Claims
- 1. A compound of formula I
- 2. A compound of formula II
- 3. The compound of claim 2 of formula II
- 4. The compound of claim 2 of formula II
- 5. The compound of claim 2 of formula II
- 6. The compound of claim 2 of formula II
- 7. The compound of claim 6
- 8. The compound of claim 6
- 9. The compound of claim 6 of the formula
- 10. The compound of claim 6 of the formula
- 11. The compound of claim 6 of the formula
- 12. The compound of claim 6 selected from the group consisting of:
1-[4-(aminosulfonyl)phenyl]-8-{[(trifluoromethyl)sulfonyl]amino}-4,5-dihydro-1H-benzo[g]indazole-3-carboxamide, 1-[4-(aminosulfonyl)phenyl]-8-[(ethylsulfonyl)amino]-4,5-dihydro-1H-benzo[g]indazole-3-carboxamide, 1-[4-(aminosulfonyl)phenyl]-8-{[(2,2,2-trifluoroethyl)sulfonyl]amino}-4,5-dihydro-1H-benzo[g]indazole-3-carboxamide, 1-[4-(aminosulfonyl)phenyl]-8-[(propylsulfonyl)amino]-4,5-dihydro-1H-benzo[g]indazole-3-carboxamide, 1-[4-(aminosulfonyl)phenyl]-8-[(isopropylsulfonyl)amino]-4,5-dihydro-1H-benzo[g]indazole-3-carboxamide, 1-[4-(aminosulfonyl)phenyl]-8-[(butylsulfonyl)amino]-4,5-dihydro-1H-benzo[g]indazole-3-carboxamide, 1-[4-(aminosulfonyl)phenyl]-8-[(benzylsulfonyl)amino]-4,5-dihydro-1H-benzo[g]indazole-3-carboxamide, 1-[4-(aminosulfonyl)phenyl]-8-[(1-naphthylsulfonyl)amino]-4,5-dihydro-1H-benzo[g]indazole-3-carboxamide, 1-[4-(aminosulfonyl)phenyl]-8-({[5-(dimethylamino)-1-naphthyl]sulfonyl}amino)-4,5-dihydro-1H-benzo[g]indazole-3-carboxamide, 1-[4-(aminosulfonyl)phenyl]-8-[(isoquinolin-5-ylsulfonyl)amino]-4,5-dihydro-1H-benzo[g]indazole-3-carboxamide, 1-[4-(aminosulfonyl)phenyl]-8-[(quinolin-7-ylsulfonyl)amino]-4,5-dihydro-1H-benzo[g]indazole-3-carboxamide, 1-[4-(aminosulfonyl)phenyl]-8-[(2,1,3-benzoxadiazol-4-ylsulfonyl)amino]-4,5-dihydro-1H-benzo[g]indazole-3-carboxamide, 1-[4-(aminosulfonyl)phenyl]-8-[(1,1′-biphenyl-4-ylsulfonyl)amino]-4,5-dihydro-1H-benzo[g]indazole-3-carboxamide, 1-[4-(aminosulfonyl)phenyl]-8-{[(5-pyridin-2-ylthien-2-yl)sulfonyl]amino}-4,5-dihydro-1H-benzo[g]indazole-3-carboxamide, 1-[4-(aminosulfonyl)phenyl]-8-{[(1-methyl-1H-imidazol-4-yl)sulfonyl]amino}-4,5-dihydro-1H-benzo[g]indazole-3-carboxamide, 1-[4-(aminosulfonyl)phenyl]-8-{[(1,2-dimethyl-1H-imidazol-4-yl)sulfonyl]amino}-4,5-dihydro-1H-benzo[g]indazole-3-carboxamide, 8-({[2-(acetylamino)-4-methyl-1,3-thiazol-5-yl]sulfonyl}amino)-1-[4-(aminosulfonyl)phenyl]-4,5-dihydro-1H-benzo[g]indazole-3-carboxamide, 1-[4-(aminosulfonyl)phenyl]-8-{[(4-methylphenyl)sulfonyl]amino}-4,5-dihydro-1H-benzo[g]indazole-3-carboxamide, 1-[4-(aminosulfonyl)phenyl]-8-{[(4-methoxyphenyl)sulfonyl]amino}-4,5-dihydro-1H-benzo[g]indazole-3-carboxamide, 1-[4-(aminosulfonyl)phenyl]-8-{[(4-fluorophenyl)sulfonyl]amino}-4,5-dihydro-1H-benzo[g]indazole-3-carboxamide, 1-[4-(aminosulfonyl)phenyl]-8-{[(4-chlorophenyl)sulfonyl]amino}-4,5-dihydro-1H-benzo[g]indazole-3-carboxamide, 1-[4-(aminosulfonyl)phenyl]-8-{[(4-bromophenyl)sulfonyl]amino}-4,5-dihydro-1H-benzo[g]indazole-3-carboxamide, 1-[4-(aminosulfonyl)phenyl]-8-({[3-(trifluoromethyl)phenyl]sulfonyl}amino)-4,5-dihydro-1H-benzo[g]indazole-3-carboxamide, 1-[4-(aminosulfonyl)phenyl]-8-{[(3,4-dichlorophenyl)sulfonyl]amino}-4,5-dihydro-1H-benzo[g]indazole-3-carboxamide, 1-[4-(aminosulfonyl)phenyl]-8-{[(2,5-dichlorophenyl)sulfonyl]amino}-4,5-dihydro-1H-benzo[g]indazole-3-carboxamide, 1-[4-(aminosulfonyl)phenyl]-8-{[(2,4-dichlorophenyl)sulfonyl]amino}-4,5-dihydro-1H-benzo[g]indazole-3-carboxamide, 1-[4-(aminosulfonyl)phenyl]-8-{[(2,4-difluorophenyl)sulfonyl]amino}-4,5-dihydro-1H-benzo[g]indazole-3-carboxamide, 1-[4-(aminosulfonyl)phenyl]-8-{[(3,4-difluorophenyl)sulfonyl]amino}-4,5-dihydro-1H-benzo[g]indazole-3-carboxamide, 1-[4-(aminosulfonyl)phenyl]-8-{[(4-bromo-2-fluorophenyl)sulfonyl]amino}-4,5-dihydro-1H-benzo[g]indazole-3-carboxamide, 1-[4-(aminosulfonyl)phenyl]-8-{[(3,4-dimethoxyphenyl)sulfonyl]amino}-4,5-dihydro-1H-benzo[g]indazole-3-carboxamide, 1-[4-(aminosulfonyl)phenyl]-8-({[3,5-bis(trifluoromethyl)phenyl]sulfonyl}amino)-4,5-dihydro-1H-benzo[g]indazole-3-carboxamide, 1-[4-(aminosulfonyl)phenyl]-8-{[(2,4,5-trichlorophenyl)sulfonyl]amino}-4,5-dihydro-1H-benzo[g]indazole-3-carboxamide, 1-[4-(aminosulfonyl)phenyl]-8-(propionylamino)-4,5-dihydro-1H-benzo[g]indazole-3-carboxamide, 1-[4-(aminosulfonyl)phenyl]-8-(benzoylamino)-4,5-dihydro-1H-benzo[g]indazole-3-carboxamide, 1-[4-(aminosulfonyl)phenyl]-8-{[(ethylamino)carbonyl]amino}-4,5-dihydro-1H-benzo[g]indazole-3-carboxamide, 1-[4-(aminosulfonyl)phenyl]-8-[(anilinocarbonyl)amino]-4,5-dihydro-1H-benzo[g]indazole-3-carboxamide, 1-[4-(aminosulfonyl)phenyl]-8-(benzylamino)-4,5-dihydro-1H-benzo[g]indazole-3-carboxamide, 1-[4-(aminosulfonyl)phenyl]-8-[(4-methylbenzyl)amino]-4,5-dihydro-1H-benzo[g]indazole-3-carboxamide, 1-[4-(aminosulfonyl)phenyl]-8-[(4-methoxybenzyl)amino]-4,5-dihydro-1H-benzo[g]indazole-3-carboxamide, 1-[4-(aminosulfonyl)phenyl]-8-[(4-chlorobenzyl)amino]-4,5-dihydro-1H-benzo[g]indazole-3-carboxamide, 1-[4-(aminosulfonyl)phenyl]-8-(isobutylamino)-4,5-dihydro-1H-benzo[g]indazole-3-carboxamide, 8-amino-1-{4-[(dimethylamino)sulfonyl]phenyl}-4,5-dihydro-1H-benzo[g]indazole-3-carboxamide, 8-amino-1-{4-[(diallylamino)sulfonyl]phenyl}-4,5-dihydro-1H-benzo[g]indazole-3-carboxamide, 8-(L-alanylamino)-1-[4-(aminosulfonyl)phenyl]-4,5-dihydro-1H-benzo[g]indazole-3-carboxamide, 8-(D-alanylamino)-1-[4-(aminosulfonyl)phenyl]-4,5-dihydro-1H-benzo[g]indazole-3-carboxamide, 1-[4-(aminosulfonyl)phenyl]-8-(pentanoylamino)-4,5-dihydro-1H-benzo[g]indazole-3-carboxamide, 1-[4-(aminosulfonyl)phenyl]-8-[(cyclohexylcarbonyl)amino]-4,5-dihydro-1H-benzo[g]indazole-3-carboxamide, 1-[4-(aminosulfonyl)phenyl]-8-[(cyclopentylcarbonyl)amino]-4,5-dihydro-1H-benzo[g]indazole-3-carboxamide, 1-[4-(aminosulfonyl)phenyl]-8-[(cyclobutylcarbonyl)amino]-4,5-dihydro-1H-benzo[g]indazole-3-carboxamide, 1-[4-(aminosulfonyl)phenyl]-8-[(cyclopropylcarbonyl)amino]-4,5-dihydro-1H-benzo[g]indazole-3-carboxamide, 1-[4-(aminosulfonyl)phenyl]-8-(butyrylamino)-4,5-dihydro-1H-benzo[g]indazole-3-carboxamide, 1-[4-(aminosulfonyl)phenyl]-8-[(phenylacetyl)amino]-4,5-dihydro-1H-benzo[g]indazole-3-carboxamide, 1-[4-(aminosulfonyl)phenyl]-8-[(methoxyacetyl)amino]-4,5-dihydro-1H-benzo[g]indazole-3-carboxamide, 1-[4-(aminosulfonyl)phenyl]-8-(isobutyrylamino)-4,5-dihydro-1H-benzo[g]indazole-3-carboxamide, 1-[4-(aminosulfonyl)phenyl]-8-{[4-(trifluoromethyl)benzoyl]amino}-4,5-dihydro-1H-benzo[g]indazole-3-carboxamide 1-[4-(aminosulfonyl)phenyl]-8-[(4-methoxybenzoyl)amino]-4,5-dihydro-1H-benzo[g]indazole-3-carboxamide, 1-[4-(aminosulfonyl)phenyl]-8-[(4-chlorobenzoyl)amino]-4,5-dihydro-1H-benzo[g]indazole-3-carboxamide, 1-[4-(aminosulfonyl)phenyl]-8-[(4-fluorobenzoyl)amino]-4,5-dihydro-1H-benzo[g]indazole-3-carboxamide, 1-[4-(aminosulfonyl)phenyl]-8-[(3,4-dimethoxybenzoyl)amino]-4,5-dihydro-1H-benzo[g]indazole-3-carboxamide, 1-[4-(aminosulfonyl)phenyl]-8-(2-furoylamino)-4,5-dihydro-1H-benzo[g]indazole-3-carboxamide, 1-[4-(aminosulfonyl)phenyl]-8-[(thien-2-ylcarbonyl)amino]-4,5-dihydro-1H-benzo[g]indazole-3-carboxamide, 1-[4-(aminosulfonyl)phenyl]-8-(isonicotinoylamino)-4,5-dihydro-1H-benzo[g]indazole-3-carboxamide, 8-[(1-adamantylcarbonyl)amino]-1-[4-(aminosulfonyl)phenyl]-4,5-dihydro-1H-benzo[g]indazole-3-carboxamide, 1-[4-(aminosulfonyl)phenyl]-8-[(phenylsulfonyl)amino]-4,5-dihydro-1H-benzo[g]indazole-3-carboxamide, 1-[4-(aminosulfonyl)phenyl]-8-{[3-(trifluoromethyl)benzoyl]amino}-4,5-dihydro-1H-benzo[g]indazole-3-carboxamide, 1-[4-(aminosulfonyl)phenyl]-8-[(3-methylbenzoyl)amino]-4,5-dihydro-1H-benzo[g]indazole-3-carboxamide, 1-[4-(aminosulfonyl)phenyl]-8-[(3-bromobenzoyl)amino]-4,5-dihydro-1H-benzo[g]indazole-3-carboxamide, 1-[4-(aminosulfonyl)phenyl]-8-{[(3-methoxyphenyl)acetyl]amino}-4,5-dihydro-1H-benzo [g]indazole-3-carboxamide, 1-[4-(aminosulfonyl)phenyl]-8-[(pyridin-3-ylcarbonyl)amino]-4,5-dihydro-1H-benzo[g]indazole-3-carboxamide, 1-[4-(aminosulfonyl)phenyl]-8-[(2-chlorobenzoyl)amino]-4,5-dihydro-1H-benzo[g]indazole-3-carboxamide, 1-[4-(aminosulfonyl)phenyl]-8-{[(3-bromophenyl)sulfonyl]amino}-4,5-dihydro-1H-benzo[g]indazole-3-carboxamide, 1-[4-(aminosulfonyl)phenyl]-8-{[(3-chlorophenyl)sulfonyl]amino}-4,5-dihydro-1H-benzo[g]indazole-3-carboxamide, 1-[4-(aminosulfonyl)phenyl]-8-[(3-cyanobenzoyl)amino]-4,5-dihydro-1H-benzo[g]indazole-3-carboxamide, 1-[4-(aminosulfonyl)phenyl]-8-{[(3-methylphenyl)sulfonyl]amino}-4,5-dihydro-1H-benzo[g]indazole-3-carboxamide, 1-[4-(aminosulfonyl)phenyl]-8-[(3-methoxybenzoyl)amino]-4,5-dihydro-1H-benzo[g]indazole-3-carboxamide, 1-[4-(aminosulfonyl)phenyl]-8-[(3-chlorobenzoyl)amino]-4,5-dihydro-1H-benzo[g]indazole-3-carboxamide, 1-[4-(aminosulfonyl)phenyl]-8-[(2-methoxybenzoyl)amino]-4,5-dihydro-1H-benzo[g]indazole-3-carboxamide, 1-[4-(aminosulfonyl)phenyl]-8-{[2-(trifluoromethyl)benzoyl]amino}-4,5-dihydro-1H-benzo[g]indazole-3-carboxamide, 1-[4-(aminosulfonyl)phenyl]-8-[(2-methylbenzoyl)amino]-4,5-dihydro-1H-benzo[g]indazole-3-carboxamide, 1-[4-(aminosulfonyl)phenyl]-8-[(2,6-dichlorobenzoyl)amino]-4,5-dihydro-1H-benzo[g]indazole-3-carboxamide, 1-[4-(aminosulfonyl)phenyl]-8-{[2-(trifluoromethoxy)benzoyl]amino}-4,5-dihydro-1H-benzo[g]indazole-3-carboxamide, 1-[4-(aminosulfonyl)phenyl]-8-[(2,3-dichlorobenzoyl)amino]-4,5-dihydro-1H-benzo[g]indazole-3-carboxamide, 1-[4-(aminosulfonyl)phenyl]-8-[(2-fluorobenzoyl)amino]-4,5-dihydro-1H-benzo[g]indazole-3-carboxamide, 1-[4-(aminosulfonyl)phenyl]-8-{[(2-chloropyridin-3-yl)carbonyl]amino}-4,5-dihydro-1H-benzo[g]indazole-3-carboxamide, 1-[4-(aminosulfonyl)phenyl]-8-{[(2-chlorophenyl)sulfonyl]amino}-4,5-dihydro-1H-benzo[g]indazole-3-carboxamide, 1-[4-(aminosulfonyl)phenyl]-8-[(2-bromobenzoyl)amino]-4,5-dihydro-1H-benzo[g]indazole-3-carboxamide, 8-[(2-chlorobenzoyl)amino]-1-{4-[(dimethylamino)sulfonyl]phenyl}-4,5-dihydro-1H-benzo[g]indazole-3-carboxamide, 8-[(2-chlorobenzoyl)amino]-1-[4-(methylsulfonyl)phenyl]-4,5-dihydro-1H-benzo[g]indazole-3-carboxamide, 1-[3-(aminosulfonyl)phenyl]-8-[(2-chlorobenzoyl)amino]-4,5-dihydro-1H-benzo[g]indazole-3-carboxamide,
- 13. The compound of claim 2 of the formula
- 14. The compound of claim 2 of the formula
- 15. The compound of claim 14 selected from the group consisting of:
1-(1,3-benzodioxol-5-yl)-8-{[(2-chloropyridin-3-yl)carbonyl]amino}-4,5-dihydro-1H-benzo[g]indazole-3-carboxamide, 1-(1,3-benzodioxol-5-yl)-8-{[(2,5-dichloropyridin-3-yl)carbonyl]amino}-4,5-dihydro-1H-benzo[g]indazole-3-carboxamide, 1-(1,3-benzodioxol-5-yl)-8-{[2-chloro-4-(methylsulfonyl)benzoyl]amino}-4,5-dihydro-1H-benzo[g]indazole-3-carboxamide, 1-(1,3-benzodioxol-5-yl)-8-[(2,5-dichloroisonicotinoyl)amino]-4,5-dihydro-1H-benzo[g]indazole-3-carboxamide, 1-(1,3-benzodioxol-5-yl)-8-[(2-chloro-4-fluorobenzoyl)amino]-4,5-dihydro-1H-benzo[g]indazole-3-carboxamide, 1-(1,3-benzodioxol-5-yl)-8-[(2-chlorobenzoyl)amino]-4,5-dihydro-1H-benzo[g]indazole-3-carboxamide, 1-(1,3-benzodioxol-5-yl)-8-[(2-chloro-4,5-difluorobenzoyl)amino]-4,5-dihydro-1H-benzo[g]indazole-3-carboxamide, 1-(1,3-benzodioxol-5-yl)-8-{[(2-chloro-6-methylpyridin-3-yl)carbonyl]amino}-4,5-dihydro-1H-benzo[g]indazole-3-carboxamide, 1-(1,3-benzodioxol-5-yl)-8-{[(6-chloro-1,3-benzodioxol-5-yl)carbonyl]amino}-4,5-dihydro-1H-benzo[g]indazole-3-carboxamide, 8-[(2-amino-6-chlorobenzoyl)amino]-1-(1,3-benzodioxol-5-yl)-4,5-dihydro-1H-benzo[g]indazole-3-carboxamide, 1-(1,3-benzodioxol-5-yl)-8-[(3-chloroisonicotinoyl)amino]-4,5-dihydro-1H-benzo[g]indazole-3-carboxamide, 8-[(3-amino-2-chlorobenzoyl)amino]-1-(1,3-benzodioxol-5-yl)-4,5-dihydro-1H-benzo[g]indazole-3-carboxamide hydrochloride, 8-[(5-amino-2-chlorobenzoyl)amino]-1-(1,3-benzodioxol-5-yl)-4,5-dihydro-1H-benzo[g]indazole-3-carboxamide, 1-(1,3-benzodioxol-5-yl)-8-[(2-chloro-5-nitrobenzoyl)amino]-4,5-dihydro-1H-benzo[g]indazole-3-carboxamide, 1-(1,3-benzodioxol-5-yl)-8-[(2-chloro-4,5-dimethoxybenzoyl)amino]-4,5-dihydro-1H-benzo[g]indazole-3-carboxamide, 1-(1,3-benzodioxol-5-yl)-8-[(2-chloro-3,4-dimethoxybenzoyl)amino]-4,5-dihydro-1H-benzo[g]indazole-3-carboxamide, 1-(1,3-benzodioxol-5-yl)-8-{[2-chloro-5-(methylsulfinyl)benzoyl]amino}-4,5-dihydro-1H-benzo[g]indazole-3-carboxamide, 1-(1,3-benzodioxol-5-yl)-8-[(2-bromobenzoyl)amino]-4,5-dihydro-1H-benzo[g]indazole-3-carboxamide, 1-(1,3-benzodioxol-5-yl)-8-({[2-(methylamino)pyridin-3-yl]carbonyl}amino)-4,5-dihydro-1H-benzo[g]indazole-3-carboxamide, 1-(1,3-benzodioxol-5-yl)-8-[(2-chloro-5-methoxybenzoyl)amino]-4,5-dihydro-1H-benzo[g]indazole-3-carboxamide, 8-[(4-acetylbenzoyl)amino]-1-(1,3-benzodioxol-5-yl)-4,5-dihydro-1H-benzo[g]indazole-3-carboxamide, 8-[(4-amino-2-chlorobenzoyl)amino]-1-(1,3-benzodioxol-5-yl)-4,5-dihydro-1H-benzo[g]indazole-3-carboxamide, 1-(1,3-benzodioxol-5-yl)-8-({[2-chloro-6-(trifluoromethyl)pyridin-3-yl]carbonyl}amino)-4,5-dihydro-1H-benzo[g]indazole-3-carboxamide, 1-(1,3-benzodioxol-5-yl)-8-[(2-chloro-4-methoxybenzoyl)amino]-4,5-dihydro-1H-benzo[g]indazole-3-carboxamide, 1-(1,3-benzodioxol-5-yl)-8-{[2-chloro-5-(dimethylamino)benzoyl]amino}-4,5-dihydro-1H-benzo[g]indazole-3-carboxamide, 1-(1,3-benzodioxol-5-yl)-8-[(2-chloro-4-nitrobenzoyl)amino]-4,5-dihydro-1H-benzo[g]indazole-3-carboxamide, 1-(1,3-benzodioxol-5-yl)-8-{[2-chloro-5-(methylsulfonyl)benzoyl]amino}-4,5-dihydro-1H-benzo[g]indazole-3-carboxamide, 1-(1,3-benzodioxol-5-yl)-8-{[(6-hydroxypyridin-3-yl)carbonyl]amino}-4,5-dihydro-1H-benzo[g]indazole-3-carboxamide, 1-(1,3-benzodioxol-5-yl)-8-{[(4-methylpyridin-3-yl)carbonyl]amino}-4,5-dihydro-1H-benzo[g]indazole-3-carboxamide, 1-(1,3-benzodioxol-5-yl)-8-[(2-methylbenzoyl)amino]-4,5-dihydro-1H-benzo[g]indazole-3-carboxamide, 1-(1,3-benzodioxol-5-yl)-8-[(2,5-dichlorobenzoyl)amino]-4,5-dihydro-1H-benzo[g]indazole-3-carboxamide, 1-(1,3-benzodioxol-5-yl)-8-{[2-chloro-5-(methylthio)benzoyl]amino}-4,5-dihydro-1H-benzo[g]indazole-3-carboxamide, 1-(1,3-benzodioxol-5-yl)-8-({2-chloro-5-[2-(dimethylamino)ethoxy]benzoyl}amino)-4,5-dihydro-1H-benzo[g]indazole-3-carboxamide, 1-(1,3-benzodioxol-5-yl)-8-[(2-nitrobenzoyl)amino]-4,5-dihydro-1H-benzo[g]indazole-3-carboxamide, 1-(1,3-benzodioxol-5-yl)-8-{[(4-methyl-1,2,3-thiadiazol-5-yl)carbonyl]amino}-4,5-dihydro-1H-benzo[g]indazole-3-carboxamide, 1-(1,3-benzodioxol-5-yl)-8-[(2,3-dichlorobenzoyl)amino]-4,5-dihydro-1H-benzo[g]indazole-3-carboxamide, 1-(1,3-benzodioxol-5-yl)-8-{[(3-chloro-6-morpholin-4-ylpyridin-2-yl)carbonyl]amino}-4,5-dihydro-1H-benzo[g]indazole-3-carboxamide, 1-(1,3-benzodioxol-5-yl)-8-[(2,4-dichlorobenzoyl)amino]-4,5-dihydro-1H-benzo[g]indazole-3-carboxamide, 1-(1,3-benzodioxol-5-yl)-8-(isonicotinoylamino)-4,5-dihydro-1H-benzo[g]indazole-3-carboxamide, 1-(1,3-benzodioxol-5-yl)-8-[(5-methoxy-2-nitrobenzoyl)amino]-4,5-dihydro-1H-benzo[g]indazole-3-carboxamide, 1-(1,3-benzodioxol-5-yl)-8-[(3-hydroxy-2-methylbenzoyl)amino]-4,5-dihydro-1H-benzo[g]indazole-3-carboxamide, 1-(1,3-benzodioxol-5-yl)-8-[(1-oxidoisonicotinoyl)amino]-4,5-dihydro-1H-benzo[g]indazole-3-carboxamide, 1-(1,3-benzodioxol-5-yl)-8-(3-furoylamino)-4,5-dihydro-1H-benzo[g]indazole-3-carboxamide, 8-[(3-amino-4-chlorobenzoyl)amino]-1-(1,3-benzodioxol-5-yl)-4,5-dihydro-1H-benzo[g]indazole-3-carboxamide, 1-(1,3-benzodioxol-5-yl)-8-{[(2-methylpyridin-3-yl)carbonyl]amino}-4,5-dihydro-1H-benzo[g]indazole-3-carboxamide, 1-(1,3-benzodioxol-5-yl)-8-({2-chloro-4-[(N,N-dimethylglycyl)amino]benzoyl}amino)-4,5-dihydro-1H-benzo[g]indazole-3-carboxamide, 1-(1,3-benzodioxol-5-yl)-8-{[(3,6-dichloropyridin-2-yl)carbonyl]amino}-4,5-dihydro-1H-benzo[g]indazole-3-carboxamide, 1-(1,3-benzodioxol-5-yl)-8-{[2-(trifluoromethoxy)benzoyl]amino}-4,5-dihydro-1H-benzo[g]indazole-3-carboxamide, 1-(1,3-benzodioxol-5-yl)-8-{[(6-hydroxypyridin-2-yl)carbonyl]amino}-4,5-dihydro-1H-benzo[g]indazole-3-carboxamide, and 1-(1,3-benzodioxol-5-yl)-8-[(4-cyanobenzoyl)amino]-4,5-dihydro-1H-benzo[g]indazole-3-carboxamide.
- 16. The compound of claim 2 of the formula
- 17. The compound of claim 16 selected from the group consisting of:
8-amino-1-[4-(methylsulfonyl)phenyl]-4,5-dihydro-1H-benzo[g]indazole-3-carboxamide hydrochloride, 1-[4-(methylsulfonyl)phenyl]-8-{[2-(trifluoromethyl)benzoyl]amino}-4,5-dihydro-1H-benzo[g]indazole-3-carboxamide, 8-[(2-methylbenzoyl)amino]-1-[4-(methylsulfonyl)phenyl]-4,5-dihydro-1H-benzo[g]indazole-3-carboxamide, 8-[(2-chlorobenzoyl)amino]-1-[4-(methylsulfonyl)phenyl]-4,5-dihydro-1H-benzo[g]indazole-3-carboxamide, 8-[(2,3-dichlorobenzoyl)amino]-1-[4-(methylsulfonyl)phenyl]-4,5-dihydro-1H-benzo[g]indazole-3-carboxamide, 8-[(2-fluorobenzoyl)amino]-1-[4-(methylsulfonyl)phenyl]-4,5-dihydro-1H-benzo[g]indazole-3-carboxamide, 8-{[(2-chloropyridin-3-yl)carbonyl]amino}-1-[4-(methylsulfonyl)phenyl]-4,5-dihydro-1H-benzo[g]indazole-3-carboxamide, 1-[4-(methylsulfonyl)phenyl]-8-[(1H-pyrazol-4-ylcarbonyl)amino]-4,5-dihydro-1H-benzo[g]indazole-3-carboxamide, 8-[(4-chloro-2-nitrobenzoyl)amino]-1-[4-(methylsulfonyl)phenyl]-4,5-dihydro-1H-benzo[g]indazole-3-carboxamide, 8-[(cyclobutylcarbonyl)amino]-1-[4-(methylsulfonyl)phenyl]-4,5-dihydro-1H-benzo[g]indazole-3-carboxamide, 8-[(2-methyl-3-nitrobenzoyl)amino]-1-[4-(methylsulfonyl)phenyl]-4,5-dihydro-1H-benzo[g]indazole-3-carboxamide, 8-[(2-chloro-6-fluorobenzoyl)amino]-1-[4-(methylsulfonyl)phenyl]-4,5-dihydro-1H-benzo[g]indazole-3-carboxamide, 8-[(2-chloro-3-nitrobenzoyl)amino]-1-[4-(methylsulfonyl)phenyl]-4,5-dihydro-1H-benzo[g]indazole-3-carboxamide, 8-[(5-bromo-2-chlorobenzoyl)amino]-1-[4-(methylsulfonyl)phenyl]-4,5-dihydro-1H-benzo[g]indazole-3-carboxamide, 8-{[2-chloro-5-(methylthio)benzoyl]amino}-1-[4-(methylsulfonyl)phenyl]-4,5-dihydro-1H-benzo[g]indazole-3-carboxamide, 8-{[(2-chloro-6-methylpyridin-3-yl)carbonyl]amino}-1-[4-(methylsulfonyl)phenyl]-4,5-dihydro-1H-benzo[g]indazole-3-carboxamide, 8-[(5-chloro-2-nitrobenzoyl)amino]-1-[4-(methylsulfonyl)phenyl]-4,5-dihydro-1H-benzo[g]indazole-3-carboxamide, 8-(benzoylamino)-1-[4-(methylsulfonyl)phenyl]-4,5-dihydro-1H-benzo[g]indazole-3-carboxamide, 1-[4-(methylsulfonyl)phenyl]-8-{[2-(methylthio)benzoyl]amino}-4,5-dihydro-1H-benzo[g]indazole-3-carboxamide, 8-[(3-methoxybenzoyl)amino]-1-[4-(methylsulfonyl)phenyl]-4,5-dihydro-1H-benzo[g]indazole-3-carboxamide, 8-[(4-methoxybenzoyl)amino]-1-[4-(methylsulfonyl)phenyl]-4,5-dihydro-1H-benzo[g]indazole-3-carboxamide, 8-[(4-cyanobenzoyl)amino]-1-[4-(methylsulfonyl)phenyl]-4,5-dihydro-1H-benzo[g]indazole-3-carboxamide, 8-{[(3,7-dimethylimidazo[1,2-a]pyridin-2-yl)carbonyl]amino}-1-[4-(methylsulfonyl)phenyl]-4,5-dihydro-1H-benzo[g]indazole-3-carboxamide, 8-{[(2-methylpyridin-3-yl)carbonyl]amino}-1-[4-(methylsulfonyl)phenyl]-4,5-dihydro-1H-benzo[g]indazole-3-carboxamide, 8-[(2,3-difluorobenzoyl)amino]-1-[4-(methylsulfonyl)phenyl]-4,5-dihydro-1H-benzo[g]indazole-3-carboxamide, 1-[4-(methylsulfonyl)phenyl]-8-[(2-nitrobenzoyl)amino]-4,5-dihydro-1H-benzo[g]indazole-3-carboxamide, 3-[({3-(aminocarbonyl)-1-[4-(methylsulfonyl)phenyl]-4,5-dihydro-1H-benzo[g]indazol-8-yl}amino)carbonyl]-2-methylphenyl acetate, 8-{[2-chloro-5-(methylsulfonyl)benzoyl]amino}-1-[4-(methylsulfonyl)phenyl]-4,5-dihydro-1H-benzo[g]indazole-3-carboxamide, 8-[(3-chloro-2-fluorobenzoyl)amino]-1-[4-(methylsulfonyl)phenyl]-4,5-dihydro-1H-benzo[g]indazole-3-carboxamide, 8-{[(4-chloropyridin-3-yl)carbonyl]amino}-1-[4-(methylsulfonyl)phenyl]-4,5-dihydro-1H-benzo[g]indazole-3-carboxamide 8-[(2,3-dimethylbenzoyl)amino]-1-[4-(methylsulfonyl)phenyl]-4,5-dihydro-1H-benzo[g]indazole-3-carboxamide, 8-[(2-chloro-4,5-dimethoxybenzoyl)amino]-1-[4-(methylsulfonyl)phenyl]-4,5-dihydro-1H-benzo[g]indazole-3-carboxamide, 1-[4-(methylsulfonyl)phenyl]-8-[(2-nitrobenzoyl)amino]-4,5-dihydro-1H-benzo[g]indazole-3-carboxamide, 8-[(2-chloro-4-nitrobenzoyl)amino]-1-[4-(methylsulfonyl)phenyl]-4,5-dihydro-1H-benzo[g]indazole-3-carboxamide, 8-[(5-methoxy-2-nitrobenzoyl)amino]-1-[4-(methylsulfonyl)phenyl]-4,5-dihydro-1H-benzo[g]indazole-3-carboxamide, 3-[({3-(aminocarbonyl)-1-[4-(methylsulfonyl)phenyl]-4,5-dihydro-1H-benzo[g]indazol-8-yl}amino)carbonyl]-4-nitrophenyl thiocyanate, 8-[(4,5-difluoro-2-nitrobenzoyl)amino]-1-[4-(methylsulfonyl)phenyl]-4,5-dihydro-1H-benzo[g]indazole-3-carboxamide, 8-[(4,5-dimethoxy-2-nitrobenzoyl)amino]-1-[4-(methylsulfonyl)phenyl]-4,5-dihydro-1H-benzo[g]indazole-3-carboxamide, 8-[(5-fluoro-2-nitrobenzoyl)amino]-1-[4-(methylsulfonyl)phenyl]-4,5-dihydro-1H-benzo[g]indazole-3-carboxamide, 1-[4-(methylsulfonyl)phenyl]-8-{[2-nitro-4-(trifluoromethyl)benzoyl]amino}-4,5-dihydro-1H-benzo[g]indazole-3-carboxamide, 8-[(5-methyl-2-nitrobenzoyl)amino]-1-[4-(methylsulfonyl)phenyl]-4,5-dihydro-1H-benzo[g]indazole-3-carboxamide, 8-[(3-methyl-2-nitrobenzoyl)amino]-1-[4-(methylsulfonyl)phenyl]-4,5-dihydro-1H-benzo[g]indazole-3-carboxamide, 8-[(2,4-dinitrobenzoyl)amino]-1-[4-(methylsulfonyl)phenyl]-4,5-dihydro-1H-benzo[g]indazole-3-carboxamide, 8-[(3-methylbenzoyl)amino]-1-[4-(methylsulfonyl)phenyl]-4,5-dihydro-1H-benzo[g]indazole-3-carboxamide, 8-{[(3-methoxyphenyl)acetyl]amino}-1-[4-(methylsulfonyl)phenyl]-4,5-dihydro-1H-benzo[g]indazole-3-carboxamide, 1-[4-(methylsulfonyl)phenyl]-8-[(phenylacetyl)amino]-4,5-dihydro-1H-benzo[g]indazole-3-carboxamide, 8-[(3-hydroxy-2-methylbenzoyl)amino]-1-[4-(methylsulfonyl)phenyl]-4,5-dihydro-1H-benzo[g]indazole-3-carboxamide, 8-[(2,5-dichlorobenzoyl)amino]-1-[4-(methylsulfonyl)phenyl]-4,5-dihydro-1H-benzo[g]indazole-3-carboxamide, 8-[(2-aminobenzoyl)amino]-1-[4-(methylsulfonyl)phenyl]-4,5-dihydro-1H-benzo[g]indazole-3-carboxamide, 8-(L-histidylamino)-1-[4-(methylsulfonyl)phenyl]-4,5-dihydro-1H-benzo[g]indazole-3-carboxamide, 8-(isonicotinoylamino)-1-[4-(methylsulfonyl)phenyl]-4,5-dihydro-1H-benzo[g]indazole-3-carboxamide, 8-[(2-chloro-5-nitrobenzoyl)amino]-1-[4-(methylsulfonyl)phenyl]-4,5-dihydro-1H-benzo[g]indazole-3-carboxamide, 8-[(5-amino-2-chlorobenzoyl)amino]-1-[4-(methylsulfonyl)phenyl]-4,5-dihydro-1H-benzo[g]indazole-3-carboxamide hydrochloride, 8-[(3-amino-4-chlorobenzoyl)amino]-1-[4-(methylsulfonyl)phenyl]-4,5-dihydro-1H-benzo[g]indazole-3-carboxamide, 8-[(4-amino-2-chlorobenzoyl)amino]-1-[4-(methylsulfonyl)phenyl]-4,5-dihydro-1H-benzo[g]indazole-3-carboxamide, 8-[(2-amino-5-chlorobenzoyl)amino]-1-[4-(methylsulfonyl)phenyl]-4,5-dihydro-1H-benzo[g]indazole-3-carboxamide, 8-[(3-amino-2-chlorobenzoyl)amino]-1-[4-(methylsulfonyl)phenyl]-4,5-dihydro-1H-benzo[g]indazole-3-carboxamide, 8-[(2-amino-4-chlorobenzoyl)amino]-1-[4-(methylsulfonyl)phenyl]-4,5-dihydro-1H-benzo[g]indazole-3-carboxamide, 8-[(2-amino-3-chlorobenzoyl)amino]-1-[4-(methylsulfonyl)phenyl]-4,5-dihydro-1H-benzo[g]indazole-3-carboxamide, 8-({2-chloro-5-[(N,N-dimethylglycyl)amino]benzoyl}amino)-1-[4-(methylsulfonyl)phenyl]-4,5-dihydro-1H-benzo[g]indazole-3-carboxamide hydrochloride, 8-{[2-chloro-5-(dimethylamino)benzoyl]amino}-1-[4-(methylsulfonyl)phenyl]-4,5-dihydro-1H-benzo[g]indazole-3-carboxamide, 8-[(5-azido-2-nitrobenzoyl)amino]-1-[4-(methylsulfonyl)phenyl]-4,5-dihydro-1H-benzo[g]indazole-3-carboxamide, 8-[(4-azidobenzoyl)amino]-1-[4-(methylsulfonyl)phenyl]-4,5-dihydro-1H-benzo[g]indazole-3-carboxamide, 8-{[(2,5-dichloropyridin-3-yl)carbonyl]amino}-1-[4-(methylsulfonyl)phenyl]-4,5-dihydro-1H-benzo[g]indazole-3-carboxamide, 8-{[2-chloro-5-(methylsulfinyl)benzoyl]amino}-1-[4-(methylsulfonyl)phenyl]-4,5-dihydro-1H-benzo[g]indazole-3-carboxamide, and 8-{[(6-chloro-1,3-benzodioxol-5-yl)carbonyl]amino}-1-[4-(methylsulfonyl)phenyl]-4,5-dihydro-1H-benzo[g]indazole-3-carboxamide.
- 18. The compound of claim 2 of the formula
- 19. The compound of claim 18 selected from the group consisting of:
8-{[2-chloro-5-(methylsulfinyl)benzoyl]amino}-1-(4-fluorophenyl)-4,5-dihydro-1H-benzo[g]indazole-3-carboxamide, 8-{[(2,5-dichloropyridin-3-yl)carbonyl]amino}-1-(4-fluorophenyl)-4,5-dihydro-1H-benzo[g]indazole-3-carboxamide, 8-[(2,5-dichloroisonicotinoyl)amino]-1-(4-fluorophenyl)-4,5-dihydro-1H-benzo[g]indazole-3-carboxamide, 8-{[(6-chloro-1,3-benzodioxol-5-yl)carbonyl]amino }-1-(4-fluorophenyl)-4,5-dihydro-1H-benzo[g]indazole-3-carboxamide, 8-{[(2-chloropyridin-3-yl)carbonyl]amino}-1-(3,4-difluorophenyl)-4,5-dihydro-1H-benzo[g]indazole-3-carboxamide, 8-{[(2-chloropyridin-3-yl)carbonyl]amino}-1-(4-fluorophenyl)-4,5-dihydro-1H-benzo[g]indazole-3-carboxamide, 8-{[2-chloro-4-(methylsulfonyl)benzoyl]amino}-1-(4-fluorophenyl)-4,5-dihydro-1H-benzo[g]indazole-3-carboxamide, 8-{[(2-chloro-6-methylpyridin-3-yl)carbonyl]amino}-1-(4-fluorophenyl)-4,5-dihydro-1H-benzo[g]indazole-3-carboxamide, 8-[(3-chloroisonicotinoyl)amino]-1-(4-fluorophenyl)-4,5-dihydro-1H-benzo[g]indazole-3-carboxamide hydrochloride, 8-[(3-amino-2-chlorobenzoyl)amino]-1-(4-fluorophenyl)-4,5-dihydro-1H-benzo[g]indazole-3-carboxamide, 8-{[(2-chloropyridin-3-yl)carbonyl]amino}-1-(2,4-difluorophenyl)-4,5-dihydro-1H-benzo[g]indazole-3-carboxamide, 8-[(2-chlorobenzoyl)amino]-1-(4-fluorophenyl)-4,5-dihydro-1H-benzo[g]indazole-3-carboxamide, 1-(4-fluorophenyl)-8-[(3-hydroxy-2-methylbenzoyl)amino]-4,5-dihydro-1H-benzo[g]indazole-3-carboxamide, 8-[(2-chlorobenzoyl)amino]-1-(2,4-difluorophenyl)-4,5-dihydro-1H-benzo[g]indazole-3-carboxamide, 8-[(4-amino-2-chlorobenzoyl)amino]-1-(4-fluorophenyl)-4,5-dihydro-1H-benzo[g]indazole-3-carboxamide, 8-[(2-chloro-4-methoxybenzoyl)amino]-1-(4-fluorophenyl)-4,5-dihydro-1H-benzo[g]indazole-3-carboxamide, 8-({[2-chloro-6-(trifluoromethyl)pyridin-3-yl]carbonyl}amino)-1-(4-fluorophenyl)-4,5-dihydro-1H-benzo[g]indazole-3-carboxamide, 8-{[2-chloro-5-(methylthio)benzoyl]amino}-1-(4-fluorophenyl)-4,5-dihydro-1H-benzo[g]indazole-3-carboxamide, 8-[(5-amino-2-chlorobenzoyl)amino]-1-(4-fluorophenyl)-4,5-dihydro-1H-benzo[g]indazole-3-carboxamide, 8-{[2-chloro-5-(dimethylamino)benzoyl]amino}-1-(4-fluorophenyl)-4,5-dihydro-1H-benzo[g]indazole-3-carboxamide, 8-[(2-chlorobenzoyl)amino]-1-(3,4-difluorophenyl)-4,5-dihydro-1H-benzo[g]indazole-3-carboxamide, 8-[(2,3-dichlorobenzoyl)amino]-1-(4-fluorophenyl)-4,5-dihydro-1H-benzo[g]indazole-3-carboxamide, 8-[(2-chloro-4,5-dimethoxybenzoyl)amino]-1-(4-fluorophenyl)-4,5-dihydro-1H-benzo[g]indazole-3-carboxamide, 1-(4-fluorophenyl)-8-[(2-methylbenzoyl)amino]-4,5-dihydro-1H-benzo[g]indazole-3-carboxamide, 8-[(2-chloro-3-nitrobenzoyl)amino]-1-(4-fluorophenyl)-4,5-dihydro-1H-benzo[g]indazole-3-carboxamide, 1-(4-fluorophenyl)-8-[(methylsulfonyl)amino]-4,5-dihydro-1H-benzo[g]indazole-3-carboxamide, 8-[(2-chlorobenzoyl)amino]-1-(3-chloro-4-fluorophenyl)-4,5-dihydro-1H-benzo[g]indazole-3-carboxamide, and 1-(4-fluorophenyl)-8-(isonicotinoylamino)-4,5-dihydro-1H-benzo[g]indazole-3-carboxamide.
- 20. The compound of claim 2 selected from the group consisting of:
8-[(2-chlorobenzoyl)amino]-1-(3-fluorophenyl)-4,5-dihydro-1H-benzo[g]indazole-3-carboxamide, 8-{[(2-chloropyridin-3-yl)carbonyl]amino}-1-(3-fluorophenyl)-4,5-dihydro-1H-benzo[g]indazole-3-carboxamide, 1-{4-[(allylamino)sulfonyl]phenyl}-8-[(2-chlorobenzoyl)amino]-4,5-dihydro-1H-benzo[g]indazole-3-carboxamide, 8-[(5-amino-2-chlorobenzoyl)amino]-1-[4-(ethylsulfonyl)phenyl]-4,5-dihydro-1H-benzo[g]indazole-3-carboxamide, 8-[(2-chlorobenzoyl)amino]-1-[4-(isopropylsulfonyl)phenyl]-4,5-dihydro-1H-benzo[g]indazole-3-carboxamide, 8-[(2-chlorobenzoyl)amino]-1-{4-[(1E)-3-hydroxybut-1-enyl]phenyl}-4,5-dihydro-1H-benzo [g]indazole-3-carboxamide, 8-{[5-(acetylamino)-2-chlorobenzoyl]amino}-1-[4-(ethylsulfonyl)phenyl]-4,5-dihydro-1H-benzo[g]indazole-3-carboxamide, 8-{[(2-chloropyridin-3-yl)carbonyl]amino}-1-[4-(3-hydroxyprop-1-ynyl)phenyl]-4,5-dihydro-1H-benzo[g]indazole-3-carboxamide, 8-[(2-chlorobenzoyl)amino]-1-[4-(ethylsulfonyl)phenyl]-4,5-dihydro-1H-benzo[g]indazole-3-carboxamide, 8-[(2-chlorobenzoyl)amino]-1-{4-[(dimethylamino)sulfonyl]phenyl}-4,5-dihydro-1H-benzo[g]indazole-3-carboxamide, 1-[4-(aminosulfonyl)phenyl]-8-[(4-azidobenzoyl)amino]-4,5-dihydro-1H-benzo[g]indazole-3-carboxamide, 8-{[(2-chloropyridin-3-yl)carbonyl]amino}-1-(3,5-difluorophenyl)-4,5-dihydro-1H-benzo[g]indazole-3-carboxamide, 1-(4-aminophenyl)-8-[(2-chlorobenzoyl)amino]-4,5-dihydro-1H-benzo[g]indazole-3-carboxamide, 1-(3-aminophenyl)-8-[(2-chlorobenzoyl)amino]-4,5-dihydro-1H-benzo[g]indazole-3-carboxamide, 8-[(2-chlorobenzoyl)amino]-1-{4-[(2-chlorobenzoyl)amino]phenyl}-4,5-dihydro-1H-benzo[g]indazole-3-carboxamide, 8-[(2-chlorobenzoyl)amino]-1-[4-(1H-pyrrol-1-yl)phenyl]-4,5-dihydro-1H-benzo[g]indazole-3-carboxamide, 1-(4-{[(benzyloxy)acetyl]amino}phenyl)-8-[(2-chlorobenzoyl)amino]-4,5-dihydro-1H-benzo[g]indazole-3-carboxamide, 8-[(2-chlorobenzoyl)amino]-1-{4-[(5-{[(2,2-dimethylpropanoyl)oxy]amino}pentanoyl)amino]phenyl}-4,5-dihydro-1H-benzo[g]indazole-3-carboxamide, 8-[(2-chlorobenzoyl)amino]-1-[4-({[2-(dimethylamino)ethyl]amino}carbonyl)phenyl]-4,5-dihydro-1H-benzo[g]indazole-3-carboxamide hydrochloride, 1-(6-aminopyridin-3-yl)-8-[(3-chloroisonicotinoyl)amino]-4,5-dihydro-1H-benzo[g]indazole-3-carboxamide, 8-[(3-chloroisonicotinoyl)amino]-1-thien-2-yl-4,5-dihydro-1H-benzo[g]indazole-3-carboxamide, 8-[(3-chloroisonicotinoyl)amino]-1-thien-3-yl-4,5-dihydro-1H-benzo[g]indazole-3-carboxamide, 1-[4-(butylsulfonyl)phenyl]-8-[(2-chlorobenzoyl)amino]-4,5-dihydro-1H-benzo[g]indazole-3-carboxamide, 8-amino-1-[4-(ethylsulfonyl)phenyl]-4,5-dihydro-1H-benzo[g]indazole-3-carboxamide, 8-amino-1-[4-(propylsulfonyl)phenyl]-4,5-dihydro-1H-benzo[g]indazole-3-carboxamide, tert-butyl 3-[({3-(aminocarbonyl)-1-[4-(propylsulfonyl)phenyl]-4,5-dihydro-1H-benzo[g]indazol-8-yl}amino)carbonyl]-4-chlorophenylcarbamate, 8-[(2-chlorobenzoyl)amino]-1-{4-[(cyclopropylmethyl)sulfonyl]phenyl}-4,5-dihydro-1H-benzo[g]indazole-3-carboxamide, 8-[(2-chlorobenzoyl)amino]-1-[4-(methylsulfinyl)phenyl]-4,5-dihydro-1H-benzo[g]indazole-3-carboxamide, 8-[(2-chlorobenzoyl)amino]-1-(4-hydroxyphenyl)-4,5-dihydro-1H-benzo[g]indazole-3-carboxamide, 1-{4-[(1E)-3-amino-3-oxoprop-1-enyl]phenyl}-8-[(2-chlorobenzoyl)amino]-4,5-dihydro-1H-benzo[g]indazole-3-carboxamide, 8-[(2-chlorobenzoyl)amino]-1-(3-chlorophenyl)-4,5-dihydro-1H-benzo[g]indazole-3-carboxamide, 8-[(5-amino-2-chlorobenzoyl)amino]-1-[4-(propylsulfonyl)phenyl]-4,5-dihydro-1H-benzo[g]indazole-3-carboxamide trifluoroacetate, 8-[(2-chlorobenzoyl)amino]-1-phenyl-4,5-dihydro-1H-benzo[g]indazole-3-carboxamide, 8-[(2-chlorobenzoyl)amino]-1-(4-cyanophenyl)-4,5-dihydro-1H-benzo[g]indazole-3-carboxamide, 8-{[(6-chloro-1,3-benzodioxol-5-yl)carbonyl]amino}-1-(3-hydroxyphenyl)-4,5-dihydro-1H-benzo[g]indazole-3-carboxamide, 8-[(2-chlorobenzoyl)amino]-1-{4-[(methylamino)sulfonyl]phenyl}-4,5-dihydro-1H-benzo[g]indazole-3-carboxamide, 1-[4-(aminosulfonyl)phenyl]-8-[(1H-indol-2-ylcarbonyl)amino]-4,5-dihydro-1H-benzo[g]indazole-3-carboxamide, 8-[(2-chlorobenzoyl)amino]-1-{4-[(1E)-3-hydroxy-3-methylbut-1-enyl]phenyl}-4,5-dihydro-1H-benzo[g]indazole-3-carboxamide, 8-[(5-amino-2-chlorobenzoyl)amino]-1-[4-(propylsulfonyl)phenyl]-4,5-dihydro-1H-benzo[g]indazole-3-carboxamide hydrochloride, 1-[4-(amino sulfonyl)phenyl]-8-[(methylsulfonyl)amino]-4,5-dihydro-1H-benzo[g]indazole-3-carboxamide, 8-[(2-chlorobenzoyl)amino]-1-[4-(2,3-dihydroxypropoxy)phenyl]-4,5-dihydro-1H-benzo[g]indazole-3-carboxamide, 1-[4-(aminosulfonyl)phenyl]-8-{[(2-methylpyridin-3-yl)carbonyl]amino}-4,5-dihydro-1H-benzo[g]indazole-3-carboxamide, 8-[(2-chlorobenzoyl)amino]-1-(3-hydroxyphenyl)-4,5-dihydro-1H-benzo[g]indazole-3-carboxamide, 8-[(2-chlorobenzoyl)amino]-1-{4-[(methylsulfonyl)amino]phenyl}-4,5-dihydro-1H-benzo[g]indazole-3-carboxamide, 8-[(2-chlorobenzoyl)amino]-1-[4-(propylsulfonyl)phenyl]-4,5-dihydro-1H-benzo[g]indazole-3-carboxamide, 8-[(2-chlorobenzoyl)amino]-1-[4-(3-oxobutyl)phenyl]-4,5-dihydro-1H-benzo[g]indazole-3-carboxamide, 8-[(2-chlorobenzoyl)amino]-1-{4-[(E)-2-(methylsulfonyl)ethenyl]phenyl}-4,5-dihydro-1H-benzo[g]indazole-3-carboxamide, 8-[(2-chlorobenzoyl)amino]-1-{4-[(1E)-4-hydroxybut-1-enyl]phenyl}-4,5-dihydro-1H-benzo[g]indazole-3-carboxamide, 8-[(2-chlorobenzoyl)amino]-1-[4-(4-hydroxy-3-oxobutyl)phenyl]-4,5-dihydro-1H-benzo[g]indazole-3-carboxamide, 8-{[(2-chloropyridin-3-yl)carbonyl]amino}-1-{4-[(1Z)-3-hydroxyprop-1-enyl]phenyl}-4,5-dihydro-1H-benzo[g]indazole-3-carboxamide, 8-{[(2-chloropyridin-3-yl)carbonyl]amino}-1-{4-[(1E)-3-(methylamino)-3-oxoprop-1-enyl]phenyl}-4,5-dihydro-1H-benzo[g]indazole-3-carboxamide, 8-{[(2-chloropyridin-3-yl)carbonyl]amino}-1-[4-(3-oxobutyl)phenyl]-4,5-dihydro-1H-benzo[g]indazole-3-carboxamide, 1-{4-[(1E)-3-amino-3-oxoprop-1-enyl]phenyl}-8-{[(2-chloropyridin-3-yl)carbonyl]amino}-4,5-dihydro-1H-benzo[g]indazole-3-carboxamide, 8-{[(2-chloropyridin-3-yl)carbonyl]amino}-1-{4-[(1E)-3-hydroxy-3-methylbut-1-enyl]phenyl}-4,5-dihydro-1H-benzo[g]indazole-3-carboxamide, 8-{[(2-chloropyridin-3-yl)carbonyl]amino}-1-{4-[(1E)-3-(dimethylamino)-3-oxoprop-1-enyl]phenyl}-4,5-dihydro-1H-benzo[g]indazole-3-carboxamide, 8-[(methylsulfonyl)amino]-1-[4-(3-oxobutyl)phenyl]-4,5-dihydro-1H-benzo[g]indazole-3-carboxamide, 1-{4-[(1E)-3-(methylamino)-3-oxoprop-1-enyl]phenyl}-8-[(methylsulfonyl)amino]-4,5-dihydro-1H-benzo[g]indazole-3-carboxamide, 8-[(2-chlorobenzoyl)amino]-1-{4-[(1E)-3-(dimethylamino)prop-1-enyl]phenyl}-4,5-dihydro-1H-benzo[g]indazole-3-carboxamide hydrochloride, 8-[(2-chlorobenzoyl)amino]-1-(4-{(1E)-3-[(2-methoxyethyl)amino]-3-oxoprop-1-enyl}phenyl)-4,5-dihydro-1H-benzo[g]indazole-3-carboxamide, 8-[(2-chlorobenzoyl)amino]-1-(4-{(1E)-3-[(2-furylmethyl)amino]-3-oxoprop-1-enyl}phenyl)-4,5-dihydro-1H-benzo[g]indazole-3-carboxamide, 8-[(2-chlorobenzoyl)amino]-1-{4-[(1E)-3-(methylamino)-3-oxoprop-1-enyl]phenyl}-4,5-dihydro-1H-benzo[g]indazole-3-carboxamide, 8-[(2-chlorobenzoyl)amino]-1-{4-[(1E)-3-(ethylamino)-3-oxoprop-1-enyl]phenyl}-4,5-dihydro-1H-benzo[g]indazole-3-carboxamide, 1-{4-[(1E)-3-(benzylamino)-3-oxoprop-1-enyl]phenyl}-8-[(2-chlorobenzoyl)amino]-4,5-dihydro-1H-benzo[g]indazole-3-carboxamide, 8-amino-1-{4-[(1E)-3-(methylamino)-3-oxoprop-1-enyl]phenyl}-4,5-dihydro-1H-benzo[g]indazole-3-carboxamide, 1-{4-[(1E)-3-(dimethylamino)-3-oxoprop-1-enyl]phenyl}-8-[(methylsulfonyl)amino]-4,5-dihydro-1H-benzo[g]indazole-3-carboxamide, 8-[(2-chlorobenzoyl)amino]-1-[4-({[2-(dimethylamino)ethyl]amino}sulfonyl)phenyl]-4,5-dihydro-1H-benzo[g]indazole-3-carboxamide methanesulfonate, 8-[(2-chloro-5-nitrobenzoyl)amino]-1-(4-hydroxyphenyl)-4,5-dihydro-1H-benzo[g]indazole-3-carboxamide, 1-[4-(acetylamino)phenyl]-8-[(2-chlorobenzoyl)amino]-4,5-dihydro-1H-benzo[g]indazole-3-carboxamide, 8-[(2-chlorobenzoyl)amino]-1-(3-methylphenyl)-4,5-dihydro-1H-benzo[g]indazole-3-carboxamide, 8-[(5-amino-2-chlorobenzoyl)amino]-1-(4-hydroxyphenyl)-4,5-dihydro-1H-benzo[g]indazole-3-carboxamide, 8-[(2,3-dichlorobenzoyl)amino]-1-(3-fluorophenyl)-4,5-dihydro-1H-benzo[g]indazole-3-carboxamide, 8-{[(2-chloropyridin-3-yl)carbonyl]amino}-1-(4-hydroxyphenyl)-4,5-dihydro-1H-benzo[g]indazole-3-carboxamide, 8-{[(6-chloro-1,3-benzodioxol-5-yl)carbonyl]amino}-1-(4-hydroxyphenyl)-4,5-dihydro-1H-benzo[g]indazole-3-carboxamide, (2E)-3-(4-{3-(aminocarbonyl)-8-[(2-chlorobenzoyl)amino]-4,5-dihydro-1H-benzo[g]indazol-1-yl}phenyl)prop-2-enoic acid, 8-[(2-chlorobenzoyl)amino]-1-{4-[(E)-2-(1H-imidazol-1-yl)ethenyl]phenyl}-4,5-dihydro-1H-benzo[g]indazole-3-carboxamide, 8-[(2-chlorobenzoyl)amino]-1-(2-fluorophenyl)-4,5-dihydro-1H-benzo[g]indazole-3-carboxamide, 1-[4-(aminosulfonyl)phenyl]-8-[(3-formylbenzoyl)amino]-4,5-dihydro-1H-benzo[g]indazole-3-carboxamide, 1-[4-(aminosulfonyl)phenyl]-8-({[2-(methylamino)pyridin-3-yl]carbonyl}amino)-4,5-dihydro-1H-benzo[g]indazole-3-carboxamide, 8-{[2-chloro-5-(methylsulfinyl)benzoyl]amino}-1-(4-hydroxyphenyl)-4,5-dihydro-1H-benzo[g]indazole-3-carboxamide, 8-[(2-chlorobenzoyl)amino]-1-(4-methylphenyl)-4,5-dihydro-1H-benzo[g]indazole-3-carboxamide, 8-[(2-chlorobenzoyl)amino]-1-(4-nitrophenyl)-4,5-dihydro-1H-benzo[g]indazole-3-carboxamide, 8-[(2-chlorobenzoyl)amino]-1-{4-[(methoxyacetyl)amino]phenyl}-4,5-dihydro-1H-benzo[g]indazole-3-carboxamide, 8-[(2-chlorobenzoyl)amino]-1-(3,5-difluorophenyl)-4,5-dihydro-1H-benzo[g]indazole-3-carboxamide, 8-[(2-chlorobenzoyl)amino]-1-[4-(2-morpholin-4-ylethoxy)phenyl]-4,5-dihydro-1H-benzo[g]indazole-3-carboxamide, 8-{[(2-chloropyridin-3-yl)carbonyl]amino}-1-[4-(ethylsulfonyl)phenyl]-4,5-dihydro-1H-benzo[g]indazole-3-carboxamide, 8-{[(2-chloropyridin-3-yl)carbonyl]amino}-1-(4-vinylphenyl)-4,5-dihydro-1H-benzo[g]indazole-3-carboxamide, 1-(4-acetylphenyl)-8-{[(2-chloropyridin-3-yl)carbonyl]amino}-4,5-dihydro-1H-benzo[g]indazole-3-carboxamide, 8-{[(2-chloropyridin-3-yl)carbonyl]amino}-1-[4-(1-hydroxyethyl)phenyl]-4,5-dihydro-1H-benzo[g]indazole-3-carboxamide, 1-[4-(aminosulfonyl)phenyl]-8-[({2-[(2-hydroxyethyl)amino]pyridin-3-yl}carbonyl)amino]-4,5-dihydro-1H-benzo[g]indazole-3-carboxamide, 8-[(2-chlorobenzoyl)amino]-1-{4-[(2,2-dimethyl-1,3-dioxolan-4-yl)methoxy]phenyl}-4,5-dihydro-1H-benzo[g]indazole-3-carboxamide, 8-[(2-chlorobenzoyl)amino]-1-(4-chlorophenyl)-4,5-dihydro-1H-benzo[g]indazole-3-carboxamide, 1-[4-(aminosulfonyl)phenyl]-8-({[2-(isopropylamino)pyridin-3-yl]carbonyl}amino)-4,5-dihydro-1H-benzo[g]indazole-3-carboxamide, 1-{4-[(3-aminopropyl)sulfonyl]phenyl}-8-{[(2-chloropyridin-3-yl)carbonyl]amino}-4,5-dihydro-1H-benzo[g]indazole-3-carboxamide hydrochloride, 8-amino-1-[4-(aminosulfonyl)phenyl]-4,5-dihydro-1H-benzo[g]indazole-3-carboxamide, 8-[(2-chlorobenzoyl)amino]-1-[4-(trifluoromethyl)phenyl]-4,5-dihydro-1H-benzo[g]indazole-3-carboxamide, 8-[(2-chlorobenzoyl)amino]-1-[4-({[2-(dimethylamino)ethyl]amino}sulfonyl)phenyl]-4,5-dihydro-1H-benzo[g]indazole-3-carboxamide, 1-(4-bromophenyl)-8-[(2-chlorobenzoyl)amino]-4,5-dihydro-1H-benzo[g]indazole-3-carboxamide, 1-{4-[(3-aminopropyl)sulfonyl]phenyl}-8-[(2-chlorobenzoyl)amino]-4,5-dihydro-1H-benzo[g]indazole-3-carboxamide hydrochloride, tert-butyl 3-[({3-(aminocarbonyl)-1-[4-(ethylsulfonyl)phenyl]-4,5-dihydro-1H-benzo[g]indazol-8-yl}amino)carbonyl]-4-chlorophenylcarbamate, 1-[4-(aminosulfonyl)phenyl]-8-[({2-[(2-methoxyethyl)amino]pyridin-3-yl}carbonyl)amino]-4,5-dihydro-1H-benzo[g]indazole-3-carboxamide, 8-[(2-chlorobenzoyl)amino]-1-(4-isopropylphenyl)-4,5-dihydro-1H-benzo[g]indazole-3-carboxamide, 8-{[(2-chloropyridin-3-yl)carbonyl]amino}-1-(4-morpholin-4-ylphenyl)-4,5-dihydro-1H-benzo[g]indazole-3-carboxamide, 1-(4-bromophenyl)-8-[(2-methylbenzoyl)amino]-4,5-dihydro-1H-benzo[g]indazole-3-carboxamide, 8-amino-1-(4-bromophenyl)-4,5-dihydro-1H-benzo[g]indazole-3-carboxamide, 8-[(2-chlorobenzoyl)amino]-1-(2,4-difluorophenyl)-4,5-dihydro-1H-benzo[g]indazole-3-carboxamide, 8-[(3-chloroisonicotinoyl)amino]-1-(3,4-difluorophenyl)-4,5-dihydro-1H-benzo[g]indazole-3-carboxamide, 8-[(3-chloroisonicotinoyl)amino]-1-(3,5-difluorophenyl)-4,5-dihydro-1H-benzo[g]indazole-3-carboxamide, 8-[(2-chlorobenzoyl)amino]-1-(3-chloro-4-fluorophenyl)-4,5-dihydro-1H-benzo[g]indazole-3-carboxamide, 8-amino-1-{4-[(trifluoromethyl)sulfonyl]phenyl}-4,5-dihydro-1H-benzo[g]indazole-3-carboxamide, 8-[(3-chloroisonicotinoyl)amino]-1-{4-[(trifluoromethyl)sulfonyl]phenyl}-4,5-dihydro-1H-benzo[g]indazole-3-carboxamide hydrochloride, 8-{[(2-chloropyridin-3-yl)carbonyl]amino}-1-{4-[(trifluoromethyl)sulfonyl]phenyl}-4,5-dihydro-1H-benzo[g]indazole-3-carboxamide, 1-(4-chlorophenyl)-8-{[(4-chloropyridin-3-yl)carbonyl]amino}-4,5-dihydro-1H-benzo[g]indazole-3-carboxamide, b 8-[(2-chlorobenzoyl)amino]-1-(3-methoxyphenyl)-4,5-dihydro-1H-benzo[g]indazole-3-carboxamide, 8-[(2-chlorobenzoyl)amino]-1-[4-(methylthio)phenyl]-4,5-dihydro-1H-benzo[g]indazole-3-carboxamide, 1-[4-(aminosulfonyl)phenyl]-8-[({2-[(3-hydroxypropyl)amino]pyridin-3-yl}carbonyl)amino]-4,5-dihydro-1H-benzo[g]indazole-3-carboxamide, 8-({[2-(allylamino)pyridin-3-yl]carbonyl}amino)-1-[4-(aminosulfonyl)phenyl]-4,5-dihydro-1H-benzo[g]indazole-3-carboxamide hydrate, 1-[4-(benzoylamino)phenyl]-8-[(2-chlorobenzoyl)amino]-4,5-dihydro-1H-benzo[g]indazole-3-carboxamide, 8-[(2-chlorobenzoyl)amino]-1-{4-[(E)-(2-oxodihydrofuran-3(2H)-ylidene)methyl]phenyl}-4,5-dihydro-1H-benzo[g]indazole-3-carboxamide, 8-[(2-chlorobenzoyl)amino]-1-[3′-(hydroxymethyl)-1,1′-biphenyl-4-yl]-4,5-dihydro-1H-benzo[g]indazole-3-carboxamide, 1-(3′-amino-1,1′-biphenyl-4-yl)-8-[(2-chlorobenzoyl)amino]-4,5-dihydro-1H-benzo[g]indazole-3-carboxamide, 4′-{3-(aminocarbonyl)-8-[(2-chlorobenzoyl)amino]-4,5-dihydro-1H-benzo[g]indazol-1-yl}-1,1′-biphenyl-3-carboxylic acid, 4′-{3-(aminocarbonyl)-8-[(2-chlorobenzoyl)amino]-4,5-dihydro-1H-benzo[g]indazol-1-yl }-1,1′-biphenyl-4-carboxylic acid, 8-[(2-chlorobenzoyl)amino]-1-(3′,4′-dimethoxy-1,1′-biphenyl-4-yl)-4,5-dihydro-1H-benzo[g]indazole-3-carboxamide, 1-[4-(benzyloxy)phenyl]-8-{[(2-chloropyridin-3-yl)carbonyl]amino}-4,5-dihydro-1H-benzo[g]indazole-3-carboxamide, 8-{[(2-chloropyridin-3-yl)carbonyl]amino}-1-[4-(propylsulfonyl)phenyl]-4,5-dihydro-1H-benzo[g]indazole-3-carboxamide, 8-[(2-chlorobenzoyl)amino]-1-(3,4-dichlorophenyl)-4,5-dihydro-1H-benzo[g]indazole-3-carboxamide, 8-[(2-chlorobenzoyl)amino]-1-(4-pyridin-3-ylphenyl)-4,5-dihydro-1H-benzo[g]indazole-3-carboxamide, 8-amino-1-[4-(trifluoromethyl)phenyl]-4,5-dihydro-1H-benzo[g]indazole-3-carboxamide, ethyl(2E)-3-(4-{3-(aminocarbonyl)-8-[(2-chlorobenzoyl)amino]-4,5-dihydro-1H-benzo[g]indazol-1-yl}phenyl)prop-2-enoate, 4-{3-(aminocarbonyl)-8-[(2-chlorobenzoyl)amino]-4,5-dihydro-1H-benzo[g]indazol-1-yl}benzoic acid, 3-({[3-(aminocarbonyl)-1-(3-fluorophenyl)-4,5-dihydro-1H-benzo[g]indazol-8-yl]amino}carbonyl)-2-methylphenyl acetate, 8-[(2-chlorobenzoyl)amino]-1-[4-(3-furyl)phenyl]-4,5-dihydro-1H-benzo[g]indazole-3-carboxamide, 8-[(2-chlorobenzoyl)amino]-1-[4-(trifluoromethoxy)phenyl]-4,5-dihydro-1H-benzo[g]indazole-3-carboxamide, 8-[(2,3-dichlorobenzoyl)amino]-1-(3,5-difluorophenyl)-4,5-dihydro-1H-benzo[g]indazole-3-carboxamide, 8-[(2,3-difluorobenzoyl)amino]-1-(3-fluorophenyl)-4,5-dihydro-1H-benzo[g]indazole-3-carboxamide, 8-[(methylsulfonyl)amino]-1-[4-(methylthio)phenyl]-4,5-dihydro-1H-benzo[g]indazole-3-carboxamide, 8-[(3-chloroisonicotinoyl)amino]-1-[4-(methylthio)phenyl]-4,5-dihydro-1H-benzo[g]indazole-3-carboxamide hydrochloride, 8-{[(6-chloro-1,3-benzodioxol-5-yl)carbonyl]amino}-1-[4-(methylthio)phenyl]-4,5-dihydro-1H-benzo[g]indazole-3-carboxamide, 8-[(5-amino-2-chlorobenzoyl)amino]-1-[4-(methylthio)phenyl]-4,5-dihydro-1H-benzo[g]indazole-3-carboxamide hydrochloride, 1-[4-(methylsulfinyl)phenyl]-8-[(methylsulfonyl)amino]-4,5-dihydro-1H-benzo[g]indazole-3-carboxamide, 8-[(3-chloroisonicotinoyl)amino]-1-[4-(methylsulfinyl)phenyl]-4,5-dihydro-1H-benzo[g]indazole-3-carboxamide hydrochloride, 8-{[(6-chloro-1,3-benzodioxol-5-yl)carbonyl]amino}-1-[4-(methylsulfinyl)phenyl]-4,5-dihydro-1H-benzo[g]indazole-3-carboxamide, 8-[(5-amino-2-chlorobenzoyl)amino]-1-[4-(methylsulfinyl)phenyl]-4,5-dihydro-1H-benzo[g]indazole-3-carboxamide hydrochloride, 8-[(2-chlorobenzoyl)amino]-1-[4-(methylsulfinyl)phenyl]-4,5-dihydro-1H-benzo[g]indazole-3-carboxamide, 8-{[(2-chloropyridin-3-yl)carbonyl]amino}-1-[4-(methylsulfinyl)phenyl]-4,5-dihydro-1H-benzo[g]indazole-3-carboxamide, 8-amino-1-[4-(2,5-dihydro-1H-pyrrol-1-ylsulfonyl)phenyl]-4,5-dihydro-1H-benzo[g]indazole-3-carboxamide, 8-amino-1-[4-(morpholin-4-ylsulfonyl)phenyl]-4,5-dihydro-1H-benzo[g]indazole-3-carboxamide, 8-amino-1-{4-[(diprop-2-ynylamino)sulfonyl]phenyl}-4,5-dihydro-1H-benzo[g]indazole-3-carboxamide, 1-{4-[(dimethylamino)sulfonyl]phenyl}-8-[(methylsulfonyl)amino]-4,5-dihydro-1H-benzo[g]indazole-3-carboxamide, 8-[(2-chlorobenzoyl)amino]-1-{4-[(dimethylamino)sulfonyl]phenyl}-4,5-dihydro-1H-benzo[g]indazole-3-carboxamide, 8-[(2-chlorobenzoyl)amino]-1-[4-({[2-(dimethylamino)ethyl]amino}sulfonyl)phenyl]-4,5-dihydro-1H-benzo[g]indazole-3-carboxamide, 8-[(3-chlorobenzoyl)amino]-1-{4-[(dimethylamino)sulfonyl]phenyl}-4,5-dihydro-1H-benzo[g]indazole-3-carboxamide, 8-(acetylamino)-1-{4-[(dimethylamino)sulfonyl]phenyl}-4,5-dihydro-1H-benzo[g]indazole-3-carboxamide, 1-{4-[(diallylamino)sulfonyl]phenyl}-8-[(methylsulfonyl)amino]-4,5-dihydro-1H-benzo[g]indazole-3-carboxamide, 8-[(2-chlorobenzoyl)amino]-1-{4-[(diprop-2-ynylamino)sulfonyl]phenyl}-4,5-dihydro-1H-benzo[g]indazole-3-carboxamide, and 8-amino-1-[4-({[2-(dimethylamino)ethyl]amino}sulfonyl)phenyl]-4,5-dihydro-1H-benzo[g]indazole-3-carboxamide.
- 21. The compound of claim 2 selected from the group consisting of:
8-[(2-chlorobenzoyl)amino]-1-[6-(methylsulfonyl)pyridin-3-yl]-4,5-dihydro-1H-benzo[g]indazole-3-carboxamide, 8-[(2-chlorobenzoyl)amino]-1-pyridin-4-yl-4,5-dihydro-1H-benzo[g]indazole-3-carboxamide, 8-[(2-chlorobenzoyl)amino]-1-[5-(methylsulfonyl)pyridin-2-yl]-4,5-dihydro-1H-benzo[g]indazole-3-carboxamide, 8-[(2-chlorobenzoyl)amino]-1-pyridin-3-yl-4,5-dihydro-1H-benzo[g]indazole-3-carboxamide methanesulfonate, 8-[(2-chlorobenzoyl)amino]-1-pyridin-4-yl-4,5-dihydro-1H-benzo[g]indazole-3-carboxamide methanesulfonate, and 8-[(2-chlorobenzoyl)amino]-1-pyridin-3-yl-4,5-dihydro-1H-benzo[g]indazole-3-1 5 carboxamide.
- 22. The compound of claim 2 selected from the group consisting of:
1-(1,3-benzodioxol-5-yl)-8-{[(2-chloropyridin-3-yl)carbonyl]amino}-5,5-dimethyl-4,5-dihydro-1H-benzo[g]indazole-3-carboxamide and 1-(1,3-benzodioxol-5-yl)-8-[(3-chloroisonicotinoyl)amino]-5,5-dimethyl-4,5-dihydro-1H-benzo[g]indazole-3-carboxamide.
- 23. The compound of claim 2 of the formula
- 24. The compound of claim 23,
- 25. The compound of claim 23 of the formula
- 26. The compound of claim 25,
- 27. The compound of claim 23 of the formula
- 28. The compound of claim 27,
- 29. The compound of claim 27 selected from the group consisting of:
1-(1,3-benzodioxol-5-yl)-8-({[2-(methylamino)pyridin-3-yl]carbonyl}amino)-4,5-dihydro-1H-benzo[g]indazole-3-carboxamide, 1-(1,3-benzodioxol-5-yl)-8-[({2-[(2-hydroxyethyl)amino]pyridin-3-yl}carbonyl)amino]-4,5-dihydro-1H-benzo[g]indazole-3-carboxamide, 1-(1,3-benzodioxol-5-yl)-8-[({2-[(4-methoxybenzyl)amino]pyridin-3-yl}carbonyl)amino]-4,5-dihydro-1H-benzo[g]indazole-3-carboxamide, 8-{[(2-aminopyridin-3-yl)carbonyl]amino}-1-(1,3-benzodioxol-5-yl)-4,5-dihydro-1H-benzo[g]indazole-3-carboxamide, 1-(1,3-benzodioxol-5-yl)-8-[(2,5-dichloroisonicotinoyl)amino]-4,5-dihydro-1H-benzo[g]indazole-3-carboxamide, 1-(1,3-benzodioxol-5-yl)-8-[(5-chloro-2-morpholin-4-ylisonicotinoyl)amino]-4,5-dihydro-1H-benzo[g]indazole-3-carboxamide, 1-(1,3-benzodioxol-5-yl)-8-({[5-chloro-2-(methylthio)pyrimidin-4-yl]carbonyl}amino)-4,5-dihydro-1H-benzo[g]indazole-3-carboxamide, 1-(1,3-benzodioxol-5-yl)-8-{[5-chloro-2-(4-methylpiperazin-1-yl)isonicotinoyl]amino}-4,5-dihydro-1H-benzo[g]indazole-3-carboxamide, 1-(1,3-benzodioxol-5-yl)-8-[(5-chloro-2-piperazin-1-ylisonicotinoyl)amino]-4,5-dihydro-1H-benzo[g]indazole-3-carboxamide, 1-(1,3-benzodioxol-5-yl)-8-{[(3,6-dichloropyridin-2-yl)carbonyl]amino}-4,5-dihydro-1H-benzo[g]indazole-3-carboxamide, 1-(1,3-benzodioxol-5-yl)-8-({[3-chloro-6-(4-methylpiperazin-1-yl)pyridin-2-yl]carbonyl}amino)-4,5-dihydro-1H-benzo[g]indazole-3-carboximide, 1-(1,3-benzodioxol-5-yl)-8-{[(3-chloro-6-{[2-(dimethylamino)ethyl]thio}pyridin-2-yl)carbonyl]amino}-4,5-dihydro-1H-benzo[g]indazole-3-carboxamide, 1-(1,3-benzodioxol-5-yl)-8-{[(3-chloro-6-morpholin-4-ylpyridin-2-yl)carbonyl]amino}-4,5-dihydro-1H-benzo[g]indazole-3-carboxamide, 1-(1,3-benzodioxol-5-yl)-8-({[3-chloro-6-(methylamino)pyridin-2-yl]carbonyl}amino)-4,5-dihydro-1H-benzo[g]indazole-3-carboxamide, 1-(1,3-benzodioxol-5-yl)-8-{[2-chloro-5-(4-methylpiperazin-1-yl)benzoyl]amino}-4,5-dihydro-1H-benzo[g]indazole-3-carboxamide 1-(1,3-benzodioxol-5-yl)-8-{[(2-chloropyridin-3-yl)carbonyl]amino}-5,5-dimethyl-4,5-dihydro-1H-benzo[g]indazole-3-carboxamide, 1-(1,3-benzodioxol-5-yl)-8-[(3-chloroisonicotinoyl)amino]-5,5-dimethyl-4,5-dihydro-1H-benzo[g]indazole-3-carboxamide, 1-(1,3-benzodioxol-5-yl)-8-[(N-isopropylglycyl)amino]-4,5-dihydro-1H-benzo[g]indazole-3-carboxamide, 1-(1,3-benzodioxol-5-yl)-8-[(N-cyclobutylglycyl)amino]-4,5-dihydro-1H-benzo[g]indazole-3-carboxamide hydrochloride, 1-(1,3-benzodioxol-5-yl)-8-[(pyrrolidin-1-ylacetyl)amino]-4,5-dihydro-1H-benzo[g]indazole-3-carboxamide hydrochloride, 1-(1,3-benzodioxol-5-yl)-8-[(N-cyclohexylglycyl)amino]-4,5-dihydro-1H-benzo[g]indazole-3-carboxamide hydrochloride, 1-(1,3-benzodioxol-5-yl)-8-[(N-methylglycyl)amino]-4,5-dihydro-1H-benzo[g]indazole-3-carboxamide hydrochloride, 1-(1,3-benzodioxol-5-yl)-8-{[N-(cyclopropylmethyl)glycyl]amino}-4,5-dihydro-1H-benzo[g]indazole-3-carboxamide hydrochloride, 1-(1,3-benzodioxol-5-yl)-8-{[N-(tert-butyl)glycyl]amino}-4,5-dihydro-1H-benzo[g]indazole-3-carboxamide, and 1-(1,3-benzodioxol-5-yl)-8-[(N-isobutylglycyl)amino]-4,5-dihydro-1H-benzo[g]indazole-3-carboxamide.
- 30. The compound of claim 23 of the formula
- 31. The compound of claim 30,
- 32. The compound of claim 23 of the formula
- 33. The compound of claim 32,
- 34. The compound of claim 32 selected from the group consisting of:
1-(4-fluorophenyl)-8-{[(2-piperazin-1-ylpyridin-3-yl)carbonyl]amino}-4,5-dihydro-1H-benzo[g]indazole-3-carboxamide, 8-{[(6-chloro-4-methylpyridin-3-yl)carbonyl]amino}-1-(4-fluorophenyl)-4,5-dihydro-1H-benzo[g]indazole-3-carboxamide, 1-(4-fluorophenyl)-8-{[(4-methyl-6-morpholin4-ylpyridin-3-yl)carbonyl]amino}-4,5-dihydro-1H-benzo[g]indazole-3-carboxamide, 8-[(2,5-dichloroisonicotinoyl)amino]-1-(4-fluorophenyl)-4,5-dihydro-1H-benzo[g]indazole-3-carboxamide, 8-[(5-chloro-2-morpholin4-ylisonicotinoyl)amino]-1-(4-fluorophenyl)-4,5-dihydro-1H-benzo[g]indazole-3-carboxamide, 8-{[5-chloro-2-(4-methylpiperazin-1-yl)isonicotinoyl]amino}-1-(4-fluorophenyl)-4,5-dihydro-1H-benzo[g]indazole-3-carboxamide, 1-(4-fluorophenyl)-8-{[2-(4-methylpiperazin-1-yl)isonicotinoyl]amino}-4,5-dihydro-1H-benzo[g]indazole-3-carboxamide, 8-{[5-chloro-2-(4-methyl-1,4-diazepan-1-yl)isonicotinoyl]amino}-1-(4-fluorophenyl)-4,5-dihydro-1H-benzo[g]indazole-3-carboxamide, 8-[(5-chloro-2-piperazin-1-ylisonicotinoyl)amino]-1-(4-fluorophenyl)-4,5-dihydro-1H-benzo[g]indazole-3-carboxamide, 8-({5-chloro-2-[[2-(dimethylamino)ethyl](methyl)amino]isonicotinoyl}amino)-1-(4-fluorophenyl)-4,5-dihydro-1H-benzo[g]indazole-3-carboxamide, 8-{[(3-chloro-6-morpholin-4-ylpyridin-2-yl)carbonyl]amino}-1-(4-fluorophenyl)-4,5-dihydro-1H-benzo[g]indazole-3-carboxamide, 8-({[3-chloro-6-(4-methylpiperazin-1-yl)pyridin-2-yl]carbonyl}amino)-1-(4-fluorophenyl)-4,5-dihydro-1H-benzo[g]indazole-3-carboxamide, 8-{[(3-chloro-6-{[2-(dimethylamino)ethyl]thio}pyridin-2-yl)carbonyl]amino}-1-(4-fluorophenyl)-4,5-dihydro-1H-benzo[g]indazole-3-carboxamide, 8-{[2-chloro-5-(4-methylpiperazin-1-yl)benzoyl]amino}-1-(4-fluorophenyl)-4,5-dihydro-1H-benzo[g]indazole-3-carboxamide, 8-[(3-chloro-2-fluorobenzoyl)amino]-1-(3-fluorophenyl)-4,5-dihydro-1H-benzo[g]indazole-3-carboxamide, 8-[(2-chlorobenzoyl)amino]-1-(3,4-difluorophenyl)-4,5-dihydro-1H-benzo[g]indazole-3-carboxamide, 8-{[(2-chloropyridin-3-yl)carbonyl]amino}-1-(3,4-difluorophenyl)-4,5-dihydro-1H-benzo[g]indazole-3-carboxamide, 8-[(2,3-dichlorobenzoyl)amino]-1-(3,4-difluorophenyl)-4,5-dihydro-1H-benzo[g]indazole-3-carboxamide, 8-{[(2-chloropyridin-3-yl)carbonyl]amino}-1-(2,4-difluorophenyl)-4,5-dihydro-1H-benzo[g]indazole-3-carboxamide, 1-(4-amino-3,5-difluorophenyl)-8-[(3-chloroisonicotinoyl)amino]-4,5-dihydro-1H-benzo[g]indazole-3-carboxamide, 1-(4-amino-2,5-difluorophenyl)-8-[(3-chloroisonicotinoyl)amino]-4,5-dihydro-1H-benzo[g]indazole-3-carboxamide, 8-[(3-chloroisonicotinoyl)amino]-1-(4-fluorophenyl)-5-methyl-4,5-dihydro-1H-benzo[g]indazole-3-carboxamide, 8-{[(2-chloropyridin-3-yl)carbonyl]amino}-1-(4-fluorophenyl)-5-methyl-4,5-dihydro-1H-benzo[g]indazole-3-carboxamide, 8-amino-1-(2,4-difluorophenyl)-5-methyl-4,5-dihydro-1H-benzo[g]indazole-3-carboxamide, 8-amino-1-(4-amino-2-fluorophenyl)-5-methyl-4,5-dihydro-1H-benzo[g]indazole-3-carboxamide, 8-[(3-chloroisonicotinoyl)amino]-1-(2,4-difluorophenyl)-5-methyl-4,5-dihydro-1H-benzo[g]indazole-3-carboxamide, 8-{[2-chloro-5-(4-methylpiperazin-1-yl)benzoyl]amino}-1-(4-fluorophenyl)-5-methyl-4,5-dihydro-1H-benzo[g]indazole-3-carboxamide, 1-(4-amino-2-fluorophenyl)-8-[(3-chloroisonicotinoyl)amino]-5-methyl-4,5-dihydro-1H-benzo[g]indazole-3-carboxamide, 8-{[(2-chloropyridin-3-yl)carbonyl]amino}-1-(2,4-difluorophenyl)-5-methyl-4,5-dihydro-1H-benzo[g]indazole-3-carboxamide, and 8-[(N-cyclobutylglycyl)amino]-1-(4-fluorophenyl)-4,5-dihydro-1H-benzo[g]indazole-3-carboxamide.
- 35. The compound of claim 2 of the formula
- 36. The compound of claim 2 of the formula
- 37. A composition comprising the compound of claim 1, or 2 and at least one pharmaceutically acceptable carrier.
- 38. A method of treating cancer, inflammation or an inflammation associated disorder in a subject, said method comprising administering to the subject having or susceptible to such cancer, inflammation or inflammation associated disorder, a therapeutically-effective amount of a compound of claim 1, or 2.
- 39. The method of claim 38 for use in the treatment of cancer.
- 40. The method of claim 38 for use in the treatment of inflammation.
- 41. The method of claim 38 for use in the treatment of an inflammation-associated disorder.
- 42. The method of claim 41 wherein the inflammation-associated disorder is arthritis.
- 43. The method of claim 41 wherein the inflammation-associated disorder is pain
- 44. The method of claim 41 wherein the inflammation-associated disorder is fever.
Parent Case Info
[0001] The present application claims priority under Title 35, United States Code, §119 to U.S. Provisional application Serial No. 60/323,423, filed Sep. 19, 2001, and U.S. Provisional application Serial No. 60/379,090, filed May 9, 2002, which are incorporated by reference in their entirety as if written herein.
Provisional Applications (2)
|
Number |
Date |
Country |
|
60323423 |
Sep 2001 |
US |
|
60379090 |
May 2002 |
US |