Claims
- 1. A substituted lactone of amino acids in all their possible stereoisomeric forms or mixtures of the formula ##STR18## wherein A is selected from the group consisting of an aliphatic hydrocarbon of 2 to 3 carbon atoms optionally containing a double bond, a monocyclic hydrocarbon of 3 to 6 carbon atoms optionally containing one unsaturation, a bicyclic hydrocarbon of 5 to 10 carbon atoms optionally containing one unsaturation, ##STR19## and X.sub.4 and X.sub.5 are individually selected from the group consisting of hydrogen, fluorine, chlorine, bromine and alkyl of 2 to 6 carbon atoms or taken together with the carbon atoms to which they are attached form a carbon homocycle of 3 to 7 carbon atoms and R is ##STR20## Y is derived from an alcohol selected from the group consisting of primary aliphatic alcohols of 1 to 12 carbon atoms, primary cycloaliphatic alcohols of 4 to 8 carbon atoms and benzyl alcohol and B is the remainder of a heterocyclic amino acid of the formula ##STR21## having a total of 3 to 6 carbon atoms in the acid.
- 2. A compound of claim 1 wherein A is an aliphatic hydrocarbon of 2 to 3 carbon atoms.
- 3. A compound of claim 1 wherein A is an aliphatic hydrocarbon of 2 to 3 carbon atoms containing one double bond.
- 4. A compound of claim 1 wherein A is a monocyclic hydrocarbon of 3 to 6 carbon atoms optionally containing an unsaturation.
- 5. A compound of claim 1 wherein A is a bicyclic hydrocarbon of 5 to 10 carbon atoms optionally containing one unsaturation.
- 6. A compound of claim 1 wherein A has the formula ##STR22##
- 7. A compound of claim 1 wherein A has the formula ##STR23## wherein X.sub.4 and X.sub.5 are individually selected from the group consisting of hydrogen, fluorine, bromine, chlorine and alkyl of 2 to 6 carbon atoms and taken together with the carbon atoms to which they are attached form a carbon homocycle of 3 to 7 carbon atoms.
- 8. A compound of claim 1 which is benzyl (.alpha.S,3S,3aS,4R,7S,7aR).alpha.-(1-oxo-3a,4,7,7a-tetrahydro-1H,3H-4,7-methano-isobenzofuran-3-yl)-D-prolinate.
- 9. A compound of claim 1 which is benzyl (.alpha.R,3R,3aR,4S,7R,7aS).alpha.-(1-oxo-3a,4,7,7a-tetrahydro-1H,3H-4,7-methano-isobenzofuran-3-yl)-L-prolinate.
Priority Claims (1)
Number |
Date |
Country |
Kind |
79 30201 |
Dec 1979 |
FRX |
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PRIOR APPLICATION
This application is a division of our copending commonly assigned U.S. patent application Ser. No. 212,569 filed Dec. 3, 1980 now U.S. Pat. No. 4,350,637.
Non-Patent Literature Citations (1)
Entry |
Capeller et al., Helv. Chim. Acta., 40, (1957), pp. 1652-1658. |
Divisions (1)
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Number |
Date |
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Parent |
212569 |
Dec 1980 |
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