Claims
- 1. A compound of the formula ##STR18## in which R.sup.1, R.sup.2 and R.sup.3 independently represent hydrogen, halogen or C.sub.1-4 haloalkyl, R.sup.6 is C.sub.1-6 alkyl, C.sub.3-7 cycloalkyl or C.sub.3-7 cycloalkyl C.sub.1-4 alkyl, R.sup.7 is hydrogen and R.sup.9 is hydrogen, C.sub.1-4 alkyl, C.sub.3-7 cycloalkyl C.sub.1-4 alkyl or benzyl.
- 2. A compound according to claim 1 in which R.sup.2 is halogen and R.sup.1 and R.sup.3 are hydrogen, or R.sup.2 and R.sup.3 are halogen and R.sup.1 is hydrogen, R.sup.6 is methyl or ethyl, R.sup.7 is hydrogen and R.sup.9 is methyl.
- 3. A compound according to claim 2 which is 7-fluoro-2,10-dihydro-2-methyl-4-(4-methyl-1-piperazinyl)pyrazolo[3,4-6][1,5]benzodiazepine.
- 4. A method of treating a human suffering from or susceptible to disorders of the central nervous system which comprises administering to the human a chemotherapeutically effective amount of a compound as defined in claim 1.
- 5. A method according to claim 4 in which R.sup.2 is halogen and R.sup.1 and R.sup.3 are hydrogen, or R.sup.2 and R.sup.3 are halogen and R.sup.1 is hydrogen, R.sup.6 is methyl or ethyl, R.sup.7 is hydrogen and R.sup.9 is methyl.
- 6. A method according to claim 5 in which the compound is 7-fluoro-2,10-dihydro-2-methyl-4-(4-methyl-1-piperazinyl)pyrazolo[3,4-b][1,5]benzodiazepine.
- 7. A pharmaceutical composition comprising a compound of claim 1 associated with a pharmaceutically acceptable carrier.
- 8. A composition according to claim 7 in which R.sup.2 is halogen and R.sup.1 and R.sup.3 are hydrogen, or R.sup.2 and R.sup.3 are halogen and R.sup.1 is hydrogen, R.sup.6 is methyl or ethyl, R.sup.7 is hydrogen and R.sup.9 is methyl.
- 9. A composition according to claim 8 in which the compound is 7-fluoro-2,10-dihydro-2-methyl-4-(4-methyl-1-piperazinyl)pyrazolo[3,4-b][1,5]benzodiazepine.
Priority Claims (1)
Number |
Date |
Country |
Kind |
7935846 |
Oct 1979 |
GBX |
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Parent Case Info
This application is a division of application Ser. No. 426,580, filed Sept. 29, 1982, which is a division of Ser. No. 193,200, filed Oct. 2, 1980, now U.S. Pat. No. 4,404,137, issued Sept. 13, 1983.
US Referenced Citations (12)
Foreign Referenced Citations (2)
Number |
Date |
Country |
3016 |
Jul 1979 |
EPX |
2707270 |
Aug 1978 |
DEX |
Non-Patent Literature Citations (5)
Entry |
Rajappa, S., et al., "Isothiazoles: Part IV. Synthesis of 5-Anilino-3-Methylisothiazole-4-Carboxylic Acids", Indian J. Chem., 14B, 394-396 (1976). |
Belgium 883,080, Derwernt Abstract, 82632. |
CA 85:177301e (1976). |
CA 80:14969m (1974). |
C. A. 92: 6514 s (1980). |
Divisions (2)
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Number |
Date |
Country |
Parent |
426580 |
Sep 1982 |
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Parent |
193200 |
Oct 1980 |
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