the substituted cyclic compounds having the structure: ##STR46## wherein the dotted line may be a carbon-carbon double bond or a carbon-carbon single bond; wherein each of R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.5, R.sub.6 and R.sub.7 may be hydrogen or lower alkyl; wherein Z may be any of the following: ##STR47## wherein R.sub.9 is hydrogen or lower alkyl; and wherein R.sub.10 and R.sub.11 are lower alkyl.