Claims
- 1. A compound of Formula I ##STR66## wherein R is --OR.sup.3, wherein R.sup.3 is hydrogen, lower alkyl, cycloalkyl of from three- to seven-member saturated hydrocarbon ring, cycloalkylalkyl wherein the cycloalkyl group is as defined above and the attached alkyl group is from one- to six-carbon atoms, phenyl lower alkyl, phenyl lower alkyl substituted by one to four substituents selected from the group consisting of lower alkyl, lower alkoxy, lower thioalkoxy, halogen and trifluoromethyl, lower alkanoyl, phenylcarbonyl, phenylcarbonyl substituted by one to four substituents selected from the group consisting of lower alkyl, lower alkoxy, lower thioalkoxy, halogen and trifluoromethyl, or phenyl lower alkanoyl, phenyl lower alkanoyl substituted by one to four substituents selected from the group consisting of lower alkyl, lower alkoxy, lower thioalkoxy and trifluoromethyl, ##STR67## wherein R.sup.4 and R.sup.5 are each independently hydrogen, lower alkyl, cycloalkyl of from three- to seven-member saturated hydrocarbon ring, cycloalkylalkyl wherein the cycloalkyl group is as defined above and the attached alkyl group is from one- to six-carbon atoms, phenyl, phenyl substituted by one to four substituents selected from the group consisting of lower alkyl, lower alkoxy, lower thioalkoxy, halogen and trifluoromethyl, 2-, 3-, or 4-pyridinyl, 2-, 3-, or 4-pyridinyl substituted by lower alkyl, lower alkoxy, or halogen, 2-, 4-, or 5-pyrimidinyl, 2-, 4-, or 5-pyrimidinyl substituted by lower alkyl, lower alkoxy, or halogen, 2-pyrazinyl, 2-pyrazinyl substituted by lower alkyl, lower alkoxy, or halogen, 2- or 3-thienyl, 2- or 3-thienyl substituted by lower alkyl or halogen, 2- or 3-furanyl, 2- or 3-furanyl substituted by lower alkyl or halogen, 2-, 4-, or 5, thiazolyl, 2-, 4-, or 5-thiazolyl substituted by lower alkyl or halogen, phenyl lower alkyl, phenyl lower alkyl substituted by one to four substituents selected from the group consisting of lower alkyl, lower alkoxy, lower thioalkoxy, halogen and trifluoromethyl, 2-, 3-, or 4-pyridinyl lower alkyl, 2-3-, or 4-pyridinyl lower alkyl substituted by lower alkyl, lower alkoxy, or halogen, 2-, 4-, or 5-pyrimidinyl lower alkyl, 2-, 4-, or 5-pyrimidinyl lower alkyl substituted by lower alkyl, lower alkoxy, or halogen, 2-pyrazinyl lower alkyl, 2-pyrazinyl lower alkyl substituted by lower alkyl, lower alkoxy or halogen, 2- or 3-thienyl lower alkyl, 2- or 3-thienyl lower alkyl substituted by lower alkyl or halogen, 2- or 3-furanyl lower alkyl, 2- or 3-furanyl lower alkyl substituted by lower alkyl or halogen, 2-, 4-, or 5-thiazolyl lower alkyl, 2-, 4-, or 5-thiazolyl lower alkyl substituted by lower alkyl or halogen, lower alkyanoyl, cycloalkanoyl, cycloalkylalkanoyl, phenyl lower alkanoyl, phenyl lower alkanoyl substituted by one to four substituents selected from the group consisting of lower alkyl, lower alkoxy, lower thioalkoxy and trifluoromethyl, 2-, 3-, or 4-pyridinyl lower alkanoyl, 2-, 3-, or 4-pyridinyl lower alkanoyl substituted by lower alkyl, lower alkoxy, or halogen, 2-, 4-, or 5-pyrimidinyl lower alkanoyl, 2-, 4-, or 5-pyrimidinyl lower alkanoyl substituted by lower alkyl, lower alkoxy, or halogen, 2-pyrazinyl lower alkanoyl, 2-pyrazinyl lower alkanoyl substituted by lower alkyl, lower alkoxy or halogen, 2- or 3-thienyl lower alkanoyl, 2- or 3-thienyl lower alkanoyl substituted by lower alkyl or halogen, 2- or 3-furanyl lower alkanoyl, 2- or 3-furanyl lower alkanoyl substituted by lower alkyl or halogen, 2-, 4-, or 5-thiazolyl lower alkanoyl, 2-, 4-, or 5-thiazolyl lower alkanoyl substituted by lower alkyl or halogen, phenylcarbonyl, phenylcarbonyl substituted by one to four substituents selected from the group consisting of lower alkyl, lower alkoxy, lower thioalkoxy, halogen and trifluoromethyl, 2-, 3-, or 4-pyridinylcarbonyl substituted by lower alkyl, lower alkoxy, or halogen, 2-, 4-, or 5-pyrimidinylcarbonyl, 2-, 4-, or 5-pyrimidinylcarbonyl substituted by lower alkyl, lower alkoxy, or halogen, 2-pyrazinylcarbonyl, 2-pyrazinylcarbonyl substituted by lower alkyl, lower alkoxy, or halogen, 2- or 3-thienylcarbonyl, 2- or 3-thienylcarbonyl substituted by lower alkyl or halogen, 2- or 3-furanylcarbonyl, 2- or 3-furanylcarbonyl substituted by lower alkyl or halogen, 2-, 4-, or 5-thiazolylcarbonyl, 2-, 4-, or 5-thiazolylcarbonyl substituted by lower alkyl or halogen, or R.sup.4 and R.sup.5 are taken together with the nitrogen atom to which they are attached to form a ring denoted by ##STR68## wherein p is zero or an integer from 1 to 4 and R.sup.6 is hydrogen, lower alkyl, cycloalkyl of from three- to seven-member saturated hydrocarbon ring, cycloalkylalkyl wherein the cycloalkyl group is as defined above and the attached alkyl group is from one- to six-carbon atoms, ##STR69## wherein X is oxygen or sulfur or ##STR70## wherein R.sup.6 is as defined above, or ##STR71## wherein R.sup.4 and R.sup.5 are each independently hydrogen, lower alkyl, cycloalkyl of from three- to seven-member saturated hydrocarbon ring, cycloalkylalkyl wherein the cycloalkyl group is as defined above and the attached alkyl group is from one- to six-carbon atoms, phenyl, phenyl substituted by one to four substituents selected from the group consisting of lower alkyl, lower alkoxy, lower thioalkoxy, halogen and trifluoromethyl, phenyl lower alkyl, phenyl lower alkyl substituted by one to four substituents selected from the group consisting of lower alkyl, lower alkoxy, lower thioalkoxy, halogen and trifluoromethyl, lower alkanoyl, phenyl lower alkanoyl, phenyl lower alkanoyl substituted by one to four substituents selected from the group consisting of lower alkyl, lower alkoxy, lower thioalkoxy and trifluoromethyl, phenylcarbonyl, phenylcarbonyl substituted by one to four substituents selected from the group consisting of lower alkyl, lower alkoxy, lower thioalkoxy, halogen and trifluoromethyl, or R.sup.4 and R.sup.5 are taken together with the oxygen and nitrogen atoms to which they are attached to form a ring denoted by ##STR72## wherein q is an integer from 2 to 3 and R.sup.6 is as defined above; m is zero or an integer from 1 to 2;
- R.sup.1 is hydrogen; or when R is --OR.sup.3 wherein R.sup.3 is cycloalkyl of from three- to seven-member saturated hydrocarbon ring or cycloalkylalkyl wherein the cycloalkyl group is as defined above and the attached alkyl group is from one- to six-carbon atoms, ##STR73## wherein R.sup.4 and R.sup.5 are each independently cycloalkyl of from three- to seven-member saturated hydrocarbon ring, cycloalkylalkyl wherein the cycloalkyl group is as defined above and the attached alkyl group is from one- to six-carbon atoms, 2-, 3-, or 4-pyridinyl, 2-, 3-, or 4-pyridinyl substituted by lower alkyl, lower alkoxy, or halogen, 2-, 4-, or 5-pyrimidinyl, 2-, 4-, or 5-pyrimidinyl substituted by lower alkyl, lower alkoxy, or halogen, 2-pyrazinyl, 2-pyrazinyl substituted by lower alkyl, lower alkoxy, or halogen, 2- or 3-thienyl, 2- or 3-thienyl substituted by lower alkyl or halogen, 2- or 3- furanyl, 2- or 3-furanyl substituted by lower alkyl or halogen, 2-, 4-, or 5-thiazolyl, 2-, 4-, or 5-thiazolyl substituted by lower alkyl or halogen, 2-, 3-, or 4-pyridinyl lower alkyl, 2-, 3-, or 4-pyridinyl lower alkyl substituted by lower alkyl, lower alkoxy, or halogen, 2-, 4-, or 5-pyrimidinyl lower alkyl, 2-, 4-, or 5-pyrimidinyl lower alkyl substituted by lower alkyl, lower alkoxy, or halogen, 2-pyrazinyl lower alkyl, 2-pyrazinyl lower alkyl substituted by lower alkyl, lower alkoxy, or halogen, 2- or 3-thienyl lower alkyl, 2- or 3-thienyl lower alkyl substituted by lower alkyl or halogen, 2- or 3-furanyl lower alkyl, 2- or 3-furanyl lower alkyl substituted by lower alkyl or halogen, 2-, 4-, or 5-thiazolyl lower alkyl, 2-, 4-, or 5-thiazolyl lower alkyl substituted by lower alkyl or halogen, cycloalkanoyl, cycloalkylalkanoyl, 2-, 3-, or 4-pyridinyl lower alkanoyl, 2-, 3-, or 4-pyridinyl lower alkanoyl substituted by lower alkyl, lower alkoxy, or halogen, 2-, 4-, or 5-pyrimidinyl lower alkanoyl, 2-, 4-, or 5-pyrimidinyl lower alkanoyl substituted by lower alkyl, lower alkoxy, or halogen, 2-pyrazinyl lower alkanoyl, 2-pyrazinyl lower alkanoyl substituted by lower alkyl, lower alkoxy or halogen, 2- or 3-thienyl lower alkanoyl, 2- or 3-thienyl lower alkanoyl substituted by lower alkyl or halogen, 2- or 3-furanyl lower alkanoyl, 2- or 3-furanyl lower alkanoyl substituted by lower alkyl or halogen, 2-, 4-, or 5-thiazolyl lower alkanoyl, 2-, 4-, or 5-thiazolyl lower alkanoyl substituted by lower alkyl or halogen, 2-, 3-, or 4-pyridinylcarbonyl, 2-, 3-, or 4-pyridinylcarbonyl substituted by lower alkyl, lower alkoxy, or halogen, 2-, 4-, or 5-pyrimidinylcarbonyl, 2-, 4-, or 5-pyrimidinylcarbonyl substituted by lower alkyl, lower alkoxy, or halogen, 2-pyrazinylcarbonyl, 2-pyrazinylcarbonyl substituted by lower alkyl, lower alkoxy, or halogen, 2- or 3-thienylcarbonyl, 2- or 3-thienylcarbonyl substituted by lower alkyl or halogen, 2- or 3-furanylcarbonyl, 2- or 3-furanylcarbonyl substituted by lower alkyl or halogen, 2-, 4-, or 5-thiazolylcarbonyl, 2-, 4-, or 5-thiazolylcarbonyl substituted by lower alkyl or halogen, or R.sup.4 and R.sup.5 are taken together with the nitrogen atom to which they are attached to form a ring denoted by ##STR74## wherein p is zero or an integer from 1 to 4 and R.sup.6 is cycloalkyl of from three- to seven-member saturated hydrocarbon ring, cycloalkylalkyl wherein the cycloalkyl group is as defined above and the attached alkyl group is from one- to six-carbon atoms, or ##STR75## wherein R.sup.6 is as defined above, or ##STR76## wherein R.sup.4 and R.sup.5 are each independently cycloalkyl of from three- to seven-member saturated hydrocarbon ring or cycloalkylalkyl wherein the cycloalkyl group is as defined above and the attached alkyl group is from one- to six-carbon atoms, or R.sup.4 and R.sup.5 are taken together with the oxygen and nitrogen atoms to which they are attached to form a ring denoted by ##STR77## wherein q is an integer from 2 to 3 and R.sup.6 is cycloalkyl of from three- to seven-member saturated hydrocarbon ring, or cycloalkylalkyl wherein the cycloalkyl group is as defined above and the attached alkyl group is from one- to six-carbon atoms
- R.sup.1 is additionally phenyl, phenyl substituted by one to four substituents selected from the group consisting of lower alkyl, lower alkoxy, lower thioalkoxy, halogen and trifluoromethyl, 2-, 3-, or 4-pyridinyl or 2-, 3-, or 4-pyridinyl substituted by lower alkyl, lower alkoxy, or halogen, 2-, 4-, or 5-, pyrimidinyl or 2-, 4-, or 5-pyrimidinyl substituted by lower alkyl, lower alkoxy, or halogen, 2-pyrazinyl or 2-pyrazinyl substituted by lower alkyl, lower alkoxy, or halogen, 2- or 3-thienyl or 2- or 3-thienyl substituted by lower alkyl or halogen, 2- or 3-furanyl or 2- or 3-furanyl substituted by lower alkyl or halogen, 2-, 4, or 5-thiazolyl or 2-, 4-, or 5-thiazolyl substituted by lower alkyl or halogen;
- n is zero or an integer from 1 to 4;
- R.sup.2 is ##STR78## wherein R.sup.7 is phenyl, phenyl substituted by one to four substituents selected from the group consisting of lower alkyl, lower alkoxy, lower thioalkoxy, halogen and trifluoromethyl. 2-, 3-, or 4-pyridinyl or 2-, 3-, or 4-pyridinyl substituted by lower alkyl, lower alkoxy, or halogen, 2-, 4-, or 5-pyrimidinyl or 2-, 4-, or 5-pyrimidinyl substituted by lower alkyl, lower alkoxy, or halogen, 2-pyrazinyl or 2-pyrazinyl substituted by lower alkyl, lower alkoxy, or halogen, 2-, or 3-thienyl or 2- or 3-thienyl substituted by lower alkyl or halogen, 2- or 3-furanyl or 2- or 3-furanyl substituted by lower alkyl or halogen, 2-, 4-, or 5-thiazolyl or 2-, 4-, or 5-thiazolyl substituted by lower alkyl or halogen; and the corresponding cis and trans isomers thereof; or a pharmaceutically acceptable acid addition salt thereof.
- 2. A compound according to claim 1, in which R is --OR.sup.3, wherein R.sup.3 is hydrogen or lower alkanoyl ##STR79## wherein R.sup.4 is hydrogen, cycloalkyl of from three- to seven-member saturated hydrocarbon ring, cycloalkylalkyl wherein the cycloalkyl group is as defined above and the attached alkyl group is from one- to six-carbon atoms, lower alkanoyl, phenylcarbonyl, phenylcarbonyl substituted by one to four substituents selected from the group consisting of lower alkyl, lower alkoxy, lower thioalkoxy, halogen and trifluoromethyl, phenyl lower alkanoyl, phenyl lower alkanoyl substituted by one to four substituents selected from the group consisting of lower alkyl, lower alkoxy, lower thioalkoxy and trifluoromethyl, or 2-, 3-, or 4-pyridinylcarbonyl, 2-, 3-, or 4-pyridinylcarbonyl substituted by lower alkyl, lower alkoxy, or halogen, 2-, 4-, or 5-pyrimidinylcarbonyl, 2-, 4-, or 5-pyrimidinylcarbonyl substituted by lower alkyl, lower alkoxy, or halogen, 2-pyrazinylcarbonyl, 2-pyrazinylcarbonyl substituted by lower alkyl, lower alkoxy, or halogen, b 2- or 3-thienylcarbonyl, 2- or 3-thienylcarbonyl substituted by lower alkyl or halogen, 2- or 3-furanylcarbonyl, 2- or 3-furanylcarbonyl substituted by lower alkyl or halogen, 2-, 4-, or 5-thiazolylcarbonyl, 2-, 4-, or 5-thiazolylcarbonyl substituted by lower alkyl or halogen and R.sup.5 is hydrogen or lower alkyl or; ##STR80## wherein one of R.sup.4 or R.sup.5 is hydrogen and the other is hydrogen, lower alkyl, cycloalkyl of from three- to seven-member saturated hydrocarbon ring, cycloalkylalkyl wherein the cycloalkyl group is as defined above and the attached alkyl group is from one- to six-carbon atoms, phenyl, phenyl substituted by one to four substituents selected from the group consisting of lower alkyl, lower alkoxy, lower thioalkoxy, halogen and trifluoromethyl, or lower alkanoyl;
- m is zero;
- R.sup.1 is hydrogen;
- n is zero or an integer from 1 to 3; and
- R.sup.2 is ##STR81## wherein R.sup.7 is phenyl, phenyl substituted by para lower alkyl, para lower alkoxy, para lower thioalkoxy, or para halogen, 2-, 3-, or 4-pyridinyl, 2- or 3-furanyl, 2- or 3-thienyl, 2-, 4-, or 5-thiazolyl, or 2-, 4-, or 5-pyrimidinyl.
- 3. A compound according to claim 2, in which R is --OH, ##STR82## wherein R.sup.4 is hydrogen, cycloalkyl of from three- to seven-member saturated hydrocarbon ring, cycloalkylalkyl wherein the cycloalkyl group is as defined above and the attached alkyl group is from one- to six-carbon atoms, lower alkanoyl, phenylcarbonyl, phenylcarbonyl substituted by one to four substituents selected from the group consisting of lower alkyl, lower alkoxy, lower thioalkoxy, halogen and trifluoromethyl or 2-, 3-, or 4-pyridinylcarbonyl, 2-, 3-, or 4-pyridinylcarbonyl substituted by lower alkyl, lower alkoxy, or halogen, 2-, 4-, or 5-pyrimidinylcarbonyl, 2-, 4-, or 5-pyrimidinylcarbonyl substituted by lower alkyl, lower alkoxy, or halogen, 2-pyrazinylcarbonyl, 2-pyrazinylcarbonyl substituted by lower alkyl, lower alkoxy, or halogen, 2- or 3-thienylcarbonyl, 2- or 3-thienylcarbonyl substituted by lower alkyl or halogen, 2- or 3-furanylcarbonyl, 2- or 3-furanylcarbonyl substituted by lower alkyl or halogen, 2-, 4-, or 5-thiazolylcarbonyl, 2-, 4-, or 5-thiazolylcarbonyl substituted by lower alkyl or halogen and R.sup.5 is hydrogen or lower alkyl; or ##STR83## wherein R.sup.4 is hydrogen, lower alkyl, cycloalkyl of from three- to seven-member saturated hydrocarbon ring, cycloalkylalkyl wherein the cycloalkyl group is as defined above and the attached alkyl group is from one- to six-carbon atoms, phenyl, phenyl substituted by one to four substituents selected from the group consisting of lower alkyl, lower alkoxy, lower thioalkoxy, halogen and trifluoromethyl, or lower alkanoyl;
- m is zero;
- R.sup.1 is hydrogen;
- n is zero or an integer from 1 to 2; and
- R.sup.2 is ##STR84## wherein R.sup.7 is hydrogen, phenyl, phenyl substituted by para lower alkyl or para halogen, 2-, 3-, or 4-pyridinyl, 2- or 3-thienyl, 2-, 4-, or 5-thiazolyl, or 2-, 4-, or 5-pyrimidinyl.
- 4. A compound according to claim 3 selected from the group consisting of
- trans N-[4-[4-(2-Pyridinyl)-1-piperazinyl]cyclohexyl]benzamide;
- trans N-[4-[4-(2-Pyridinyl)-1-piperazinyl]cyclohexyl]-2-methoxybenzamide;
- trans N-Methyl-N-[4-[4-(2-pyridinyl)-1-piperazinyl]cyclohexyl]benzamide;
- trans 4-Chloro-N-[4-[4-(2-pyridinyl)-1-piperazinyl]cyclohexyl]benzamide;
- trans N-[4-[4-(2-Pyridinyl)-1-piperazinyl]cyclohexyl]-2-thiophenecarboxamide;
- trans N-[4-[4-(2-Pyridinyl)-1-piperazinyl]cyclohexyl]-3-thiophenecarboxamide;
- trans N-[4-(3,6-Dihydro-4-phenyl-1(2H)-pyridinyl)cyclohexyl]benzamide;
- trans N-[4-(3,6-Dihydro-4-phenyl-1(2H)-pyridinyl)cyclohexyl]-2-thiophenecarboxamide;
- trans N-[4-(3,6-Dihydro-4-phenyl-1(2H)-pyridinyl)cyclohexyl]-3-thiophenecarboxamide;
- trans N-[4-(3,6-Dihydro-4-phenyl-1(2H)-pyridinyl)cyclohexyl]-3-pyridinecarboxamide;
- trans N-[4-(3,6-Dihydro-4-phenyl-1(2H)-pyridinyl)cyclohexyl]cyclohexanecarboxamide;
- trans 4-Methyl-N-[4-[4-(2-pyridinyl)-1-piperazinyl]cyclohexyl]benzamide;
- trans N-[4-[2-[4-(2-Pyridinyl)-1-piperazinyl]ethyl]cyclohexyl]benzamide;
- cis N-[4-[2-[4-(2-Pyridinyl)-1-piperazinyl]ethyl]cyclohexyl]benzamide;
- trans 4-Methyl-N-[4-[2-[4-(2pyridinyl)-1-piperazinyl]ethyl]cyclohexyl]benzamide;
- cis 4-Methyl-N-[4-[2-[4-(2-pyridinyl)-1-piperazinyl]ethyl]cyclohexyl]benzamide
- cis 4-Chloro-N-[4-[2-[4-(2pyridinyl)-1piperazinyl]ethyl]cyclohexyl]benzamide;
- trans 4-Chloro-N-[4-[2-[4-(2-pyridinyl)-1-piperazinyl]ethyl]cyclohexyl]benzamide;
- trans N-[4-[2-[4-(2-Pyridinyl)-1-piperazinyl]ethyl]cyclohexyl]acetamide;
- trans 3,4-Dichloro-N-[4-[2-[4-(2-pyridinyl)-1-piperazinyl]ethyl]cyclohexyl]benzamide;
- trans N-[4-]]4-(2-Pyridinyl)-1-piperazinyl]methyl]cyclohexyl]benzamide;
- cis 3,4-Dichloro-N-[4-[2-[4-(2-pyridinyl)-1-piperazinyl]ethyl]cyclohexyl]benzamide;
- trans -4-Chloro-N-[4-(3,6-dihydro-4-phenyl)-1(2H)-pyridinyl)cyclohexyl]benzamide;
- trans N-[4-(3,6-Dihydro-4-phenyl-1(2H)-pyridinyl)cyclohexyl]-4-fluorobenzamide;
- trans N-[4-]]4-(2-Pyridinyl)-1-piperazinyl]methyl]cyclohexyl]-3-thiophenecarboxamide;
- trans 4-Methoxy-N-[4-[2-[4-(2-pyridinyl)-1-piperazinyl]ethyl]cyclohexyl]benzamide;
- cis N-[4-[2-[4-(2-Pyridinyl)-1-piperazinyl]ethyl]cyclohexyl]-3-thiophenecarboxamide;
- cis N-[4-[2-[4-(2-Pyridinyl)-1-piperazinyl]ethyl]cyclohexyl]- 2-furancarboxamide;
- cis 4-Methoxy-N-[4-[2-[4-(2-pyridinyl)-1-piperazinyl]ethyl]cyclohexyl]benzamide;
- cis N-[4-[2-[(3,6-Dihydro-4-phenyl-1(2H)-pyridinyl)ethyl]cyclohexyl]benzamide;
- cis N-[4-[2-(3,6-Dihydro-4-phenyl-1(2H)-pyridinyl)ethyl]cyclohexyl]-2-thiophenecarboxamide;
- trans N-[4-[2-(3,6-Dihydro-4-phenyl-1(2H)-pyridinyl)ethyl]cyclohexyl]-2-thiophenecarboxamide;
- trans N-[4-[2-(3,6-Dihydro-4-phenyl-1(2H)-pyridinyl)ethyl]cyclohexyl]benzamide;
- trans N-[4-[2-[4-(2-Pyridinyl)-1-piperazinyl]ethyl]cyclohexyl]-2-ethyl]cyclohexyl]-2-thiophenecarboxamide; and
- cis N-[4-[2-[4-(2-Pyridinyl)-1-piperazinyl]ethyl]cyclohexyl]-2-thiophenecarboxamide.
- 5. A method of treating schizophrenia comprising administering to a host suffering therefrom a therapeutic effective amount of a compound according to claim 1 in unit dosage form.
- 6. A method of treating depression comprising administering to a host suffering therefrom a therapeutic effective amount of a compound according to claim 1 in unit dosage form.
- 7. A pharmaceutical composition adapted for administration as a dopaminergic, antipsychotic, antihypertensive or antidepressant agent comprising a therapeutic effective amount of a compound according to claim 1 in admixture with a pharmaceutically acceptable excipient, diluent or carrier.
Parent Case Info
This is a continuation-in-part of U.S. application Ser. No. 446,901, filed Dec. 6, 1989, which application issued Sept. 18, 1990, as U.S. Pat. No. 4,957,921.
US Referenced Citations (1)
Number |
Name |
Date |
Kind |
4329353 |
Stokbroekx et al. |
May 1982 |
|
Foreign Referenced Citations (1)
Number |
Date |
Country |
790836 |
Apr 1973 |
BEX |
Continuation in Parts (1)
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Number |
Date |
Country |
Parent |
446901 |
Dec 1989 |
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