Claims
- 1. A method of treating an ophthalmic condition in a patient afflicted therewith which comprises administering to such patient afflicted therewith an ophthalmically beneficial amount of a substituted phenoxyalkanolamine or phenoxylalkanol-cycloalkylamine of the general formula I ##STR11## in which R.sup.1 and R.sup.2, which can be identical or different, denote alkyl groups with in each case 1 to 4 carbon atoms, or R.sup.1 and R.sup.2 together denote the group --(CH.sub.2).sub.n --, wherein n is the number 4 or 5, R.sup.3 denotes hydrogen, R.sup.4 denotes an alkyl group with 1 to 4 carbon atoms or the cyclopropylmethyl group and R.sup.5 denotes hydrogen, halogen or alkyl, or an acid addition salt thereof.
- 2. The method according to claim 1, in which R.sub.1 and R.sub.2 each denote alkyl.
- 3. The method according to claim 1, in which R.sub.1 and R.sub.2 each denote methyl.
- 4. The method according to claim 2, in which R.sup.4 is methyl or cyclopropylmethyl.
- 5. The method according to claim 1, in which R.sup.5 denotes hydrogen.
- 6. The method according to claim 1, in which the compound administered to the patient is 1-[4-(2-methoxyethyl)-phenoxy]-3-amino-3-methyl-butan-2-ol.
- 7. The method according to claim 1, in which the compound administered to the patient is 1-[4-(2-cyclopropylmethoxyethyl)-phenoxy]-3-amino-3-methyl-butan-2ol.
- 8. An intra-ocular pressure-reducing composition comprising an amount effective therefor of a substituted phenoxyalkanolamine or phenoxyalkanol-cycloalkylamine of the general formula I ##STR12## in which R.sup.1 and R.sup.2, which can be identical or different, denote alkyl groups with in each case 1 to 4 carbon atoms, or R.sup.1 and R.sup.2 together denote the group --(CH.sub.2).sub.n --, wherein n is the number 4 or 5, R.sup.3 denotes hydrogen, R.sup.4 denotes an alkyl group with 1 to 4 carbon atoms or the cyclopropylmethyl group and R.sup.5 denotes hydrogen, halogen or alkyl, or an acid addition salt thereof, and a pharmaceutically acceptable diluent.
- 9. A composition according to claim 8, in which R.sub.1 and R.sub.2 each denote alkyl.
- 10. A composition according to claim 8, in which R.sub.1 and R.sub.2 each denote methyl.
- 11. A composition according to claim 8, in which R.sup.4 is methyl or cyclopropylmethyl.
- 12. A composition according to claim 8, in which R.sup.5 denotes hydrogen.
- 13. A composition according to claim 8, in which the compound administered to the patient is 1-[4-(2-methoxyethyl)-phenoxy]-3-amino-3-methyl-butan-2-ol.
- 14. A composition according to claim 8, in which the compound administered to the patient is 1-[4-(2-cyclopropylmethoxyethyl)-phenoxy]-3-amino-3-methyl-butan-2-ol.
Priority Claims (1)
Number |
Date |
Country |
Kind |
3151201 |
Dec 1981 |
DEX |
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Parent Case Info
This is a division of application Ser. No. 883,208, filed July 8, 1986, now pending, which is a continuation of application Ser. No. 722,906, filed Apr. 12, 1985, now abandoned, which was a continuation of application Ser. No. 450,161, filed Dec. 16, 1982, now abandoned.
US Referenced Citations (10)
Foreign Referenced Citations (5)
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Country |
082461 |
Mar 1987 |
EPX |
2649605 |
May 1977 |
DEX |
2081523 |
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FRX |
2139740 |
Jan 1973 |
FRX |
2289172 |
May 1976 |
FRX |
Non-Patent Literature Citations (5)
Entry |
Goodman et al., The Pharmacological Basis of Therapeutics, 6th Ed., (1980), pp. 113, 114, 188, 189. |
The Merck Index, 9th Ed., (1976), p. ONR-42. |
The Merck Index, 10th Ed., (1983), pp. 1203 & 6031. |
Schid, Brit. J. Pharmacol., vol. 2, (1947), pp. 189-206. |
Lumley et al., J. Pharmac., vol. 29, (1977), pp. 598-604. |
Divisions (1)
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Number |
Date |
Country |
Parent |
883208 |
Jul 1986 |
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Continuations (2)
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Number |
Date |
Country |
Parent |
722906 |
Apr 1985 |
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Parent |
450161 |
Dec 1982 |
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