Claims
- 1. A compound of the formula ##STR14## wherein R.sub.1 is hydrogen or alkyl of 1 to 3 carbon atoms,
- R.sub.2 is hydrogen, halogen, hydroxy, or alkyl, alkoxy or alkylthio each of 1 to 3 carbon atoms, and
- R.sub.3 is hydrogen, halogen, alkyl or alkoxy each of 1 to 3 carbon atoms, or hydroxy, and
- A is dimethylene, wherein one hydrogen atom may be replaced by hydroxyl or alkyl of 1 to 3 carbon atoms,
- or a pharmaceutically acceptable acid addition salt thereof.
- 2. A compound of claim 1 having the formula ##STR15## wherein R.sub.1 is hydrogen or alkyl of 1 to 3 carbon atoms,
- R.sub.2 is hydrogen, halogen, hydroxy or alkyl, alkoxy or alkylthio each of 1 to 3 carbon atoms, and
- R.sub.3 is hydrogen, halogen, alkyl or alkoxy each of 1 to 3 carbon atoms, or hydroxy, and
- R is hydrogen, hydroxyl or alkyl of 1 to 3 carbon atoms,
- with the proviso that at least one of R.sub.1, R.sub.2, R.sub.3 and R are other than hydrogen.
- 3. A compound of claim 1 of the formula ##STR16## wherein R.sub.1 is hydrogen or alkyl of 1 to 3 carbon atoms,
- R.sub.2 is hydrogen, halogen, hydroxy, or alkyl, alkoxy or alkylthio each of 1 to 3 carbon atoms, and
- R.sub.3 is hydrogen, halogen, alkyl or alkoxy each of 1 to 3 carbon atoms, or hydroxy, and
- A is dimethylene wherein one hydrogen atom is replaced by hydroxyl or alkyl of 1 to 3 carbon atoms.
- 4. A compound of claim 1, wherein at least one of R.sub.1, R.sub.2, and R.sub.3 are other than hydrogen.
- 5. A compound of claim 1, which is 4-(2-imidazolin-2-ylamino)-1H-indazole.
- 6. A compound of claim 2, which is 3-chloro-4-(2-imidazolin-2-ylamino)-1H-indazole.
- 7. The compound of claim 1, wherein R.sub.1 is H, R.sub.2 is 5-Cl and R.sub.3 is H and A is dimethylene.
- 8. The compound of claim 1, wherein R.sub.1 is CH.sub.3, R.sub.2 is 5-CH.sub.3 and R.sub.3 is H and A is dimethylene.
- 9. The compound of claim 1, wherein R.sub.1 is CH.sub.3, R.sub.2 is H and R.sub.3 is Cl and A is dimethylene.
- 10. The compound of claim 1, wherein R.sub.1 is H, R.sub.2 is H and R.sub.3 is Br and A is dimethylene.
- 11. The compound of claim 1, wherein R.sub.1 is H, R.sub.2 is H and R.sub.3 is OH and A is dimethylene.
- 12. The compound of claim 1, wherein R.sub.1 is CH.sub.3, R.sub.2 is H and R.sub.3 is CH.sub.3 O and A is dimethylene.
- 13. The compound of claim 1, wherein R.sub.1 is CH.sub.3, R.sub.2 is 5-CH.sub.3 S and R.sub.3 is H and A is dimethylene.
- 14. The compound of claim 1, wherein R.sub.1 is H, R.sub.2 is 6-CH.sub.3 is H and A is dimethylene.
- 15. The compound of claim 1, wherein R.sub.1 is H, R.sub.2 is 7-CH.sub.3 and R.sub.3 is H and A is dimethylene.
- 16. The compound of claim 1, wherein R.sub.1 is H, R.sub.2 is 6-OH and R.sub.3 is H and A is dimethylene.
- 17. The compound of claim 1, wherein R.sub.1 is CH.sub.3, R.sub.2 is 6-CH.sub.3 O and R.sub.3 is H and A is dimethylene.
- 18. The compound of claim 1, wherein R.sub.1 is CH.sub.3, R.sub.2 is 6-CH.sub.3 S and R.sub.3 is H and A is dimethylene.
- 19. The compound of claim 1, wherein R.sub.1 is CH.sub.3, R.sub.2 is 5-Cl and R.sub.3 is H and A is dimethylene.
- 20. The compound of claim 1, wherein R.sub.1 is H, R.sub.2 is 5-CH.sub.3 and R.sub.3 is H and A is dimethylene.
- 21. The compound of claim 1, wherein R.sub.1 is CH.sub.3, R.sub.2 is H and R.sub.3 is H and A is dimethylene.
- 22. The compound of claim 1 wherein R.sub.1 is H, R.sub.2 is H, R.sub.3 is H and A is --CH.sub.2 CH(OH)-- .
- 23. A pharmaceutical composition useful in treating hypertension comprising a therapeutically effective amount of a compound of claim 1 in association with a pharmaceutical carrier or diluent.
- 24. A pharmaceutical composition according to claim 23, comprising 0.1 to 15 milligrams per unit dosage.
- 25. A method of treating hypertension in animals, which comprises administering to an animal in need of such treatment a therapeutically effective amount of a compound of claim 1.
- 26. A method according to claim 25 in which 0.5 to 30 milligrams of the compound are administered daily.
- 27. A method according to claim 25 in which 0.1 to 15 milligrams of the compound are administered orally per unit dose.
- 28. A method according to claim 25 in which the compound is 4-(2-imidazolin-2-ylamino)-1H-imidazole.
- 29. A method of treating hypertension in animals, which comprises administering to an animal in need of such treatment in therapeutically effective amount of a compound of claim 12.
Priority Claims (1)
Number |
Date |
Country |
Kind |
4916/73 |
Apr 1973 |
CH |
|
Parent Case Info
This application is a continuation-in-part of my copending application Ser. No. 456,521 filed Apr. 1, 1974 now abandoned the contents of which are incorporated herein by reference.
US Referenced Citations (6)
Foreign Referenced Citations (3)
Number |
Date |
Country |
2,258,318 |
Jun 1973 |
DT |
599,834 |
Mar 1948 |
UK |
753,573 |
Jul 1956 |
UK |
Non-Patent Literature Citations (2)
Entry |
Neumann Chem. Abst. 1973, vol. 79, No. 53324w. |
Neumann Chem. Abst. 1975, vol. 82, No. 31323e. |
Continuation in Parts (1)
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Number |
Date |
Country |
Parent |
456521 |
Apr 1974 |
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