Claims
- 1. A method for preventing thrombus formation in a mammal in need thereof, comprising administering an effective amount of a compound of the structural formula ##STR209## or a pharmaceutically acceptable salt thereof, wherein R.sup.4 is aryl, C.sub.1-10 alkyl, or C.sub.4-10 aralkyl, wherein aryl is phenyl, pyridyl, thienyl, tetrazole or oxazole;
- R.sup.5 is ##STR210## wherein R.sup.8 is hydroxy or C.sub.1-10 alkyloxy, ##STR211## wherein R.sup.9 and R.sup.10 are selected from the group consisting of hydrogen, C.sub.1-10 alkyl and phenyl C.sub.1-4 alkyl; ##STR212## p is zero or one; and m is an integer from two to six, in combination with an effective amount of an anticoagulant agent.
- 2. A method of claim 1, wherein the compound has the structural formula ##STR213## or a pharmaceutically acceptable salt thereof, wherein R.sup.4 is aryl, C.sub.1-10 alkyl, or C.sub.4-10 aralkyl, wherein aryl is phenyl, pyridyl, thiophenyl, tetrazole, or oxazole;
- R.sup.5 is ##STR214## wherein R.sup.8 is hydroxy or C.sub.1-10 alkyloxy, ##STR215## wherein R.sup.9 and R.sup.10 are selected from the group consisting of hydrogen, C.sub.1-10 alkyl and phenyl C.sub.1-4 alkyl;
- Z is O;
- p is zero or one; and m is an integer from two to six
- and the anticoagulant agent is selected from the group consisting of aspirin, heparin and warfarin.
- 3. A method of claim 2, wherein the compound is ##STR216## or a pharmaceutically acceptable salt thereof, and the anticoagulant agent is heparin.
- 4. The method of claim 3, wherein the salt is ##STR217##
CROSS-REFERENCE
This is a division of application Ser. No. 08/861,545 filed May 22, 1997, now U.S. Pat. No. 5,814,643, which is a Division of application Ser. No. 08/505,417, filed Jul. 21, 1995, now U.S. Pat. No. 5,658,929, which is a continuation-in-part of U.S. Ser. No. 750,647, filed Aug. 30, 1991, abandonded, which is a continuation-in-part of U.S. Ser. No. 589,130, filed Sep. 27, 1990, abandoned.
US Referenced Citations (11)
Divisions (2)
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Number |
Date |
Country |
Parent |
861545 |
May 1997 |
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Parent |
505417 |
Jul 1995 |
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Continuation in Parts (2)
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Date |
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Parent |
750647 |
Aug 1991 |
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Parent |
589130 |
Sep 1990 |
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