Claims
- 1. A compound having the formula
- A(CH.sub.2).sub.n O-B
- wherein
- A is a group having the formula ##STR33## wherein R.sup.1 is hydrogen, lower alkyl, phenyl or phenyl substituted with trifluoromethyl;
- R.sup.2 is hydrogen or lower alkyl; or
- R.sup.1 and R.sup.2 taken together form a benzene ring;
- R.sup.3 is hydrogen or lower alkyl;
- n is 1-2;
- B is ##STR34## wherein R.sup.4 is ##STR35## m is0-3; R.sup.5 is ##STR36## or phenyl or phenyl substituted by halo, lower alkylthio, lower alkylsulfinyl or lower alkylsulfonyl;
- R.sup.6 is A(CH.sub.2).sub.n O-- or halo
- R.sup.7 is lower alkyl;
- Y is --CH.sub.2 -- or --O--;
- R.sup.8 is lower alkyl or --(CH.sub.2).sub.m CO.sub.2 R.sub.3 ;
- R.sup.9 is ##STR37## o is 1-4; R.sup.10 is lower alkyl, phenyl, phenyl substituted with carboxy, halo, lower alkyl, loweralkylthio or loweralkylsulfinyl; naphthyl, pyridyl, furanyl, quinolinyl, ##STR38## R.sup.11 is lower alkyl or phenyl; R.sup.12 is hydrogen or loweralkylcarbonyl
- R.sup.13 is hydrogen, hydroxy, lower alkyl or lower alkoxy;
- R.sup.14 is phenyl or halophenyl;
- Z.sup.2 is hydrogen, lower alkyl or --N(CH.sub.3)OH; and the pharmacologically acceptable salts thereof.
- 2. The compound of claim 1, 1-[(4-chlorophenyl)methyl]-2-methyl-5-(2-benzothiazolylmethoxy)-1H -indole-3-acetic acid.
- 3. The compound of claim 1, 1-[(4-chlorophenyl)methyl]-2-methyl-5-[(2-phenyl-4-thiazolyl)methoxy ]-1H-indole-3-acetic acid.
- 4. The compound of claim 1, 1-[(4-chlorophenyl)methyl]-2-methyl-5-[[2-(4-trifluoromethylphenyl) -4-thiazolyl]methoxy]-1H-indole-3-acetic acid.
- 5. The compound of claim 1, 1-[(phenyl)methyl]-2-methyl-5-[(2-phenyl-4-thiazolyl)methoxy]-1H -indole-3-acetic acid.
- 6. The compound of claim 1, 5-(2-benzothiazolylmethoxy)-1-[(4-chlorophenyl)methyl]-2-methyl- 1H -indole-3-acetamide.
- 7. The compound of claim 1, 5-(2-benzothiazolylmethoxy)-1-[(4-chlorophenyl)methyl]-N-hydroxyl-2-methyl -1H-indole-3-acetamide.
- 8. The compound of claim 1, 5-(2-benzothiazolylmethoxy)-1-[(4-chlorophenyl)methyl]-N-methoxy-2-methyl -1H-indole-3-acetamide.
- 9. The compound of claim 1, 5-(2-benzothiazolylmethoxy)-1-[(4-chlorophenyl)methyl]-N-(phenylmethoxy)-2-methyl-1H-indole-3-acetamide.
- 10. The compound of claim 1, 5-(2-benzothiazolylmethoxy)-1-[(4-chlorophenyl)methyl]-N-hydroxyl-N.2-dimethyl-1H-indole-3-acetamide.
- 11. The compound of claim 1, 5-(2-benzothiazolylmethoxy)-1-(phenylmethyl)-2-methyl-1H-indole-3-acetic acid ethyl ester.
- 12. The compound of claim 1, 5-(2-benzothiazolylmethoxy)-1- (phenylmethyl)-2-methyl-1H-indole-3-acetic acid.
- 13. The compound of claim 1, 5-(2-benzothiazolylmethoxy)-N,N-diethyl-1-(phenylmethyl)-2-methyl-1H-indole -3-acetamide.
- 14. The compound of claim 1, 5-(2-benzothiazolylmethoxy)-1-[[4-(methylthio)phenyl]methyl]-2-methyl -1H-indole-3-acetic acid ethyl ester.
- 15. The compound of claim 1, 5-(2-benzothiazolylmethoxy)-1-[[4-(methylthio)phenyl]methyl]-2-methyl -1H-indole-3-acetic acid.
- 16. The compound of claim 1, 5-[(2-phenyl-4-thiazolyl)methoxy]-1-(phenylmethyl)-2-methyl- 1H -indole-3-ethanol.
- 17. The compound of claim 1, 5-[(2-phenyl-4-thiazolyl)methoxy]-1-(phenylmethyl)-2-methyl-1H -indole-3-ethanol acetate ester.
- 18. The compound of claim 1, N-hydroxy-5-[(2-phenyl-4-thiazolyl)methoxyl-1-(phenylmethyl)-N.2-dimethyl-1H-indole-3-acetamide.
- 19. The compound of claim 1, 5-[(2-phenyl-4-thiazolyl)methoxy]-1-[[(4methylthio)phenyl]methyl]-2-methyl-1H-indole-3-acetic acid.
- 20. The compound of claim 1, 5-[(2-phenyl-4-thiazolyl)methoxy]-1-[[(3-methoxy)-phenyl]methyl]-2-methyl-1H-indole-3-acetic acid ethyl ester.
- 21. The compound of claim 1, 5-[(2-phenyl-4-thiazolyl)methoxy)-1-[[(3-methoxy)-phenyl]methyl]-2-methyl-1H-indole-3-acetic acid.
- 22. The compound of claim 1, 5-[(2-phenyl-4-thiazolyl)methoxy]-1-[[4-(1.1-dimethylethyl)phenyl ]methyl]-2-methyl-1H-indole-3-acetic acid ethyl ester.
- 23. The compound of claim 1, 5-[(2-phenyl-4-thiazolyl)methoxy]-1-[[4-(1.1-dimethylethyl)phenyl ]methyl]-2-methyl-1H-indole-3-acetic acid.
- 24. The compound of claim 1, 5-[(phenyl-4-thiazolyl)methoxy]-1-(3-phenylpropyl)-2-methyl-1H -indole-3-acetic acid.
- 25. The compound of claim 1, 5-[(2-phenyl-4-thiazolyl)methoxy]-1-[[2-(4-chlorophenyl)-4-thiazolyl]methyl]-2-methyl-1H-indole-3-acetic acid ethyl ester.
- 26. The compound of claim 1, 5-[(2-phenyl-4-thiazolyl)methoxy]-1-[[2-(4-chlorophenyl)-4-thiazolyl]methyl]-2-methyl-1H-indole-3-acetic acid.
- 27. The compound of claim 1, 5-[(2-phenyl-4-thiazolyl)methoxy]-1-(2-naphthalenylmethyl)-2-methyl -1H-indole-3-acetic acid ethyl ester.
- 28. The compound of claim 1, 5-[(2-phenyl-4-thiazolyl)methoxy]-1-(2-naphthalenylmethyl)-2-methyl -1H-indole-3-acetic acid.
- 29. The compound of claim 1, 5-[[(4-chlorophenyl)-4-thiazolyl]methoxy]--[(4-chlorophenyl)methyl]-2-methyl-1H-indole-3-acetic acid ethyl ester.
- 30. The compound of claim 1, 5-[[2-(4-chlorophenyl)-4thiazolyl]methoxy]-1-[(4-chlorophenyl) methyl]-2-methyl-1H-indole-3-acetic acid.
Parent Case Info
This is a continuation-in-part of U.S. Ser. No. 07/911,434, filed Jul. 10, 1992, now U.S. Pat. No. 5,229,516, which is a continuation-in-part of U.S. Ser. No. 07/596,134, filed Oct. 11, 1990, now abandoned, which is a continuation-in-part of U.S. Ser. No. 07/428,260, filed Oct. 27, 1989, and now abandoned.
US Referenced Citations (3)
Number |
Name |
Date |
Kind |
4798898 |
Gandolfi et al. |
Jan 1989 |
|
4857539 |
Diana et al. |
Aug 1989 |
|
4857643 |
Gandolfi et al. |
Aug 1989 |
|
Continuation in Parts (3)
|
Number |
Date |
Country |
Parent |
911434 |
Jul 1992 |
|
Parent |
596134 |
Oct 1990 |
|
Parent |
428260 |
Oct 1989 |
|