Claims
- 1. A compound having the formula
- A(CH.sub.2).sub.n O-B
- wherein
- A is a group having the formula ##STR39## n is 1-2; B is ##STR40## wherein R.sup.2 is hydrogen or lower alkyl;
- R.sup.3 is hydrogen or lower alkyl;
- R.sup.4 is --CO.sub.2 R.sup.2 ;
- m is 0-3;
- R.sup.5 is phenyl or phenyl substituted by halo, lower alkylthio, lower alkylsulfinyl or lower alkylsulfonyl;
- R.sup.6 is halo;
- R.sup.7 is lower alkyl;
- Y is --CH.sub.2 -- or --O--;
- R.sup.8 is lower alkyl or --(CH.sub.2).sub.m CO.sub.2 R.sup.3 ;
- R.sup.9 is ##STR41## or --CH.sub.2 R.sup.10 ; R.sup.10 is lower alkyl, phenyl or phenyl substituted with carboxy, halo, loweralkylthio or loweralkylsulfonyl;
- Z is hydrogen, lower alkyl or --N(CH.sub.3)OH;
- and the pharmacologically acceptable salts thereof.
- 2. The compound of claim 1, 3-[(4-chlorophenyl)methylene]-[2-methyl-6-(2-quinolinylmethoxy)]-3H-indene-1-acetic acid.
- 3. The compound of claim 1, 2-methyl-3-[[4-(methylthio)phenyl]methylene]-6-(2-quinolinylmethoxy)-3H-indene-1-acetic acid.
- 4. The compound of claim 1, 2-methyl-3-[[(4-methylsulfinyl)phenyl]methylene]-6-(2-quinolylmethoxy)-3H-indene-1-acetic acid.
- 5. The compound of claim 1, 5-fluoro-2-methyl-1-[[4-(2-quinolinylmethoxy)phenyl]methylene]-1H-indene-3-acetic acid.
- 6. The compound of claim 1, 3-[(4-chlorophenyl)methylene]-[2-methyl-6-(2-quinolinylmethoxy)]-3H-indene-1-acetic acid methylester.
- 7. The compound of claim 1, 1,8-diethyl-1,3,4,9-tetrahydro-6-(2-quinolinylmethoxy)pyrano[3,4-b]indole-1-acetic acid.
- 8. The compound of claim 1, 1-ethyl-1,3,4,9-tetrahydro-6-(quinolinylmethoxy)pyrano[3,4-b]indole-1-acetic acid.
- 9. The compound of claim 1, 1-methyl-1,3,4,9-tetrahydro-6-(2-quinolinylmethoxy)pyrano[3,4-b]indole-1-acetic acid.
- 10. The compound of claim 1, 1-ethyl-2,3,4,9-tetrahydro-6-(2-quinolinylmethoxy)-1H-carbazole-1-acetic acid.
- 11. The compound of claim 1, 1,3,4,9-tetrahydro-1-propyl-6-(2-quinolinylmethoxy)pyrano[3,4-b]indole-1-acetic acid.
- 12. The compound of claim 1, 1-ethyl-1,3,4,9-tetrahydro-6-(2-quinolinylmethoxy)pyrano[3,4-b]indole-1-acetic acid, methyl ester.
- 13. The compound of claim 1, 1,3,4,9-tetrahydro-1,1-dimethyl-6-(2-quinolinylmethoxy)pyrano[3,4-b]indole
- 14. The compound of claim 1, 1,3,4,9-tetrahydro-1,1-diethyl-6-(2-quinolinylmethoxy)pyrano[3,4-b]indole.
- 15. The compound of claim 1, 1-[(4-chlorophenyl)methyl]-2-methyl-5-(2-quinolinylmethoxy)-1H-indole-3-acetic acid.
- 16. The compound of claim 1, 1-[(4-chlorophenyl)methyl]-2-methyl-5-(2-quinolinylmethoxy)-1H-indole-3-acetic acid methyl ester.
- 17. The compound of claim 1, 1-(4-chlorobenzoyl)-2-methyl-5-(2-quinolinylmethoxy)-1H-indole-3-acetic acid.
- 18. The compound of claim 1, 1-(4-chlorobenzoyl)-2-methyl-5-(2-quinolinylmethoxy)-1H-indole-3-acetic acid methyl ester.
- 19. The compound of claim 1, 1-[(4-fluorophenyl)methyl]-2-methyl-5-(2-quinolinylmethoxy)-1H-indole-3-acetic acid.
- 20. The compound of claim 1, 1-[(4-bromophenyl)methyl]-2-methyl-5-(2-quinolinylmethoxy)-1H-indole-3-acetic acid.
- 21. The compound of claim 1, 1-[(phenyl)methyl-2-methyl]-5-(2-quinolinylmethoxy)-1H-indole-3-acetic acid.
- 22. The compound of claim 1, 1-[(4-carboxyphenyl)methyl]-2-methyl-5-(2-quinolinylmethoxy)-1H-indole-3-acetic acid.
- 23. The compound of claim 1, 2-methyl-1-pentyl-5-(2-quinolinylmethoxy)-1H-indole-3-acetic acid.
- 24. The compound of claim 1, 1-hexyl-2-methyl-5-(2-quinolinylmethoxy)-1H-indole-3-acetic acid.
- 25. The compound of claim 1, 1-heptyl-2-methyl-5-(2-quinolinylmethoxy)-1H-indole-3-acetic acid.
- 26. The compound of claim 1, 1-methyl-2-methyl-5-(2-quinolinylmethoxy)-1H-indole-3-acetic acid.
- 27. The compound of claim 1, 1-[(4-chlorophenyl)methyl]-5-(2-quinolinylmethoxy)-1H-indole-3-acetic acid.
- 28. The compound of claim 1, 1-[(4-chlorophenyl)methyl]-2-methyl-5-(2-quinolinylmethoxy)-1H-indole-acetic acid, tromethamine salt.
- 29. The compound of claim 1, 5-fluoro-N-hydroxy-N,2-dimethyl-1-[[4-(2-quinolinylmethoxy)phenyl]methylene]-1H-indene-3-acetamide hydrochloride.
Parent Case Info
This is a continuation-in-part of U.S. Ser. No. 07/596,134, filed Oct. 11, 1990, now abandoned which is a continuation-in-part of U.S. Ser. No. 07/428,260, filed Oct. 27, 1989, and now abandoned.
US Referenced Citations (6)
Foreign Referenced Citations (1)
Number |
Date |
Country |
0275667 |
Jul 1988 |
EPX |
Continuation in Parts (2)
|
Number |
Date |
Country |
Parent |
596134 |
Oct 1990 |
|
Parent |
428260 |
Oct 1989 |
|