Claims
- 1. A pharmaceutical composition in unit dosage form for treating of immunodeficiency disease causally connected to human immunodeficiency virus, comprising at least one pharmaceutically acceptable excipient and a quantity of a sulfated vinyl polymer active ingredient selected from the group consisting of sulfated polyvinylalcohol and sulfated copolymers of (meth)acrylic acid and vinylalcohol, wherein said sulfated vinyl polymer further has a sulfation degree between 50 and 60%, in an amount which upon administration of one or more unit doses thereof establishes a blood plasma concentration of 0.8-4 .mu.g/ml, effective to treat said immunodeficiency disease, and to demonstrate improved effectiveness against HIV-1 and HIV-2 virus, in a patient to which one or more unit doses are administered.
- 2. The pharmaceutical composition according to claim 1 wherein said active ingredient is a sulfated copolymer of acrylic acid and vinylalcohol in a monomer ratio of about 1:9.
- 3. The pharmaceutical composition according to claim 2 wherein said sulfated copolymer has a molecular weight of about 10,000 and a sulfation degree of about 60%.
- 4. The pharmaceutical composition according to claim 2 wherein said sulfated copolymer has a molecular weight of about 20,000 and a sulfation degree of about 50%.
- 5. The pharmaceutical composition according to claim 1 wherein said active ingredient is a sulfated polyvinylalcohol having a molecular weight of about 20,000 and a sulfation degree of about 50%.
- 6. The pharmaceutical composition as set forth in any one of claims 1-5, wherein said active ingredient is present in a concentration of 0.1 to 100%.
- 7. The pharmaceutical composition as set forth in any one of claims 3-5, wherein said pharmaceutical composition has the form of a powder, suspension, solution, spray, emulsion, unguent or cream.
Priority Claims (1)
Number |
Date |
Country |
Kind |
8900442 |
Feb 1989 |
NLX |
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Parent Case Info
This application is a division of application Ser. No. 07/315,413, filed Feb. 23, 1989, now U.S. Pat. No. 5,152,978.
US Referenced Citations (3)
Number |
Name |
Date |
Kind |
3466365 |
Schlesinger |
Sep 1969 |
|
3702843 |
Schweiger |
Nov 1972 |
|
4762715 |
Lukas et al. |
Aug 1988 |
|
Foreign Referenced Citations (1)
Number |
Date |
Country |
0093489 |
Mar 1986 |
EPX |
Divisions (1)
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Number |
Date |
Country |
Parent |
315413 |
Feb 1989 |
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