Claims
- 1. A compound of the formula ##STR4## and pharmaceutically acceptable salts of said compound.
- 2. A compound of the formula ##STR5## and pharmaceutically acceptable salts of said compound.
- 3. A pharmaceutical composition comprising a compound of formula ##STR6## or a pharmaceutically acceptable salt of said compound and a pharmaceutically acceptable carrier.
- 4. A pharmaceutical composition comprising a compound of formula ##STR7## or a pharmaceutically acceptable salt of said compound and a pharmaceutically acceptable carrier.
- 5. A method for treating solid tumors in a human patient comprising administering to the patient a therapeutically effective amount of compound I or a pharmaceutically acceptable salt of said compound.
- 6. A method for treating solid tumors in a human patient comprising administering to the patient a therapeutically effective amount of compound II or a pharmaceutically acceptable salt of said compound.
- 7. The method of claim 5 wherein the therapeutically effective amount of compound I is from about 200 mg to about 5,000 mg per 70 kg patient.
- 8. The method of claim 6 wherein the therapeutically effective amount of compound II is from about 200 mg to about 5,000 mg per 70 kg patient.
- 9. An antitumor composition in unit dosage form comprising at least one compound selected from compound I, compound II, and pharmaceutically acceptable salts of said compounds, and a pharmaceutically acceptable carrier, wherein compound I, II, or salt of said compounds is present in an amount of from about 5 mg to about 5,000 mg.
- 10. The composition of claim 13 wherein compound I, II or salt of said compounds is present in an amount of from about 200 mg to about 1,000 mg.
- 11. The composition of claim 9 wherein said unit dosage form is a capsule or tablet.
Parent Case Info
Provisional application no 60/078,331 filed on Mar. 17, 1998.
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5057614 |
Davis et al. |
Oct 1991 |
|
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|
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Non-Patent Literature Citations (2)
Entry |
Jackson B. Hester, J. Org. Chem., vol. 29, pp. 1158-1160 (1964). |
Peter D. Davis et al., Journal of Medicinal Chemistry, vol. 35, No. 1, p. 177-184 (1992). |