Claims
- 1. A compound of Formula I ##STR10## wherein R is ##STR11## X is ##STR12## or --CH.sub.2 --; n is an integer of 2 to 4;
- R.sup.1 is aryl, 2- or 3-1H-indolyl, or 2- or 3-1H-indolyl substituted by lower alkyl, lower alkoxy, or halogen, 2-, 3-, or 4-pyridinyl, or 2-, 3-, or 4-pyridinyl substituted by lower alkyl, lower alkoxy, or halogen, 2-, 4-, or 5-pyrimidinyl, or 2-, or 4-, or 5-pyrimidinyl substituted by lower alkyl, lower alkoxy, or halogen, 2-pyrazinyl or 2-pyrazinyl substituted by lower alkyl, lower alkoxy, or halogen, 2- or 3-thienyl, or 2- or 3-thienyl substituted by lower alkyl or halogen, 2- or 3-furanyl, or 2- or 3-furanyl substituted by lower alkyl or halogen, 2-, 4-, or 5-thiazolyl, or 2-, or 5-thiazolyl substituted by lower alkyl or halogen; or a pharmaceutically acceptable acid addition salt thereof.
- 2. A compound according to claim 1, in which R.sup.1 is aryl, 2- 3-1H-indolyl, or 2- or 3-1H-indolyl substituted by lower alkyl, lower alkoxy, or halogen, 2-, 3-, or 4-pyridinyl, or 2-, 3-, or 4-pyridinyl substituted by lower alkyl, lower alkoxy, or halogen, 2-, 4-, or 5-pyrimidinyl, or 2-, 4-, or 5-pyrimidinyl substituted by lower alkyl, lower alkoxy, or halogen, 2- or 3-thienyl or 2- or 3-thienyl substituted by lower alkyl or halogen.
- 3. A compound according to claim 2, in which R.sup.1 is aryl, 2- or 3-1H-indolyl, 2-, 3-, or 4-pyridinyl, 2-, 4-, or 5-pyrimidinyl, or 2- or 3-thienyl.
- 4. A compound according to claim 3 selected from the group consisting of:
- 3-[4-(3,6-Dihydro-4-phenyl-1(2H)-pyridinyl)-butyl]quinoline;
- 3-[4-[3,6-Dihydro-4-(2-pyridinyl)-1-(2H)-pyridinyl]butyl]quinoline;
- 4-(3,6-Dihydro-4-phenyl-1(2H)-pyridinyl)-1-(3-quinolinyl)-1-butanone;
- 3-[3-[3,6-Dihydro-4-(2-thienyl)-1(2H)-pyridinyl]propyl]quinoline;
- 3-[3-(3,6-Dihydro-4-phenyl-1(2H)-pyridinyl)-propyl]quinoline;
- 3-[5-[3,6-Dihydro-4-(2-thienyl)-1-(2H)-pyridinyl]butyl]quinoline;
- 3-[5-(3,6-Dihydro-4-phenyl-1(2H)-pyridinyl)-pentyl]quinoline; and
- 3-[5-(3,6-Dihydro-4-(2-thienyl)-1(2H)-pyridinyl]-pentyl]quinoline.
- 5. A method of treating schizophrenia comprising administering to a host suffering therefrom a therapeutic effective amount of a compound according to claim 1 in unit dosage form.
- 6. A pharmaceutical composition adapted for administration as a dopaminergic, antipsychotic, antihypertensive or antidepressant agent comprising a therapeutic effective amount of a compound according to claim 1 in admixture with a pharmaceutically acceptable excipient, diluent or carrier.
Parent Case Info
This is a divisional application of U.S. Ser. No. 07/585,758 filed Sep. 20, 1990, now U.S. Pat. No. 5,045,550.
US Referenced Citations (3)
Number |
Name |
Date |
Kind |
4665187 |
Bottcher et al. |
May 1987 |
|
4743692 |
Teller et al. |
May 1988 |
|
4942169 |
Sugimoto et al. |
Jul 1990 |
|
Divisions (1)
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Number |
Date |
Country |
Parent |
585758 |
Sep 1990 |
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