Claims
- 1. A compound having the formula ##STR27## wherein n is 1 to 2;
- R is H, benzoyl, (C.sub.1 -C.sub.5)alkanoyl or --CO(CH.sub.2).sub.m Y, wherein m is 1, 2, 3 or 4, Y is --COOH, or --NR'R", R' and R" when taken separately are each independently H or (C.sub.1 -C.sub.4)alkyl, and R' and R" when taken together with the nitrogen to which they are attached are piperidino, pyrrolo, pyrrolidino, morpholino or N-[(C.sub.1 -C.sub.4)alkyl]piperazino; and
- Z is (C.sub.5 -C.sub.13)alkyl, (C.sub.5 -C.sub.13)alkoxy, (C.sub.5 -C.sub.13)alkoxyalkyl, (C.sub.8 -C.sub.13)pyridylalkyl, (C.sub.8 -C.sub.13)pyridylalkoxy, (C.sub.8 -C.sub.13)pyridyloxyalkyl, (C.sub.8 -C.sub.13)pyridylalkoxyalkyl, (C.sub.9 -C.sub.14)phenylalkyl, (C.sub.9 -C.sub.14)phenylalkoxy, (C.sub.9 -C.sub.14)phenoxyalkyl, or (C.sub.9 -C.sub.14)phenylalkoxyalkyl, wherein said phenyl groups are optionally substituted with a chloro or a fluoro;
- a pharmaceutically-acceptable acid addition salt thereof when R is --CO(CH.sub.2).sub.m Y and Y is --NR'R"; or
- a pharmaceutically-acceptable cationic salt thereof when R is --CO(CH.sub.2).sub.m Y and Y is --COOH.
- 2. A compound of claim 1 having the absolute or relative stereochemical formula ##STR28##
- 3. A compound of claim 2 having the absolute or relative stereochemical formula ##STR29##
- 4. A compound of claim 3 having the absolute stereochemical formula ##STR30##
- 5. A compound of any one of claims 1, 2, 3 or 4 wherein Z is 5-phenyl-2-pentyloxy.
- 6. A compound having the formula: ##STR31## wherein R is acetyl and Z is 5-phenyl-2-pentyloxy.
- 7. A compound of claim 6 wherein Z is 5-phenyl-2R-pentyloxy.
Parent Case Info
This is a division of application Ser. No. 358,765, filed on Mar. 16, 1982, now U.S. Pat. No. 4,473,704, issued Sept. 25, 1984.
US Referenced Citations (4)
Divisions (1)
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Number |
Date |
Country |
Parent |
358765 |
Mar 1982 |
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