Claims
- 1. A compound having the structural formula ##STR17## wherein A is ##STR18## where B is ##STR19## where alkyl is of from one to four carbon atoms; ##STR20## where R.sub.18 is hydrogen, hydroxy, halogen, alkyl of from one to four carbon atoms, or alkoxy of from one to four carbon atoms; alkylamino of from one to four carbon atoms; or amino alkylamino of from one to four carbon atoms.
- 2. A compound as defined in claim 1 having the name 2,4,4a,5-tetrahydro-7-(1-piperidinyl)-3H-indeno-(1,2-c)pyridazinone, or a pharmaceutically acceptable acid addition salt thereof.
- 3. A compound as defined in claim 1 having the name 2,4,4a,5-tetrahydro-7-(3-hydroxy-1-piperidinyl)-3H-indeno(1,2-c)pyridazinone, or a pharmaceutically acceptable acid addition salt thereof.
- 4. A compound as defined in claim 1 having the name 2,4,4a,5-tetrahydro-7-(1,4-dioxa-8-azaspiro(4,5)-dec-8-yl)-3H-indeno(1,2-c)pyridazin-3-one, or a pharmaceutically acceptable acid addition salt thereof.
- 5. A compound as defined in claim 1 having the name 2,4,4a,5-tetrahydro-7-(4-thiomorpholinyl)-3H-indeno(1,2-c)pyridazin-3-one, or a pharmaceutically acceptable acid addition salt thereof.
- 6. A compound as defined in claim 1 having the name 2,4,4a,5-tetrahydro-7-(4-(2-pyridyl)-1-piperazinyl)-3H-indeno(1,2-c)pyridazin-3-one, or a pharmaceutically acceptable acid addition salt thereof.
- 7. A compound as defined by claim 1 having the name 2,4,4a,5-tetrahydro-7-(1-morpholinyl)-3H-indeno-(1,2-c)pyridazin-3-one, or a pharmaceutically acceptable acid addition salt thereof.
- 8. A compound as defined in claim 1 having the name 2,4,4a,5-tetrahydro-7-(3-aminopropyl)amino)3H-indeno(1,2-c)pyridazin-3-one, or a pharmaceutically acceptable acid addition salt thereof.
- 9. A compound as defined in claim 1 having the name 2,4,4a,5-tetrahydro-7-(4-methyl-1-piperazinyl)-3H-indeno(1,2-c)pyridazin-3-one, or a pharmaceutically acceptable acid addition salt thereof.
- 10. A compound as defined in claim 1 having the name 2,4,4a,5-tetrahydro-7-(butylamino)-3H-indeno(1,2-c)pyridazin-3-one, or a pharmaceutically acceptable acid addition salt thereof.
- 11. A pharmaceutical composition for increasing cardiac contractility or for lowering blood pressure comprising an effective amount of a compound as claimed in claim 1 and a pharmaceutically acceptable carrier.
- 12. A method for increasing cardiac contractility and lowering blood pressure in a patient which comprises administering an effective amount of a pharmaceutical composition according to claim 11.
CROSS-REFERENCE TO RELATED APPLICATIONS
This application is a divisional of copending application Ser. No. 575,412 filed Feb. 2, 1984, now U.S. Pat. No. 4,602,019 which is a continuation-in-part of application Ser. No. 487,780 filed Apr. 22, 1983, now abandoned.
Non-Patent Literature Citations (4)
Entry |
Cignarella, et al., Chem. Abstracts, vol. 96 (1982), entry 199612m. |
Cignarella, et al., Chem. Abstracts, vol. 90 (1979), entry 121523q. |
Cignarella, et al., Chem. Abstracts, vol. 90 (1979), entry 72131z. |
Mukherjee, et al., Chem. Abstracts, vol. 96 (1982), entry 52254n. |
Divisions (1)
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Number |
Date |
Country |
Parent |
575412 |
Feb 1984 |
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Continuation in Parts (1)
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Number |
Date |
Country |
Parent |
487780 |
Apr 1983 |
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