Sulfonylaminocarboxylic acid N-arylamides as guanylate cyclase activators

Description

The present invention relates to compounds of the formula I

in which A

1

, A

2

, R

2

and R

3

have the meanings indicated below, which are valuable pharmaceutical active compounds for the therapy and prophylaxis of diseases, for example of cardiovascular disorders such as high blood pressure, angina pectoris, cardiac insufficiency, thromboses or atherosclerosis. The compounds of the formula I have the ability to modulate the endogenous production of cyclic guanosine monophosphate (cGMP) and are generally suitable for the therapy and prophylaxis of disease states which are associated with a disturbed cGMP balance. The invention relates to the use of compounds of the formula I for the therapy and prophylaxis of the designated disease states and for the production of pharmaceuticals therefor, novel compounds of the formula I, pharmaceutical preparations comprising them and processes for their preparation.

cGMP is an important intracellular messenger, which elicits a number of pharmacological effects by means of the modulation of cGMP-dependent protein kinases, phosphodiesterases and ion channels. Examples are smooth muscle relaxation, the inhibition of platelet activation and the inhibition of smooth muscle cell proliferation and leukocyte adhesion. cGMP is produced by particulate and soluble guanylate cyclases as a response to a number of extracellular and intracellular stimuli. In the case of the particulate guanylate cyclases, the stimulation essentially takes place by means of peptidic messenger substances, such as the atrial natriuretic peptide or the cerebral natriuretic peptide. The soluble guanylate cyclases (sGC), which are cytosolic, heterodimeric heme proteins, however, are essentially regulated by a family of low molecular weight, enzymatically formed factors. The most important stimulant is nitrogen monoxide (NO) or a closely relates species. The importance of other factors such as carbon monoxide or the hydroxyl radical is still largely unclarified. The binding of NO to the heme with formation of a pentacoordinated heme-nitrosyl complex is discussed as an activation mechanism of activation by NO. The release associated therewith of the histidine which is bound to the iron in the basal state converts the enzyme into the activated conformation.

Active soluble guanylate cyclases are each composed of one α- and one β-subunit. Several subtypes of the subunits have been described, which differ from one another with respect to sequence, tissue-specific distribution and expression in various stages of development. The subtypes α

1

and β

1

are mainly expressed in the brain and lung, while β

2

is especially found in liver and kidney. The subtype α

2

was detected in human fetal brain. The subunits designated as α

3

and β

3

were isolated from human brain and are homologous to α

1

and β

1

. More recent studies point to an α

2i

subunit, which contains an insert in the catalytic domain. All subunits show great homology in the area of the catalytic domain. The enzymes presumably contain one heme per heterodimer, which is bonded via β

1

-Cys-78 and/or β

1

-His-105 and is part of the regulatory center.

The formation of guanylate cyclase-activating factors can be decreased under pathological conditions or increased degradation thereof can take place as a result of the increased occurrence of free radicals. The decreased activation of the sGC resulting therefrom leads, via the attenuation of the respective cGMP-mediated cell response, for example, to an increase in the blood pressure, to platelet activation or to increased cell proliferation and cell adhesion. As a result, the formation of endothelial dysfunction, atherosclerosis, high blood pressure, stable and unstable angina pectoris, thromboses, myocardial infarct, strokes or erectile dysfunction occurs. The pharmacological stimulation of the sGC offers a possibility for the normalization of cGMP production and thus allows the treatment or prevention of diseases of this type.

For the pharmacological stimulation of sGC, until now compounds have almost exclusively been used whose action is based on an intermediate release of NO, for example organic nitrates. The disadvantage of this method of treatment lies in the development of tolerance and reduction of activity and the higher dosage which therefore becomes necessary.

Various sGC stimulators which do not act via a release of NO have been described in a series of publications by Vesely. The compounds, which are mostly hormones, plant hormones, vitamins or, for example, natural substances such as lizard toxins, however, predominantly show only weak effects on cGMP formation in cell lysates (D. L. Vesely, Eur. J. Clin. Invest. 15 (1985) 258; D. L. Vesely, Biochem. Biophys. Res. Comm. 88 (1979) 1244). Stimulation of heme-free guanylate cyclase by protoporphyrin IX was detected by Ignarro et al. (Adv. Pharmacol. 26 (1994) 35). Pettibone et al. (Eur. J. Pharmacol. 116 (1985) 307) described a hypotensive action for diphenyliodonium hexafluorophosphate and attributed this to a stimulation of sGC. Isoliquiritiginin, which shows a relaxant action on isolated rat aortas, likewise activates sGC according to Yu et al. (Brit. J. Pharmacol. 114 (1995) 1587). Ko et al. (Blood 84 (1994) 4226), Yu et al. (Biochem. J. 306 (1995) 787) and Wu et al. (Brit. J. Pharmacol. 116 (1995) 1973) detected an sGC stimulating activity of 1-benzyl-3-(5-hydroxymethyl-2-furyl)indazole and demonstrated an antiproliferative and platelet-inhibiting action.

A number of sulfonylaminocarboxylic acid N-arylamides of the formula I are already known. Compounds of this type are used, for example, in the production of photographic materials (see, for example, Chemical Abstracts 119, 105 755; 116, 245 151 and 104, 177 628) and, for this purpose, then in general contain in the N-aryl group as substituents easily oxidizable groups such as, for example, two hydroxyl groups in the para-position to one another. For various compounds of the formula I, a pharmacological action has also already been described. Thus, for example, in DE-A-35 23 705, an anthelmintic action is described for a series of 2-phenylsulfonylaminobenzamides. Antiparasitic, antimicrobial or fungicidal actions of 2-sulfonylaminobenzoic acid N-(hetero)arylamides are also mentioned, for example, in EP-A-420 805 and in Chemical Abstracts 122, 136 749; 120, 560; 119, 116 978; 116, 228 237; 116, 207 806; 115, 158 666 and 106, 152 850. According to EP-A-347 168, certain compounds of the formula I having a phenyl pivalate structure are elastase inhibitors and can be used in the treatment of atherosclerosis or arthritis. In Chemical Abstracts 104, 33 896, a psychotropic action is described for certain 2-sulfonylaminobenzoic acid N-phenoxyphenylamides. Various 2-trifluoromethylsulfonylamino- and 2-methylsulfonylamino-substituted benzamides are described as angiotensin II receptor antagonists having antihypertensive activity in Hypertension 15 (1998) 823, J. Med. Chem. 33 (1990) 1312, EP-A-253 310, EP-A-324 377, EP-A-449 699, EP-A-530 702 and U.S. Pat. No. 4,880,804.

Surprisingly, it has now been found that the compounds of the formula I bring about strong guanylate cyclase activation, on account of which they are suitable for the therapy and prophylaxis of diseases which are associated with a low cGMP level.

The present invention thus relates to the use of compounds of the formula I

in which

A

1

is a radical from the group consisting of phenyl, naphthyl and heteroaryl, which can all be substituted by one or more identical or different radicals R

1

;

the ring A

2

, which includes the carbon atoms which carry the groups CO—NH— and NH—SO

2

R

2

, is a benzene ring, a naphthalene ring, a saturated or partially unsaturated 3-membered to 7-membered carbocycle, a saturated, partially unsaturated or aromatic monocyclic 5-membered to 7-membered heterocycle which contains one or more ring heteroatoms from the group consisting of N, O and S, or a saturated, partially unsaturated or aromatic bicyclic 8-membered to 10-membered heterocycle which contains one or more ring heteroatoms from the group consisting of N, O and S;

R

1

is halogen, aryl, CF

3

, NO

2

, OH, —O—(C

1

-C

7

)-alkyl, —O—(C

2

-C

4

)-alkyl-O—(C

1

-C

7

)-alkyl, —O-aryl, (C

1

-C

2

)-alkylenedioxy, NR

5

R

6

, CN, CO—NR

5

R

6

, COOH, CO—O—(C

1

-C

5

)-alkyl, heterocyclyl, CHO, CO—(C

1

-C

10

)-alkyl, CO-aryl or (C

1

-C

10

)-alkyl which can be substituted by one or more identical or different radicals R

4

;

R

2

is aryl, heterocyclyl, NR

5

R

6

or (C

1

-C

10

)-alkyl which can be substituted by one or more identical or different radicals R

4

;

R

3

is one or more identical or different substituents from the group consisting of hydrogen, halogen, CF

3

, OH, —O—(C

1

-C

10

)-alkyl, —O—(C

1

-C

7

)-alkyl-R

7

, —O-aryl, SH, —S—(C

1

-C

10

)-alkyl, —S—(C

1

-C

7

)-alkyl-R

7

, —S-aryl, (C

1

-C

3

)-alkylenedioxy, CN, NO

2

, NR

8

R

9

, CO—NR

5

R

6

, COOH, CO—O—(C

1

-C

5

)-alkyl, heterocyclyl, S(O)

n

—(C

1

-C

7

)-alkyl, S(O)

n

-aryl, S(O)

n

—NR

5

R

6

and (C

1

-C

7

)-alkyl which can be substituted by one or more identical or different radicals R

4

;

R

4

is fluorine, OH, —O—(C

1

-C

10

)-alkyl, —O—(C

1

-C

7

)-alkyl-R

7

, —O-aryl, SH, —S—(C

1

-C

10

)-alkyl, —S—(C

1

-C

7

)-alkyl-R

7

, —S-aryl, —P(O)(O—(C

1

-C

5

)-alkyl)

2

, —P(O)(OH)

2

, CN, NR

8

R

9

, CO—NH

2

, CO—NH—(C

1

-C

3

)-alkyl, CO—N((C

1

-C

3

)-alkyl)

2

, COOH, CO—O—(C

1

-C

5

)-alkyl, heterocyclyl or oxo;

R

5

is hydrogen, (C

1

-C

10

)-alkyl which can be substituted by one or more identical or different substituents R

4

and/or by aryl, or is aryl, heterocyclyl, CO—(C

1

-C

10

)-alkyl, CO-aryl, CO-heterocyclyl, SO

2

—(C

1

-C

10

)-alkyl, SO

2

-aryl or SO

2

-heterocyclyl;

R

6

, independently of R

5

, has one of the meanings indicated for R

5

, or R

5

and R

6

, together with the nitrogen atom to which they are bonded, form a 5-membered to 8-membered saturated or partially unsaturated ring which, in addition to the nitrogen atom carrying the groups R

5

and R

6

, can also contain one or more further ring heteroatoms from the group consisting of N, O and S and which can be substituted by one or more identical or different substituents from the group consisting of fluorine, (C

1

-C

5

)-alkyl, (C

1

-C

3

)-hydroxyalkyl, —(C

1

-C

3

)-alkyl-O—(C

1

-C

4

)-alkyl, aryl, CF

3

, OH, —O—(C

1

-C

7

)-alkyl, —O-aryl, —O—(C

2

-C

4

)-alkyl-O—(C

1

-C

7

)-alkyl, (C

2

-C

3

)-alkylenedioxy, NR

8

R

9

, CN, CO—NH

2

, CO—NH—(C

1

-C

3

)-alkyl, CO—N((C

1

-C

3

)-alkyl)

2

, COOH, CO—O—(C

1

-C

5

)-alkyl, CHO, CO—(C

1

-C

5

)-alkyl, S(O)

n

—(C

1

-C

4

)-alkyl, S(O)

n

—NH

2

, S(O)

n

—NH—(C

1

-C

3

)-alkyl, S(O)

n

—N((C

1

-C

3

)-alkyl)

2

, oxo, —(CH

2

)

m

—NH

2

, —(CH

2

)

m

—NH—(C

1

-C

4

)-alkyl and —(CH

2

)

m

—N((C

1

-C

4

)-alkyl)

2

, where in the substituent —(CH

2

)

m

—N((C

1

-C

4

)-alkyl)

2

the two alkyl groups can be linked by a single bond and then, together with the nitrogen atom carrying them, form a 5-membered to 7-membered ring which, in addition to the nitrogen atom and the carbon atoms, can additionally also contain an oxygen atom, a sulfur atom or a group NR

5

as a ring member;

R

7

is OH, —O—(C

1

-C

7

)-alkyl, NH

2

, —NH—(C

1

-C

4

)-alkyl or —N((C

1

-C

4

)-alkyl)

2

, where in the substituent N((C

1

-C

4

)-alkyl)

2

the two alkyl groups can be linked by a single bond and then, together with the nitrogen atom carrying them, form a 5-membered to 7-membered ring which, in addition to the nitrogen atom and the carbon atoms can additionally also contain an oxygen atom, a sulfur atom or a group NR

5

as a ring member;

R

8

is hydrogen or (C

1

-C

7

)-alkyl which can be substituted by one or more identical or different substituents from the group consisting of OH, —O—(C

1

-C

5

)-alkyl, NH

2

, —NH—(C

1

-C

4

)-alkyl and —N((C

1

-C

4

)-alkyl)

2

;

R

9

, independently of R

8

, has one of the meanings of R

8

or is CO—(C

1

-C

4

)-alkyl;

aryl is phenyl, naphthyl or heteroaryl, which can all be substituted by one or more identical or different substituents from the group consisting of halogen, (C

1

-C

5

)-alkyl, phenyl, tolyl, CF

3

, NO

2

, OH, —O—(C

1

-C

5

)-alkyl, —O—(C

2

-C

4

)-alkyl-O—(C

1

-C

3

)-alkyl, (C

1

-C

2

)-alkylenedioxy, NH

2

, —NH—(C

1

-C

3

)-alkyl, —N((C

1

-C

3

)-alkyl)

2

, NH—CHO, —NH—CO—(C

1

-C

5

)-alkyl, CN, CO—NH

2

, CO—NH—(C

1

-C

3

)-alkyl, CO—N((C

1

-C

3

)-alkyl)

2

, COOH, CO—O—(C

1

-C

5

)-alkyl, heterocyclyl, CHO, CO—(C

1

-C

5

)-alkyl, S(O)

n

—(C

1

-C

4

)-alkyl, S(O)

n

-phenyl, S(O)

n

-tolyl, S(O)

2

-NH

2

, S(O)

2

—NH—(C

1

-C

3

)-alkyl and S(O)

2

—N((C

1

-C

3

)-alkyl)

2

;

heteroaryl is the radical of a monocyclic 5-membered or 6-membered aromatic heterocycle or of a bicyclic 8-membered to 10-membered aromatic heterocycle, each of which contain one or more ring heteroatoms from the group consisting of N, O and S;

heterocyclyl is the radical of a monocyclic or polycyclic, 5-membered to 11-membered saturated or partially unsaturated heterocycle which contains one or more ring heteroatoms from the group consisting of N, O and S and which can be substituted by one or more identical or different substituents from the group consisting of fluorine, (C

1

-C

5

)-alkyl, OH, —O—(C

1

-C

5

)-alkyl, —O—(C

2

-C

4

)-alkyl-O—(C

1

-C

3

)-alkyl, NH

2

, —NH—(C

1

-C

3

)-alkyl, —N((C

1

-C

3

)-alkyl)

2

, CN, CO—NH

2

, CO—NH—(C

1

-C

3

)-alkyl, CO—N((C

1

-C

3

)-alkyl)

2

, COOH and CO—O—(C

1

-C

5

)-alkyl;

n is 0, 1 or 2;

m is 2, 3 or 4;

in all their stereoisomeric forms and mixtures thereof in all ratios, and their physiologically tolerable salts for the production of a medicament for the activation of soluble guanylate cyclase.

If groups or substituents can occur a number of times in the compounds of the formula I, they can all independently of one another have the indicated meanings and can each be identical or different.

Alkyl radicals can be straight-chain or branched. This also applies if they are contained in other groups, for example in alkoxy groups, alkoxycarbonyl groups or in amino groups, or if they are substituted. Examples of alkyl groups are methyl, ethyl, propyl, butyl, pentyl, hexyl, heptyl, octyl, nonyl, decyl, the n-isomers of these radicals, isopropyl, isobutyl, isopentyl, sec-butyl, tert-butyl, neopentyl, 3,3-dimethylbutyl. The term alkyl here is expressly also understood as meaning unsaturated alkyl radicals, i.e. alkyl radicals which contain one or more double bonds and/or one or more triple bonds, i.e. alkenyl radicals and alkynyl radicals. Examples of such radicals are the vinyl radical, the 2-propenyl radical (allyl radical), the 2-butenyl radical, the 2-methyl-2-propenyl radical, the ethynyl radical, the 2-propynyl radical (propargyl radical) or the 3-butynyl radical. Furthermore, the term alkyl here is expressly also understood as meaning radicals in which a cyclic system is formed by means of an internal ring closure, i.e., the term alkyl also includes saturated and partially unsaturated cycloalkyl radicals and cycloalkylalkyl radicals (alkyl substituted by cycloalkyl). Examples of such cycloalkyl radicals are cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, cycloheptyl and cyclooctyl, which all can also be substituted, for example, by one or more identical or different (C

1

-C

4

)-alkyl radicals, in particular by methyl. Examples of such substituted cycloalkyl radicals are 4-methylcyclohexyl, 4-tert-butylcyclohexyl or 2,3-dimethylcyclopentyl. Furthermore, the term alkyl, if not stated otherwise, here expressly also includes both unsubstituted alkyl radicals and alkyl radicals which are substituted by one or more, for example one, two, three or four, identical or different aryl radicals. I.e., the term alkyl here is expressly also understood as meaning arylalkyl radicals, for example benzyl radicals, phenylethyl radicals or indanyl radicals.

A saturated or partially unsaturated 3-membered to 7-membered carbocycle representing the ring A

2

can be derived from the monocyclic parent structures cyclopropane, cyclobutane, cyclopentane, cyclohexane or cycloheptane. If the carbocycle is unsaturated, it can contain, for example, a double bond or, in the case of the 5-membered ring, 6-membered ring or 7-membered ring, also two double bonds, which can be isolated or conjugated. Double bonds can be situated in any desired positions with respect to the groups CO—NH— and NH—SO

2

—R

2

, thus, for example, a double bond can also be situated between the two ring carbon atoms which carry these two groups.

Phenyl radicals, naphthyl radicals and heterocyclic radicals, for example heteroaryl radicals, if not stated otherwise, can be unsubstituted or can carry one or more, for example one, two, three or four, identical or different substituents, which can be situated in any desired positions. If not stated otherwise, the substituents indicated in the definition of the group aryl, for example, can occur in these radicals as substituents. If, in compounds of the formula I, nitro groups are present as substituents, altogether only up to two nitro groups can be present in the molecule. If, for example, phenyl radicals, phenoxy radicals, benzyl radicals or benzyloxy radicals are present in aryl radicals such as, for example, phenyl radicals and/or in heterocyclic radicals as substituents, the benzene ring in these can also in turn be unsubstituted or can be substituted by one or more, for example one, two, three or four, identical or different radicals, for example by radicals from the group consisting of (C

1

-C

4

)-alkyl, halogen, hydroxyl, (C

1

-C

4

)-alkoxy, trifluoromethyl, cyano, hydroxycarbonyl, ((C

1

-C

4

)-alkoxy)carbonyl, aminocarbonyl, nitro, amino, (C

1

-C

4

)-alkylamino, di-((C

1

-C

4

)-alkyl)amino and ((C

1

-C

4

)-alkyl)carbonylamino.

In monosubstituted phenyl radicals, the substituent can be situated in the 2-position, the 3-position or the 4-position, in disubstituted phenyl radicals the substituents can be situated in the 2,3-position, 2,4-position, 2,5-position, 2,6-position, 3,4-position or 3,5-position. In trisubstituted phenyl radicals, the substituents can be situated in the 2,3,4-position, 2,3,5-position, 2,3,6-position, 2,4,5-position, 2,4,6-position or 3,4,5-position. Tolyl (=methylphenyl) is 2-tolyl, 3-tolyl or 4-tolyl. Naphthyl can be 1-naphthyl or 2-naphthyl. In monosubstituted 1-naphthyl radicals, the substituent can be situated in the 2-position, the 3-position, the 4-position, the 5-position, the 6-position, the 7-position or the 8-position, in monosubstituted 2-naphthyl radicals in the 1-position, the 3-position, the 4-position, the 5-position, the 6-position, the 7-position or the 8-position. In higher substituted naphthyl radicals, for example 1-naphthyl radicals or 2-naphthyl radicals which carry two or three substituents, the substituents can also be situated in all possible positions.

Heteroaryl radicals, heterocyclyl radicals, heterocycles representing the ring A

2

and rings which are formed from two groups bonded to a nitrogen atom together with this nitrogen atom, are preferably derived from heterocycles which contain one, two, three or four identical or different ring heteroatoms, particularly preferably from heterocycles which contain one or two or three, in particular one or two, identical or different heteroatoms. If not stated otherwise, the heterocycles can be monocyclic or polycyclic, for example monocyclic, bicyclic or tricyclic. They are preferably monocyclic or bicyclic. The rings are preferably 5-membered rings, 6-membered rings or 7-membered rings. Examples of monocyclic and bicyclic heterocyclic systems from which radicals occurring in the compounds of the formula I can be derived are pyrrole, furan, thiophene, imidazole, pyrazole, 1,2,3-triazole, 1,2,4-triazole, 1,3-dioxole, 1,3-oxazole, 1,2-oxazole, 1,3-thiazole, 1,2-thiazole, tetrazole, pyridine, pyridazine, pyrimidine, pyrazine, pyran, thiopyran, 1,4-dioxin, 1,2-oxazine, 1,3-oxazine, 1,4-oxazine, 1,2-thiazine, 1,3-thiazine, 1,4-thiazine, 1,2,3-triazine, 1,2,4-triazine, 1,3,5-triazine, 1,2,4,5-tetrazine, azepine, 1,2-diazepine, 1,3-diazepine, 1,4-diazepine, 1,3-oxazepine, 1,3-thiazepine, indole, benzothiophene, benzofuran, benzothiazole, benzimidazole, quinoline, isoquinoline, cinnoline, quinazoline, quinoxaline, phthalazine, thienothiophenes, 1,8-naphthyridine and other naphthyridines, pteridine, or phenothiazine, all in each case in saturated form (perhydro form) or in partially unsaturated form (for example dihydroform and tetrahydro form) or in maximally unsaturated form if the forms concerned are known and stable. The suitable heterocycles thus also include, for example, the saturated heterocycles pyrrolidine, piperidine, piperazine, morpholine and thiomorpholine. The degree of saturation of heterocyclic groups is indicated in the individual definitions. Unsaturated heterocycles can contain, for example, one, two or three double bonds in the ring system. 5-Membered rings and 6-membered rings in monocyclic and polycyclic heterocycles can in particular also be aromatic.

The radicals derived from these heterocycles can be bonded via any suitable carbon atom. Nitrogen heterocycles which carry a hydrogen atom (or a substituent) on a ring nitrogen atom, for [lacuna] pyrrole, imidazole, pyrrolidine, morpholine, piperazine etc. can also be bonded via a ring nitrogen atom, in particular if the nitrogen heterocycle concerned is bonded to a carbon atom. A thienyl radical can be present, for example, as a 2-thienyl radical or 3-thienyl radical, a furan radical as a 2-furyl radical or 3-furyl radical, a pyridyl radical as a 2-pyridyl radical, 3-pyridyl radical or 4-pyridyl radical, a piperidine radical as a 1-piperidyl radical, 2-piperidyl radical, 3-piperidyl radical or 4-piperidyl radical, a thiomorpholine radical as a 2-thiomorpholinyl radical, 3-thiomorpholinyl radical or 4-thiomorpholinyl radical (=thiomorpholino radical). A radical bonded via a carbon atom, which is derived from 1,3-thiazole or from imidazole, can be bonded via the 2-position, the 4-position or the 5-position.

If not stated otherwise, the heterocyclic groups, such as, for example, heteroaryl radicals, can be unsubstituted or can carry one or more, for example one, two, three or four, identical or different substituents. The substituents in heterocycles can be situated in any desired positions, for example in the 3-position and/or in the 4-position and/or in the 5-position in a 2-thienyl radical or 2-furyl radical, in the 2-position and/or in the 4-position and/or in the 5-position in a 3-thienyl radical or 3-furyl radical, in the 3-position and/or in the 4-position and/or in the 5-position and/or in the 6-position in a 2-pyridyl radical, in the 2-position and/or in the 4-position and/or in the 5-position and/or in the 6-position in a 3-pyridyl radical, in the 2-position and/or in the 3-position and/or in the 5-position and/or in the 6-position in a 4-pyridyl radical. If not stated otherwise, the substituents which can occur are, for example, the substituents indicated in the definition of the group aryl, in the case of saturated or partially unsaturated heterocycles as further substituents also the oxo group and the thioxo group. Substituents on a heterocycle and substituents on a carbocycle can also form a ring, thus further rings can be fused to a ring system so that, for example, cyclopenta-fused, cyclohexa-fused or benzo-fused rings can be present. Suitable substituents on a substitutable nitrogen atom of a heterocycle are in particular, for example, unsubstituted (C

1

-C

5

)-alkyl radicals and aryl-substituted alkyl radicals, aryl radicals, acyl radicals such as CO—(C

1

-C

5

)-alkyl, or sulfonyl radicals such as SO

2

—(C

1

-C

5

)-alkyl. Suitable nitrogen heterocycles can also be present as N-oxides or as quaternary salts having an anion derived from a physiologically tolerable acid as a counterion. Pyridyl radicals can be present, for example, as pyridine N-oxides.

Halogen is fluorine, chlorine, bromine or iodine, preferably fluorine or chlorine.

Without restricting the present invention, examples of groups of compounds which can be used according to the invention are shown in the formulae Ia, Ib, Ic, Id, Ie, If, Ig and Ih, in which A

2

in the formula I has specific meanings. In the formulae Ia, Ib, Ic, Id, Ie, If, Ig and Ih, A

1

, R

2

and R

3

have the meanings indicated above for the formula I, the number k in the formula Ib is 1, 2, 3, 4 or 5.

The present invention includes all stereoisomeric forms of the compounds of the formula I. Asymmetric centers contained in the compounds of the formula I can all independently of one another have the S configuration or the R configuration. The invention includes all possible enantiomers and diastereomers, as well as mixtures of two or more stereoisomeric forms, for example mixtures of enantiomers and/or diastereomers, in all ratios. Enantiomers are thus included by the invention in enantiomerically pure form, both as dextrorotatory and as levorotatory antipodes, in the form of racemates and in the form of mixtures of the two enantiomers in all ratios. In the presence of cis/trans isomerism the invention relates both to the cis form and the trans form and mixtures of these forms in all ratios. Individual stereoisomers can be prepared, if desired, by resolution of a mixture according to customary methods, for example by chromatography or crystallization, by use of stereochemically homogeneous starting substances in the synthesis or by stereoselective synthesis. If appropriate, derivatization can be carried out before separation of stereoisomers. The separation of a stereoisomer mixture can be carried out at the stage of the compounds of the formula I or at the stage of an intermediate in the course of the synthesis. If mobile hydrogen atoms are present, the present invention also includes all tautomeric forms of the compounds of the formula I.

If the compounds of the formula I contain one or more acidic or basic groups, the invention also relates to the corresponding physiologically or toxicologically tolerable salts, in particular the pharmaceutically utilizable salts. Thus the compounds of the formula I which contain acidic groups can be present in these groups, for example, as alkali metal salts, alkaline earth metal salts or as ammonium salts and can be used according to the invention. Examples of such salts are sodium salts, potassium salts, calcium salts, magnesium salts or salts with ammonia or organic amines such as, for example, ethylamine, ethanolamine, triethanolamine or amino acids. Compounds of the formula I which contain one or more basic, i.e. protonatable, groups can be present and can be used according to the invention in the form of their acid addition salts with physiologically tolerable inorganic or organic acids, for example as salts with hydrogen chloride, hydrogen bromide, phosphoric acid, sulfuric acid, nitric acid, methanesulfonic acid, p-toluenesulfonic acid, naphthalenedisulfonic acids, oxalic acid, acetic acid, tartaric acid, lactic acid, salicylic acid, benzoic acid, formic acid, propionic acid, pivalic acid, diethylacetic acid, malonic acid, succinic acid, pimelic acid, fumaric acid, maleic acid, malic acid, sulfamic acid, phenylpropionic acid, gluconic acid, ascorbic acid, isonicotinic acid, citric acid, adipic acid etc. If the compounds of the formula I simultaneously contain acidic and basic groups in the molecule, in addition to the salt forms outlined the invention also includes internal salts or betaines (zwitterions). Salts can be obtained from the compounds of the formula I by customary processes known to the person skilled in the art, for example by combination with an organic or inorganic acid or base in a solvent or dispersant, or alternatively from other salts by anion exchange or cation exchange.

The present invention furthermore includes all solvates of compounds of the formula I, for example hydrates or adducts with alcohols, and also derivatives of the compounds of the formula I such as, for example, esters, and prodrugs and active metabolites.

A

1

is preferably phenyl, naphthyl or bicyclic heteroaryl, which can all be substituted by one or more identical or different radicals R

1

. Bicyclic heteroaryl representing A

1

is particularly preferably bicyclic heteroaryl having 10 ring members, which preferably contains one or two nitrogen atoms, in particular one nitrogen atom, as ring heteroatoms. Very particularly preferably, bicyclic heteroaryl representing A

1

is a radical derived from quinoline.

A

2

, together with the two atoms carrying the group R

2

—SO

2

—NH and the group CO—NH, preferably forms an aromatic ring, particularly preferably a benzene ring or a thiophene ring.

A

1

can be unsubstituted, that is only carry hydrogen atoms, or can be substituted as indicated by one or more, for example one, two, three or four, identical or different radicals R

1

. Preferably, a substituted radical A

1

is substituted by one, two or three, in particular one or two, radicals R

1

. Radicals R

1

are preferably bonded to carbon atoms in A

1

which are not directly adjacent to the carbon atom which carries the group CO—NH. If A

1

is phenyl, radicals R

1

are particularly preferably in the meta-position and/or in the para-position, relative to the carbon atom which carries the group CO—NH. If a phenyl radical representing A

1

carries a radical R

1

, this radical in many cases is particularly advantageously present in the para-position. If a phenyl radical representing A

1

carries a trifluoromethyl group as a radical R

1

, this is preferably in the meta-position. If a phenyl radical representing A

1

carries two radicals R

1

representing chlorine, the two chlorine atoms are preferably in positions 3 and 4.

Preferred radicals R

1

are halogen, in particular chlorine, trifluoromethyl, (C

3

-C

7

)-alkyl, carboxymethyl, CONR

5

R

6

, 5-membered to 7-membered heterocyclyl, —O-aryl, —CO—(C

1

-C

10

)-alkyl, —CO-aryl, —NH—CO—(C

1

-C

10

)-alkyl, —NH—CO-aryl, —N(CO—(C

1

-C

10

)-alkyl)

2

, —N(CO-aryl)

2

, —NH—SO

2

—(C

1

-C

10

)-alkyl, —NH—SO

2

-aryl, —N(SO

2

-aryl)

2

and —N(SO

2

—(C

1

-C

10

)-alkyl)

2

, where all alkyl radicals can be substituted by one or more identical or different radicals R

4

. In a group CONR

5

R

6

representing R

1

, R

5

and R

6

, together with the nitrogen atom to which they are bonded, preferably form a 5-membered to 8-membered saturated or partially unsaturated ring, which in addition to the nitrogen atom carrying the groups R

5

and R

6

can also contain one or more further ring heteroatoms from the group consisting of N, O and S and which can be substituted as indicated above by one or more identical or different substituents. A group of particularly preferred radicals R

1

is formed by the radicals halogen, in particular chlorine, trifluoromethyl, —O-aryl, —NH—CO—(C

1

-C

10

)-alkyl, —NH—CO-aryl, —NH—SO

2

—(C

1

-C

10

)-alkyl and —NH—SO

2

-aryl, where all alkyl radicals can be substituted by one or more identical or different radicals R

4

. A further group of particularly preferred radicals R

1

is formed by the radicals CONR

5

R

6

, —CO—(C

1

-C

10

)-alkyl, —CO-aryl, —NH—CO—(C

1

-C

10

)-alkyl, —NH—CO-aryl, —N(CO—(C

1

-C

10

)-alkyl)

2

, —N(CO-aryl)

2

, —NH—SO

2

—(C

1

-C

10

)-alkyl, —NH—SO

2

-aryl, —N(SO

2

-aryl)

2

and —N(SO

2

—(C

1

-C

10

)-alkyl)

2

, where all alkyl radicals can be substituted by one or more identical or different radicals R

4

.

R

2

is preferably aryl, particularly preferably phenyl or 5-membered or 6-membered heteroaryl, where the radicals can be unsubstituted or substituted as indicated above. Very particularly preferably, R

2

is phenyl, thienyl or pyrazolyl, which can all in each case be substituted by one or two identical or different radicals from the group consisting of halogen, CF

3

and (C

1

-C

3

)-alkyl.

The rings representing A

2

can be unsubstituted, that is only carry R

3

representing hydrogen, or be substituted as indicated, that is carry one or more radicals R

3

other than hydrogen. The other substituent positions on the ring A

2

, which do not carry any radical R

3

other than hydrogen, carry hydrogen atoms. If the ring A

2

carries one or more radicals R

3

which are other than hydrogen, it preferably carries one or two radicals R

3

of this type, in particular one radical R

3

of this type. Radicals R

3

of this type are preferably present in those positions of the ring A

2

which are not directly adjacent to the groups CO—NH and R

2

SO

2

—NH. If A

2

is a saturated or partially unsaturated carbocycle, R

3

of this type is preferably (C

1

-C

4

)-alkyl, in particular methyl. If A

2

is an aromatic ring, in particular if A

2

is a benzene ring, R

3

of this type is preferably (C

1

-C

3

)-alkyl, methoxy, halogen or CF

3

, particularly preferably methyl or chlorine. If A

2

is an aromatic ring, in particular a benzene ring, it is very particularly preferred if this carries one chlorine atom as a substituent, that is if one radical R

3

representing chlorine is present and the other substituent positions on the benzene ring carry hydrogen atoms. If A

2

is a benzene ring, radicals R

3

other than hydrogen are preferably in positions 4 and/or 5. If only one radical R

3

of this type is present on a benzene ring representing A

2

, this radical is preferably present in position 5 (relative to the group CO—NH in the 1-position).

If a group is substituted by one or more radicals R

4

, it is preferably substituted by one, two or three, in particular one or two, identical or different radicals R

4

. R

4

is preferably hydroxyl, (C

1

-C

4

)-alkyloxy, di-((C

1

-C

4

)-alkyl)amino or heteroaryl.

R

5

and R

6

are preferably independently of one another hydrogen, (C

1

-C

9

)-alkyl, —(C

1

-C

3

)-alkyl-O—(C

1

-C

4

)-alkyl or 5-membered or 6-membered aryl or, together with the nitrogen atom carrying R

5

and R

6

, form a 5-membered to 7-membered heterocycle which additionally to the nitrogen atom carrying the groups R

5

and R

6

can also contain a further ring heteroatom from the group consisting of N, O and S and which can be substituted by one or more, for example one, two, three or four, identical or different radicals as indicated above, in particular by radicals from the group consisting of (C

1

-C

3

)-alkyl, 5-membered aryl and 6-membered aryl. Particularly preferably, R

5

and R

6

, together with the nitrogen atom carrying them, form a 5-membered to 7-membered heterocycle which in addition to the nitrogen atom carrying the groups R

5

and R

6

can also contain a further ring heteroatom from the group consisting of N, O and S and which can be substituted by one or more, for example one, two, three or four, identical or different radicals as indicated above, in particular by radicals from the group consisting of (C

1

-C

3

)-alkyl, 5-membered aryl and 6-membered aryl. Very particularly preferably, such a ring, which is formed from R

5

and R

6

together with the nitrogen atom carrying them, is derived from morpholine, thiomorpholine, 1,1-dioxo-thiomorpholine, 1-oxothiomorpholine, 3,5-dimethylmorpholine, cis-3,5-dimethylmorpholine, 1-(pyrimidin-2-yl)piperazine, piperidin-4-carboxamide, 1-(2-hydroxyethyl)piperazine, 1-methylpiperazine, 1-ethylpiperazine, from 1-arylpiperazines, from ethyl piperazine-1-carboxylate, piperidine, 2-methylpiperidine, 4-hydroxypiperidine, from 4-oxopiperidine or a ketal thereof such as 1,4-dioxa-8-azaspiro[4.5]decane, from tetrahydropyridine, tetrahydropyrimidine, 1-methylhomopiperazine, thiazolidine, pyrroline, 3-hydroxypyrrolidine, 1,2,3,4-tetrahydroisoquinoline or 2,3-dihydro-1H-isoindole, where the ring is bonded via the ring nitrogen atom or, in the case of the piperazine derivatives, via the nonsubstituted ring nitrogen atom. Especially preferably, such a ring which is formed from R

5

and R

6

together with the nitrogen atom carrying them is derived from morpholine, thiomorpholine, 1,1-dioxothiomorpholine, 1-oxothiomorpholine, 3,5-dimethylmorpholline, cis-3,5-dimethylmorpholine, 1-(pyrimidin-2-yl)-piperazine, piperidine-4-carboxamide, 1,2,3,4-tetrahydroisoquinoline or 2,3-dihydro-1H-isoindole.

R

8

is preferably hydrogen, (C

1

-C

3

)-alkyl, di-((C

1

-C

4

)-alkyl)amino or —(C

1

-C

3

)-alkyl-O—(C

1

-C

4

)-alkyl.

R

9

is preferably hydrogen, (C

1

-C

3

)-alkyl or acetyl.

Aryl is preferably phenyl or heteroaryl, in particular phenyl or 5-membered or 6-membered heteroaryl. Preferred substituents in aryl radicals are halogen, CF

3

, (C

1

-C

3

)-alkyl, cyano, nitro and (C

1

-C

3

)-alkyloxy, particularly preferred substituents are CF

3

, chlorine, methyl and methoxy.

Heteroaryl preferably represents radicals which are derived from the heteroaromatics thiophene, pyrazole, thiazole, oxazole, pyridine, pyrimidine, pyridazine and tetrazole.

Heterocyclyl preferably represents radicals which are derived from saturated heterocycles, in particular radicals which are derived from pyrrolidine, piperidine, from N-alkylpiperazines, from morpholine, from dialkylmorpholines, from thiomorpholine or tetrahydrofuran.

If a group S(O)

n

is bonded to a nitrogen atom, the number n therein is preferably 1 or 2, particularly preferably 2.

Preferred compounds according to the present invention are compounds of the formula I in which one or more of-the radicals contained therein have preferred meanings, where all combinations of preferred substituent definitions are the subject of the present invention. Also, of all preferred compounds of the formula I, the present invention relates to all their stereoisomeric forms and mixtures thereof in all ratios, and their physiologically tolerable salts. A group of preferred compounds according to the present invention is formed, for example, from those compounds of the formula I in which A

1

is phenyl which carries a radical R

1

in the 4-position; the ring A

2

which includes the carbon atoms which carry the groups CO—NH— and NH—SO

2

R

2

is a benzene ring or a thiophene ring; and R

1

is a substituent from the group consisting of CO—(C

1

-C

10

)-alkyl, CO-aryl, CO—NR

5

R

6

, —NH—CO—(C

1

-C

10

)-alkyl, —NH—CO-aryl, —N(CO—(C

1

-C

10

)-alkyl)

2

, —N(CO-aryl)

2

, —NH—SO

2

—(C

1

-C

10

)-alkyl, —NH—SO

2

-aryl, —N(SO

2

—(C

1

-C

10

)-alkyl)

2

and —N(SO

2

-aryl)

2

, in which all alkyl radicals can be substituted by one or more identical or different radicals R

4

; in all their stereoisomeric forms and mixtures thereof in all ratios, and their physiologically tolerable salts.

Compounds of the formula I can be prepared according to or analogously to the processes described in the literature. Reference is expressly made here to the corresponding contents of documents in which compounds of the formula I are already described, for example DE-A-35 23 705 and its equivalents. The respective contents of these documents is part of the present disclosure. The preparation of compounds of the formula I is moreover explained below.

According to scheme 1, an aminocarboxylic acid of the formula II can first be reacted with a sulfonyl chloride of the formula R

2

—SO

2

—Cl or a sulfonic anhydride in the presence of a base in a solvent such as water, pyridine or an ether.

Suitable bases are inorganic bases such as, for example, sodium carbonate or organic bases such as, for example, pyridine or triethylamine. The sulfonylaminocarboxylic acid of the formula III obtained can then be activated, for example, by reaction with a chlorinating agent such as, for example, phosphorus pentachloride, phosphorus oxychloride or thionyl chloride in an inert solvent to give an acid chloride of the formula IV and then reacted with an arylamine. The activation of the carboxylic acid group in the compound of the formula III, however, can also be carried out in another way, for example by one of the numerous methods familiar to the person skilled in the art, which are used in peptide chemistry for the linkage of amide bonds, for example by conversion into a mixed anhydride or an activated ester or using a carbodiimide such as dicyclohexylcarbodiimide.

The reaction of the activated sulfonylaminocarboxylic acid with an arylamine is advantageously carried out in an inert solvent such as, for example, pyridine, tetrahydrofuran or toluene with without without addition of an inert auxiliary base, for example of a tertiary amine or of pyridine. If the arylamine employed in the reaction with the activated carboxylic acid already contains the desired substituent(s) R

1

in the group A

1

, i.e., if the arylamine has the formula A

1

-NH

2

in which the group A

1

as indicated above can contain one or more substituents R

1

, the reaction thus leads directly to the final product of the formula I. The activated carboxylic acids, however, can also first be reacted with an arylamine of the formula R

1a

—A

1

—NH

2

, in which R

1a

is hydrogen or one or more of the groups R

1

which can be contained as substituents in A

1

, or R

1a

is one or more groups which can be converted into groups R

1

according to the above definition. For example, R

1a

can be a hydrogen atom which is replaced in an electrophilic reaction by another radical such as, for example, a halogen atom or an aldehyde group, or an ester group which is converted into an amide group. The conversion of the reaction product of the formula V first obtained into a compound of the formula I can be carried out by standard processes.

Compounds of the formula I can also be obtained, for example, by first activating a suitably substituted nitrocarboxylic acid of the formula VI, for example by conversion into the corresponding acid chloride of the formula VII or in another way, and then reacted, for example, with a substituted arylamine of the formula A

1

—NH

2

analogously to the processes described above (see Scheme 2).

Before the nitro group is reduced to the amino group in the nitro intermediate products of the formula VIII obtained, the activating action of the nitro group on the ring A

2

can be utilized and a suitable radical R

3

, for example a halogen atom, can be replaced by another radical R

3

by reaction with a nucleophile, for example an amine. The reduction of the nitro group to the amino group can be carried out, for example, by catalytic hydrogenation in the presence of a noble metal catalyst or preferably in the presence of Raney nickel in a solvent such as ethanol, glacial acetic acid or ethanolic hydrochloric acid, or by reduction with a base metal such as tin, zinc or iron in the presence of acid. The reduction can also be carried out, for example, with tin(II) chloride or by reaction with sodium dithionite, advantageously, for example, in a mixture of methanol, tetrahydrofuran and water as the solvent. The sulfonylation of the amino group in the reduction product of the formula IX using an activated sulfonic acid derivative analogously to the reactions described above, for example using a sulfonyl chloride in the presence of pyridine, finally affords the compound of the formula I. Instead of an arylamine of the formula A

1

—NH

2

, an arylamine of the formula R

1a

—A

1

—NH

2

can also in turn be employed, in which R

1a

has the meaning indicated above, and the group or the groups R

1a

are then converted into the group or the groups R

1

.

All reactions for the synthesis of the compounds of the formula I are well known per se to the person skilled in the art and can be carried out under standard conditions. Details to this end are found, for example, in Houben-Weyl, Methoden der Organischen Chemie [Methods of Organic Chemistry], Thieme-Verlag, Stuttgart, or Organic Reactions, John Wiley & Sons, New York. Depending on the conditions in the individual case, it can also be advantageous or necessary, in order to avoid side reactions in the synthesis of the compounds of the formula I, to temporarily block certain functional groups by the introduction of protective groups and later to liberate them again or first to employ functional groups in the form of precursors from which the desired functional group is then produced in a later step. Such synthesis strategies and the protective groups or precursors suitable for the individual case are known to the person skilled in the art. The compounds of the formula I obtained can optionally be purified by customary purification methods, for example by recrystallization or chromatography. Starting compounds for the preparation of the compounds of the formula I are commercially obtainable or can be prepared according to or analogously to literature procedures.

The compounds of the formula I bring about an increase in the cGMP concentration by means of the activation of soluble guanylate cyclase (sGC) and are therefore valuable agents for the therapy and prophylaxis of diseases which are associated with a low or reduced cGMP level or are caused by such a level or for whose therapy or prophylaxis an increase or normalization in the cGMP level present is desired. The activation of sGC by the compounds of the formula I can be investigated, for example, in the activity assay described below.

Diseases and pathological conditions which are associated with a low cGMP level or in which an increase or normalization in the cGMP level is desired and for whose therapy and prophylaxis compounds of the formula I can be employed are, for example, cardiovascular disorders such as endothelial dysfunction, diastolic dysfunction, atherosclerosis, high blood pressure, stable and unstable angina pectoris, thromboses, restenoses, myocardial infarct, strokes, cardiac insufficiency or pulmonary hypertension, or, for example, erectile dysfunction, bronchial asthma, chronic renal insufficiency and diabetes. Compounds of the formula I can moreover be employed in the therapy of liver cirrhosis and for improving restricted learning capacity or memory power. Preferably, the compounds of the formula I are employed in cardiovascular disorders such as endothelial dysfunction, diastolic dysfunction, atherosclerosis, high blood pressure, stable and unstable angina pectoris, thromboses, restenoses, myocardial infarct, strokes, cardiac insufficiency or pulmonary hypertension, in erectile dysfunction or for improving restricted learning capacity or memory power.

The compounds of the formula I and their physiologically tolerable salts can thus be used in animals, preferably in mammals, and in particular in man, as pharmaceuticals on their own, in mixtures with one another or together with other active compounds. The present invention therefore in particular also relates to the use of compounds of the formula I and their physiologically tolerable salts for the production of a medicament for the therapy or prophylaxis of the abovementioned syndromes, and the use for the production of a medicament for increasing or normalizing a disturbed cGMP balance. The invention likewise relates to the use of the compounds of the formula I and their physiologically tolerable salts for the activation of soluble guanylate cyclase, their use for the therapy or prophylaxis of the abovementioned syndromes and their use for increasing or normalizing a disturbed cGMP balance.

Pharmaceuticals according to the present invention can be administered orally, for example in the form of pills, tablets, film-coated tablets, coated tablets, granules, hard and soft gelatin capsules, aqueous, alcoholic or oily solutions, syrups, emulsions or suspensions, or rectally, for example in the form of suppositories. Administration, however, can also be carried out parenterally, for example subcutaneously, intramuscularly or intravenously in the form of injection solutions or infusion solutions. Further possible administration forms are, for example, percutaneous or topical application, for example in the form of ointments, tinctures, sprays or transdermal therapeutic systems, or administration by inhalation in the form of nasal sprays or aerosol mixtures, or, for example, microcapsules, implants or rods. The preferred administration form depends, for example, on the disease to be treated and its severity.

The medicaments according to the invention can be produced according to known standard processes for the production of pharmaceutical preparations. For this, one or more compounds of the formula I and/or their physiologically tolerable salts are brought, together with one or more solid or liquid pharmaceutical vehicles and/or additives or auxiliaries and, if desired, in combination with other pharmaceutical active compounds having therapeutic or prophylactic action, into a suitable administration form or dose form, which can then be used as a pharmaceutical in human or veterinary medicine. The pharmaceutical preparations contain a therapeutically or prophylactically active dose of the compounds of the formula I and/or their physiologically tolerable salts, which normally makes up 0.5 to 90% by weight of the pharmaceutical preparation.

For the production, for example, of pills, tablets, coated tablets and hard gelatin capsules, it is possible to use lactose, starch, for example corn starch, or starch derivatives, talc, stearic acid or its salts, etc. Vehicles for soft gelatin capsules and suppositories are, for example, fats, waxes, semisolid and liquid polyols, natural or hardened oils etc. Suitable vehicles for the preparation of solutions, for example injection solutions, or of emulsions or syrups are, for example, water, physiological saline solution, alcohols such as ethanol, glycerol, polyols, sucrose, invert sugar, glucose, mannitol, vegetable oils etc. The compounds of the formula I and their physiologically tolerable salts can also be lyophilized and the lyophilizates obtained used, for example, for the production of injection preparations or infusion preparations. Suitable vehicles for microcapsules, implants or rods are, for example, copolymers of glycolic acid and lactic acid.

In addition to the active compounds and vehicles, the pharmaceutical preparations can additionally contain customary additives, for example fillers, disintegrants, binders, lubricants, wetting agents, stabilizers, emulsifiers, dispersants, preservatives, sweetening agents, colorants, flavorings or aromatizers, thickening agents, diluents, buffer substances, furthermore solvents or solubilizers or agents for achieving a depot effect, salts for altering the osmotic pressure, coating agents or antioxidants.

The dose of the active compound of the formula I to be administered and/or of one of [lacuna] physiologically tolerable salts depends on the individual case and is to be suited to the individual conditions as customary for an optimal action. Thus it depends on the nature and severity of the disease to be treated, on the sex, age, weight and individual responsiveness of the human or animal to be treated, on the potency and duration of action of the compounds employed, on whether the therapy is acute or chronic or prophylaxis is carried out, or on whether further active compounds are administered in addition to compounds of the formula I. In general, a daily dose of approximately 0.01 to 100 mg/kg, preferably 0.1 to 10 mg/kg, in particular 0.3 to 5 mg/kg (in each case mg/kg of body weight) is appropriate in the case of administration to an adult of about 75 kg in weight to achieve the desired action. The daily dose can be administered in a single dose or, in particular in the case of administration of relatively large amounts, divided into a number of, for example two, three or four, individual doses. If appropriate, depending on individual behavior, it may be necessary to deviate upward or downward from the daily dose indicated. Pharmaceutical preparations normally contain 0.2 to 500 mg, preferably 1 to 200 mg, of active compound of the formula I and/or its physiologically tolerable salts.

The compounds of the formula I activate soluble guanylate cyclase, especially by binding in the heme binding pocket of the enzyme. On account of this property, apart from as pharmaceutical active compounds in human medicine and veterinary medicine, they can also be employed as a scientific tool or as an aid for biochemical investigations in which an effect on guanylate cyclase of this type is intended, and also for diagnostic purposes, for example in the in vitro diagnosis of cell or tissue samples. In addition, the compounds of the formula I and their salts, as already mentioned above, can serve as intermediates for the preparation of further pharmaceutical active compounds.

In addition to already known compounds, the formula I with the above general definition of the radicals also includes compounds which have not yet been described. The present invention also relates to the not yet known compounds of the formula I as such. The present invention thus also relates to compounds of the formula Ii

in which

the ring A

2

, which includes the carbon atoms which carry the groups CO—NH— and NH—SO

2

R

2

, is a benzene ring or a thiophene ring;

R

1

is a substituent from the group consisting of CO—(C

1

-C

10

)-alkyl, CO-aryl, CO—NR

5

R

6

, —NH—CO—(C

1

-C

10

)-alkyl, —NH—CO-aryl, —N(CO—(C

1

-C

10

)-alkyl)

2

, —N(CO-aryl)

2

, —NH—SO

2

—(C

1

-C

10

)-alkyl, —NH—SO

2

-aryl, —N(SO

2

—(C

1

-C

10

)-alkyl)

2

and —N(SO

2

-aryl)

2

, in which all alkyl radicals can be substituted by one or more identical or different radicals R

4

;

R

2

is aryl, heterocyclyl or NR

5

R

6

;

R

3

is one or more identical or different substituents from the group consisting of hydrogen, halogen, CF

3

, OH, —O—(C

1

-C

7

)-alkyl-R

7

, —O-aryl, SH, —S—(C

1

-C

10

)-alkyl, —S—(C

1

-C

7

)-alkyl-R

7

, —S-aryl, (C

1

-C

2

)-alkylenedioxy, CN, NO

2

, NR

8

R

9

, CO—NR

5

R

6

, COOH, CO—O—(C

1

-C

5

)-alkyl, heterocyclyl, S(O)

n

—(C

1

-C

7

)-alkyl, S(O)

n

-aryl, S(O)

n

—NR

5

R

6

and (C

1

-C

7

)-alkyl which can be substituted by one or more identical or different radicals R

4

;

R

4

is fluorine, OH, —O—(C

1

-C

10

)-alkyl, —O—(C

1

-C

7

)-alkyl-R

7

, —O-aryl, SH, —S—(C

1

-C

10

)-alkyl, —S—(C

1

-C

7

)-alkyl-R

7

, —S-aryl, —P(O)(O—(C

1

-C

5

)-alkyl)

2

, —P(O)(OH)

2

, CN, NR

8

R

9

, CO—NH

2

, CO—NH—(C

1

-C

3

)-alkyl, CO—N((C

1

-C

3

)-alkyl)

2

, COOH, CO—O—(C

1

-C

5

)-alkyl, heterocyclyl or oxo;

R

5

is hydrogen, (C

1

-C

10

)-alkyl which can be substituted by one or more identical or different substituents R

4

and/or by aryl, or is aryl, heterocyclyl, CO—(C

1

-C

10

)-alkyl, CO-aryl, CO-heterocyclyl, SO

2

—(C

1

-C

10

)-alkyl, SO

2

-aryl or SO

2

-heterocyclyl;

R

6

, independently of R

5

, has one of the meanings indicated for R

5

, or R

5

and R

6

, together with the nitrogen atom to which they are bonded, form a 5-membered to 8-membered saturated or partially unsaturated ring, which in addition to the nitrogen atom carrying the groups R

5

and R

6

can also contain one or more further ring heteroatoms from the group consisting of N, O and S and which can be substituted by one or more identical or different substituents from the group consisting of fluorine, (C

1

-C

5

)-alkyl, (C

1

-C

3

)-hydroxyalkyl, —(C

1

-C

3

)-alkyl-O—(C

1

-C

4

)-alkyl, aryl, CF

3

, OH, —O—(C

1

-C

7

)-alkyl, —O-aryl, —O—(C

2

-C

4

)-alkyl-O—(C

1

-C

7

)-alkyl, (C

2

-C

3

)-alkylenedioxy, NR

8

R

9

, CN, CO—NH

2

, CO—NH—(C

1

-C

3

)-alkyl, CO—N((C

1

-C

3

)-alkyl)

2

, COOH, CO—O—(C

1

-C

5

)-alkyl, CHO, CO—(C

1

-C

5

)-alkyl, S(O)

n

—(C

1

-C

4

)-alkyl, S(O)

n

—NH

2

, S(O)

n

—NH—(C

1

-C

3

)-alkyl, S(O)

n

—N((C

1

-C

3

)-alkyl)

2

, oxo, —(CH

2

)

m

—NH

2

, —(CH

2

)

m

—NH—(C

1

-C

4

)-alkyl and —(CH

2

)

m

—N((C

1

-C

4

)-alkyl)

2

, where in the substituent —(CH

2

)

m

—N((C

1

-C

4

)-alkyl)

2

the two alkyl groups can be linked by a single bond and then together with the nitrogen atom carrying them form a 5-membered to 7-membered ring which in addition to the nitrogen atom and the carbon atoms can additionally also contain an oxygen atom, a sulfur atom or a group NR

5

as a ring member;

R

7

is OH, —O—(C

1

-C

7

)-alkyl, NH

2

, —NH—(C

1

-C

4

)-alkyl or —N((C

1

-C

4

)-alkyl)

2

, where in the substituent N((C

1

-C

4

)-alkyl)

2

the two alkyl groups can be linked by a single bond and then together with the nitrogen atom carrying them form a 5-membered to 7-membered ring which in addition to the nitrogen atom and the carbon atoms can additionally also contain an oxygen atom, a sulfur atom or a group NR

5

as a ring member;

R

8

is hydrogen or (C

1

-C

7

)-alkyl which can be substituted by one or more identical or different substituents from the group consisting of OH, —O—(C

1

-C

5

)-alkyl, NH

2

, —NH—(C

1

-C

4

)-alkyl and —N((C

1

-C

4

)-alkyl)

2

, where in the substituent N((C

1

-C

4

)-alkyl)

2

the two alkyl groups can be linked by a single bond and then together with the nitrogen atom carrying them form a 5-membered to 7-membered ring which in addition to the nitrogen atom and the carbon atoms can additionally also contain an oxygen atom, a sulfur atom or a group NR

5

as a ring member;

R

9

, independently of R

8

, has one of the meanings of R

8

or is CO—(C

1

-C

4

)-alkyl;

aryl is phenyl, naphthyl or heteroaryl, which can all be substituted by one or more identical or different substituents from the group consisting of halogen, (C

1

-C

5

)-alkyl, phenyl, tolyl, CF

3

, NO

2

, OH, —O—(C

1

-C

5

)-alkyl, —O—(C

2

-C

4

)-alkyl-O—(C

1

-C

3

)-alkyl, (C

1

-C

2

)-alkylenedioxy, NH

2

, —NH—(C

1

-C

3

)-alkyl, —N((C

1

-C

3

)-alkyl)

2

, NH—CHO, —NH—CO—(C

1

-C

5

)-alkyl, CN, CO—NH

2

, CO—NH—(C

1

-C

3

)-alkyl, CO—N((C

1

-C

3

)-alkyl)

2

, COOH, CO—O—(C

1

-C

5

)-alkyl, heterocyclyl, CHO, CO—(C

1

-C

5

)-alkyl, S(O)

n

—(C

1

-C

4

)-alkyl, S(O)

n

-phenyl, S(O)

n

-tolyl, S(O)

2

—NH

2

, S(O)

2

—NH—(C

1

-C

3

)-alkyl and S(O)

2

—N((C

1

-C

3

)-alkyl)

2

;

heteroaryl is the radical of a monocyclic 5-membered or 6-membered aromatic heterocycle or of a bicyclic 8-membered to 10-membered aromatic heterocycle which in each case contain one or more ring heteroatoms from the group consisting of N, O and S;

heterocyclyl is the radical of a monocyclic or polycyclic, 5-membered to 11-membered saturated or partially unsaturated heterocycle which contains one or more ring heteroatoms from the group consisting of N, O and S and which can be substituted by one or more identical or different substituents from the group consisting of fluorine, (C

1

-C

5

)-alkyl, OH, —O—(C

1

-C

5

)-alkyl, —O—(C

2

-C

4

)-alkyl-O—(C

1

-C

3

)-alkyl, NH

2

, —NH—(C

1

-C

3

)-alkyl, —N((C

1

-C

3

)-alkyl)

2

, CN, CO—NH

2

, CO—NH—(C

1

-C

3

)-alkyl, CO—N((C

1

-C

3

)-alkyl)

2

, COOH and CO—O—(C

1

-C

5

)-alkyl;

n is 0, 1 or 2;

m is 2, 3 or 4;

in all their stereoisomeric forms and mixtures thereof in all ratios, and their physiologically tolerable salts.

All explanations which were given for the compounds of the formula I having the associated definition of the substituents given at the outset also apply, if applicable, correspondingly to the compounds of the formula Ik having the above definition of the substituents. This applies, for example, to the fact that groups and substituents which occur a number of times are all independent of one another, or to all explanations for alkyl groups, aryl groups, heterocyclic radicals, possible substituents, salts, isomers, tautomers, etc. The present invention also includes all salts of the compounds of the formula Ik which, because of low physiological tolerability, are not directly suitable for use in pharmaceuticals, but are suitable, for example, as intermediates for chemical syntheses or for the production of physiologically tolerable salts. As in the compounds of the formula I, the ring A

2

in the compounds of the formula Ik can also, for example, have the meanings shown in the formulae Ia, If, Ig and Ih. All preferred meanings of the radicals in the formula I also apply correspondingly to the radicals in the formula Ik. Likewise, preferred compounds of the formula Ik are those compounds in which one or more of the radicals have preferred meanings, where all combinations of preferred substituent definitions are a subject of the present invention.

Furthermore, the above details for the preparation of the compounds of the formula I and for their biological properties and for their use, and for pharmaceutical preparations comprising them naturally also apply to the compounds of the formulae Ii and Ik. The present invention also relates to processes for the preparation of the compounds of the formulae Ii and Ik defined above by the synthesis process described above, the compounds of the formulae Ii and Ik and their physiologically tolerable salts for use as pharmaceuticals and pharmaceutical preparations which contain an efficacious dose of at least one compound of the formulae Ii or Ik or of a physiologically tolerable salt thereof as active constituent in addition to customary pharmaceutically acceptable vehicles and/or additives.

The following example compounds, which were prepared according to or analogously to processes described in the literature, illustrate the invention without restricting it.

EXAMPLES

1) 2-(4-Chlorophenylsulfonylamino)-N-(3-trifluoromethylphenyl)benzamide M.p.: 169° C.

2) 5-Bromo-2-(4-chlorophenylsulfonylamino)-N-(3-trifluoromethylphenyl)benzamide M.p.: 220° C.

3) 2-(4-Chlorophenylsulfonylamino)-N-(2-naphthyl)benzamide M.p.: 189° C.

4) 5-Chloro-2-(4-chlorophenylsulfonylamino)-N-(3-trifluoromethylphenyl)benzamide M.p.: 216° C.

5) 5-Chloro-2-(4-chlorophenylsulfonylamino)-N-(4-phenoxyphenyl)benzamide M.p.: 205° C.

6) 5-Chloro-2-(4-chlorophenylsulfonylamino)-N-(4-(4-chlorophenoxy)-phenyl)benzamide M.p.: 207° C.

7) 2-(4-Chlorophenylsulfonylamino)-N-(4-phenoxyphenyl)benzamide M.p.: 143° C.

8) 5-Chloro-2-(4-chlorophenylsulfonylamino)-N-(3,4-dichlorophenyl)benzamide M.p.: 244° C.

9) 5-Chloro-2-(4-chlorophenylsulfonylamino)-N-(4-bromophenyl)benzamide M.p.: 210° C.

10) 5-Chloro-2-(4-chlorophenylsulfonylamino)-N-(3-chlorophenyl)benzamide M.p.: 228° C.

11) 5-Chloro-2-(4-chlorophenylsulfonylamino)-N-(4-methoxyphenyl)benzamide M.p.: 190° C.

12) 5-Chloro-2-(4-chlorophenylsulfonylamino)-N-(2-naphthyl)benzamide M.p.: 211° C.

13) 5-Chloro-2-(4-fluorophenylsulfonylamino)-N-(3,5-dichlorophenyl)benzamide M.p.: 250° C.

14) Ethyl 4-(5-chloro-2-(4-chlorophenylsulfonylamino)benzoylamino)benzoate M.p.: 185°

15) 5-Chloro-2-(4-chlorophenylsulfonylamino)-N-(4-(bismethylsulfonylamino)phenyl)benzamide M.p.: 235° C.

16) 5-Chloro-2-(4-chlorophenylsulfonylamino)-N-(4-isopropylphenyl)benzamide M.p.: 188° C.

17) 5-Chloro-2-(3-chloro-4-methoxyphenylsulfonylamino)-N-(4-fluorophenyl)benzamide M.p.: 188° C.

18) Ethyl 2-chloro-5-(5-chloro-2-(3,4-dichlorophenylsulfonylamino)benzoylamino)benzoate M.p.: 202° C.

19) 5-Chloro-2-(4-chlorophenylsulfonylamino)-N-(3-chloro-4-(4-chloronaphthalene-1-yloxy)phenyl)benzamide

20) 2-(4-Chlorophenylsulfonylamino)-5-chloro-N-(4-tert-butylphenyl)benzamide M.p.: 91° C.

21) 5-Chloro-2-(4-chlorophenylsulfonylamino)-N-(4-(morpholin-4-yl)phenyl)benzamide M.p.: 228.5° C.

22) 5-Chloro-2-(4-chlorophenylsulfonylamino)-N-(4-(phenylamino)-phenyl)benzamide M.p.: 192.5° C.

23) 5-Chloro-2-(4-chlorophenylsulfonylamino)-N-(4-(benzyloxy)phenyl)benzamide M.p.: 191° C.

24) 5-Chloro-2-(4-chlorophenylsulfonylamino)-N-(4-acetylphenyl)benzamide M.p.: 226° C.

25) 2-Phenylsulfonylamino-5-chloro-N-(4-(2-oxopyrrolidin-1-yl)phenyl)benzamide M.p.: 218° C.

26) 5-Chloro-2-(4-chlorophenylsulfonylamino)-N-(5-methylpyrazin-3-yl)benzamide M.p.: 248° C.

27) 5-Chloro-2-(4-chlorophenylsulfonylamino)-N-(3-(2-thienyl)pyrazol-5-yl)benzamide M.p.: 117° C.

28) 5-Chloro-2-(4-chlorophenylsulfonylamino)-N-(3,5-bis-trifluoromethylphenyl)benzamide M.p.: 182.5° C.

29) 5-Chloro-2-(4-chlorophenylsulfonylamino)-N-(2-methoxy-5-trifluoromethylphenyl)benzamide M.p.: 164.5° C.

30) 5-Chloro-2-(4-chlorophenylsulfonylamino)-N-(2-trifluoromethylphenyl)benzamide M.p.: 182° C.

31) 5-Chloro-2-(4-chlorophenylsulfonylamino)-N-(3-methoxyphenyl)benzamide M.p.: 163.5° C.

32) 5-Chloro-2-(4-chlorophenylsulfonylamino)-N-(3,5-dimethoxyphenyl)benzamide M.p.: 74.5° C.

33) 5-Chloro-2-(4-chlorophenylsulfonylamino)-N-(4-(morpholine-4-carbonyl)phenyl)benzamide

34) 5-Chloro-2-(4-chlorophenylsulfonylamino)-N-(4-(2,5-dioxopyrrolidin-1-yl)phenyl)benzamide

35) 5-Chloro-2-(4-chlorophenylsulfonylamino)-N-(1H-indol-5-yl)benzamide

36) 5-Chloro-2-(4-chlorophenylsulfonylamino)-N-(quinolin-8-yl)benzamide

37) 5-Chloro-2-(4-chlorophenylsulfonylamino)-N-(4-methyl-2-oxo-2H-chromen-7-yl)benzamide

38) 5-Chloro-2-(4-chlorophenylsulfonylamino)-N-(isoquinolin-5-yl)benzamide

39) 5-Chloro-2-(4-chlorophenylsulfonylamino)-N-(4-ethoxy-2-nitrophenyl)benzamide

40) 5-Chloro-2-(4-chlorophenylsulfonylamino)-N-(2-methoxy-5-nitrophenyl)benzamide

41) 5-Chloro-2-(4-chlorophenylsulfonylamino)-N-(2,5-dimethoxy-4-nitrophenyl)benzamide

42) 5-Chloro-2-(4-chlorophenylsulfonylamino)-N-(2-methoxy-4-nitrophenyl)benzamide

43) 5-Chloro-2-(4-chlorophenylsulfonylamino)-N-(2-cyanophenyl)benzamide

44) 5-Chloro-2-(4-chlorophenylsulfonylamino)-N-(4-cyano-2,3,5,6-tetrafluorophenyl)benzamide

45) 5-Chloro-2-(4-chlorophenylsulfonylamino)-N-(2-(2-hydroxyethyl)-phenyl)benzamide

46) 5-Chloro-2-(4-chlorophenylsulfonylamino)-N-(3-cyanophenyl)benzamide

47) 5-Chloro-2-(4-chlorophenylsulfonylamino)-N-(4-benzoylamino-5-chloro-2-methylphenyl)benzamide

48) 5-Chloro-2-(4-chlorophenylsulfonylamino)-N-(3-(1-hydroxyethyl)-phenyl)benzamide

49) 5-Chloro-2-(4-chlorophenylsulfonylamino)-N-(4-cyanophenyl)benzamide

50) N-(2-Benzoyl4-chlorophenyl)-5-chloro-2-(4-chlorophenylsulfonylamino)benzamide

51) 5-Chloro-2-(4-chlorophenylsulfonylamino)-N-(4-diethylaminophenyl)benzamide

52) N-(4-Butoxyphenyl)-5-chloro-2-(4-chlorophenylsulfonylamino)benzamide

53) 5-Chloro-2-(4-chlorophenylsulfonylamino)-N-(4-hexyloxyphenyl)benzamide

54) Diethyl (4-(5-chloro-2-(4-chlorophenylsulfonylamino)benzoylamino)benzyl)phosphonate

55) 5-Chloro-2-(4-chlorophenylsulfonylamino)-N-(4-pentylphenyl)benzamide

56) 5-Chloro-2-(4-chlorophenylsulfonylamino)-N-(3,4,5-trimethoxyphenyl)benzamide

57) Diethyl 2-(4-(5-chloro-2-(4-chlorophenylsulfonylamino)benzoylamino)benzoylamino)pentanedioate

58) 5-Chloro-2-(4-chlorophenylsulfonylamino)-N-(2-methoxydibenzofuran-3-yl)benzamide

59) Butyl 4-(5-chloro-2-(4-chlorophenylsulfonylamino)benzoylamino)benzoate

60) 5-Chloro-2-(4-chlorophenylsulfonylamino)-N-(2-phenoxyphenyl)benzamide

61) 5-Chloro-2-(4-chlorophenylsulfonylamino)-N-(3-phenoxyphenyl)benzamide

62) 5-Chloro-2-(4-chlorophenylsulfonylamino)-N-(4-hydroxybiphenyl-3-yl)benzamide

63) 5-Chloro-2-(4-chlorophenylsulfonylamino)-N-(4-hydroxy-2-nitrophenyl)benzamide

64) 5-Chloro-2-(4-chlorophenylsulfonylamino)-N-(3-hydroxymethyl-2-methylphenyl)benzamide

65) 5-Chloro-2-(4-chlorophenylsulfonylamino)-N-(5-hydroxymethyl-2-methylphenyl)benzamide

66) 5-Chloro-2-(4-chlorophenylsulfonylamino)-N-(4-(4-methylphenylsulfonylamino)phenyl)benzamide

67) 2-(5-Chloro-2-(4-chlorophenylsulfonylamino)benzoylamino)benzoic acid

68) tert-Butyl (4-(5-chloro-2-(4-chlorophenylsulfonylamino)benzoylamino)phenyl)carbamate

69) 5-Chloro-2-(4-chlorophenylsulfonylamino)-N-(3,4,5-trifluorophenyl)benzamide

70) 5-Chloro-2-(4-chlorophenylsulfonylamino)-N-(4-methyl-2-oxo-1,2-dihydroquinolin-7-yl)benzamide

71) 3-(5-Chloro-2-(4-chlorophenylsulfonylamino)benzoylamino)benzoic acid

72) 2-Diethylaminoethyl 4-(5-chloro-2-(4-chlorophenylsulfonylamino)benzoylamino)benzoate

73) 5-Chloro-2-(4-chlorophenylsulfonylamino)-N-(2-oxo-4-trifluoromethyl-2H-chromen-7-yl)benzamide

74) 5-Chloro-2-(4-chlorophenylsulfonylamino)-N-(2-hydroxymethyl-4-methylphenyl)benzamide

75) 5-Chloro-2-(4-chlorophenylsulfonylamino)-N-(2-(pyrrol-1-yl)phenyl)benzamide

76) 5-Chloro-2-(4-chlorophenylsulfonylamino)-N-(2-methyl-1,3-dioxo-2,3-dihydro-1H-isoindol-5-yl)benzamide

77) Ethyl 3-(5-chloro-2-(4-chlorophenylsulfonylamino)benzoylamino)benzoate

78) N-(Benzo[1,3]dioxol-5-yl)-5-chloro-2-(4-chlorophenylsulfonylamino)benzamide

79) 5-Chloro-2-(4-chlorophenylsulfonylamino)-N-(3-chloro-4-cyanophenyl)benzamide

80) Methyl 2-(5-chloro-2-(4-chlorophenylsulfonylamino)benzoylamino)-4,5-dimethoxybenzoate

81) 5-Chloro-2-(4-chlorophenylsulfonylamino)-N-(3-nitrophenyl)benzamide

82) Methyl 3-(5-chloro-2-(4-chlorophenylsulfonylamino)benzoylamino)benzoate

83) 5-Chloro-2-(4-chlorophenylsulfonylamino)-N-(2-(morpholin4-yl)-5-trifluoromethylphenyl)benzamide

84) N-(1H-Benzotriazol-5-yl)-5-chloro-2-(4-chlorophenylsulfonylamino)benzamide

85) 5-Chloro-2-(4-chlorophenylsulfonylamino)-N-(4-methoxymethyl-2-oxo-2H-chromen-7-yl)benzamide

86) N-(2-(1H-Benzimidazol-2-yl)phenyl)-5-chloro-2-(4-chlorophenylsulfonylamino)benzamide

87) 5-Chloro-2-(4-chlorophenylsulfonylamino)-N-(2-(N-phenylcarbamoyl)phenyl)benzamide

88) N-(3-Benzoylphenyl)-5-chloro-2-(4-chlorophenylsulfonylamino)benzamide

89) Methyl 4-(5-chloro-2-(4-chlorophenylsulfonylamino)benzoylamino)-2-methoxybenzoate

90) 5-Chloro-2-(4-chlorophenylsulfonylamino)-N-(2-carbamoylphenyl)benzamide

91) 5-Chloro-2-(4-chlorophenylsulfonylamino)-N-(4-carbamoylphenyl)benzamide

92) 5-Chloro-2-(4-chlorophenylsulfonylamino)-N-(3-carbamoyl-2-methoxyphenyl)benzamide

93) 5-Chloro-2-(4-chlorophenylsulfonylamino)-N-(3-diethylaminomethyl-4-hydroxyphenyl)benzamide

94) 5-Chloro-2-(4-chlorophenylsulfonylamino)-N-(2,5-diethoxy-4-(morpholin-4-yl)phenyl)benzamide

95) N-(3-Acetylaminophenyl)-5-chloro-2-(4-chlorophenylsulfonylamino)benzamide

96) 3-(4-(5-Chloro-2-(4-chlorophenylsulfonylamino)benzoylamino)phenyl)acrylic acid

97) 5-Chloro-2-(4-chlorophenylsulfonylamino)-N-(4-(cyanophenylmethyl)phenyl)benzamide

98) 5-Chloro-2-4-chlorophenylsulfonylamino)-N-(4-(ethyl(2-hydroxyethyl)amino)phenyl)benzamide

99) 5-Chloro-2-(4-chlorophenylsulfonylamino)-N-(2-(2,4-dichlorophenoxy)phenyl)benzamide

100) 5-Chloro-2-(4-chlorophenylsulfonylamino)-N-(2-oxo-2H-chromen-6-yl)benzamide

101) N-(4-(5-chloro-2-(4-chlorophenylsulfonylamino)benzoylamino)phenyl)oxamide

102) (4-(5-Chloro-2-(4-chlorophenylsulfonylamino)benzoylamino)benzoylamino)acetic acid

103) (4-(5-Chloro-2-(4-chlorophenylsulfonylamino)benzoylamino)phenyl)acetic acid

104) 3-(4-(5-Chloro-2-(4-chlorophenylsulfonylamino)benzoylamino)benzoylamino)propionic acid

105) (4-(5-Chloro-2-(4-chlorophenylsulfonylamino)benzoylamino)benzyl)-phosphonic acid

106) 4-(4-(5-Chloro-2-(4-chlorophenylsulfonylamino)benzoylamino)phenyl)butyric acid

107) 2-(4-(5-Chloro-2-(4-chlorophenylsulfonylamino)benzoylamino)benzoylamino)pentanedioic acid

108) (3-(5-Chloro-2-(4-chlorophenylsulfonylamino)benzoylamino)phenyl)acetic acid

109) 5-Chloro-2-(4-chlorophenylsulfonylamino)-N-(1H-indazol6-yl))benzamide

110) 5-Chloro-2-(4-chlorophenylsulfonylamino)-N-(quinolin-5-yl )benzamide

111) 5-Chloro-2-(4-chlorophenylsulfonylamino)-N-(quinolin-6-yl)benzamide

Pharmacological Investigations

Activation of Soluble Guanylate Cyclase

The activation of soluble guanylate cyclase (sGC), which catalyzes the conversion of guanosine triphosphate (GTP) to cyclic guanosine monophosphate (cGMP) and pyrophosphate, by the compounds according to the invention was quantified with the aid of an enzyme immunoassay (EIA) from Amersham. For this, the test substances were first incubated with sGC in microtiter plates and then the quantity of the resulting cGMP was determined.

The sGC employed had been isolated from bovine lung (see Methods in Enzymology, Volume 195, p. 377). The test solutions (100 μl per well) contained 50 mM triethanolamine (TEA) buffer (pH 7.5), 3 mM MgCl

2

, 3 mM reduced glutathione (GSH), 0.1 mM GTP, 1 mM 3-isobutyl-1-methylxanthine (IBMX), suitably diluted enzyme solution and the test substance or, in the control experiments, solvent. The test substances were dissolved in dimethyl sulfoxide (DMSO) and the solution was diluted with DMSO/water such that the final concentration c of test substance in the test batch had the value indicated below. The DMSO concentration in the test batch was 5% (v/v). The reaction was started by addition of the sGC. The reaction mix was incubated at 37° C. for 15 to 20 minutes and then stopped by ice-cooling and addition of the stop reagent (50 mM EDTA, pH 8.0). An aliquot of 50 μl was taken and employed for the determination of the cGMP content using the acetylation protocol of the Amersham cGMP EIA kit. The absorption of the samples was measured at 450 nm (reference wavelength 620 nm) in a microtiter plate reading apparatus. The cGMP concentration was determined by means of a calibration curve, which was obtained under the same experimental conditions. The activation of the sGC by a test substance is indicated as n-fold stimulation of the basal enzyme activity which was found in the control experiments (with solvent instead of test substance) (calculated according to the formula n-fold stimulation=[cGMP]

test substance

/[cGMP]

control

).

The following results were obtained:

Compound of

Concentration c

n-fold

Example No.

(μM)

stimulation

1

100

3.6

2

100

9.2

3

100

2

4

25

5.5

5

10

9.3

6

100

4.2

7

100

2.8

8

10

5.3

9

100

1.6

10

100

1.7

11

100

1.8

12

25

2.8

13

100

1.8

14

100

1.7

15

10

9.9

16

100

4.1

17

100

2

18

100

3.2

19

100

26.3

21

50

8

23

25

2.2

24

50

2.4

25

50

2.4

33

50

3.8

93

50

1.5

97

12.5

4.9

102

50

1.7

108

50

2.5

111

50

6.1

Claims

1. A method for activating soluble guanylate cyclase, which comprises administering to a host in need of the activation at least one compound of the formula I in any stereoisomeric form, or a physiologically tolerable salt thereof, in which A1 is a radical from the group consisting of phenyl, naphthyl and heteroaryl, which can all be substituted by one or more identical or different radicals R1; the ring A2, which includes the carbon atoms which carry the groups CO—NH—A1 and NH—SO2R2, is a benzene ring, a naphthalene ring, a saturated or partially unsaturated 3-membered to 7-membered carbocycle, a saturated, partially unsaturated or aromatic monocyclic 5-membered to 7-membered heterocycle that contains one or more ring heteroatoms from the group consisting of N, O and S, or a saturated, partially unsaturated or aromatic bicyclic 8-membered to 10-membered heterocycle that contains one or more ring heteroatoms from the group consisting of N, O and S; R1 is halogen, aryl, CF3, NO2, OH, —O—(C1-C7)-alkyl, —O—(C2-C4)-alkyl-O—(C1-C7)-alkyl, —O-aryl, (C1-C2)-alkylenedioxy, NR5R6, CN, CO—NR5R6, COOH, CO—O—(C1-C5)-alkyl, heterocyclyl, CHO, CO—(C1-C10)-alkyl, CO-aryl or (C1-C10)-alkyl that can be substituted by one or more identical or different radicals R4; R2 is aryl, heterocyclyl, NR5R6 or (C1-C10)-alkyl that can be substituted by one or more identical or different radicals R4; R3 is one or more identical or different substituents from the group consisting of hydrogen, halogen, CF3, OH, —O—(C1-C10)-alkyl, —O—(C1-C7)-alkyl-R7, —O-aryl, SH, —S—(C1-C10)-alkyl, —S—(C1-C7)-alkyl-R7, —S-aryl, (C1-C3)-alkylenedioxy, CN, NO2, NR8R9, CO—NR5R6, COOH, CO—O—(C1-C5)-alkyl, heterocyclyl, S(O)n—(C1-C7)-alkyl, S(O)n-aryl, S(O)n—NR5R6 and (C1-C7)-alkyl which can be substituted by one or more identical or different radicals R4; R4 is fluorine, OH, —O—(C1-C10)-alkyl, —O—(C1-C7)-alkyl-R7, —O-aryl, SH, —S—(C1-C10)-alkyl —S—(C1-C7)-alkyl-R7, —S-aryl, —P(O)(O—(C1-C5)-alkyl)2, —P(O)(OH)2, CN, NR8R9, CO—NH2, CO—NH—(C1-C3)-alkyl, CO—N((C1-C3)-alkyl)2, COOH, CO—O—(C1-C5)-alkyl, heterocyclyl or oxo; R5 is hydrogen, (C1-C10)-alkyl which can be substituted by one or more identical or different substituents R4 and/or by aryl, or is aryl, heterocyclyl, CO—(C1-C10)-alkyl, CO-aryl, CO-heterocyclyl, SO2—(C1-C10)-alkyl, SO2-aryl or SO2-heterocyclyl; R6, independently of R5, has one of the meanings indicated for R5, or R5 and R6, together with the nitrogen atom to which they are bonded, form a 5-membered to 8-membered saturated or partially unsaturated ring which, in addition to the nitrogen atom carrying the groups R5 and R6, can also contain one or more further ring heteroatoms from the group consisting of N, O and S and which can be substituted by one or more identical or different substituents from the group consisting of fluorine, (C1-C5)-alkyl, (C1-C3)-hydroxyalkyl, —(C1-C3)-alkyl-O—(C1-C4)-alkyl, aryl, CF3, OH, —O—(C1-C7)-alkyl, —O-aryl, —O—(C2-C4)-alkyl-O—(C1-C7)-alkyl, (C2-C3)-alkylenedioxy, NR8R9, CN, CO—NH2, CO—NH—(C1-C3)-alkyl, CO—N((C1-C3)-alkyl)2, COOH, CO—O—(C1-C5)-alkyl, CHO, CO—(C1-C5)-alkyl, S(O)n—(C1-C4)-alkyl, S(O)n—NH2, S(O)n—NH—(C1-C3)-alkyl, S(O)n—N((C1-C3)-alkyl)2, oxo, —(CH2)m—NH2, —(CH2)m—NH—(C1-C4)-alkyl and —(CH2)m—N((C1-C4)-alkyl)2, where in the substituent —(CH2)m—N((C1-C4)-alkyl)2 the two alkyl groups can be linked by a single bond and then, together with the nitrogen atom carrying them, form a 5-membered to 7-membered ring which, in addition to the nitrogen atom and the carbon atoms, can additionally also contain an oxygen atom, a sulfur atom or a group NR5 as a ring member; R7 is OH, —O—(C1-C7)-alkyl, NH2, —NH—(C1-C4)-alkyl or —N((C1-C4)-alkyl)2, where in the substituent N((C1-C4)-alkyl)2 the two alkyl groups can be linked by a single bond and then, together with the nitrogen atom carrying them, form a 5-membered to 7-membered ring which, in addition to the nitrogen atom and the carbon atoms can additionally also contain an oxygen atom, a sulfur atom or a group NR5 as a ring member; R8 is hydrogen or (C1-C7)-alkyl which can be substituted by one or more identical or different substituents from the group consisting of OH, —O—(C1-C5)-alkyl, NH2, —NH—(C1-C4)-alkyl and —N((C1-C4)-alkyl)2; R9, independently of R8, has one of the meanings of R8 or is CO—(C1-C4)-alkyl; aryl is phenyl, naphthyl or heteroaryl, which can all be substituted by one or more identical or different substituents from the group consisting of halogen, (C1-C5)-alkyl, phenyl, tolyl, CF3, NO2, OH, —O—(C1-C5)-alkyl, —O—(C2-C4)-alkyl-O—(C1-C3)-alkyl, (C1-C2)-alkylenedioxy, NH2, —NH—(C1-C3)-alkyl, —N((C1-C3)-alkyl)2, NH—CHO, —NH—CO—(C1-C5)-alkyl, CN, CO—NH2, CO—NH—(C1-C3)-alkyl, CO—N((C1-C3)-alkyl)2, COOH, CO—O—(C1-C5)-alkyl, heterocyclyl, CHO, CO—(C1-C5)-alkyl, S(O)n—(C1-C4)-alkyl, S(O)n-phenyl, S(O)n-tolyl, S(O)2—NH2, S(O)2—NH—(C1-C3)-alkyl and S(O)2—N((C1-C3)-alkyl)2; heteroaryl is the radical of a monocyclic 5-membered or 6-membered aromatic heterocycle or of a bicyclic 8-membered to 10-membered aromatic heterocycle, each of which contain one or more ring heteroatoms from the group consisting of N, O and S; heterocyclyl is the radical of a monocyclic or polycyclic, 5-membered to 11-membered saturated or partially unsaturated heterocycle which contains one or more ring heteroatoms from the group consisting of N, O and S and which can be substituted by one or more identical or different substituents from the group consisting of fluorine, (C1-C5)-alkyl, OH, —O—(C1-C5)-alkyl, —O—(C2-C4)-alkyl-O—(C1-C3)-alkyl, NH2, —NH—(C1-C3)-alkyl, —N((C1-C3)-alkyl)2, CN, CO—NH2, CO—NH—(C1-C3)-alkyl, CO—N((C1-C3)-alkyl)2, COOH and CO—O—(C1-C5)-alkyl; n is 0, 1 or 2; and m is 2, 3 or 4.
2. The method as claimed in claim 1, in which A1 is phenyl, naphthyl or bicyclic heteroaryl, where these radicals can be unsubstituted or substituted.
3. The method as claimed in claim 1, in which A2 together with the atoms carrying both the group R2—SO2—NH and the group CO-NH-A1 forms an aromatic ring.
4. The method as claimed in claim 1, in which R2 is unsubstituted or substituted aryl.
5. The method as claimed in claim 1, in which A2 together with the atoms carrying both the group R2—SO2—NH and the group CO-NH-A1 forms an unsubstituted or substituted benzene ring and R2 is unsubstituted or substituted aryl.
6. The method as claimed in claim 1, which provides for the therapy in the host of a cardiovascular disorder, endothelial dysfunction, diastolic dysfunction, atherosclerosis, high blood pressure, angina pectoris, thrombosis, restenosis, myocardial infarct, stroke, cardiac insufficiency, pulmonary hypertension, erectile dysfunction, bronchial asthma, chronic renal insufficiency, diabetes or liver cirrhosis or which provides for improving a restricted learning capacity or memory power of the host.
7. A method as claimed in claim 1, wherein the radical A1 is substituted by at least one radical R1, wherein the at least one radical R1 is —O-aryl, wherein aryl is unsubstituted or substituted as defined in claim 1.
8. A method as claimed in claim 11, wherein the at least one radical R1 is —O-phenyl, wherein phenyl is unsubstituted or substituted as defined in claim 1.
9. A method for the therapy of a cardiovascular disorder, endothelial dysfunction, diastolic dysfunction, atherosclerosis, high blood pressure, angina pectoris, thrombosis, restenosis, myocardial infarct, stroke, cardiac insufficiency, pulmonary hypertension, erectile dysfunction, bronchial asthma, chronic renal insufficiency, diabetes or liver cirrhosis or which provides for improving a restricted learning capacity or memory power of the host, which comprises administering to a host in need of the therapy at least one compound of the formula I in any stereoisomeric form, or a physiologically tolerable salt thereof, in which A1 is a radical from the group consisting of phenyl, naphthyl and heteroaryl, which can all be substituted by one or more identical or different radicals R1; the ring A2, which includes the carbon atoms which carry the groups CO—N H—A1 and NH—SO2R2, is a benzene ring, a naphthalene ring, a saturated or partially unsaturated 3-membered to 7-membered carbocycle, a saturated, partially unsaturated or aromatic monocyclic 5-membered to 7-membered heterocycle that contains one or more ring heteroatoms from the group consisting of N, O and S, or a saturated, partially unsaturated or aromatic bicyclic 8-membered to 10-membered heterocycle that contains one or more ring heteroatoms from the group consisting of N, O and S; R1 is halogen, aryl, CF3, NO2, OH, —O—(C1-C7)-alkyl, —O—(C2-C4)-alkyl-O—(C1-C7)-alkyl, —O-aryl, (C1-C2)-alkylenedioxy, NR5R6, CN, CO—NR5R6, COOH, CO—O—(C1-C5)-alkyl, heterocyclyl, CHO, CO—(C1-C10)-alkyl, CO-aryl or (C1-C10)-alkyl which can be substituted by one or more identical or different radicals R4; R2 is aryl, heterocyclyl, NR5R6or (C1-C10)-alkyl that can be substituted by one or more identical or different radicals R4; R3 is one or more identical or different substituents from the group consisting of hydrogen, halogen, CF3, OH, —O—(C1-C10)-alkyl, —O—(C1-C7)-alkyl-R7, —O-aryl, SH, —S—(C1-C10)-alkyl, —S—(C1-C7)-alkyl-R7, —S-aryl, (C1-C3)-alkylenedioxy, CN, NO2, NRNR5R6, COOH, CO—O—(C1-C5)-alkyl, heterocyclyl, S(O)n—(C1-C7)-alkyl, S(O)n-aryl, S(O)n—NR5R6 and (C1-C7)-alkyl that can be substituted by one or more identical or different radicals R4; R4 is fluorine, OH, —O—(C1-C10)-alkyl, —O—(C1-C7)-alkyl-R7, —O-aryl, SH, —S—(C1-C10)-alkyl, —S—(C1-C7)-alkyl-R7, —S-aryl, —P(O)(O—(C1-C5)-alkyl)2, —P(O)(OH)2, CN, NR8R9, CO—NH2, CO—NH—(C1-C3)-alkyl, CO—N((C1-C3)-alkyl)2, COOH, CO—O—(C1-C5)-alkyl, heterocyclyl or oxo; R5 is hydrogen, (C1-C10)-alkyl which can be substituted by one or more identical or different substituents R4 and/or by aryl, or is aryl, heterocyclyl, CO—(C1-C10)-alkyl, CO-aryl, CO-heterocyclyl, SO2—(C1-C10)-alkyl, SO2-aryl or SO2-heterocyclyl; R6, independently of R5, has one of the meanings indicated for R5, or R5 and R6, together with the nitrogen atom to which they are bonded, form a 5-membered to 8-membered saturated or partially unsaturated ring which, in addition to the nitrogen atom carrying the groups R5 and R6 can also contain one or more further ring heteroatoms from the group consisting of N, O and S and which can be substituted by one or more identical or different substituents from the group consisting of fluorine, (C1-C5)-alkyl, (C1-C3)-hydroxyalkyl, —(C1-C3)-alkyl-O—(C1-C4)-alkyl, aryl, CF3, OH, —O—(C1-C7)-alkyl, —O-aryl, —O—(C2-C4)-alkyl-O—(C1-C7)-alkyl, (C2-C3)-alkylenedioxy, NR8R9, CN, CO—NH2, CO—NH—(C1-C3)-alkyl, CO—N((C1-C3)-alkyl)2, COOH, CO—O—(C1-C5)-alkyl, CHO, CO—(C1-C5)-alkyl, S(O)n—(C1-C4)-alkyl, S(O)n—NH2, S(O)n—NH—(C1-C3)-alkyl, S(O)n—N((C1-C3)-alkyl)2,oxo —(CH2)m—NH2, —(CH2)m—NH—(C1-C4)-alkyl and —(CH2)m—N((C1-C4)-alkyl)2, where in the substituent —(CH2)m—N((C1-C4)-alkyl)2 the two alkyl groups can be linked by a single bond and then together with the nitrogen atom carrying them form a 5-membered to 7-membered ring which in addition to the nitrogen atom and the carbon atoms, can additionally also contain an oxygen atom, a sulfur atom or a group NR5 as a ring member; R7 is OH, —O—(C1-C7)-alkyl, NH2, —NH—(C1-C4)-alkyl or —N((C1-C4)-alkyl)2, where in the substituent N((C1-C4)-alkyl)2 the two alkyl groups can be linked by a single bond and then together with the nitrogen atom carrying them form a 5-membered to 7-membered ring which, in addition to the nitrogen atom and the carbon atoms, can additionally also contain an oxygen atom, a sulfur atom or a group NR5 as a ring member; R8 is hydrogen or (C1-C7)-alkyl which can be substituted by one or more identical or different substituents from the group consisting of OH, —O—(C1-C5)-alkyl, NH2, —NH—(C1-C4)-alkyl and —N((C1-C4)-alkyl)2; R9, independently of R8, has one of the meanings of R8 or is CO—(C1-C4)-alkyl; aryl is phenyl, naphthyl or heteroaryl, which can all be substituted by one or more identical or different substituents from the group consisting of halogen, (C1-C5)-alkyl, phenyl, tolyl, CF3, NO2, OH, —O—(C1-C5)-alkyl, —O—(C2-C4)-alkyl-O—(C1-C3)-alkyl, (C1-C2)-alkylenedioxy, NH2, —NH—(C1-C3)-alkyl, —N((C1-C3)-alkyl)2, NH—CHO, —NH—CO—(C1-C5)-alkyl, CN, CO—NH2, CO—NH—(C1-C3)-alkyl, CO—N((C1-C3)-alkyl)2, COOH, CO—O—(C1-C5)-alkyl, heterocyclyl, CHO, CO—(C1-C5)-alkyl, S(O)n—(C1-C4)-alkyl, S(O)n-phenyl, S(O)n-tolyl, S(O)2—NH2, S(O)2—NH—(C1-C3)-alkyl and S(O)2—N((C1-C3)-alkyl)2; heteroaryl is the radical of a monocyclic 5-membered or 6-membered aromatic heterocycle or a bicyclic 8-membered to 10-membered aromatic heterocycle, each of which contain one or more ring heteroatoms from the group consisting of N, O and S; heterocyclyl is the radical of a monocyclic or polycyclic, 5-membered to 11-membered saturated or partially unsaturated heterocycle which contains one or more ring heteroatoms from the group consisting of N, O and S and which can be substituted by one or more identical or different substituents from the group consisting of fluorine, (C1-C5)-alkyl, OH, —O—(C1-C5)-alkyl, —O—(C2-C4)-alkyl-O—(C1-C3)-alkyl, NH2, —NH—(C1-C3)-alkyl, —N((C1-C3)-alkyl)2, CN, CO—NH2, CO—NH—(C1-C3)-alkyl, CO—N((C1-C3)-alkyl)2, COOH and CO—O—(C1-C5)-alkyl; n is 0, 1 or 2; and m is 2, 3 or 4.

Priority Claims (1)

Number	Date	Country	Kind
19830431	Jul 1998	DE

Parent Case Info

This application is a continuation of prior U.S. application Ser. No. 09/743,199, filed on Mar. 8, 2001 now U.S. Pat. No. 6,548,547, (the contents of which are incorporated by reference herein), which is a national stage filing under 35 U.S.C. § 371 of international application no. PCT/EP99/04427, filed on Jun. 25, 1999.

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Continuations (1)

	Number	Date	Country
Parent	09/743199		US
Child	10/349907		US

Sulfonylaminocarboxylic acid N-arylamides as guanylate cyclase activators

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