Claims
- 1. A sulfonamide compound of the formula (I) or pharmacologically acceptable salts thereof: ##STR144## wherein: R.sup.1 represents a lower alkoxy group, hydroxyl group, phenoxy group, cyano group, acetyl group; R.sup.2 and R.sup.3 may be the same or different from each other and each represent a lower alkoxy group; R.sup.4 and R.sup.7 may be the same or different from each other and each represents a hydrogen atom or a lower alkyl group; R.sup.5 and R.sup.6 may be the same or different from each other and each represents a hydrogen atom, halogen atom, lower alkoxy group, amino group or amino group substituted with a lower alkyl or a phenyl group; A is .dbd.CH--; B is .dbd.CH--; and E is selected from the group consisting of ##STR145## in which Q represents an oxygen atom or a sulfur atom; and R.sup.11 is selected from the group consisting of a hydrogen atom, a lower alkyl group, an amino group, an amino group substituted with a lower alkyl group, a lower alkoxy group, a 2-thienyl group, a 2-furyl group, a phenyl group and a phenyl group having from 1 to 3 substituents, said substituents being the same or different from one another and selected from the group consisting of a halogen atom, lower alkyl group, lower alkoxy group, hydroxyl group, carboxyl group, esterified carboxyl group, amidated carboxyl group, lower alkylthio group and phenoxy group; and (b) a phenyl group or a phenyl group having from 1 to 3 substituents, said substituents being the same or different from one another and selected from the group consisting of a halogen atom, lower alkyl group, lower alkoxy group, hydroxyl group, protected hydroxyl group, carboxyl group, esterified carboxyl group, amidated carboxyl group, lower alkylthio group and phenoxy group.
- 2. A sulfonamide compound or a pharmacologically acceptable salt thereof according to claim 1, wherein R.sup.1 represents a lower alkoxy group.
- 3. A sulfonamide compound according to claim 2, wherein E is ##STR146##
- 4. A sulfonamide compound according to claim 3, wherein R.sup.11 is hydrogen or lower alkyl.
- 5. A sulfonamide compound according to claim 4, wherein the compound is N-[2-(4-Methoxybenzenesulfonamido)phenyl]formamide.
- 6. A sulfonamide compound according to claim 4, wherein the compound is N-[2-(4-Methoxybenzenesulfonamido)phenyl]acetamide.
- 7. A sulfonamide compound according to claim 3, wherein R.sup.11 is an amino group substituted with a lower alkyl group.
- 8. A sulfonamide compound according to claim 7, wherein the compound is N-[2-[(Ethylaminocarbonyl)amino]phenyl]-4-methoxybenzenesulfonamide.
- 9. A sulfonamide compound according to claim 3, wherein R.sup.11 is a 2-thienyl group.
- 10. A sulfonamide compound according to claim 9, wherein the compound is N-[2-(4-Methoxybenzenesulfonamido)phenyl]-2-thiophenecarboxamide.
- 11. A sulfonamide compound according to claim 3, wherein R.sup.11 is a 2-furyl group.
- 12. A sulfonamide compound according to claim 11, wherein the compound is N-[2-(4-methoxybenzenesulfonamido)phenyl]-2-furancarboxamide.
- 13. A sulfonamide compound according to claim 2, wherein E is a phenyl group which may be substituted with 1 to 3 substituents which may be the same or different from one another and are selected from the group consisting of a halogen atom, lower alkyl group, lower alkoxy group, an amino group, hydroxyl group which may be protected, carboxyl group which may be esterified or amidated, lower alkylthio group or phenoxy group.
- 14. A sulfonamide compound according to claim 13, wherein the compound is N-(2-anilinophenyl)-4-methoxybenzenesulfonamide.
- 15. A sulfonamide compound according to claim 13, wherein the compound is N-(2-[4-hydroxyphenyl)aminophenyl]-4-methoxybenzenesulfonamide.
- 16. A sulfonamide compound according to claim 13, wherein the compound is N-(2-anilino-4-fluorophenyl)-4-methoxybenzenesulfonamide.
- 17. A sulfonamide compound according to claim 13, wherein the compound is N-(2-[(4-chlorophenyl)aminophenyl]-4-methoxybenzenesulfonamide.
- 18. A sulfonamide compound according to claim 13, wherein the compound is N-[2-[(3-hydroxyphenyl)amino]phenyl]-4-methoxybenzenesulfonamide.
- 19. A sulfonamide compound of the formula (I) or pharmacologically acceptable salts thereof: ##STR147## wherein: R.sup.1 represents a halogen atom, lower alkoxy group, hydroxyl group, phenoxy group, cyano group, acetyl group, amino group or a protected amino group; R.sup.2 and R.sup.3 may be the same or different from each other and each represent a hydrogen atom, halogen atom, lower alkyl group or lower alkoxy group; R.sup.4 and R.sup.7 may be the same or different from each other and each represents a hydrogen atom or a lower alkyl group; R.sup.5 and R.sup.6 may be the same or different from each other and each represents a hydrogen atom, halogen atom, lower alkoxy group, amino group or amino group substituted with a lower alkyl or a phenyl group; A is .dbd.CH--; B is .dbd.CH--; and E is the group ##STR148## in which Q represents an oxygen atom or a sulfur atom; and R.sup.11 is a phenyl group or a phenyl group having from 1 to 3 substituents, said substituents being the same or different from one another and selected from the group consisting of a halogen atom, lower alkyl group, lower alkoxy group, hydroxyl group, carboxyl group, esterified carboxyl group, amidated carboxyl group, lower alkylthio group and phenoxy group.
- 20. A sulfonamide compound according to claim 19, selected from the group consisting of 4-Benzyloxy-N-[2-(4-methoxybenzenesulfonamido)phenyl]benzamide, 4-Hydroxy-N-[2-(4-methoxybenzenesulfonamido)phenyl]benzamide, 4-Fluoro-N-[2-(4-methoxybenzenesulfonamido)phenyl]benzamide, 3-Hydroxy-N-[2-(4-methoxybenzenesulfonamido)phenyl]benzamide, 4-Fluoro-N-[2-(4-methoxybenzenesulfonamide)-6-methyl-phenyl]benzamide, N-[2-(4-Methoxybenzenesulfonamido)phenyl]-2-nitrobenzamide, 2-Chloro-4-fluoro-N-[2-(4-methoxybenzenesulfonamido)phenyl]benzamide, N-[2(4-Methoxybenzenesulfonamido)phenyl]-2-methylbenzamide, N-[5-fluoro-2-(4-methoxybenzenesulfonamido)phenyl]benzamide, N-[2-(4-Aminobenzenesulfonamido)phenyl]-4-fluorobenzamide, N-[2-(4-Chlorobenzenesulfonamido)phenyl]benzamide, N-[2-(3,4-Dimethoxybenzenesulfonamido)phenyl]benzamide and N-[2-(4-Methoxybenzenesulfonamido)phenyl]benzamide.
Priority Claims (3)
Number |
Date |
Country |
Kind |
2-218710 |
Aug 1990 |
JPX |
|
3-038509 |
Mar 1991 |
JPX |
|
3-121041 |
May 1991 |
JPX |
|
Parent Case Info
This is a division of Ser. No. 08/231,272, filed Apr. 22, 1994, now U.S. Pat. No. 5,434,172 which is a division of Ser. No. 08/085,962, filed Jun. 30, 1993, now U.S. Pat. No. 5,332,751 which is a division of Ser. No. 07/923,345, filed Jul. 31, 1992, now U.S. Pat. No. 5,292,758 which is a division of Ser. No. 07/742,618, filed Aug. 8, 1991 now U.S. Pat. No. 5,250,549.
Foreign Referenced Citations (1)
Number |
Date |
Country |
0263229 |
Apr 1988 |
EPX |
Non-Patent Literature Citations (2)
Entry |
Chemical Abstracts, vol. 58, No. 5, Abstract 5665h, Mar. 4, 1963. |
Chemical Abstracts, vol. 54, No. 5, Abstract 5523b, Mar. 10, 1960. |
Divisions (4)
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Number |
Date |
Country |
Parent |
231272 |
Apr 1994 |
|
Parent |
85962 |
Jun 1993 |
|
Parent |
923345 |
Jul 1992 |
|
Parent |
742618 |
Aug 1991 |
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