Claims
- 1. A method for the treatment of a patient suffering from gastrointestinal disorders comprising administering thereto a gastrointestinal effective amount of a compound according to the formula ##STR17## wherein X is hydrogen, hydroxy, amino, mono- and di-loweralkylamino, halo, trifluoromethyl, sulfamyl, mono- and di-loweralkylsulfamyl or loweralkylsulfonyl;
- R is hydrogen or loweralkyl;
- R.sub.1 and R.sub.2 are independently hydrogen or loweralkyl;
- vicinal R.sub.2 groups together may be --(CH.sub.2).sub.a -- where a is 1 to 4, thus forming a 3 to 6 member ring;
- n is 2 to 4;
- Y is loweralkyl, --(CR.sub.1 R.sub.2).sub.b --SO-loweralkyl or --(CR.sub.1 R.sub.2).sub.b --CO-loweralkyl;
- b and d are 1 to 3; and
- Z is --(CR.sub.1 R.sub.2).sub.d --NR.sub.1 R.sub.2, ##STR18## or a pharmaceutically acceptable salt thereof.
- 2. A pharmaceutical composition including an effective 5-HT.sub.3 -antagonist amount of a compound according to the formula ##STR19## wherein X is hydrogen, hydroxy, amino, mono- and di-loweralkylamino, halo, trifluoromethyl, sulfamyl, mono- and di-loweralkylsulfamyl or loweralkylsulfonyl;
- R is hydrogen or loweralkyl;
- R.sub.1 and R.sub.2 are independently hydrogen or loweralkyl;
- vicinal R.sub.2 groups together may be --(CH.sub.2).sub.a -- where a is 1 to 4, thus forming a 3 to 6 member ring;
- n is 2 to 4;
- Y is loweralkyl, --(CR.sub.1 R.sub.2).sub.b --SO-loweralkyl or --(CR.sub.1 R.sub.2).sub.b --CO-loweralkyl;
- b and d are 1 to 3; and
- Z is --(CR.sub.1 R.sub.2).sub.d --NR.sub.1 R.sub.2, ##STR20## or a pharmaceutically acceptable salt thereof in admixture with a pharmaceutical carrier.
Parent Case Info
This is a divisional of co-pending application Ser. No. 07/277,582 filed on Nov. 29, 1988 now U.S. Pat. No. 4,920,219.
Foreign Referenced Citations (1)
Number |
Date |
Country |
8403281 |
Aug 1984 |
WOX |
Divisions (1)
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Number |
Date |
Country |
Parent |
277582 |
Nov 1988 |
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