Substituted hydantoins

Abstract

The present invention relates to compounds of the formula

Description

Claims

1. A compound of formula I:

2. The compound of claim 1 with the formula:

3. The compound of claim 2 wherein R1 is selected from the group consisting of iodo, ethynyl, and cyclopropyl.

4. The compound of claim 3 wherein R2 is selected from the group consisting of hydrogen, chloro, and fluoro.

5. The compound of claim 4 wherein R3 is hydrogen.

6. The compound of claim 5 wherein R5 is

7. The compound of claim 6 wherein R4 is optionally substituted aryl.

8. The compound of claim 7 wherein R1 is selected from the group consisting of iodo, ethynyl, and cyclopropyl, R2 is selected from the group consisting of hydrogen, fluoro, and chloro, R3 is hydrogen, R4 is optionally substituted phenyl, R5 is

9. The compound of claim 8 wherein R4 is phenyl substituted with alkoxy.

10. The compound of claim 9 wherein R1 is iodo and R2 is selected from the group consisting of chloro and fluoro.

11. The compound of claim 10, wherein R6 is phenyl and R4 is phenyl substituted with a member selected from a 2,3-dihydroxy-propoxy group and a 2-hydroxy-ethoxy group.

12. A compound selected from the group consisting of:

13. A compound selected from the group consisting of:

14. A pharmaceutical composition comprising a compound of claim 1 and a pharmaceutically acceptable diluent, excipient, or adjuvant.

15. A pharmaceutical composition comprising a compound of claim 11 and a pharmaceutically acceptable diluent, excipient, or adjuvant.

16. A pharmaceutical composition comprising a compound of claim 13 and a pharmaceutically acceptable diluent, excipient, or adjuvant.