Claims
- 1. An indole derivative of the formula ##STR11## wherein Ind is 3-indolyl or 3-indolyl substituted by (a) a hydroxymethyl, methylenedioxy, S-alkyl, SO-alkyl, SO.sub.2 -alkyl, CN or COW group, or (b) substituted once or twice by alkyl, O-alkyl, OH, F, Cl or Br, or (c) a combination of (a) and (b),
- W is H, OH, O-alkyl, NH.sub.2, NH-alkyl or N(alkyl).sub.2,
- A is --(CH.sub.2).sub.n --, --CH.sub.2 --S--CH.sub.2 CH.sub.2 --, --CH.sub.2 --SO--CH.sub.2 CH.sub.2 -- or --CH.sub.2 --SO.sub.2 --CH.sub.2 CH.sub.2 --,
- Z is --(CH.sub.2).sub.m --, --CH.dbd.CH--, --CHOH--, --CO--, S, SO, SO.sub.2 or O,
- n is 2, 3, 4 or 5 and
- m is 1, 2 or 3,
- each alkyl group independently is of 1-4C atoms, or a physiologically acceptable salt thereof.
- 2. A compound of claim 1, wherein Ind is hydroxy-3-indolyl, methoxy-3-indolyl or 3-indolyl.
- 3. A compound of claim 1, wherein Ind is 5- or 6-hydroxy-3-indolyl, 5- or 6-methoxy-3-indolyl or 3-indolyl.
- 4. A compound of claim 1, wherein A is --(CH.sub.2).sub.n -- or --CH.sub.2 --S--CH.sub.2 CH.sub.2 --.
- 5. A compound of claim 1, wherein A is --(CH.sub.2).sub.4 --.
- 6. A compound of claim 1, wherein Z is --(CH.sub.2).sub.2 or --CH.dbd.CH--.
- 7. A compound of claim 1, wherein Z is --CHOH--.
- 8. A compound of claim 1, wherein Z is S.
- 9. A compound of claim 1, wherein Z is O.
- 10. A compound of claim 1, wherein
- Ind is 5- or 6-hydroxy-3-indolyl, 5- or 6-methoxy-3-indolyl or 3-indolyl,
- A is --(CH.sub.2).sub.n -- or --CH.sub.2 --S--CH.sub.2 CH.sub.2 -- and
- Z is --(CH.sub.2).sub.2.
- 11. A compound of claim 1, wherein
- Ind is 5- or 6-hydroxy-3-indolyl, 5- or 6-methoxy-3-indolyl or 3-indolyl,
- A is --(CH.sub.2).sub.n -- or --CH.sub.2 --S--CH.sub.2 CH.sub.2 -- and
- Z is --CHOH.
- 12. A compound of claim 1, wherein
- Ind is 5- or 6-hydroxy-3-indolyl, 5- or 6-methoxy-3-indolyl or 3-indolyl,
- A is --(CH.sub.2).sub.n -- or --CH.sub.2 --S--CH.sub.2 CH.sub.2 -- and
- Z is S.
- 13. A compound of claim 1, wherein
- Ind is 5- or 6-hydroxy-3-indolyl, 5- or 6-methoxy-3-indolyl or 3-indolyl,
- A is --(CH.sub.2).sub.n -- or --CH.sub.2 --S--CH.sub.2 CH.sub.2 -- and
- Z is O.
- 14. 2-[4-(5-Hydroxy-3-indolyl)butyl]-1,2,3,4-tetrahydrobenzothieno[2,3-c]pyridine, a compound of claim 1.
- 15. 2-[4-(5-Hydroxy-3-indolyl)butyl]-1,2,3,4-tetrahydrobenzofuro[2,3-c]pyridine, a compound of claim 1.
- 16. 3-[4-(5-Hydroxy-3-indolyl)butyl]-1,2,3,4,5,6-hexahydrobenzo[f]isoquinoline, a compound of claim 1.
- 17. A pharmaceutical comoposition comprising an effective amount of at least one compound of claim 1 and a physiologically acceptable carrier.
- 18. A pharmaceutical composition comprising 0.2-500 mg of a compound of claim 1 and a pharmaceutically acceptable carrier.
- 19. A method of treating migraine comprising administering to a patient in need of such treatment an amount effective to treat said migraine of a compound of claim 1.
- 20. A method of treating parkinsonism, comprising administering to a patient in need of such treatment an amount effective to treat said parkinsonism of a compound of claim 1.
- 21. A method of treating depression comprising administering to a patient in need of such treatment an antidepressantly effective amount of a compound of claim 1.
- 22. A method of treating psychosis comprising administering to a patient in need of such treatment an antipsychotic effective amount of a compound of claim 1.
Priority Claims (1)
Number |
Date |
Country |
Kind |
3522959 |
Jun 1985 |
DEX |
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Parent Case Info
This is a division of application Ser. No. 878,559 filed June 26, 1986, now U.S. Pat. No. 4,740,602.
US Referenced Citations (3)
Divisions (1)
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Number |
Date |
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Parent |
878559 |
Jun 1986 |
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