Claims
- 1. A compound of a formula I:
- 2. The compound of claim 1, wherein:
(a) W1 and W2 are independently L, V, or C(R1)(R2)—(CH2)c-V where c is 1 or 2; and (b) R1 or R2 are independently (C1-C6)alkyl, (C2-C6)alkenyl, (C2-C6)alkynyl, phenyl, or benzyl.
- 3. The compound of claim 1, wherein W1 is L.
- 4. The compound of claim 1, wherein W1 is V.
- 5. The compound of claim 1, wherein W1 is C(R1)(R2)—(CH2)c—C(R3)(R4)—(CH2)n—Y where n is an integer from 0 to 4.
- 6. The compound of claim 1, wherein W1 is C(R1)(R2)—(CH2)c-V.
- 7. The compound of claim 1, wherein W1 and W2 are independent L groups.
- 8. The compound of claim 7, wherein each occurrence of Y is independently OH, COOR5, or COOH.
- 9. A compound of the formula Ia:
- 10. The compound of claim 9, wherein W1 is L.
- 11. The compound of claim 9, wherein W1 is V.
- 12. The compound of claim 9, wherein W1 is C(R1)(R2)—(CH2)c-V.
- 13. The compound of claim 9, wherein W1 and W2 are independent L groups.
- 14. The compound of claim 13, wherein each occurrence of Y is independently OH, COOR3, or COOH.
- 15. A compound of the formula Ib
- 16. The compound of claim 15, wherein each occurrence of Y is independently OH, COOR3, or COOH.
- 17. The compound of claim 16, wherein each R1 or R2 is the same or different (C1-C6)alkyl group.
- 18. A compound of the formula Ic
- 19. A compound according to claim 1, having the formula 5-[2-(4-carboxy-4-methyl-pentylsulfanyl)-ethylsufanyl]-2,2-dimethyl-pentanoic acid.
- 20. A compound of the formula II:
- 21. A compound of the formula Ia:
- 22. The compound as in claim 21 wherein C*1 is a chiral-carbon center of the stereochemical configuration R or substantially R.
- 23. The compound as in claim 21 wherein C*1 is a chiral-center of the stereochemical configuration S or substantially S.
- 24. The compound as in claim 21 wherein C*2 is a chiral-carbon center of the stereochemical configuration R or substantially R.
- 25. The compound as in claim 21 wherein C*2 is a chiral-center of the stereochemical configuration S or substantially S.
- 26. A compound of the formula III:
- 27. The compound of claim 26, wherein W1 and W2 are independent C(R1)(R2)—(CH2)n—Y groups and each occurrence of Y is independently OH, COOR3, or COOH.
- 28. The compound of claim 26, wherein p is 2.
- 29. The compound of claim 26, wherein p is 3.
- 30. The compound of claim 26, wherein each occurrence of R6 and R7 is H.
- 31. A compound of the formula IIIa:
- 32. The compound of claim 31, wherein W1 and W2 are independent C(R1)(R2)—(CH2)n—Y groups and each occurrence of Y is independently OH, COOR3, or COOH.
- 33. The compound of claim 31, wherein p is 0.
- 34. The compound of claim 31, wherein p is 1.
- 35. A compound of the formula:
I-1 4-[4-(3-Hydroxy-3-methyl-butylsulfanylmethyl)-benzylsulfanyl]-2-methyl-butan-2-ol; I-2 4-[4-(4-Hydroxy-3,3-dimethyl-butylsulfanylmethyl)-benzylsulfanyl]-2,2-dimethyl-butan-1-ol; I-3 4-[4-(3-Carboxy-3-methyl-butylsulfanylmethyl)-benzylsulfanyl]-2,2-dimethyl-butyric acid; I-4 4-[4-(3,3-Dimethyl-4-oxo-butylsulfanylmethyl)-benzylsulfanyl]-2,2-dimethyl-butyraldehyde; I-5 4-[4-(3-Methoxycarbonyl-3-methyl-butylsulfanylmethyl)-benzylsulfanyl]-2,2-dimethyl-butyric acid methyl ester; I-6 2,2-Dimethyl-4-[4-(3-methyl-3-phenoxycarbonyl-butylsulfanylmethyl)-benzylsulfanyl]-butyric acid phenyl ester; I-7 4-[4-(3-Benzyloxycarbonyl-3-methyl-butylsulfanylmethyl)-benzylsulfanyl]-2,2-dimethyl-butyric acid benzyl ester; I-8 2-Methyl-4-[4-(3-methyl-3-sulfo-butylsulfanylmethyl)-benzylsulfanyl]-butane-2-sulfonic acid; I-9 Phosphoric acid mono-{1,1-dimethyl-3-[4-(3-methyl-3-phosphonooxy-butylsulfanylmethyl)-benzylsulfanyl]-propyl} ester; I-10 4-[4-(3-Hydroxy-3-methyl-butylsulfanyl)-phenylsulfanyl]-2-methyl-butan-2-ol; I-11 4-[4-(4-Hydroxy-3,3-dimethyl-butylsulfanyl)-phenylsulfanyl]-2,2-dimethyl-butan-1-ol; I-12 4-[4-(3-Carboxy-3-methyl-butylsulfanyl)-phenylsulfanyl]-2,2-dimethyl-butyric acid; I-13 4-[4-(3,3-Dimethyl-4-oxo-butylsulfanyl)-phenylsulfanyl]-2,2-dimethyl-butyraldehyde; I-14 4-[4-(3-Methoxycarbonyl-3-methyl-butylsulfanyl)-phenylsulfanyl]-2,2-dimethyl-butyric acid methyl ester; I-15 2,2-Dimethyl-4-[4-(3-methyl-3-phenoxycarbonyl-butylsulfanyl)-phenylsulfanyl]-butyric acid phenyl ester; I-16 4-[4-(3-Benzyloxycarbonyl-3-methyl-butylsulfanyl)-phenylsulfanyl]-2,2-dimethyl-butyric acid benzyl ester; I-17 2-Methyl-4-[4-(3-methyl-3-sulfo-butylsulfanyl)-phenylsulfanyl]-butane-2-sulfonic acid; I-18 Phosphoric acid mono-{1,1-dimethyl-3-[4-(3-methyl-3-phosphonooxy-butylsulfanyl)-phenylsulfanyl]-propyl} ester; Ib-1 4-[3-(3-Hydroxy-3-methyl-butylsulfanyl)-propylsulfanyl]-2-methyl-butan-2-ol; Ib-2 4-[3-(4-Hydroxy-3,3-dimethyl-butylsulfanyl)-propylsulfanyl]-2,2-dimethyl-butan-1-ol; Ib-3 4-[3-(3-Carboxy-3-methyl-butylsulfanyl)-propylsulfanyl]-2,2-dimethyl-butyric acid; Ib-4 4-[3-(3,3-Dimethyl-4-oxo-butylsulfanyl)-propylsulfanyl]-2,2-dimethyl-butyraldehyde; Ib-5 4-[3-(3-Methoxycarbonyl-3-methyl-butylsulfanyl)-propylsulfanyl]-2,2-dimethyl-butyric acid methyl ester; Ib-6 2,2-Dimethyl-4-[3-(3-methyl-3-phenoxycarbonyl-butylsulfanyl)-propylsulfanyl]-butyric acid phenyl ester; Ib-7 4-[3-(3-Benzyloxycarbonyl-3-methyl-butylsulfanyl)-propylsulfanyl]-2,2-dimethyl-butyric acid benzyl ester; Ib-8 2-Methyl-4-[3-(3-methyl-3-sulfo-butylsulfanyl)-propylsulfanyl]-butane-2-sulfonic acid; Ib-9 Phosphoric acid mono-{1,1-dimethyl-3-[3-(3-methyl-3-phosphonooxy-butylsulfanyl)-propylsulfanyl]-propyl} ester; Ib-10 2,12-Bis-(4,6-dioxo-2,3,3a,6-tetrahydro-4H-thieno[3,2-c]pyridin-5-yl)-2,12-dimethyl-5,9-thia-tridecane; Ib-11 2,12-Bis-(4,6-dithioxo-2,3,3a,6-tetrahydro-4H-thieno[3,2-c]pyridin-5-yl)-2,12-dimethyl-5,9-thia-tridecane; Ib-12 4-[3-(3-Cyanocarbamoyl-3-methyl-butane-1-sulfanyl)-propane-1-sulf anyl]-2,2-dimethyl-butyrcyanimide; Ib-13 Phosphoramidic acid mono-(3-{3-[3-(amino-hydroxy-phosphoryloxy)-3-methyl-butylsulfanyl]-propylsulfanyl}-1,1-dimethyl-propyl) ester; Ib-14 3-(Amino-hydroxy-phosphoryloxy)-3-methyl-b 1-[3-(3-{amino-hydroxy-phosphoryloxy}-3-methyl-butane-1-sulfanyl)-propane-1-sul fanyl]-butane; Ib-15 2,12-Dimethyl-2,12-bis-tetrazol-1-yl-5,9-lithia-tridecane; Ib-16 2,12-Dimethyl-2,12-bis-(1H-tetrazol-5-yl)-5,9-lithia-tridecane; Ib-17 2,12-Bis-(3-hydroxy-isoxazol-5-yl)-2,12-dimethyl-5,9-dithia-tridecane; Ib-18 2,12-Bis-(3-hydroxy-isoxazol-4-yl)-2,12-dimethyl-5,9-dithia-tridecane; Ib-19 2,12-Bis-(5-hydroxy-4-oxo-4H-pyran-3-yl)-2,12-dimethyl-5,9-dithia-tridecane: Ib-20 2,12-Bis-(5-hydroxy-4-oxo-4H-pyran-2-yl)-2,12-dimethyl-5,9-dithia-tridecane; Ib-21 1-Ethyl-3-(3-{3-[3-(3-ethyl-2,5-dithioxo-imidazolidin-1-yl)-3-methyl-butylsulfanyl]-propylsulfanyl}1,1-dimethyl-propyl)-imidazolidine-2,4-dione; Ib-22 2,12-Bis-(3-ethyl-2,5-dioxo-imidazolidin-1-yl)-2,12-dimethyl-5,9-dithia-tridecane; Ib-23 2,12-Bis-(3-ethyl-5-oxo-2-thioxo-imidazolidin-1-yl)-2,12-dimethyl-5,9-dithia-tridecane; Ib-24 2,12-Bis-(3-ethyl-2-oxo-5-thioxo-imidazolidin-1-yl)-2,12-dimethyl-5,9-dithia-tridecane; Ib-25 5-[3-(5-Hydroxy-3,3-dimethyl-pentylsulfanyl)-propylsulfanyl]-3,3-dimethyl-pentan-1-ol; Ib-26 5-[3-(4-Carboxy-3,3-dimethyl-butylsulfanyl)-propylsulfanyl]-3,3-dimethyl-pentanoic acid; Ib-27 5-[3-(3,3-Dimethyl-5-oxo-pentylsulfanyl)-propylsulfanyl]-3,3-dimethyl-pentanal; Ib-28 5-[3-(4-Methoxycarbonyl-3,3-dimethyl-butylsulfanyl)-propylsulfanyl]-3,3-dimethyl-pentanoic acid methyl ester; Ib-29 3,3-Dimethyl-5-[3-(3-methyl-3-phenoxycarbonyl-butylsulfanyl)-propylsulfanyl]-pentanoic acid phenyl ester; Ib-30 5-[3-(3-Benzyloxycarbonyl-3-methyl-butylsulfanyl)-propylsulfanyl]-3,3-dimethyl-pentanoic acid benzyl ester; Ib-31 4-[3-(3,3-Dimethyl-4-sulfo-butylsulfanyl)-propylsulfanyl]-2,2-dimethyl-butane-1 -sulfonic acid; Ib-32 Phosphoric acid mono-{4-[3-(3,3-dimethyl-4-phosphonooxy-butylsulfanyl)-propylsulfanyl]-2,2-dimethyl-butyl} ester; Ib-33 1,13-Bis-(4,6-dioxo-2,3,3a,6-tetrahydro-4H-thieno[3,2-c]pyridin-5-yl)-5,9-dithia-2,2,12,12-tetramethyl-tridecane; Ib-34 1,13-Bis-(4,6-dithioxo-2,3,3a,6-tetrahydro-4H-thieno[3,2-c]pyridin-5-yl)-5,9-dithia-2,2,12,12-tetramethyl-tridecane; Ib-35 5-[3-(4-Cyanocarbamoyl-3,3-dimethyl-butane-1-sulfanyl)-propane-1-sulfanyl]-3,3-dimethyl-pentanoic acid cyanamide; Ib-36 Phosphoramidic acid mono-(4-{3-[4-(amino-hydroxy-phosphoryloxy)-3,3-dimethyl-butylsulfanyl]-propylsulfanyl}-2,2-dimethyl-butyl) ester; Ib-37 2,2,12,12-Tetramethyl-1,13-bis-tetrazol-1-yl-5,9-dithia-tridecane; Ib-38 2,2,12,12-Tetramethyl-1,13-bis-(1H-tetrazol-5-yl)-5,9-dithia-tridecane; Ib-39 1,13-Bis-(3-hydroxy-isoxazol-5-yl)-5,9-dithia-2,2,12,12-tetramethyl-tridecane; Ib-40 1,13-Bis-(3-hydroxy-isoxazol-4-yl)-5,9-dithia-2,2,12,12-tetramethyl-tridecane; Ib-41 1-(5-Hydroxy-4-oxo-4H-pyran-3-yl)-13-(5-hydroxy-4-oxo-4H-pyran-2-yl)-5,9-dithia-2,2,12,12-tetramethyl-tridecane; Ib-42 1,13-Bis-(5-hydroxy-4-oxo-4H-pyran-2-yl)-5,9-dithia-2,2,12,12-tetramethyl-tridecane; Ib-43 1,13-Bis-(5-hydroxy-4-oxo-4H-pyran-3-yl)-5,9-dithia-2,2,12,12-tetramethyl-tridecane; Ib-44 1-Ethyl-3-(4-{3-[4-(3-ethyl-2,5-dithioxo-imidazolidin-1-yl)-3,3-dimethyl-butylsulfanyl]-propylsulfanyl}-2,2-dimethyl-butyl)-imidazolidine-2,4-dione Ib-45 1,13-Bis-(3-ethyl-2,5-dioxo-imidazolidin-1-yl)-5,9-dithia-2,2,12,12-tetramethyl-tridecane; Ib-46 1,13-Bis-(3-ethyl-2,5-dithioxo-imidazolidin-1-yl)-5,9-dithia-2,2,12,12-tetramethyl-tridecane; Ib-47 1,13-Bis-(3-ethyl-5-oxo-2-thioxo-imidazolidin-1-yl)-5,9-dithia-2,2,12,12-tetramethyl-tridecane: Ib-48 1,13-Bis-(3-ethyl-2-oxo-5-thioxo-imidazolidin-1-yl)-5,9-dithia-2,2,12,1 2-tetramethyl-tridecane; Ib-49 4-[2-(3-Hydroxy-3-methyl-butylsulfanyl)-ethylsulfanyl]-2-methyl-butan-2-ol; Ib-50 4-[2-(4-Hydroxy-3,3-dimethyl-butylsulfanyl)-ethylsulfanyl]-2,2-dimethyl-butan-1-ol; Ib-51 4-[2-(3-Carboxy-3-methyl-butylsulfanyl)-ethylsulfanyl]-2,2-dimethyl-butyric acid; Ib-52 2-Methyl-4-[2-(3-methyl-3-sulfo-butylsulfanyl)-ethylsulfanyl]-butane-2-sulfonic acid; Ib-53 4-[2-(3,3-Dimethyl-4-oxo-butylsulfanyl)-ethylsulfanyl]-2,2-dimethyl-butyraldehyde; Ib-54 4-[2-(3-Methoxycarbonyl-3-methyl-butylsulfanyl)-ethylsulfanyl]-2,2-dimethyl-butyric acid methyl ester; Ib-55 2,2-Dimethyl-4-[2-(3-methyl-3-phenoxycarbonyl-butylsulfanyl)-ethylsulfanyl]-butyric acid phenyl ester; Ib-56 4-[2-(3-Benzyloxycarbonyl-3-methyl-butylsulfanyl)-ethylsulfanyl]-2,2-dimethyl-butyric acid benzyl ester; Ib-57 Phosphoric acid mono-{1,1-dimethyl-3-[2-(3-methyl-3-phosphonooxy-butylsulfanyl)-ethylsulfanyl]-propyl} ester; Ib-58 5-[3-(4-Hydroxy-4-methyl-pentylsulfanyl)-propylsulfanyl]-2-methyl-pentan-2-ol; Ib-59 5-[3-(5-Hydroxy-4,4-dimethyl-pentylsulfanyl)-propylsulfanyl]-2,2-dimethyl-pentan-1-ol; Ib-60 5-[3-(4-Carboxy-4-methyl-pentylsulfanyl)-propylsulfanyl]-2,2-dimethyl-pentanoic acid; Ib-61 5-[3-(4,4-Dimethyl-5-oxo-pentylsulfanyl)-propylsulfanyl]-2,2-dimethyl-pentanal; Ib-62 5-[3-(4-Methoxycarbonyl-4-methyl-pentylsulfanyl)-propylsulfanyl]-2,2-dimethyl-pentanoic acid methyl ester; Ib-63 3,3-Dimethyl-6-[3-(4-methyl-4-phenoxycarbonyl-pentylsulfanyl)-propylsulfanyl]-hexanoic acid phenyl ester; Ib-64 6-[3-(4-Benzyloxycarbonyl-4-methyl-pentylsulfanyl)-propylsulfanyl]-3,3-dimethyl-hexanoic acid benzyl ester; Ib-65 2-Methyl-5-[3-(4-methyl-4-sulfo-pentylsulfanyl)-propylsulfanyl]-pentane-2-sulfonic acid; Ib-66 Phosphoric acid mono-{1,1-dimethyl-4-[3-(4-methyl-4-phosphonooxy-pentylsulfanyl)-propylsulfanyl]-butyl} ester; Ib-67 2,14-Bis-(4,6-dioxo-2,3,3a,6-tetrahydro-4H-thieno[3,2-c]pyridin-5-yl)-6,10-dithia-2,14-dimethyl-pentadecane; Ib-68 2,14-Bis-(4,6-dithioxo-2,3,3a,6-tetrahydro-4H-thieno[3,2-c]pyridin-5-yl)-6,10-dithia-2,14-dimethyl-pentadecane; Ib-69 5-[3-(4-Cyanocarbamoyl-4-methyl-pentane-1-sulfanyl)-propane-1-sul fanyl]-2,2-dimethyl-pentanoic acid cyanamide; Ib-70 Phosphoramidic acid mono-(4-{3-[4-(amino-hydroxy-phosphoryloxy)-4-methyl-pentylsulfanyl]-propylsulfanyl}-1,1-dimethyl-butyl) ester; Ib-71 4-(Amino-hydroxy-phosphoryloxy)-4-methyl-1-[3-(4-{amino-hydrox y-phosphoryloxy}-4-methyl-pentane-1-sulfanyl)-propane-1-sulfanyl]-pentane; Ib-72 1-(1,1-Dimethyl-4-{3-[4-methyl-4-(1H-[1,2,3]triazol-4-yl)-pentylsulfanyl]-propylsulfanyl}-butyl)-1H-tetrazole; Ib-73 5-(1,1-Dimethyl-4-{3-[4-methyl-4-(3H-[1,2,3]triazol-4-yl)-pentylsulfanyl]-propylsulfanyl}-butyl)-1H-tetrazole; Ib-74 2,14-Bis-(3-hydroxy-isoxazol-5-yl)-2,14-dimethyl-6,10-dithia-pentadecane; Ib-75 2,14-Bis-(3-hydroxy-isoxazol-4-yl)-2,14-dimethyl-6,10-dithia-pentadecane; Ib-76 2,14-Bis-(5-hydroxy-4-oxo-4H-pyran-3-yl)-2,14-dimethyl-6,10-dithia-pentadecane; Ib-77 2-(5-Hydroxy-4-oxo-4H-pyran-2-yl)-2,14-dimethyl-6,10-dithia-14-(5-methyl-4-oxo-4H-pyran-2-yl)-pentadecane; Ib-78 2,14-Bis-(3-ethyl-2,5-dioxo-imidazolidin-1-yl)-2,14-dimethyl-6,10-dithia-pentadecane; Ib-79 2,14-Bis-(3-ethyl-2,5-dithioxo-imidazolidin-1-yl)-2,14-dimethyl-6,10-dithia-pentadecane; Ib-80 2,14-Bis-(3-ethyl-5-oxo-2-thioxo-imidazolidin-1-yl)-2,14-dimethyl-6,10-dithia-pentadecane; Ib-81 2,14-Bis-(3-ethyl-2-oxo-5-thioxo-imidazolidin-1-yl)-2,14-dimethyl-6,10-dithia-pentadecane; Ib-82 5-[2-(5-Hydroxy-3,3-dimethyl-pentylsulfanyl)-ethylsulfanyl]-3,3-dimethyl-pentan-1-ol; Ib-83 5-[2-(4-Carboxy-3,3-dimethyl-butylsulfanyl)-ethylsulfanyl]-3,3-dimethyl-pentanoic acid; Ib-84 5-[2-(3,3-Dimethyl-5-oxo-pentylsulfanyl)-ethylsulfanyl]-3,3-dimethyl-pentanal; Ib-85 5-[2-(4-Methoxycarbonyl-3,3-dimethyl-butylsulfanyl)-ethylsulfanyl]-3,3-dimethyl-pentanoic acid methyl ester; Ib-86 5-[2-(3,3-Dimethyl-4-phenoxycarbonyl-butylsulfanyl)-ethylsulfanyl]-3,3-dimethyl-pentanoic acid phenyl ester; Ib-87 5-[2-(4-Benzyloxycarbonyl-3,3-dimethyl-butylsulfanyl)-ethylsulfanyl]-3,3-dimethyl-pentanoic acid benzyl ester; Ib-88 4-[2-(3,3-Dimethyl-4-sulfo-butylsulfanyl)-ethylsulfanyl]-2,2-dimethyl-butane-1-sulfonic acid; Ib-89 Phosphoric acid mono-{4-[2-(3,3-dimethyl-4-phosphonooxy-butylsulfanyl)-ethylsulfanyl]-2,2-dimethyl-butyl} ester; Ib-90 1,12-Bis-(4,6-dithioxo-2,3,3a,6-tetrahydro-4H-thieno[3,2-c]pyridin-5-yl)-5,8-dithio-2,2,11,11-tetramethyl-dodecane; Ib-91 1,12-Bis-(4,6-dithioxo-2,3,3a,6-tetrahydro-4H-thieno[3,2-c]pyridin-5-yl)-5,8-dithio-2,2,11,11-tetramethyl-dodecane; Ib-92 5-[2-(4-Cyanocarbamoyl-3,3-dimethyl-butane-1-sulfanyl)-ethanesulfa nyl]-3,3-dimethyl-pentanoic acid cyanamide; Ib-93 Phosphoramidic acid mono-(4-{2-[4-(amino-hydroxy-phosphoryloxy)-3,3-dimethyl-butylsulfanyl]-ethylsulfanyl}-2,2-dimethyl-butyl) ester; Ib-94 1-[2-(3,3-Dimethyl-4{amino-hydroxy-phosphoryloxy}-butane-1-sulfa nyl)-ethanesulfanyl]-3,3-dimethyl-4 {amino-hydroxy-phosphoryloxy}-butane; Ib-95 2,2,11,11-Tetramethyl-1,12-bis-(1H-tetrazol-5-yl)-5,8-dithio-dodecane; Ib-96 2,2,11,11-Tetramethyl-1,12-bis-(tetrazol-1-yl)-5,8-dithio-dodecane; Ib-97 1,12-Bis-(3-hydroxy-isoxazol-5-yl)-2,2,11,11-tetramethyl-5,8-dithio-dodecane; Ib-98 1,12-Bis-(3-hydroxy-isoxazol-4-yl)-2,2,11,11-tetramethyl-5,8-dithio-dodecane; Ib-99 1-(5-Hydroxy-4-oxo-4H-pyran-3-yl)-12-(5-hydroxy-4-oxo-4H-pyran-2-yl)-5,8-dithio-2,2,11,11-tetramethyl-dodecane; Ib-100 1,12-Bis-(5-hydroxy-4-oxo-4H-pyran-3-yl)-5,8-dithio-2,2,11,11-tetramethyl-dodecane; Ib-101 1,12-Bis-(5-hydroxy-4-oxo-4H-pyran-3-yl)-5,8-dithio-2,2,11,11-tetramethyl-dodecane; Ib-102 1-Ethyl-3-(4-{2-[4-(3-ethyl-2,5-dithioxo-imidazolidin-1-yl)-3,3-dimethyl-butylsulfanyl]-ethylsulfanyl}-2,2-dimethyl-butyl)-imidazolidine-2,4-dithione; Ib-103 1-Ethyl-3-(4-{2-[4-(3-ethyl-2,5-dithioxo-imidazolidin-1-yl)-3,3-dimethyl-butylsulfanyl]-ethylsulfanyl}-2,2-dimethyl-butyl)-imidazolidine-2,4-dione; Ib-104 1-Ethyl-3-[12-(3-ethyl-2,5-dioxo-imidazolidin-1-yl)-2,2,11,11-tetramethyl-5,8-dithio-dodecyl]-imidazolidine-2,4-dione; Ib-105 1,12-Bis-(3-ethyl-5-oxo-2-thioxo-imidazolidin-1-yl)-5,8-dithio-2,2,11,11-tetramethyl-dodecane. Ib-106 1,12-Bis-(3-ethyl-2-oxo-5-thioxo-imidazolidin-1-yl)-5,8-dithio-2,2,11,11-tetramethyl-dodecane; Ib-107 6-[2-(6-Hydroxy-3,3-dimethyl-hexylsulfanyl)-ethylsulfanyl]-4,4-dimethyl-hexan-1-ol; Ib-108 6-[2-(5-Carboxy-3,3-dimethyl-pentylsulfanyl)-ethylsulfanyl]-4,4-dimethyl-hexanoic acid; Ib-109 6-[2-(3,3-Dimethyl-6-oxo-hexylsulfanyl)-ethylsulfanyl]-4,4-dimethyl-hexanal; Ib-110 6-[2-(5-Methoxycarbonyl-3,3-dimethyl-pentylsulfanyl)-ethylsulfanyl]-4,4-dimethyl-hexanoic acid methyl ester; Ib-111 6-[2-(3,3-Dimethyl-5-phenoxycarbonyl-pentylsulfanyl)-ethylsulfanyl]-4,4-dimethyl-hexanoic acid phenyl ester Ib-112 6-[2-(5-Benzyloxycarbonyl-3,3-dimethyl-pentylsulfanyl)-ethylsulfanyl]-4,4-dimethyl-hexanoic acid benzyl ester; Ib-113 5-[2-(3,3-Dimethyl-5-sulfo-pentylsulfanyl)-ethylsulfanyl]-3,3-dimethyl-pentane-1-sulfonic acid; Ib-114 Phosphoric acid mono-{5-[2-(3,3-dimethyl-5-phosphonooxy-pentylsulfanyl)-ethylsulfanyl]-3,3-dimethyl-pentyl} ester; Ib-115 1,14-Bis-(4,6-dioxo-2,3,3a,6-tetrahydro-4H-thieno[3,2-c]pyridin-5-yl)-6,9-dithio-3,3,12,12-tetramethyl-tetradecane; Ib-116 1,14-Bis-(4,6-dithioxo-2,3,3a,6-tetrahydro-4H-thieno[3,2-c]pyridin-5-yl)-6,9-dithio-3,3,12,12-tetramethyl-tetradecane; Ib-117 6-[2-(5-Cyanocarbamoyl-3,3-dimethyl-pentane-1-sulfanyl)-ethanesulf anyl]-4,4-dimethyl-hexanoic acid cyanimide; Ib-118 Phosphoramidic acid mono-(5-{2-[5-(amino-hydroxy-phosphoryloxy)-3,3-dimethyl-pentylsulfanyl]-ethylsulfanyl}-3,3-dimethyl-pentyl) ester; Ib-119 1-[2-(3,3-Dimethyl-5-{amino-hydroxy-phosphoryloxy}-pentane-1-sul fanyl)-ethanesulfanyl]-3,3-dimethyl-5-{amino-hydroxy-phosphory loxy; Ib-120 4-[2-(4-Hydroxy-3,3-dimethyl-butylsulfanyl)-ethylsulfanyl]-2,2-dimethyl-butan-1-ol; Ib-121 4-[2-(3-Carboxy-3-methyl-butylsulfanyl)-ethylsulfanyl]-2,2-dimethyl-butyric acid; Ib-122 4-[2-(3,3-Dimethyl-4-oxo-butylsulfanyl)-ethylsulfanyl]-2,2-dimethyl-butyraldehyde; Ib-123 4-[2-(3-Methoxycarbonyl-3-methyl-butylsulfanyl)-ethylsulfanyl]-2,2-dimethyl-butyric acid methyl ester; Ib-124 2,2-Dimethyl-4-[2-(3-methyl-3-phenoxycarbonyl-butylsulfanyl)-ethylsulfanyl]-butyric acid phenyl ester; Ib-125 4-[2-(3-Benzyloxycarbonyl-3-methyl-butylsulfanyl)-ethylsulfanyl]-2,2-dimethyl-butyric acid benzyl ester; Ib-126 2-Methyl-4-[2-(3-methyl-3-sulfo-butylsulfanyl)-ethylsulfanyl]-butane-2-sulfonic acid; Ib-127 Phosphoric acid mono-{1,1-dimethyl-3-[2-(3-methyl-3-phosphonooxy-butylsulfanyl)-ethylsulfanyl]-propyl} ester; Ib-128 2,11-Bis-(4,6-dioxo-2,3,3a,6-tetrahydro-4H-thieno[3,2-c]pyridin-5-yl)-2,11-dimethyl-5,8-dithio-dodecane; Ib-129 2,11-Bis-(4,6-dithioxo-2,3,3a,6-tetrahydro-4H-thieno[3,2-c]pyridin-5-yl)-2,11-dimethyl-5,8-dithio-dodecane; Ib-130 4-[2-(3-Cyanocarbamoyl-3-methyl-butane-1-sulfanyl)-ethanesulfanyl]-2,2-dimethyl-butyrcyanimide; Ib-131 Phosphoramidic acid mono-(3-{2-[3-(amino-hydroxy-phosphoryloxy)-3-methyl-butylsulfanyl]-ethylsulfanyl}-1,1-dimethyl-propyl) ester; Ib-132 1-{5-[2-(3,3-Dimethyl-5-{tetrazol-1-yl}-pentane-1-sulfanyl)-ethylsulf anyl]-3,3-dimethyl-pentyl}-1H-tetrazole; Ib-133 6,9-Dithio-3,3,12,12-tetramethyl-1,14-bis-tetrazol-1-yl-tetradecane; Ib-134 6,9-Dithio-3,3,12,12-tetramethyl-1,14-bis-(1H-tetrazol-5-yl)-tetradecane; Ib-135 1,14-Bis-(3-hydroxy-isoxazol-5-yl)-6,9-dithio-3,3,12,12-tetramethyl-tetradecane; Ib-136 1,14-Bis-(3-hydroxy-isoxazol-4-yl)-3,3,12,12-tetramethyl-tetradecane-6,9-dithiol; Ib-137 1-(5-Hydroxy-4-oxo-4H-pyran-2-yl)-14-(5-hydroxy-4-oxo-4H-pyran-3-yl)-6,9-dithio-3,3,12,12-tetramethyl-tetradecane; Ib-138 1,14-Bis-(5-hydroxy-4-oxo-4H-pyran-2-yl)-6,9-dithio-3,3,12,12-tetramethyl-tetradecane; Ib-139 1,14-Bis-(5-hydroxy-4-oxo-4H-pyran-3-yl)-6,9-dithio-3,3,12,12-tetramethyl-tetradecane; Ib-140 1-Ethyl-3-(5-{2-[5-(3-ethyl-2,5-dithioxo-imidazolidin-1-yl)-3,3-dimethyl-pentylsulfanyl]-ethylsulfanyl}-3,3-dimethyl-pentyl)-imidazolidine-2,4-dione; Ib-141 1-Ethyl-3-[14-(3-ethyl-2,5-dioxo-imidazolidin-1-yl)-3,3,12,12-tetramethyl-6,9-dithio-tetradecyl]-imidazolidine-2,4-dione; Ib-142 1-Ethyl-3-[14-(3-ethyl-2,5-dithioxo-imidazolidin-1-yl)-3,3,12,12-tetramethyl-6,9-dithio-tetradecyl]-imidazolidine-2,4-dithione; Ib-143 1,14-Bis-(3-ethyl-5-oxo-2-thioxo-imidazolidin-1-yl)-6,9-dithio-3,3,12,12-tetramethyl-tetradecane; Ib-144 1,14-Bis-(3-ethyl-2-oxo-5-thioxo-imidazolidin-1-yl)-6,9-dithio-3,3,12,12-tetramethyl-tetradecane; Ib-145 6-[3-(5-Carboxy-4,4-dimethyl-pentylsulfanyl)-propylsulfanyl]-3,3-di methyl-hexanoic acid; Ib-146 6-[3-(4,4-Dimethyl-6-oxo-hexylsulfanyl)-propylsulfanyl]-3,3-dimethyl-hexanal; Ib-147 6-[3-(6-Hydroxy-4,4-dimethyl-hexane-1-sulfanyl)-propane-1-sulfanyl]-3,3-dimethyl-hexan-1-ol; Ib-148 6-[3-(4,4-Dimethyl-5-phenoxycarbonyl-pentane-1-sulfanyl)-propane-1-sulfanyl]-3,3-dimethyl-hexanoic acid phenyl ester; Ib-149 6-[3-(5-Benzyloxycarbonyl-4,4-dimethyl-pentane-1-sulfanyl)-propane 1-sulfanyl]-3,3-dimethyl-hexanoic acid benzyl ester; Ib-150 5-(3-{2-[3-(3-Ethyl-2,6-dioxo-3,6-dihydro-2H-pyridin-1-yl)-3-methyl-butane-1-sulfanyl]-ethanesulfanyl}-1,1-dimethyl-propyl)-3,3a-dihydro-2H-thieno[3,2-c]pyridine-4,6-dione; Ib-151 3-(3,3a-Dihydro-2H-thieno[3,2-c]pyridine-4,6-dithione)-3-methyl-1-[2-(3-{3,3a-Dihydro-2H-thieno[3,2-c]pyridine-4,6-dithione}-3-methyl-butane-1-sulfanyl)-ethanesulfanyl]-butane; Ib-152 4-[2-(3-Cyanocarbamoyl-3-methyl-butane-1-sulfanyl)-ethanesulfanyl]-2,2-dimethyl-cyanobutyramide; Ib-153 Phosphoramidic acid mono-(3-{2-[3-(amino-hydroxy-phosphoryloxy)-3-methyl-butane-1-sulfanyl]-ethanesulfanyl}-1,1-dimethyl-propyl) ester; Ib-154 3-(Amino-hydroxy-phosphoryloxy)-3-methyl-1-[2-(3-{amino-hyroxy-phosphoyloxy}-3-methyl-butane-1-sulfanyl)-ethanesulfanyl]-butane; Ib-155 3-Methyl-3-tetrazol-1-yl-1-[2-(3-methyl-3-tetrazol-1-yl-butane-1-sulf anyl)-ethanesulfanyl]-butane; Ib-156 3-Methyl-3-1H-tetrazol-5-yl-1-[2-(3-methyl-3-1H-tetrazol-5-yl-butane-1-sulfanyl)-ethanesulfanyl]-butane; Ib-157 5-[3-(4,4-Dimethyl-5-sulfo-pentane-1-sulfanyl)-propane-1-sulfanyl]-2,2-dimethyl-pentane-1-sulfonic acid; Ib-158 Phosphoric acid mono-{5-[3-(4,4-dimethyl-5-phosphonooxy-pentane-1-sulfanyl)-propane-1-sulfanyl]-2,2-dimethyl-pentyl} ester; Ib-159 1-[3-(5-{3,3a-Dihydro-2H-thieno[3,2-c]pyridine-4,6-dione}-4,4-Dim ethyl-pentane-1-sulfanyl)-propane-1-sulfanyl]-5-(3,3a-Dihydro-2H-thi eno[3,2-c]pyridine-4,6-dione)-4,4-dimethyl-pentane; Ib-160 1-[3-(5-{3,3a-Dihydro-2H-thieno[3,2-c]pyridine-4,6-dithione}-4,4-Di methyl-pentane-1-sulfanyl)-propane-1-sulfanyl]-5-(3,3a-Dihydro-2H-thieno[3,2-c]pyridine-4,6-dithione)-4,4-dimethyl-pentane; Ib-161 6-[3-(5-Cyanocarbamoyl-4,4-dimethyl-pentane-1-sulfanyl)-propane-1-sulfanyl]-3,3-dimethyl-hexanoic acid cyanamide; Ib-162 Phosphoramidic acid mono-[16-(amino-hydroxy-phosphoryloxy)-4,4,15,15-tetramethyl-7,11-dioxo-hexadecyl] ester; Ib-163 1-[3-(4,4-Dimethyl-5-{amino-hydroxy-phosphoryloxy}-pentane-1-sul fanyl)-propane-1-sulfanyl]-4,4-dimethyl-5-(amino-hydroxy-phosphor yloxy)-pentane; Ib-164 4,4-Dimethyl-5-tetrazol-1-yl-1-[3-(4,4-dimethyl-5-tetrazol-1-yl-penta ne-1-sulfanyl)-propane-1-sulfanyl]-pentane; Ib-165 4,4-Dimethyl-5-1H-tetrazol-5-yl-1-[3-(4,4-dimethyl-5-1H-tetrazol-5-yl-pentane-1-sulfanyl)-propane-1-sulfanyl]-pentane; Ib-166 1-[3-(5-isoxazol-5-yl-4,4-dimethyl-pentane-1-sulfanyl)-propane-1-sul fanyl]-5-isoxazol-5-yl-4,4-dimethyl-hexane; Ib-167 1-[3-(5-isoxazol-4-yl-4,4-dimethyl-pentane-1-sulfanyl)-propane-1-sul fanyl]-5-isoxazol-4-yl-4,4-dimethyl-hexane; Ib-168 1-[3-(5-{5-Hydroxy-4-oxo-4H-pyran-3-yl}-4,4-dimethyl-pentane-1-sulfanyl)-propane-1-sulfanyl]-5-(5-hydroxy-4-oxo-4H-pyran-2-yl)-4,4-dimethyl-pentane; Ib-169 1-[3-(5-{5-Hydroxy-4-oxo-4H-pyran-2-yl}-4,4-dimethyl-pentane-1-sulfanyl)-propane-1-sulfanyl]-5-(5-hydroxy-4-oxo-4H-pyran-2-yl)-4,4-dimethyl-pentane; Ib-170 1-[3-(5-{5-Hydroxy-4-oxo-4H-pyran-3-yl}-4,4-dimethyl-pentane-1-sulfanyl)-propane-1-sulfanyl]-5-(5-hydroxy-4-oxo-4H-pyran-3-yl)-4,4-dimethyl-pentane; Ib-171 1-[3-(5-{1-ethyl-2,4-dithioxo-imidazolidinyl}-4,4-dimethyl-pentane-1-sulfanyl)-propane-1-sulfanyl]-5-(1-ethyl-2,4-dithioxo-imidazolidinyl)-4,4-dimethyl-pentane; Ib-172 1-[3-(5-{1-ethyl-2,4-dithioxo-imidazolidinyl}-4,4-dimethyl-pentane-1-sulfanyl)-propane-1-sulfanyl]-5-(1-ethyl-2,4-dioxo-imidazolidinyl)-4,4-dimethyl-pentane; Ib-173 1-[3-(5-{1-ethyl-2,4-dioxo-imidazolidinyl}-4,4-dimethyl-pentane-1-sulfanyl)-propane-1-sulfanyl]-5-(1-ethyl-2,4-dioxo-imidazolidinyl)-4,4-dimethyl-pentane; Ib-174 1-[3-(5-{1-ethyl-2-thioxo-imidazolidin-4-one}-4,4-dimethyl-pentane-1-sulfanyl)-propane-1-sulfanyl]-4-(1-ethyl-2-thioxo-imidazolidin-4-one)-4,4-dimethyl-pentane; Ib-175 1-[3-(5-{1-ethyl-4-thioxo-imidazolidin-2-one}-4,4-dimethyl-pentane-1-sulfanyl)-propane-1-sulfanyl]-5-(1-ethyl-4-thioxo-imidazolidin-2-one)-4,4-dimethyl-pentane; Ib-176 5-[2-(5-Hydroxy-3,3-dimethyl-pentane-i-sulfanyl)-ethanesulfanyl]-3,3-dimethyl-pentan-1-ol; Ic-1 1,9-Bis-(tetrahydro-pyran-2-yloxy)-3,7-lithia-nonage; Ic-2 1,9-Bis-(4-oxo-oxetan-2-yl)-3,7-lithia-nonage; Ic-3 1,9-Bis-(2-oxo-oxetan-3-yl)-3,7-lithia-nonage; Ic-4 1,9-Bis-(5-oxo-tetrahydrofuran-2-yl)-3,7-lithia-nonage; Ic-5 1,9-Bis-(5-oxo-tetrahydrofuran-3-yl)-3,7-lithia-nonage; Ic-6 1,9-Bis-(2-oxo-tetrahydrofuran-3-yl)-3,7-lithia-nonage; Ic-7 [2-(2-{3-[2-(4-Carboxymethyl-4-hydroxy-6-oxo-tetrahydro-pyran-2-yl)-ethylsulfanyl]-propylsulfanyl}-ethyl)-4-hydroxy-6-oxo-tetrahydro-pyran-4-yl]-acetic acid; Ic-8 1,9-Bis-(6-oxo-tetrahydropyran-2-yl)-3,7-lithia-nonage; Ic-9 1,9-Bis-(6-oxo-tetrahydropyran-3-yl)-3,7-lithia-nonage; Ic-10 1,9-Bis-(2-oxo-tetrahydropyran-4-yl)-3,7-lithia-nonage; Ic-11 1,9-Bis-(2-oxo-tetrahydropyran-3-yl)-3,7-lithia-nonage; Ic-12 1,11-Bis-(tetrahydro-pyran-2-yloxy)-4,8-lithia-undecane; Ic-13 1,11-Bis-(2-oxo-oxetan-3-yl)-4,8-lithia-undecane; Ic-14 1,11-Bis-(2-oxo-oxetan-3-yl)-4,8-lithia-undecane; Ic-15 1,11-Bis-(5-oxo-tetrahydrofuran-2-yl)-4,8-lithia-undecane; Ic-16 1,11-Bis-(5-oxo-tetrahydrofuran-3-yl)-4,8-lithia-undecane; Ic-17 1,11-Bis-(2-oxo-tetrahydrofuran-3-yl)-4,8-lithia-undecane; Ic-18 {2-[11-(4-Carboxymethyl-4-hydroxy-6-oxo-tetrahydro-pyran-2-yl)-4,8-dithia-undecyl]-4-hydroxy-6-oxo-tetrahydropyran-4-yl}-acetic acid; Ic-19 1,11-Bis-(6-oxo-tetrahydropyran-2-yl)-4,8-dithia-undecane; Ic-20 1,11-Bis-(6-oxo-tetrahydropyran-3-yl)-4,8-lithia-undecane; Ic-21 1,11-Bis-(2-oxo-tetrahydropyran-4-yl)-4,8-dithia-undecane; Ic-22 1,11-Bis-(2-oxo-tetrahydropyran-3-yl)-4,8-lithia-undecane; Ic-23 1,8-Bis-(tetrahydropyran-2-yloxy)-3,6-dithio-octane; Ic-24 1,8-Bis-(4-oxo-oxetan-2-yl)-3,6-dithio-octane; Ic-25 1,8-Bis-(2-oxo-oxetan-3-yl)-3,6-dithio-octane; Ic-26 1,8-Bis-(5-oxo-tetrahydro-furan-2-yl)-3,6-dithio-octane; Ic-27 1,8-Bis-(5-oxo-tetrahydro-furan-3-yl)-3,6-dithio-octane; Ic-28 1,8-Bis-(2-oxo-tetrahydro-furan-3-yl)-3,6-dithiol-octane; Ic-29 [2-(2-{2-[2-(4-Carboxymethyl-4-hydroxy-6-oxo-tetrahydro-pyran-2-yl)-ethylsulfanyl]-ethylsulfanyl}-ethyl)-4-hydroxy-6-oxo-tetrahydropyran-4-yl]-acetic acid; Ic-30 1,8-Bis-(6-oxo-tetrahydropyran-2-yl)-3,6-dithio-octane; Ic-31 1,8-Bis-(6-oxo-tetrahydropyran-3-yl)-3,6-dithio-octane; Ic-32 1,8-Bis-(2-oxo-tetrahydropyran-4-yl)-3,6-dithio-octane; Ic-33 1,8-Bis-(2-oxo-tetrahydropyran-3-yl)-3,6-dithio-octane; II-1 6-(6-Hydroxy-5,5-dimethyl-hexylsulfanyl)-2,2-dimethyl-hexan-1-ol; II-2 6-(5-Carboxy-5-methyl-hexylsulfanyl)-2,2-dimethyl-hexanoic acid; II-3 5-(5-Hydroperoxy-4,4-dimethyl-pentylsulfanyl)-2,2-dimethyl-pentano ic acid; II-4 5-(5-Hydroxy-4,4-dimethyl-pentylsulfanyl)-2,2-dimethyl-pentan-1-ol; II-5 5-(5-Hydroxy-4,4-dimethyl-pentylsulfanyl)-2,2-dimethyl-pentanoic acid; II-6 5-(4-Carboxy-4-methyl-pentylsulfanyl)-2,2-dimethyl-pentanoic acid; II-7 7-(7-Hydroxy-6,6-dimethyl-heptylsulfanyl)-2,2-dimethyl-heptan-1-ol; II-8 7-(7-Hydroxy-6,6-dimethyl-heptylsulfanyl)-2,2-dimethyl-heptanoic acid; II-9 7-(6-Carboxy-6-methyl-heptylsulfanyl)-2,2-dimethyl-heptanoic acid; II-10 2,2,12,12-Tetramethyl-7-oxo-tridecanedial; II-11 6-(5-Methoxycarbonyl-5-methyl-hexylsulfanyl)-2,2-dimethyl-hexanoi c acid methyl ester; II-12 6-(5,5-Dimethyl-6-oxo-6-phenyl-hexylsulfanyl)-2,2-dimethyl-1-phen yl-hexan-1-one; II-13 7-(5,5-Dimethyl-6-oxo-7-phenyl-heptylsulfanyl)-3,3-dimethyl-1-phen yl-heptan-2-one; II-14 2,12-Dimethyl-7-oxo-tridecane-2,12-disulfonic acid; II-15 Phosphoric acid mono-[1,1-dimethyl-5-(5-methyl-5-phosphonooxy-hexyl sulfanyl)-pentyl] ester; II-16 2,2,14,14-Tetramethyl-8-oxo-pentadecanedial; II-17 7-(6-Methoxycarbonyl-6-methyl-heptylsulfanyl)-2,2-dimethyl-heptan oic acid methyl ester; II-18 7-(6,6-Dimethyl-7-oxo-7-phenyl-heptylsulfanyl)-2,2-dimethyl-1-phen yl-heptan-1-one; II-19 8-(6,6-Dimethyl-7-oxo-8-phenyl-octylsulfanyl)-3,3-dimethyl-1-pheny 1-octan-2-one; II-20 2-Methyl-7-(6-methyl-6-sulfo-heptylsulfanyl)-heptane-2-sulfonic acid; II-21 Phosphoric acid mono-[1,1-dimethyl-6-(6-methyl-6-phosphonooxy-heptylsulfanyl)-hexyl] ester; II-22 7-(7-Hydroxy-5,5-dimethyl-heptylsulfanyl)-3,3-dimethyl-heptan-1-ol; II-23 7-(7-Hydroxy-5,5-dimethyl-heptylsulfanyl)-3,3-dimethyl-heptanoic acid; II-24 7-(6-Carboxy-5,5-dimethyl-hexylsulfanyl)-3,3-dimethyl-heptanoic acid; II-25 6-(6-Hydroxy-4,4-dimethyl-hexylsulfanyl)-3,3-dimethyl-hexan-1-ol; II-26 6-(6-Hydroxy-4,4-dimethyl-hexylsulfanyl)-3,3-dimethyl-hexanoic acid; II-27 6-(5-Carboxy-4,4-dimethyl-pentylsulfanyl)-3,3-dimethyl-hexanoic acid; II-28 8-(8-Hydroxy-6,6-dimethyl-octylsulfanyl)-3,3-dimethyl-octan-1-ol; II-29 8-(8-Hydroxy-6,6-dimethyl-octylsulfanyl)-3,3-dimethyl-octanoic acid; II-30 8-(7-Carboxy-6,6-dimethyl-heptylsulfanyl)-3,3-dimethyl-octanoic acid; II-31 8-(7-Hydroxy-5,5-dimethyl-heptylsulfanyl)-4,4-dimethyl-octan-1-ol; II-32 8-(8-Hydroxy-5,5-dimethyl-octane-1-sulfanyl)-4,4-dimethyl-octanoic acid; II-33 8-(6-Carboxy-5,5-dimethyl-hexylsulfanyl)-4,4-dimethyl-octanoic acid; II-34 7-(7-Hydroxy-4,4-dimethyl-heptylsulfanyl)-4,4-dimethyl-heptan-1-ol; II-35 7-(7-Hydroxy-4,4-dimethyl-heptylsulfanyl)-4,4-dimethyl-heptanoic acid; II-36 7-(6-Carboxy-4,4-dimethyl-hexylsulfanyl)-4,4-dimethyl-heptanoic acid; II-37 9-(9-Hydroxy-6,6-dimethyl-nonylsulfanyl)-4,4-dimethyl-nonan-1-ol; II-38 9-(9-Hydroxy-6,6-dimethyl-nonane-1-sulfanyl)-4,4-dimethyl-nonanoic acid; II-39 8-(7-Carboxy-6,6-dimethyl-heptylsulfanyl)-3,3-dimethyl-octanoic acid; II-40 5-[1,1-Dimethyl-4-(4-{3,3a-dihydro-4,6-dioxo-2H-thieno[3,2-c]pyridi n-5-yl}-4-ethyl-pentane-1-sulfanyl)-butyl]-3,3a-dihydro-2H-thieno [3,2-c]pyridine-4,6-dione; II-41 5-[1,1-Dimethyl-4-(4-{3,3a-dihydro-4,6-dithioxo-2H-thienoi[3,2-c]pyr idin-5-yl}-4-methyl-pentane-1-sulfanyl)-butyl]-3,3a-dihydro-2H-thien o[3,2-c]pyridine-4,6-ithione; II-42 5-(4-Cyanocarbamoyl-4-methyl-pentane-1-sulfanyl)-2,2-dimethyl-pen tanoic acid cyanimide; II-43 Phosphoramidic acid mono-{4-[4-(amino-hydroxy-phosphoryloxy)-4-methyl-pentylsulfanyl]-1,1-dimethyl-butyl} ester; II-44 4-(Amino-hydroxy-phosphoryloxy)-4-methyl-1-(4-[amino-hydroxy-p hosphoryloxy]-4-methyl-pentane-1-sulfanyl)-pentane; II-45 5-[1,1-Dimethyl-5-(5-{3,3a-dihydro-4,6-dioxo-2H-thieno[3,2-c] pyridin-5-yl}-5-methyl-hexane-1-sulfanyl)-pentyl]-3,3a-dihydro-2H-thieno[3,2-c] pyridine-4,6-dione; II-46 5-[1,1-Dimethyl-5-(5-{3,3a-dihydro-4,6-dithioxo-2H-thieno[3,2-c] pyridin-5-yl}-5-methyl-hexane-1-sulfanyl)-pentyl]-3,3a-dihydro-2H-thieno[3,2-c] pyridine-4,6-dithione; II-47 6-(5-Cyanocarbamoyl-5-methyl-hexylsulfanyl)-2,2-dimethyl-hexanoic acid cyanimide; II-48 Phosphoramidic acid mono-{5-[5-(amino-hydroxy-phosphoryloxy)-5-methyl-hexylsulfanyl]-1,1-dimethyl-pentyl} ester; II-49 5-(Amino-hydroxy-phosphoryloxy)-5-methyl-1-([5-amino-hydroxy-phosphoryloxy]-5-methyl-hexane-1-sulfanyl)-hexane; II-50 1-[1,1-Dimethyl-5-(5-methyl-5-tetrazol-1-yl-hexane-1-sulfanyl)-pentyl]-1H-tetrazole; II-51 5-[1,1-Dimethyl-5-(5-methyl-5-tetrazol-5-yl-hexane-1-sulfanyl)-pentyl]-1H-tetrazole; II-52 2,12-Bis-(3-hydroxy-isoxazol-5-yl)-2,12-dimethyl-tridecan-7-one; II-53 4-[1,1-Dimethyl-5-(5-{isoxazol-3-4-yl}-5-methyl-hexane-1-sulfanyl)-pentyl]-isoxazol-3-ol; II-54 4-[1,1-Dimethyl-5-(5-{2-oxo-oxetan-4-yl}-5-methyl-hexane-1-sulfan yl)-pentyl]-oxetan-2-one; II-55 3-[1,1-Dimethyl-5-(5-{2-oxo-oxetan-3-yl}-5-methyl-hexane-1-sulfan yl)-pentyl]-oxetan-2-one; II-56 5-[1,1-Dimethyl-5-(5-(2-oxo-dihydro-furan-5-yl}-5-methyl-hexane-1-sulfanyl)-pentyl]-dihydro-furan-2-one; II-57 3-[1,1-Dimethyl-5-(5-(2-oxo-dihydro-furan-3-yl}-5-methyl-hexane-1-sulfanyl)-pentyl]-dihydro-furan-2-one; II-58 4-[1,1-Dimethyl-5-(5-(2-oxo-dihydro-furan-4-yl}-5-methyl-hexane-1-sulfanyl)-pentyl]-dihydro-furan-2-one; II-59 2-[1,1-Dimethyl-5-{tetrahydro-pyran-2-oxy}-5-methyl-hexane-1-sulf anyl)-pentyloxy]-tetrahydro-pyran; II-60 (2-{5-[5-(4-Carboxymethyl-4-hydroxy-6-oxo-tetrahydro-pyran-2-yl)-5-methyl-hexylsulfanyl]-1,1-dimethyl-pentyl}-4-hydroxy-6-oxo-tetra hydro-pyran-4-yl)-acetic acid; IIa-1 7-(7-Hydroxy-6-methyl-6-phenyl-heptylsulfanyl)-2-methyl-2-phenyl-heptan-1-ol; IIa-2 7-(7-Hydroxy-6-methyl-6-phenyl-heptylsulfanyl)-2-methyl-2-phenyl-heptanoic acid; IIa-3 7-(6-Carboxy-6-phenyl-heptylsulfanyl)-2-methyl-2-phenyl-heptanoic acid; IIa-4 6-(6-Hydroxy-5-methyl-5-phenyl-hexylsulfanyl)-2-methyl-2-phenyl-hexan-1-ol; IIa-5 6-(6-Hydroxy-5-methyl-5-phenyl-hexylsulfanyl)-2-methyl-2-phenyl-hexanoic acid; IIa-6 6-(5-Carboxy-5-phenyl-hexylsulfanyl)-2-methyl-2-phenyl-hexanoic acid; IIa-7 5-(5-Hydroxy-4-methyl-4-phenyl-pentylsulfanyl)-2-methyl-2-phenyl-pentan-1-ol; IIa-8 5-(5-Hydroxy-4-methyl-4-phenyl-pentylsulfanyl)-2-methyl-2-phenyl-pentanoic acid; IIa-9 5-(4-Carboxy-4-phenyl-pentylsulfanyl)-2-methyl-2-phenyl-pentanoic acid; IIa-10 2-Methyl-7-(6-methyl-7-oxo-6-phenyl-heptylsulfanyl)-2-phenyl-heptanal; IIa-11 7-(6-Methoxycarbonyl-6-phenyl-heptylsulfanyl)-2-methyl-2-phenyl-h eptanoic acid methyl ester; IIa-12 2-Methyl-7-(6-methyl-7-oxo-6,7-diphenyl-heptylsulfanyl)-1,2-diphen yl-heptan-1-one; IIa-13 3-Methyl-8-(6-methyl-7-oxo-6,8-diphenyl-octylsulfanyl)-1,3-diphenyl-octan-2-one; IIa-14 2-Phenyl-7-(6-phenyl-6-sulfo-heptylsulfanyl)-heptane-2-sulfonic acid; IIa-15 Phosphoric acid mono-[1-methyl-1-phenyl-6-(6-phenyl-6-phosphonooxy-heptylsulfanyl)-hexyl] ester; IIa-16 8-(8-Hydroxy-6-methyl-6-phenyl-octylsulfanyl)-3-methyl-3-phenyl-octan-1-ol; IIa-17 8-(8-Hydroxy-6-methyl-6-phenyl-octylsulfanyl)-3-methyl-3-phenyl-octanoic acid; IIa-18 3,15-Dimethyl-9-oxo-3,15-diphenyl-heptadecanedioic acid; IIa-19 7-(7-Hydroxy-5-methyl-5-phenyl-heptylsulfanyl)-3-methyl-3-phenyl-heptan-1-ol; IIa-20 15-Hydroxy-3,13-dimethyl-8-oxo-3,13-diphenyl-pentadecanoic acid; IIa-21 7-(6-Carboxy-5-methyl-5-phenyl-hexylsulfanyl)-3-methyl-3-phenyl-h eptanoic acid; IIa-22 6-(6-Hydroxy-4-methyl-4-phenyl-hexylsulfanyl)-3-methyl-3-phenyl-h exan-1-ol; IIa-23 6-(6-Hydroxy-4-methyl-4-phenyl-hexylsulfanyl)-3-methyl-3-phenyl-h exanoic acid; IIa-24 6-(5-Carboxy-4-methyl-4-phenyl-pentylsulfanyl)-3-methyl-3-phenyl-hexanoic acid; IIa-25 6-(6-Hydroxy-4-methyl-4-phenyl-hexylsulfanyl)-3-methyl-3-phenyl-h exanoic acid IIa-26 6-(5-Carboxy-4-methyl-4-phenyl-pentylsulfanyl)-3-methyl-3-phenyl-hexanoic acid; IIa-27 9-(9-Hydroxy-6-methyl-6-phenyl-nonylsulfanyl)-4-methyl-4-phenyl-n onan-1-ol; IIa-28 8-(9-Hydroxy-6-methyl-6-phenyl-nonylsulfanyl)-3-methyl-3-phenyl-o ctanoic acid; IIa-29 9-(8-Carboxy-6-methyl-6-phenyl-octane-1-sulfanyl)-4-methyl-4-phen yl-nonanoic acid; IIa-30 8-(8-Hydroxy-5-methyl-5-phenyl-octylsulfanyl)-4-methyl-4-phenyl-o ctan-1-ol; IIa-31 8-(8-Hydroxy-5-methyl-5-phenyl-octane-1-sulfanyl)-4-methyl-4-phen yl-octanoic acid; IIa-32 8-(7-Carboxy-5-methyl-5-phenyl-heptylsulfanyl)-4-methyl-4-phenyl-octanoic acid; IIa-33 7-(7-Hydroxy-4-methyl-4-phenyl-heptylsulfanyl)-4-methyl-4-phenyl-heptan-1-ol; IIa-34 7-(7-Hydroxy-4-methyl-4-phenyl-heptane-1-sulfanyl)-4-methyl-4-phenyl-heptanoic acid; IIa-35 7-(6-Carboxy-4-methyl-4-phenyl-hexane-1-sulfanyl)-4-methyl-4-phenyl-heptanoic acid; IIa-36 5-[1-Methyl-1-phenyl-5-(5-phenyl-5-{3,3a-dihydro-4,6-dioxo-2H-thieno [3,2-c]pyridin-5-yl}-hexane-1-sulfanyl)-pentyl]-3,3a-dihydro-2H-thieno[3,2-c] pyridine-4,6-dione; IIa-37 5-[1-Methyl-1-phenyl-5-(5-phenyl-5-{3,3a-dihydro-4,6-dithioxo-2H-thieno[3,2-c]pyridin-5-yl}-hexane-1-salfanyl)-pentyl]-3,3a-dihydro-2 H-thieno[3,2-c]pyridine-4,6-dithione; IIa-38 6-(5-Cyanocarbamoyl-5-phenyl-hexane-1-sulfanyl)-2-methyl-2-pheny 1-hexanoic acid cyanimide; IIa-39 Phosphoramidic acid mono-{5-[5-(amino-hydroxy-phosphoryloxy)-5-phenyl-hexylsulfanyl]-1-methyl-1-phenyl-pentyl} ester; IIa-40 1-(5-[Amino-hydroxy-phosphoryloxy]-5-phenyl-hexane-1-sulfanyl)-5-[amino-hydroxy-phosphoryloxy]-5-phenyhexane; IIa-41 1-[1-Methyl-1-phenyl-5-(5-phenyl-5-{tetrazol-1-yl}-hexane-1-sulfanyl)-pentyl]-1H-tetrazole; IIa-42 5-[1-Methyl-1-phenyl-5-(5-phenyl-5-{tetrazol-5-yl}-hexane-1-sulfanyl)-pentyl]-1H-tetrazole; IIa-43 5-[1-Methyl-1-phenyl-5-(5-{3-hydroxy-isoxazol-5-yl}-5-phenyl-hexane-1-sulfanyl)-pentyl]-isoxazol-3-ol; IIa-44 4-[1-Methyl-1-phenyl-5-(5-{3-hydroxy-isoxazol-4-yl}-5-phenyl-hexane-1-sulfanyl)-pentyl]-isoxazol-3-ol; IIa-45 2-[1-Methyl-1-phenyl-5-(5-{2-hydroxy-tetrahydro-pyranoxy}-5-phenyl-hexane-1-)-pentyloxy]-tetrahydro-pyran; IIa-46 5-[i-Methyl-1-phenyl-5-(5-{2-oxo-dihydro-furan-5-yl}-5-phenyl-hexane-1-)-pentyl]-dihydro-furan-2-one; IIa-47 4-[1-Methyl-1-phenyl-5-(5-{2-oxo-oxetan-4-yl}-5-phenyl-hexane-1-sulfanyl)-pentyl]-oxetan-2-one; IIa-48 4-[1-Methyl-1-phenyl-5-(5-{2-oxo-dihydro-furan-4-yl}-5-phenyl-hexane-1-)-pentyl]-dihydro-furan-2-one; IIa-49 3-[1-Methyl-1-phenyl-5-(5-{2-oxo-dihydro-furan-3-yl}-5-phenyl-hexane-1-)-pentyl]-dihydro-furan-2-one; IIa-50 (2-{5-[5-(4-Carboxymethyl-4-hydroxy-6-oxo-tetrahydro-pyran-2-yl)-5-phenyl-hexylsulfanyl]-1-methyl-1-phenyl-pentyl}-4-hydroxy-6-oxo-tetrahydro-pyran-4-yl)-acetic acid; III-1 5-(6-{3-[6-(5-Hydroxy-4,4-dimethyl-pentyl)-4-oxo-4H-thiopyran-2-yl]-propyl}-4-oxo-4H-thiopyran-2-yl)-2,2-dimethyl-pentan-1-ol; III-2 5-(6-{3-[6-(5-Hydroxy-4,4-dimethyl-pentyl)-4-oxo-4H-thiopyran-2-yl]-propyl}-4-oxo-4H-thiopyran-2-yl)-2,2-dimethyl-pentanoic acid; III-3 5-(6-{3-[6-(4-Carboxy-4-methyl-pentyl)-4-oxo-4H-thiopyran-2-yl]-propyl}-4-oxo-4H-thiopyran-2-yl)-2,2-dimethyl-pentanoic acid; III-4 5-(6-{3-[6-(5-Hydroxy-4,4-dimethyl-pentyl)-4,4-dimethyl-4H-thiopyran-2-yl]-propyl}-4,4-dimethyl-4H-thiopyran-2-yl)-2,2-dimethyl-pentan-1-ol; III-5 5-(6-{3-[6-(5-Hydroxy-4,4-dimethyl-pentyl)-4,4-dimethyl-4H-thiopyran-2-yl]-propyl}-4,4-dimethyl-4H-thiopyran-2-yl)-2,2-dimethyl-pentanoic acid; III-6 5-(6-{3-[6-(4-Carboxy-4-methyl-pentyl)-4,4-dimethyl-4H-thiopyran-2-yl]-propyl}-4,4-dimethyl-4H-thiopyran-2-yl)-2,2-dimethyl-pentanoic acid; III-7 6-(6-{3-[6-(6-Hydroxy-5,5-dimethyl-hexyl)-4-oxo-4H-thiopyran-2-yl]-propyl}-4-oxo-4H-thiopyran-2-yl)-2,2-dimethyl-hexan-1-ol; III-8 6-(6-{3-[6-(6-Hydroxy-5,5-dimethyl-hexyl)-4-oxo-4H-thiopyran-2-yl]-propyl}-4-oxo-4H-thiopyran-2-yl)-2,2-dimethyl-hexanoic acid; III-9 6-(6-{3-[6-(5-Carboxy-5-methyl-hexyl)-4-oxo-4H-thiopyran-2-yl]-propyl}-4-oxo-4H-thiopyran-2-yl)-2,2-dimethyl-hexanoic acid; III-10 6-(6-{3-[6-(6-Hydroxy-5,5-dimethyl-hexyl)-4,4-dimethyl-4H-thiopyran-2-yl]-propyl}-4,4-dimethyl-4H-thiopyran-2-yl)-2,2-dimethyl-hexan-1-ol; III-11 6-(6-{3-[6-(6-Hydroxy-5,5-dimethyl-hexyl)-4,4-dimethyl-4H-thiopyran-2-yl]-propyl}-4,4-dimethyl-4H-thiopyran-2-yl)-2,2-dimethyl-hexanoic acid; III-12 6-(6-{3-[6-(5-Carboxy-5-methyl-hexyl)-4,4-dimethyl-4H-thiopyran-2-yl]-propyl}-4,4-dimethyl-4H-thiopyran-2-yl)-2,2-dimethyl-hexanoic acid; III-13 6-(6-{2-[6-(6-Hydroxy-5,5-dimethyl-hexyl)-tetrahydro-thiopyran-2-yl]-vinyl}-tetrahydro-thiopyran-2-yl)-2,2-dimethyl-hexan-1-ol; III-14 6-(6-{2-[6-(6-Hydroxy-5,5-dimethyl-hexyl)-tetrahydro-thiopyran-2-yl]-vinyl}-tetrahydro-thiopyran-2-yl)-2,2-dimethyl-hexanoic acid; III-15 6-(6-{2-[6-(5-Carboxy-5-methyl-hexyl)-tetrahydro-thiopyran-2-yl]-vinyl}-tetrahydro-thiopyran-2-yl)-2,2-dimethyl-hexanoic acid; III-16 6-(6-{2-[6-(6-Hydroxy-5,5-dimethyl-hexyl)-4-oxo-4H-thiopyran-2-yl]-vinyl}-4-oxo-4H-thiopyran-2-yl)-2,2-dimethyl-hexan-1-ol; III-17 6-(6-{2-[6-(6-Hydroxy-5,5-dimethyl-hexyl)-4-oxo-4H-thiopyran-2-yl]-vinyl}-4-oxo-4H-thiopyran-2-yl)-2,2-dimethyl-hexanoic acid; III-18 6-(6-{2-[6-(5-Carboxy-5-methyl-hexyl)-4-oxo-4H-thiopyran-2-yl]-vinyl}-4-oxo-4H-thiopyran-2-yl)-2,2-dimethyl-hexanoic acid; III-19 6-(6-{2-[6-(6-Hydroxy-5,5-dimethyl-hexyl)-4,4-dimethyl-4H-thiopyran-2-yl]-vinyl}-4,4-dimethyl-4H-thiopyran-2-yl)-2,2-dimethyl-hexan-1-ol; III-20 6-(6-{2-[6-(6-Hydroxy-5,5-dimethyl-hexyl)-4,4-dimethyl-4H-thiopyran-2-yl]-vinyl}-4,4-dimethyl-4H-thiopyran-2-yl)-2,2-dimethyl-hexanoic acid; III-21 6-(6-{2-[6-(5-Carboxy-5-methyl-hexyl)-4,4-dimethyl-4H-thiopyran-2-yl]-vinyl}-4,4-dimethyl-4H-thiopyran-2-yl)-2,2-dimethyl-hexanoic acid; III-22 5-(6-{2-[6-(5-Hydroxy-4,4-dimethyl-pentyl)-tetrahydro-thiopyran-2-yl]-vinyl}-tetrahydro-thiopyran-2-yl)-2,2-dimethyl-pentan-1-ol; III-23 5-(6-{2-[6-(5-Hydroxy-4,4-dimethyl-pentyl)-tetrahydro-thiopyran-2-yl]-vinyl}-tetrahydro-thiopyran-2-yl)-2,2-dimethyl-pentanoic acid; III-24 5-(6-{2-[6-(4-Carboxy-4-methyl-pentyl)-tetrahydro-thiopyran-2-yl]-vinyl}-tetrahydro-thiopyran-2-yl)-2,2-dimethyl-pentanoic acid; III-25 5-(6-{2-[6-(5-Hydroxy-4,4-dimethyl-pentyl)-4-oxo-4H-thiopyran-2-yl]-vinyl}-4-oxo-4H-thiopyran-2-yl)-2,2-dimethyl-pentan-1-ol; III-26 5-(6-{2-[6-(5-Hydroxy-4,4-dimethyl-pentyl)-4-oxo-4H-thiopyran-2-yl]-vinyl}-4-oxo-4H-thiopyran-2-yl)-2,2-dimethyl-pentanoic acid; III-27 5-(6-{2-[6-(4-Carboxy-4-methyl-pentyl)-4-oxo-4H-thiopyran-2-yl]-vinyl}-4-oxo-4H-thiopyran-2-yl)-2,2-dimethyl-pentanoic acid; III-28 5-(6-{2-[6-(5-Hydroxy-4,4-dimethyl-pentyl)-4,4-dimethyl-4H-thiopyran-2-yl]-vinyl}-4,4-dimethyl-4H-thiopyran-2-yl)-2,2-dimethyl-pentan-1-ol; III-29 5-(6-{2-[6-(5-Hydroxy-4,4-dimethyl-pentyl)-4,4-dimethyl-4H-thiopyran-2-yl]-vinyl}-4,4-dimethyl-4H-thiopyran-2-yl)-2,2-dimethyl-pentanoic acid; III-30 5-(6-{2-[6,-(4-Carboxy-4-methyl-pentyl)-4,4-dimethyl-4H-thiopyran-2-yl]-vinyl}-4,4-dimethyl-4H-thiopyran-2-yl)-2,2-dimethyl-pentanoic acid; III-31 6-(6-{2-[6-(6-Hydroxy-5,5-dimethyl-hexyl)-4-oxo-4H-thiopyran-2-yl]-ethyl}-4-oxo-4H-thiopyran-2-yl)-2,2-dimethyl-hexan-1-ol; III-32 6-(6-{2-[6-(6-Hydroxy-5,5-dimethyl-hexyl)-4-oxo-4H-thiopyran-2-yl]-ethyl}-4-oxo-4H-thiopyran-2-yl)-2,2-dimethyl-hexanoic acid; III-33 6-(6-{2-[6-(5-Carboxy-5-methyl-hexyl)-4-oxo-4H-thiopyran-2-yl]-ethyl}-4-oxo-4H-thiopyran-2-yl)-2,2-dimethyl-hexanoic acid; III-34 6-(6-{2-[6-(6-Hydroxy-5,5-dimethyl-hexyl)-4,4-dimethyl-4H-thiopyran-2-yl]-ethyl}-4,4-dimethyl-4H-thiopyran-2-yl)-2,2-dimethyl-hexan-1-ol; III-35 6-(6-{2-[6-(6-Hydroxy-5,5-dimethyl-hexyl)-4,4-dimethyl-4H-thiopyran-2-yl]-ethyl}-4,4-dimethyl-4H-thiopyran-2-yl)-2,2-dimethyl-hexanoic acid; III-36 6-(6-{2-[6-(5-Carboxy-5-methyl-hexyl)-4,4-dimethyl-4H-thiopyran-2-yl]-ethyl}-4,4-dimethyl-4H-thiopyran-2-yl)-2,2-dimethyl-hexanoic acid; III-37 5-(6-{2-[6-(5-Hydroxy-4,4-dimethyl-pentyl)-4-oxo-4H-thiopyran-2-yl]-ethyl}-4-oxo-4H-thiopyran-2-yl)-2,2-dimethyl-pentan-1-ol; III-38 5-(6-{2-[6-(5-Hydroxy-4,4-dimethyl-pentyl)-4-oxo-4H-thiopyran-2-yl]-ethyl}-4-oxo-4H-thiopyran-2-yl)-2,2-dimethyl-pentanoic acid; III-39 5-(6-{2-[6-(4-Carboxy-4-methyl-pentyl)-4-oxo-4H-thiopyran-2-yl]-ethyl}-4-oxo-4H-thlopyran-2-yl)-2,2-dimethyl-pentanoic acid; III-40 5-(6-{2-[6-(5-Hydroxy-4,4-dimethyl-pentyl)-4,4-dimethyl-4H-thiopyran-2-yl]-ethyl}-4,4-dimethyl-4H-thiopyran-2-yl)-2,2-dimethyl-pentan-1-ol; III-41 5-(6-{2-[6-(5-Hydroxy-4,4-dimethyl-pentyl)-4,4-dimethyl-4H-thiopyran-2-yl]-ethyl}-4,4-dimethyl-4H-thiopyran-2-yl)-2,2-dimethyl-pentanoic acid; III-42 5-(6-{2-[6-(4-Carboxy-4-methyl-pentyl)-4,4-dimethyl-4H-thiopyran 2-yl]-ethyl}-4,4-dimethyl-4H-thiopyran-2-yl)-2,2-dimethyl-pentanoic acid; III-43 6-(6-{2-[6-(6-Hydroxy-5,5-dimethyl-hexyl)-tetrahydro-thiopyran-2-yl]-phenyl}-tetrahydro-thiopyran-2-yl)-2,2-dimethyl-hexan-1-ol; III-44 6-(6-{2-[6-(6-Hydroxy-5,5-dimethyl-hexyl)-tetrahydro-thiopyran-2-yl]-phenyl}-tetrahydro-thiopyran-2-yl)-2,2-dimethyl-hexanoic acid; III-45 6-(6-{2-[6-(6-Carboxy-5,5-dimethyl-hexyl)-tetrahydro-thiopyran-2-yl]-phenyl}-tetrahydro-thiopyran-2-yl)-2,2-dimethyl-hexanoic acid; III-46 6-(6-{2-[6-(6-Hydroxy-5,5-dimethyl-hexyl)-4-oxo-4H-thiopyran-2-yl]-phenyl}-tetrahydro-thiopyran-2-yl)-2,2-dimethyl-hexan-1-ol; III-47 6-(6-{2-[6-(6-Hydroxy-5,5-dimethyl-hexyl)-4-oxo-4H-thiopyran-2-yl]-phenyl}-4-oxo-4H-thiopyran-2-yl)-2,2-dimethyl-hexanoic acid; III-48 6-(6-{2-[6-(5-Carboxy-5-methyl-hexyl)-4-oxo-4H-thiopyran-2-yl]-phenyl}-4-oxo-4H-thiopyran-2-yl)-2,2-dimethyl-hexanoic acid; III-49 6-(6-{2-[6-(6-Hydroxy-5,5-dimethyl-hexyl)-4,4-dimethyl-4H-thiopyran-2-yl]-phenyl}-4,4-dimethyl-4H-thiopyran-2-yl)-2,2-dimethyl-hexan-1-ol; III-50 6-(6-{2-[6-(6-Hydroxy-5,5-dimethyl-hexyl)-4,4-dimethyl-4H-thiopyran-2-yl]-phenyl}-4,4-dimethyl-4H-thiopyran-2-yl)-2,2-dimethyl-hexanoic acid; III-51 6-(6-{2-[6-(5-Carboxy-5-methyl-hexyl)-4,4-dimethyl-4H-thiopyran-2-yl]-phenyl}-4,4-dimethyl-4H-thiopyran-2-yl)-2,2-dimethyl-hexanoic acid; III-52 5-(6-{2-[6-(5-Hydroxy-4,4-dimethyl-pentyl)-tetrahydro-thiopyran-2-yl]-phenyl}-tetrahydro-thiopyran-2-yl)-2,2-dimethyl-pentan-1-ol; III-53 5-(6-{2-[6-(5-Hydroxy-4,4-dimethyl-pentyl)-tetrahydro-thiopyran-2-yl]-phenyl}-tetrahydro-thiopyran-2-yl)-2,2-dimethyl-pentanoic acid; III-54 5-(6-{2-[6-(4-Carboxy-4-methyl-pentyl)-tetrahydro-thiopyran-2-yl]-phenyl}-tetrahydro-thiopyran-2-yl)-2,2-dimethyl-pentanoic acid; III-55 5-(6-{2-[6-(5-Hydroxy-4-methyl-pentyl)-4-oxo-4H-thiopyran-2-yl]-phenyl}-4-oxo-4H-thiopyran-2-yl)-2,2-dimethyl-pentan-1-ol; III-56 5-(6-{2-[6-(5-Hydroxy-4-methyl-pentyl)-4-oxo-4H-thiopyran-2-yl]-phenyl}-4-oxo-4H-thiopyran-2-yl)-2,2-dimethyl-pentanoic acid; III-57 5-(6-{2-[6-(4-Carboxy-4-methyl-pentyl)-4-oxo-4H-thiopyran-2-yl]-phenyl}-4-oxo-4H-thiopyran-2-yl)-2,2-dimethyl-pentanoic acid; III-58 5-(6-{2-[6-(5-Hydroxy-4,4-dimethyl-pentyl)-4,4-dimethyl-4H-thiopyran-2-yl]-phenyl}-4,4-dimethyl-4H-thiopyran-2-yl)-2,2-dimethyl-pentan-1-ol; III-59 5-(6-{2-[6-(5-Hydroxy-4,4-dimethyl-pentyl)-4,4-dimethyl-4H-thiopyran-2-yl]-phenyl}-4,4-dimethyl-4H-thiopyran-2-yl)-2,2-dimethyl-pentanoic acid; III-60 5-(6-{2-[6-(4-Carboxy-4-methyl-pentyl)-4,4-dimethyl-4H-thiopyran-2-yl]-phenyl}-4,4-dimethyl-4H-thiopyran-2-yl)-2,2-dimethyl-pentanoic acid; III-61 5-(5-{3-[5-(5-Hydroxy-4,4-dimethyl-pentyl)-thiophen-2-yl]-propyl}-thiophen-2-yl)-2,2-dimethyl-pentan-1-ol; III-62 5-(5-{3-[5-(5-Hydroxy-4,4-dimethyl-pentyl)-thiophen-2-yl]-propyl}thiophen-2-yl)-2,2-dimethyl-pentanoic acid; III-63 5-(5-{3-[5-(4-Carboxy-4-methyl-pentyl)-thiophen-2-yl]-propyl}-thiophen-2-yl)-2,2-dimethyl-pentanoic acid; III-64 6-(5-{3-[5-(6-Hydroxy-5,5-dimethyl-hexyl)-thiophen-2-yl]-propyl}-thiophen-2-yl)-2,2-dimethyl-hexan-1-ol; III-65 6-(5-{3-[5-(6-Hydroxy-5,5-dimethyl-hexyl)-thiophen-2-yl]-propyl}-thiophen-2-yl)-2,2-dimethyl-hexanoic acid; III-66 6-(5-{3-[5-(5-Carboxy-5-methyl-hexyl)-thiophen-2-yl]-propyl}-thiophen-2-yl)-2,2-dimethyl-hexanoic acid; III-67 6-(5-{2-[5-(6-Hydroxy-5,5-dimethyl-hexyl)-tetrahydro-thiophen-2-yl]-vinyl}-tetrahydro-thiophen-2-yl)-2,2-dimethyl-hexan-1-ol; III-68 6-(5-{2-[5-(6-Hydroxy-5,5-dimethyl-hexyl)-tetrahydro-thiophen-2-yl]-vinyl}-tetrahydro-thiophen-2-yl)-2,2-dimethyl-hexanoic acid; III-69 6-(5-{2-[5-(5-Carboxy-5-methyl-hexyl)-tetrahydro-thiophen-2-yl]-vinyl}-tetrahydro-thiophen-2-yl)-2,2-dimethyl-hexanoic acid; III-70 6-(5-{2-[5-(6-Hydroxy-5,5-dimethyl-hexyl)-thiophen-2-yl]-vinyl}-thiophen-2-yl)-2,2-dimethyl-hexan-1-ol; III-71 6-(5-{2-[5-(6-Hydroxy-5,5-dimethyl-hexyl)-thiophen-2-yl]-vinyl}-thiophen-2-yl)-2,2-dimethyl-hexanoic acid; III-72 6-(5-{2-[5-(5-Carboxy-5-methyl-hexyl)-thiophen-2-yl]-vinyl}-thiophen-2-yl)-2,2-dimethyl-hexanoic acid; III-73 5-(5-{2-[5-(5-Hydroxy-4,4-dimethyl-pentyl)-tetrahydro-thiophen-2-yl]-vinyl}-tetrahydro-thiophen-2-yl)-2,2-dimethyl-pentan-1-ol; III-74 5-(5-{2-[5-(5-Hydroxy-4,4-dimethyl-pentyl)-tetrahydro-thiophen-2-yl]-vinyl}-tetrahydro-thiophen-2-yl)-2,2-dimethyl-pentanoic acid; III-75 5-(5-{2-[5-(4-Carboxy-4-methyl-pentyl)-tetrahydro-thiophen-2-yl]-vinyl}-tetrahydro-thiophen-2-yl)-2,2-dimethyl-pentanoic acid; III-76 5-(5-{2-[5-(5-Hydroxy-4,4-dimethyl-pentyl)-thiophen-2-yl]-vinyl}-thiophen-2-yl)-2,2-dimethyl-pentan-1-ol; III-77 5-(5-{2-[5-(5-Hydroxy-4,4-dimethyl-pentyl)-thiophen-2-yl]-vinyl}-thiophen-2-yl)-2,2-dimethyl-pentanoic acid; III-78 5-(5-{2-[5-(4-Carboxy-4-methyl-pentyl)-thiophen-2-yl]-vinyl}-thiophen-2-yl)-2,2-dimethyl-pentanoic acid; III-79 6-(5-{2-[5-(6-Hydroxy-5,5-dimethyl-hexyl)-tetrahydro-thiophen-2-yl]-vinyl}-tetrahydro-thiophen-2-yl)-2,2-dimethyl-hexan-1-ol; III-80 6-(5-≡2-[5-(6-Hydroxy-5,5-dimethyl-hexyl)-tetrahydro-thiophen-2-yl]-vinyl}-tetrahydro-thiophen-2-yl)-2,2-dimethyl-hexanoic acid; III-81 6-(5-{2-[5-(5-Carboxy-5-methyl-hexyl)-tetrahydro-thiophen-2-yl]-vinyl}-tetrahydro-thiophen-2-yl)-2,2-dimethyl-hexanoic acid; III-82 6-(5-{2-[5-(6-Hydroxy-5,5-dimethyl-hexyl)-thiophen-2-yl]-vinyl}-thiophen-2-yl)-2,2-dimethyl-hexan-1-ol; III-83 6-(5-{2-[5-(6-Hydroxy-5,5-dimethyl-hexyl)-thiophen-2-yl]-vinyl}-thiophen-2-yl)-2,2-dimethyl-hexanoic acid; III-84 6-(5-{2-[5-(5-Carboxy-5-methyl-hexyl)-thiophen-2-yl]-vinyl}-thiophen-2-yl)-2,2-dimethyl-hexanoic acid; III-85 5-(5-{2-[5-(5-Hydroxy-4,4-dimethyl-pentyl)-thiophen-2-yl]-ethyl}-thiophen-2-yl)-2,2-dimethyl-pentan-1-ol; III-86 5-(5-{2-[5-(5-Hydroxy-4,4-dimethyl-pentyl)-thiophen-2-yl]-ethyl}-thiophen-2-yl)-2,2-dimethyl-pentanoic acid; III-87 5-(5-{2-[5-(4-Carboxy-4-methyl-pentyl)-thiophen-2-yl]-ethyl}-thiophen-2-yl)-2,2-dimethyl-pentanoic acid; IIIa-1 5-(6-{3-[6-(5-Hydroxy-4,4-dimethyl-pentyl)-tetrahydro-thiopyran-2-yl]-propyl}-tetrahydro-thiopyran-2-yl)-2,2-dimethyl-pentan-1-ol; IIIa-2 5-(6-{3-[6-(5-Hydroxy-4,4-dimethyl-pentyl)-tetrahydro-thiopyran-2-yl]-propyl}-tetrahydro-thiopyran-2-yl)-2,2-dimethyl-pentanoic acid; IIIa-3 5-(6-{3-[6-(4-Carboxy-4-methyl-pentyl)-tetrahydro-thiopyran-2-yl]-propyl}-tetrahydro-thiopyran-2-yl)-2,2-dimethyl-pentanoic acid; IIIa-4 6-(6-{3-[6-(6-Hydroxy-5,5-dimethyl-hexyl)-tetrahydro-thiopyran-2-yl]-propyl}-tetrahydro-thiopyran-2-yl)-2,2-dimethyl-hexan-1-ol; IIIa-5 6-(6-{3-[6-(6-Hydroxy-5,5-dimethyl-hexyl)-tetrahydro-thiopyran-2-yl]-propyl}-tetrahydro-thiopyran-2-yl)-2,2-dimethyl-hexanoic acid; IIIa-6 6-(6-{3-[6-(5-Carboxy-5-methyl-hexyl)-tetrahydro-thiopyran-2-yl]-propyl}-tetrahydro-thiopyran-2-yl)-2,2-dimethyl-hexanoic acid; IIIa-7 6-(6-{2-[6-(6-Hydroxy-5,5-dimethyl-hexyl)-tetrahydro-thiopyran-2-yl]-ethyl}-tetrahydro-thiopyran-2-yl)-2,2-dimethyl-hexan-1-ol; IIIa-8 6-(6-{2-[6-(6-Hydroxy-5,5-dimethyl-hexyl)-tetrahydro-thiopyran-2-yl]-ethyl}-tetrahydro-thiopyran-2-yl)-2,2-dimethyl-hexanoic acid; IIIa-9 6-(6-{2-[6-(5-Carboxy-5-methyl-hexyl)-tetrahydro-thiopyran-2-yl]-ethyl}-tetrahydro-thiopyran-2-yl)-2,2-dimethyl-hexanoic acid; IIIa-10 5-(6-{2-[6-(5-Hydroxy-4,4-dimethyl-pentyl)-tetrahydro-thiopyran-2-yl]-ethyl}-tetrahydro-thiopyran-2-yl)-2,2-dimethyl-pentan-1-ol; IIIa-11 5-(6-{2-[6-(5-Hydroxy-4,4-dimethyl-pentyl)-tetrahydro-thiopyran-2-yl]-ethyl}-tetrahydro-thiopyran-2-yl)-2,2-dimethyl-pentanoic acid; IIIa-12 5-(6-{2-[6-(4-Carboxy-4-methyl-pentyl)-tetrahydro-thiopyran-2-yl]-ethyl}-tetrahydro-thiopyran-2-yl)-2,2-dimethyl-pentanoic acid; IIIa-13 5-(5-{3-[5-(5-Hydroxy-4,4-dimethyl-pentyl)-tetrahydro-thiophen-2-yl]-propyl}-tetrahydro-thiophen-2-yl)-2,2-dimethyl-pentan-1-ol; IIIa-14 5-(5-{3-[5-(5-Hydroxy-4,4-dimethyl-pentyl)-tetrahydro-thiophen-2-yl]-propyl}-tetrahydro-thiophen-2-yl)-2,2-dimethyl-pentanoic acid; IIIa-15 5-(5-{3-[5-(4-Carboxy-4-methyl-pentyl)-tetrahydro-thiophen-2-yl]-propyl}-tetrahydro-thiophen-2-yl)-2,2-dimethyl-pentanoic acid; IIIa-16 6-(5-{3-[5-(6-Hydroxy-5,5-dimethyl-hexyl)-tetrahydro-thiophen-2-yl]-propyl}-tetrahydro-thiophen-2-yl)-2,2-dimethyl-hexan-1-ol; IIIa-17 6-(5-{3-[5-(6-Hydroxy-5,5-dimethyl-hexyl)-tetrahydro-thiophen-2-yl]-propyl}-tetrahydro-thiophen-2-yl)-2,2-dimethyl-hexanoic acid; IIIa-18 6-(5-{3-[5-(5-Carboxy-5-methyl-hexyl)-tetrahydro-thiophen-2-yl]-propyl}-tetrahydro-thiophen-2-yl)-2,2-dimethyl-hexanoic acid; IIIa-19 5-(5-{2-[5-(5-Hydroxy-4,4-dimethyl-pentyl)-tetrahydro-thiophen-2-yl]-ethyl}-tetrahydro-thiophen-2-yl)-2,2-dimethyl-pentan-1-ol; IIIa-20 5-(5-{2-[5-(5-Hydroxy-4,4-dimethyl-pentyl)-tetrahydro-thiophen-2-yl]-ethyl}-tetrahydro-thiophen-2-yl)-2,2-dimethyl-pentanoic acid; and IIIa-21 5-(5-{2-[5-(4-Carboxy-4-methyl-pentyl)-tetrahydro-thiophen-2-yl]-ethyl}-tetrahydro-thiophen-2-yl)-2,2-dimethyl-pentanoic acid.
- 36. A pharmaceutical composition comprising a compound of claim 1, 9, 15, 18, 20, 21, 26, 31 or 35 and a pharmaceutically acceptable vehicle, excipient, or diluent.
- 37. A pharmaceutical composition comprising one of the following compounds: 5-[2-(5-hydroxy-4,4-dimethyl-pentasulfanyl)-ethoxysulfanyl]-2,2-dimethyl-pentan-1-ol or 5-[2-(4-Carboxy-4-methyl-pentylsulfanyl)-ethylsulfanyl]-2,2-dimethyl-pentanoic acid or pharmaceutically acceptable salts, hydrates, solvates, clathrates, enantiomers, diastereomers, racemates or mixtures of steroisomers thereof and a pharmaceutically acceptable vehicle, excipient, or diluent.
- 38. A method for treating or preventing a cardiovascular disease in a patient, comprising administering to a patient in need of such treatment or prevention a therapeutically effective amount of a compound of claim 1, 9, 15, 18, 20, 21, 26, 31 or 35.
- 39. A method for treating or preventing a dyslipidemia in a patient, comprising administering to a patient in need of such treatment or prevention a therapeutically effective amount of a compound of claim 1, 9, 15, 18, 20, 21, 26, 31 or 35.
- 40. A method for treating or preventing a dyslipoproteinemia in a patient, comprising administering to a patient in need of such treatment or prevention a therapeutically effective amount of a compound of claim 1, 9, 15, 18, 20, 21, 26, 31 or 35.
- 41. A method for treating or preventing a disorder of glucose metabolism in a patient, comprising administering to a patient in need of such treatment or prevention a therapeutically effective amount of a compound of claim 1, 9, 15; 18, 20, 21, 26, 31 or 35.
- 42. A method for treating or preventing hypertension in a patient, comprising administering to a patient in need of such treatment or prevention a therapeutically effective amount of a compound of claim 1, 9, 15, 18, 20, 21, 26, 31 or 35.
Parent Case Info
[0001] This application claims the benefit of U.S. Provisional Application No. 60/239,231, filed Oct. 11, 2000, which is hereby expressly incorporated herein by reference.
Provisional Applications (1)
|
Number |
Date |
Country |
|
60239231 |
Oct 2000 |
US |