Claims
- 1. A compound of the formula ##STR40## wherein A is an oxygen or sulfur atom; B is a straight chain alkylene group of 3 to 8 carbon atoms or ##STR41## wherein R is hydrogen, halogen, lower alkyl or lower alkoxy; and D is carboxy or tetrazolyl; with the proviso that when A is sulfur, B is ##STR42## and, with the further proviso that when A is oxygen, D is tetrazolyl; or a derivative of a compound wherein D is carboxy selected from the group consisting of a lower alkyl ester, a (lower)alkylamino(lower)alkyl ester, a pharmaceutically acceptable lower(alkyl)amino(lower)alkyl ester acid addition salt, or a pharmaceutically acceptable carboxylate salt; or a derivative of a compound wherein D is tetrazolyl selected from a pharmaceutically acceptable alkali metal or alkaline earth salt of the tetrazolyl moiety.
- 2. A compound according to claim 1, wherein A is an oxygen atom.
- 3. A compound according to claim 2, wherein B is said alkylene group.
- 4. A compound according to claim 2, wherein B is said ##STR43## group.
- 5. 5-[4-(3,5-di-t-butyl-4-hydroxyphenoxymethyl)phenyl]tetrazole or a pharmaceutically acceptable alkali metal or alkaline earth salt thereof according to claim 1.
- 6. 5-[6-(3,5-di-t-butyl-4-hydroxyphenoxy)hexyl]tetrazole or a pharmaceutically acceptable alkali metal or alkaline earth salt thereof according to claim 1.
- 7. 5-[2-(3,5-di-t-butyl-4-hydroxyphenoxymethyl) phenyl]tetrazole or a pharmaceutically acceptable alkali metal or alkaline earth salt thereof according to claim 1.
- 8. 5-[3-(3,5-di-t-butyl-4-hydroxyphenoxy)propyl]tetrazole or a pharmaceutically acceptable alkali metal or alkaline earth salt thereof according to claim 1.
- 9. 5-[3-(3,5-di-t-butyl-4-hydroxy-phenoxymethyl) phenyl]tetrazole or a pharmaceutically acceptable alkali metal or alkaline earth salt thereof according to claim 1.
- 10. 5-[5-(3,5-di-t-butyl-4-hydroxy)pentyl]tetrazole or a pharmaceutically acceptable alkali metal or alkaline earth salt thereof according to claim 1.
- 11. 5-[4-(3,5-di-t-butyl-4-hydroxyphenoxy)-butyl]tetrazole or a pharmaceutically acceptable alkali metal alkaline earth salt thereof according to claim 1.
- 12. A compound according to claim 1, wherein A is a sulfur atom.
- 13. A compound according to claim 12, wherein D is carboxy.
- 14. A compound according to claim 12, wherein D is tetrazolyl.
- 15. 5-[4(3,5-di-t-butyl-4-hydroxyphenylthio)methylphenyl]tetrazole or a pharmaceutically acceptable alkali metal or alkaline earth salt thereof according to claim 1.
- 16. 5-[3-(3,5-di-t-butyl-4-hydroxyphenylthiomethyl)phenyl]tetrazole or a pharmaceutically acceptable alkali metal or alkaline earth salt thereof according to claim 1.
- 17. 4-(3,5-di-t-butyl-4-hydroxyphenylthiomethyl)benzoic acid or a said derivative thereof according to claim 1.
- 18. An antiallergic pharmaceutical composition comprising a compound according to claim 1 and a pharmaceutically acceptable vehicle, said compound being present in an amount effective to inhibit an allergic condition.
- 19. An antiallergic pharmaceutical composition according to claim 18, wherein A of said compound is an oxygen atom.
- 20. An antiallergic pharmaceutical composition according to claim 18, wherein A of said compound is a sulfur atom.
- 21. A method for inhibiting bronchoconstriction in a mammal wherein a compound according to claim 1 is administered to said mammal in an amount sufficient to inhibit bronchoconstriction.
- 22. A method according to claim 21, wherein said compound is administered orally.
- 23. A method for inhibiting leukotriene biosynthesis in a mammal comprising administering to said mammal a compound according to claim 1 in an amount effective to inhibit said biosynthesis.
CROSS REFERENCE TO RELATED APPLICATION
This application is a continuation-in-part of copending application Ser. No. 120,468 which was filed Nov. 13, 1987, abandoned.
US Referenced Citations (5)
Foreign Referenced Citations (6)
Number |
Date |
Country |
0132367 |
Jan 1985 |
EPX |
0181568 |
May 1986 |
EPX |
0218872 |
Apr 1987 |
EPX |
0235575 |
Sep 1987 |
EPX |
50-39262 |
Sep 1985 |
JPX |
2143817A |
Feb 1985 |
GBX |
Continuation in Parts (1)
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Number |
Date |
Country |
Parent |
120468 |
Nov 1987 |
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