Zhang et al.(I), “Synthesis and Properties of Novel Thiono Triester Modified Antisense Oligodeoxynucleotide Phosphorothioates,” Bioorganic & Medicinal Chemistry Letters, 5(15), 1735-1740(Aug. 3, 1995).* |
Zhang et al. (II), “Thiono Triester Modified Antisense Oligonucleotides for Inhibition of Human Cytomegalovirus In Vitro,” Bioorganic & Medicinal Chemistry Letters, 6(16), 1911-1916(Aug. 20, 1996).* |
Bokarev et al., “Synthesis of Bis(Alkyl Xanthyl) Trisulfides,” Izv. Akad. Nauk SSR, Ser. Khim., 1964(12), 2175-2182; Chemical Abstracts, 62(7), Abstract No. 7631d (Mar. 29, 1965); only Abstract supplied.* |
Scholl et al., “Novel Symmetrical and Mixed Carbamoyl and Amino Polysulfanes by Reactions of (Alkoxydichloromethyl)polysulfuranyl Substrates with N-Methylaniline,” Journal of Organic Chemistry, 51(10), 1866-1881 (1986).* |
Barany et al., “A General Strategy for Elaboration of the Dithiocarbonyl Functionality, -(C=O)SS-: Application to the Synthesis of Bis(chlorocarbonyl)disulfine and Related Derivatives of Thiocarbonic Acids,” Journal of Organic Chemistry, 48(24), 4750-4761 (Dec. 2, 1983).* |
Tittelbach, “Synthesis and Dimroth Rearrangement of Disubstituted 5-Imino-1,2,4-dithiazolidino-3-thione (Mustard Oil Sulfides),” J. Prakt. Chem., 333(1), 1078-117 (1991); Chemical Abstracts, 115(9), p. 755, Abstract No. 92183c (Sep. 2, 1991); only abstract supplied.†\* |
Tittelbach et al., “Cycloaddition-elimination Reactions of Phenyl Isocyanate with Oxo and Thiono Derivatives of Aliphatic Substituted 5-imino-1,2,4-dithiazolidines and 3-Thiono-1,2,4-thiadiazolidines (Mustard Oil Oxides and Sulfides),” J. Prakt. Chem., 334(8), 685-690 (1992); Chemical Abstracts, 118(19), p. 947, Abstract No. 191647d (May 10, 1993); only abstract supplied.††* |
Vu et al., “Internucleotide Phosphite Sulfurization with Tetraethylthiuram Disulfide. Phosphorothioate Oligonucleotide Synthesis via Phosphoramidite Chemistry,” Tetrahedron Letters, 32(26), 3005-3008 (1991).††* |
Rao et al., “Dibenzoyl Tetrasulfide—A Rapid Sulfur Transfer Agent in the Synthesis of Phosphorotioate Analogues of Oligonucleotides,” Tetrahedron Letters, 33(33), 4839-4842 (1992).††* |
Stec et al., “Bis(O,O-Diisoproxy Phosphinothioyl)Disulfide—A Highly Efficient Sulfurizing Reagent for Cost-Effective Synthesis of Oligo(Nucleoside Phosphorothioate)s,” Tetrahedron Letters, 34(33), 5317-5320 (1993).††* |
Efimov et al., “New Efficient Sulfurizing Reagents for the Preparation of Oligodeoxyribonucleotide Phosphorothioate Analogues,” Nucleic Acids Research, 23(20), 4029-4033 (1995).††* |
PCT International Preliminary Examination Report (PCT Article 36 and Rule 70) International Application No. PCT/US98/10653; Date of Completion of Report: Jul. 22, 1999 (5 pages). |
PCT International Preliminary Examination Report (PCT Article 36 and Rule 70) International Application No. PCT/US98/08763; Date of Completion of Report: 30/07/99 (6 pages). |
Chemical Abstracts, vol. 59, No. 6, Sep. 16, 1963, Columbus, Ohio, US; Abstract No. 6934e, M. Nagasawa et al., “Organophosphorous insecticides containing sulfonyl radicals” and JP 62 015 649 A (Ihara Agricultural Chemical Co.) Oct. 1, 1960. |
Chemical Abstracts, vol. 85, No. 25, Dec. 20, 1976, Columbus, Ohio, US; Abstract No. 187433p, T. Chiyonishio, “Effect of nematicides on the occurrence of black and scurf of Chinese yam in sand dune fields”, p. 112; Col. 1 and Tottori-Ken Nogyo Shikenjo Kenkyu Hokoku, vol. 13, 1973, pp. 29-52. |
Chemical Abstracts, vol. 58, No. 10, May 13, 1963, Columbus, Ohio, US; Abstract No. 10125e, F. Cano et al., “S-Alkyl and arylsulfonyalkyl dithiophosphates” and IT 605 426 A (S.A.R.I.F.) May 27, 1960. |
Chemical Abstracts, vol. 68, No. 7, Feb. 12, 1968, Columbus, Ohio, US; Abstract No. 28718t, T. Saito et al., “Systemic insecticidal properties of certain organic phosporus compounds to the green peach aphid, Myzus persicae, and the tobacco cutworm, Prodenis litura”, p. 2767, Col. 1 and Bochu Kaguku, vol. 31, No. 2, 1966, pp. 77-81. |
Nucleic Acids Research, vol. 24, No. 9, May 1, 1996, XU Q et al., “Use of 1,2,4-dithiazolidine-3,5,-dione (DtsNH) and 3-ethoxy-1,2,4-dithiazoline-5-one (Edith) for synthesis of phosphorothioate-containing oligodeoxyribonucleotides”, pp. 1602-1607. |
Nucleic Acids Research, vol. 24, No. 18, Sep. 15, 1996, Xu Q et al., “Efficient introduction of phosphorothioates into RNA oligonucleotides by 3-ethoxy-1,2,4-dithiazoline-5-one (Edith)”, pp. 3643-3644. |
Journal of Organic Chemistry, vol. 55, No. 15, Jul. 20, 1990, Iyer, R.P. et al., “The Automated synthesis of sulfur-containing oligodeoxyribonucleotides Using 3H- 1,2-Benzodithiol-3-one 1,1,-Dioxide as a Sulfur-Transfer Reagent”, pp. 4693-4699. |