Claims
- 1. A compound of the formula ##STR28## where: R.sub.12 is
- --(CH.sub.2).sub.d --D--(CH.sub.2).sub.e --E
- where D is a chemical bond, O, --CH.sub.2 or --(CH.dbd.CH).sub.x where x is 1 or 2 and E is --COOR' or tetrazolyl where R' is hydrogen or C.sub.1-6 alkyl;
- R.sub.14 is ##STR29## where A is --CH.sub.2 or O; B is phenyl or substituted phenyl where the substituents are C.sub.1-6 alkyl, halo C.sub.1-6 alkyl, C.sub.1-6 alkoxy or halo and R' is hydrogen or C.sub.1-6 alkyl;
- R.sub.18 is
- --(CH.sub.2).sub.f --(CH.sub.2).sub.g --G
- where F is O or --CH.sub.2 and G is phenyl or substituted phenyl where the substituents are C.sub.1-6 alkyl, halo C.sub.1-6 alkyl, C.sub.1-6 alkoxy or halo; and
- a, b, d, e, f and g are independently 0-4; or a pharmaceutically acceptable salt thereof.
- 2. A compound according to claim 1 which is 4-[(N-methyl-N-phenethyl)-carbamoylmethyl]-8-benzyloxy-2-naphthoic acid or a pharmaceutically acceptable salt thereof.
- 3. A compound according to claim 1 which is 4-[(N-methyl-N-phenethyl)-carbamoylmethyl]-8-phenyl-2-naphthoic acid or a pharmaceutically acceptable salt thereof.
- 4. A compound according to claim 1 which is 4-[(N-methyl-N-phenethyl)-carbamoylmethyl]-8-phenyl-2-(2-carboxy)vinylnaphthalene or a pharmaceutically acceptable salt thereof.
- 5. A compound according to claim 1 which is 2-(2-carboxy)ethyl-4[-(N-methyl-N-phenethyl)carbamoylmethyl]-8-phenylnaphthalene or a pharmaceutically acceptable salt thereof.
- 6. A compound according to claim 1 which is 8-benzyloxy-2-(2-carboxy)vinyl-4-[(N-methyl-N-phenethyl)carbamoylmethyl]naphthalene or a pharmaceutically acceptable salt thereof.
Parent Case Info
This application is a continuation-in-part application of U.S. Ser. No. 07/580,243 filed on Sep. 10, 1990, abandoned.
PCT Information
Filing Document |
Filing Date |
Country |
Kind |
102e Date |
371c Date |
PCT/US91/06447 |
9/6/1991 |
|
|
4/23/1993 |
4/23/1993 |
Publishing Document |
Publishing Date |
Country |
Kind |
WO92/04315 |
3/19/1992 |
|
|
US Referenced Citations (4)
Foreign Referenced Citations (6)
Number |
Date |
Country |
0276064 |
Jul 1988 |
EPX |
0276065 |
Jul 1988 |
EPX |
0292977 |
Nov 1988 |
EPX |
2230349 |
Dec 1974 |
FRX |
WO9204315 |
Mar 1992 |
WOX |
WO9205145 |
Apr 1992 |
WOX |
Continuation in Parts (1)
|
Number |
Date |
Country |
Parent |
580243 |
Sep 1990 |
|