Claims
- 1. A compound of the formula ##STR173## the pharmaceutically acceptable nontoxic salts thereof or the hydrated forms thereof, wherein R.sup.1 is substituted or unsubstituted benzofuranyl wherein said substituent is alkylsulfonamido wherein the alkyl portion is 1 to 4 carbon atoms with the proviso that R.sup.1 is unsubstituted benzofuranyl only when ##STR174## is alkyl sulfonamido substituted phenyl; n is an integer of from one to ten;
- R.sup.2 is unsubstituted or is alkyl of from one to ten carbon atoms or oxygen that is present as an N-oxide;
- R.sup.3 is hydrogen, carboxyalkyl of from one to ten carbon atoms or alkoxycarbonylalkyl of from one to ten carbon atoms; ##STR175## is hydrogen; pyridinyl; cycloalkyl of three to eight carbon atoms or hydroxy substituted cycloalkyl of three to eight carbon atoms; furanyl; or unsubstituted or substituted phenyl wherein said phenyl substituent is one or more of alkyl, halogen substituted alkyl of one to ten carbon atoms, alkoxy from one to ten carbon atoms, nitro, amine, mono or dialkylamine, acetyl amine, acetylamide, halogen, alkylsulfonamido wherein the alkyl portion is 1 to 4 carbon atoms, alkoxy itself substituted by halogen substituted phenyl.
- 2. A compound according to claim 1 of the formula ##STR176## the pharmaceutically acceptable nontoxic salts thereof or the hydrated forms thereof, wherein R.sup.1 is substituted or unsubstituted benzofuranyl wherein said substituent is alkylsulfonamido wherein the alkyl portion is 1 to 4 carbon atoms with the proviso that R.sup.1 is unsubstituted benzofuranyl only when ##STR177## is alkylsulfonamido substituented phenyl; n is an integer of from one to ten;
- R.sup.2 is unsubstituted or is alkyl of from one to ten carbon atoms; R.sup.3 is hydrogen; ##STR178## is hydrogen; unsubstituted or substituted phenyl wherein said phenyl substituent is one or more of alkyl, halogen substituted alkyl of one to ten carbon atoms, alkoxy from one to ten carbon atoms, nitro, amine, mono or dialkylamine, acetyl amine, acetylamide, halogen, alkylsulfonamido wherein the alkyl portion is 1 to 4 carbon atoms, alkoxy itself substituted by halogen substituted phenyl.
- 3. A compound according to claim 1 which is N-[1-[[4[(methylsulfonyl)amino]phenyl]methyl]-4-piperidinyl]-2-benzofurancarboxamide.
- 4. A compound according to claim 1 which is 7-[(methylsulfonyl)amino]-N-[1-[[4-[(methylsulfonyl) amino]phenyl]methyl]-4-piperidinyl]-2-benzofurancarboxamide.
- 5. A compound according to claim 1 which is 7-[(methylsulfonyl)amino]-N-[1-(phenylmethyl)-4-piperidinyl]-2-benzofurancarboxamide.
- 6. A pharmaceutical composition useful for regulating cardiac arrhythmias comprising a therapeutically effective amount of a compound according to claim 1, together with one or more non-toxic pharmaceutically acceptable carriers.
- 7. A pharmaceutical composition according to claim 6 wherein said compound is selected from the group consisting of
- N-[1-[[4-[(methylsulfonyl)amino]phenyl]methyl]-4-piperidinyl]-2-benzofurancarboxamide;
- 7-[(methylsulfonyl)amino]-N-[l-[[4-[(methylsulfonyl) amino]phenyl]methyl]-4-piperidinyl]-2-benzofurancarboxamide and
- 7-[(methylsulfonyl)amino]-N-[1-(phenylmethyl)-4-piperidinyl]-2-benzofurancarboxamide.
- 8. A method of regulating cardiac arrhythmias comprising administering a therapeutically effective dose of a compound of claim 1 to a mammal in need of such treatment.
- 9. A method according to claim 8 wherein said compound is selected from the group consisting of N-[1-[[4-[(methylsulfonyl)amino]phenyl]methyl]-4piperidinyl]-2-benzofurancarboxamide;
- 7-[(methylsulfonyl)amino]-N-[1-[[4-[(methylsulfonyl) amino]phenyl]methyl]-4-piperidinyl]-2-benzofurancarboxamide and
- 7-[(methylsulfonyl)amino]-N-[I-(phenylmethyl)-4-piperidinyl]-2-benzofurancarboxamide.
Parent Case Info
This application is a continuation-in-part of Ser. No. 07/403,205, filed Sep. 5, 1989, now U.S. Pat. No. 5,098,915.
US Referenced Citations (17)
Foreign Referenced Citations (1)
Number |
Date |
Country |
1345872 |
Feb 1974 |
GBX |
Non-Patent Literature Citations (1)
Entry |
Effects of a Unique, New, Antihypertensive Agent (MJ-14712) on Arterial Blood Pressure and the Blood Pressure Response to Tilt (Orthostatic Hypotensive Potential) in Conscious Rats and Dogs. Flemming, J. S., et al., Federation Proceedings, vol. 43, p. 553 (1984). |
Continuation in Parts (1)
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Number |
Date |
Country |
Parent |
403205 |
Sep 1989 |
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