Sunscreen compositions

BACKGROUND OF THE INVENTION
This invention relates to new and useful ultraviolet radiation sunscreen agents and compositions and to methods of protecting the human skin against the potentially harmful effects of sunlight.
It is well documented that human skin is sensitive to sunlight containing radiation of wavelengths between about 290 nanometers (nm) and 400 nm as well as artificial light. Ultraviolet radiation of wavelengths between about 290 nm and 320 nm (UV-B region) has been known to rapidly produce damaging effects on the skin including reddening or erythema, edema, blistering or other skin eruptions in more severe cases. Prolonged or chronic exposure to radiation in this wavelength range has been associated with serious skin conditions such as actinic keratoses and carcinomas. In recent years concern has also been expressed regarding ultraviolet radiation of wavelengths above 320 nm (UV-A region) and the adverse effects of such radiation on human skin.
In view of the above, protection from the erythemal effects of sunlight produced by ultraviolet radiation within the UV-B region has been the traditional objective of sunscreen agents and compositions and as a result most compounds utilized as sunscreen agents have had light absorbance maxima within this UV-B region. Recently, as a result of growing concern for damage to the skin in the UV-A region, compounds capable of absorbing ultraviolet radiation in this region of the spectrum are becoming increasingly desirable but are generally unavailable.
Currently, the most widely utilized commercial sunscreen agents include para-amino benzoic acid derivatives, oxybenzones, methoxycinnamates and salicylates.
A desirable sunscreen agent should have absorbance maxima in the range of between 290 nm and 350 nm; have a molar absorptivity of greater than 10,000; be non-toxic, colorless and odorless; be heat and light stable; be water-insoluble and be easily and relatively inexpensively produced. While the readily available commercial sunscreen agents have enjoyed a measure of success, they all lack one or more of the above desirable properties.
OBJECTS OF THE INVENTION
It is an object of the present invention to provide improved sunscreen agents and compositions.
It is another object of the present invention to provide sunscreen compositions containing sunscreen agents that overcome the disadvantages of heretofore available materials and provide adequate and safe protection for human skin.
It is a further object of this invention to provide methods of protecting human skin against the harmful effects of sunlight.
These and other objects and features of the present invention will become readily apparent to one skilled in the art from the detailed description given hereinafter.
SUMMARY OF THE INVENTION
The foregoing objects and other features and advantages of the present invention are achieved by sunscreen compositions containing one or more vinylogous amides as the sunscreen agent.
DETAILED DESCRIPTION OF THE INVENTION
The sunscreen compositions of the present invention contain as an active sunscreen agent at least one vinylogous amide compound of the formula ##STR1## wherein R.sub.1 is selected from alkyl, cycloalkyl, alkenyl, cycloalkenyl, aryl, substituted aryl or alkaryl of from 1 to 18 carbon atoms;
R.sub.2 and R.sub.3 may be the same or different and are selected from hydrogen, alkyl, alkenyl, cycloalkyl or cycloalkenyl of from 1 to 18 carbon atoms;
R.sub.4 and R.sub.5 may be the same or different and are selected from hydrogen, alkyl, alkenyl, aryl and substituted aryl, alkaryl, cycloalkyl or cycloalkenyl of from 1 to 18 carbon atoms; provided that at least one of R.sub.1, R.sub.2, R.sub.3, R.sub.4, or R.sub.5 is interrupted or substituted by N or O. When N is present it may be as primary, secondary, or tertiary amine, quaternary ammonium salt, or amide. When O is present it may be as an alcohol, carboxylic acid or ester, or ether. R.sub.2 together with R.sub.1 and/or R.sub.3 may form carbocyclic and/or heterocyclic rings, and R.sub.4 together with R.sub.5 may form heterocyclic rings.
The vinylogous amides useful in the present invention can be prepared by mixing equivalent amounts of a suitable amine with a suitable .beta.-dicarbonyl compound. This may be done without solvent or with an appropriate amount of a solvent such as lower alcohols, toluene, water or the like. The reaction may require heating, usually at 50.degree. C. to 80.degree. C., for a period of time to complete the reaction.
The vinylogous amides described above include all cis-trans positional isomers thereof.
Specific examples of vinylogous amides which are useful in the present invention include: ##STR2##
The vinylogous amides useful in the formulations of the present invention exhibit light absorbance maxima in either the UV-A or UV-B regions and thus depending on the choice of specific vinylogous amides one can formulate compositions which are effective sunscreens in either of these regions or by selecting a mixture of said vinylogous amides in both regions of the spectrum. It is also possible and may sometimes be desirable to combine the vinylogous amide sunscreen agents with conventional sunscreen agents to form effective sunscreen compositions. Such conventional sunscreen agents include Padimate O (2-ethylhexyl-p-dimethylaminobenzoate), oxybenzone, salicylates and the like.
The sunscreen compositions of the present invention contain the sunscreen agent or combination of sunscreen agents and a pharmaceutically extending medium such as a carrier or vehicle which adapts said agents for application to the skin. These compositions can be in either solid, liquid or aerosol form. The sunscreen agents of the present invention can also be incorporated into various cosmetic and personal care products such as hand and body lotions, oils, ointments lip balm products, facial cosmetics and the like.
The amount of sunscreen agent present in the sunscreen compositions or the cosmetic and personal care products may vary greatly but is preferable in a range of about 1 to 20% by weight of the total composition. One or more sunscreen agents may be utilized with the combined concentration of said agents preferably in the range of 1 to 20% by weight of the composition. Greater amounts of these agents may be incorporated into various products limited only by processing and economic considerations.
Specific embodiments of the present invention are illustrated by the following examples. It will be understood, however, that the invention is not confined to the specific limitations set forth in the individual examples, but rather to the scope of the appended claims.

EXAMPLE I
Preparation of Compound (A)
In a suitable reactor equipped with heating, stirring and reflux facilities are combined under nitrogen atmosphere 100.12 g of pentane-2,4-dione (1.0 mole), 242.08 of aminoethyl lauramide (1.0 mole) and 500 ml methanol. The mixture is heated at the boil for two hours. Removal of the solvent yields 324 g of a compound of the formula ##STR3##
EXAMPLE II
Preparation of Compound (C)
In the reactor of Example I are combined 162.0 g of benzoyl acetone (1.0 mole), 242.0 g of aminoethyl lauramide (1.0 mole) and 700 ml of toluene. The mixture is heated at 80.degree. C. for one hour. After removal of the solvent, there remains 386.0 g of a compound of the formula ##STR4##
EXAMPLE III
Preparation of Compound (E)
In the reactor of Example I are combined 170.0 g of 3-propionyl-2-heptanone (1.0 mole), 61.0 g ethanolamine (1.0 mole) and 500 ml methanol. The mixture is heated at the boil for two hours. Removal of the solvent produces 213.0 g of a compound of the formula ##STR5##
EXAMPLE IV
Preparation of Compound (G)
In a suitable reactor are combined 13.0 g of 1-methoxy-2,4-pentanedione (0.1 mole) and 18.5 g of dodecylamine (0.1 mole). After sufficient heating to melt the reagents, the mixture is heated to 50.degree. C. over a ten minute period. After one hour the mixture cools and yields 29.7 g of a compound of the formula ##STR6##
EXAMPLE V
Preparation of Compound (I)
In a suitable reactor are combined 32.4 g of stearoyl acetone (0.1 mole), 8.7 g of morpholine (0.1 mole) and 100 ml of methanol. The mixture is heated at the boil for two hours. Removal of the solvent produces a compound of formula ##STR7##
EXAMPLE VI
Preparation of Compound (N)
In a suitable reactor are combined 100.12 g of pentane-2,4-dione (1.0 mole), 117.0 g of 6-amino-1-hexanol (1.0 mole) and 300 ml of methanol. The mixture is heated at the boil for two hours. Removal of the solvent yields 199.0 g of a compound of the formula ##STR8##
EXAMPLE VII
Preparation of Compound (O)
19.9 g (0.1 mole) of the product of Example VI in 200 ml of methylene chloride is treated by the gradual addition of 8.4 g (0.1 mole) diketene. When the reaction is complete, 3.1 g of methylamine (0.1 mole) is added and the mixture is heated at the boil for two hours. Removal of the solvent yields a compound of the formula ##STR9##
EXAMPLE VIII
Preparation of Compound (DD)
In a suitable reactor are combined 100.12 g of pentane-2,4-dione (1.0 mole), 75.0 g of glycine (1.0 mole) and 500 ml of water. The mixture is stirred at 60.degree. C. and the pH maintained near 8 until the pH is stable. The mixture is cooled, acidified to pH 3, and evaporated to yield a compound of the formula ##STR10##
EXAMPLE IX
Preparation of Compound (HH)
In a suitable reactor are combined 100.12 g of pentane-2,4-dione (1.0 mole), 286.0 g of the condensation product of lauric acid with aminoethyl ethanolamine (1.0 mole) and 1000 ml of ethanol. The mixture is heated at the boil for four hours. Removal of the solvent yields a compound of the formula ##STR11##
EXAMPLE X
A sunscreen formulation is prepared according to the following procedure. In a suitable beaker, with vigorous agitation, 1.50 g of Carbopol 941 thickening agent, 0.25 g disodium ethylenediamine tetraacetate (disodium EDTA) preservative and chelating agent, 1.00 g Methocel K100LV stabilizer and 0.65 g Kathon CG preservative are added to 354.1 g of deionized water and heated to 70.degree. C. 15.00 g of a 7.5% solution of ammonium hydroxide are added and mixing continues for 5 minutes. In a second beaker, 5.00 g stearyl alcohol emollient, 10.00 g Emerest 2400 emollient, 10.00 g mineral oil emollient, 2.50 g dimethicone emollient, 25.00 g Finsolv TN emollient and 15.00 g isostearic acid emulsifier are heated to 70.degree. C. In a third beaker, 25.00 g of Compound A and 15.00 g of Compound C are premelted at 70.degree. C. and then added to the contents in the second beaker and mixed for five minutes at 70.degree. C. The contents of the second beaker are then added to the first beaker and the resulting emulsion is cooled to 50.degree. C., homogenized, and cooled to room temperature.
The resulting composition is an emulsion which is an opaque, free flowing lotion.
The resulting composition has the following formulation:
______________________________________Ingredient % by wt.______________________________________Carbopol 941 (B. F. Goodrich's 0.30tradename for carboxy vinyl polymer)disodium EDTA 0.05Methocel KIOOLV (Dow Chemical's 0.20tradename for hydroxypropylmethylcellulose)Kathon CG (Rohm & Haas' 0.13tradename for methyl-and methylchloro-isothiazolinones)ammonium hydroxide (7.5%) 3.00stearyl alcohol 1.00Emerest 2400 (Emery Industries 2.00tradename for glycerol stearate)mineral oil 2.00isostearic acid 3.00dimethicone, 50 cs. 0.50Finsolv TN (Finetex's tradename 5.00for C.sub.12 -C.sub.15 alcohol benzoates)Compound A 5.00Compound C 3.00deionized water balance to 100.00______________________________________
EXAMPLE XI
A sunscreen composition is prepared in accordance with the procedure of Example X and consists of the following ingredients:
______________________________________Ingredient % by wt.______________________________________Carbopol 934 (B. F. Goodrich's 0.30tradename for carboxy vinyl polymer)disodium EDTA 0.05Methocel J40MS (Dow Chemical's trade- 0.50name for hydroxypropyl methyl-cellulose)Kathon CG 0.13ammonium hydroxide (7.5%) 3.00stearyl alcohol 1.00Emerest 2400 2.00mineral oil 2.00isostearic acid 3.00dimethicone, 50 cs. 0.50Finsolv TN 5.00BHT (trade usage for butylated 0.05hydroxytoluene)Compound E 5.00Compound C 3.00deionized water balance to 100.00______________________________________
The resulting composition is a white, opaque lotion.
EXAMPLE XII
A sunscreen composition is prepared in accordance with the procedure of Example X and consists of the following ingredients:
______________________________________Ingredient % by wt.______________________________________Carbopol 934 0.30disodium EDTA 0.05Methocel J40MS 0.50Kathon CG 0.13ammonium hydroxide (7.5%) 3.00stearyl alcohol 1.00Emerest 2400 2.00mineral oil 2.00isostearic acid 3.00dimethicone, 50 cs. 0.50Finsolv TN 5.00BHT 0.05Compound G 5.00deionized water balance to 100.00______________________________________
The resulting composition is a white, opaque lotion.
EXAMPLE XIII
A sunscreen composition is prepared in accordance with the procedure of Example X and consists of the following ingredients:
______________________________________Ingredient % by wt.______________________________________Carbopol 934 0.30disodium EDTA 0.05Methocel J40MS 0.50Kathon CG 0.13ammonium hydroxide (7.5%) 3.00stearyl alcohol 1.00Emerest 2400 2.00mineral oil 2.00isostearic acid 3.00dimethicone, 50 cs. 0.50Finsolv TN 5.00BHT 0.05Compound A 5.00Padimate O 4.00deionized water balance to 100.00______________________________________
The resulting composition is a white, opaque lotion.
EXAMPLE XIV
A sunscreen composition is prepared in accordance with the procedure of Example X and consists of the following ingredients:
______________________________________Ingredient % by wt.______________________________________Carbopol 934 0.30disodium EDTA 0.05Methocel J40MS 0.50Kathon CG 0.13ammonium hydroxide (7.5%) 3.00stearyl alcohol 1.00Emerest 2400 2.00mineral oil 2.00isostearic acid 3.00dimethicone, 50 cs. 0.50Finsolv TN 5.00BHT 0.05Compound I 7.00deionized water balance to 100.00______________________________________
The resulting composition is a white, opaque lotion.
EXAMPLE XV
A sunscreen composition is prepared in accordance with the procedure of Example X and consists of the following ingredients:
______________________________________Ingredient % by wt.______________________________________Carbopol 934 0.30disodium EDTA 0.05Methocel J40MS 0.50Kathon CG 0.13ammonium hydroxide (7.5%) 3.00stearyl alcohol 1.00Emerest 2400 2.00mineral oil 2.00isostearic acid 3.00dimethicone, 50 cs. 0.50Finsolv TN 5.00BHT 0.05Compound O 8.00deionized water balance to 100.00______________________________________
The resulting composition is a white, opaque lotion.
EXAMPLE XVI
A sunscreen composition is prepared in accordance with the procedure of Example X and consists of the following ingredients:
______________________________________Ingredient % by wt.______________________________________Carbopol 934 0.30disodium EDTA 0.05Methocel J40MS 0.50Kathon CG 0.13ammonium hydroxide (7.5%) 3.00stearyl alcohol 1.00Emerest 2400 2.00mineral oil 2.00isostearic acid 3.00dimethicone, 50 cs. 0.50Finsolv TN 5.00BHT 0.05Compound HH 5.00Padimate O 3.00deionized water balance to 100.00______________________________________
The resulting composition is a white, opaque lotion.
EXAMPLE XVII
A hand and body lotion composition is prepared as follows:
In a suitable beaker with vigorous agitation, 3.0 g of Carbopol 934 and 40 g propylene glycol are added to 788.7 g deionized water and heated to 70.degree. C. In a second beaker, 10 g isopropylpalmitate, 10.0 g dimethicone (50 cs), 12.5 g oleic acid, 10.0 g stearoxymethylsilane, 8.0 g sorbitan stearate, 5.0 g cetyl alcohol, 5.0 g stearyl alcohol, 5.0 g synthetic beeswax, 12.5 g glyceryl monostearate, 12.5 g stearic acid, 12.0 g polysorbate 61, 15.0 g myristyl myristate, 2.0 g BHT and 3.0 g benzyl alcohol are melted. The contents of the second beaker are added to the contents of the first beaker and to the resultant mixture are added 0.5 g butylparaben, 1.0 g propylparaben and 1.5 g methylparaben followed by the addition of 2.6 g of a 50% solution of sodium hydroxide, 20.0 g of Compound A and 20.0 g of Compound C. The resulting emulsion is homogenized and cooled to 45.degree. C. at which point 2.0 g of fragrance are added followed by cooling to room temperature resulting in a thick, white lotion.
The resulting composition has the following formulation:
______________________________________Ingredients % by wt.______________________________________Carbopol 934 0.30propylene glycol 4.00isopropyl palmitate 1.00dimethicone, 50 cs. 1.00oleic acid 1.25stearoxymethylsilane 1.00sorbitan stearate 0.80cetyl alcohol 0.50stearyl alcohol 0.50synthetic beeswax 0.50glyceryl monostearate 1.25stearic acid 1.25polysorbate 61 1.20myristyl myristate 1.50butylparaben 0.05propylparaben 0.10methylparaben 0.15BHT 0.02sodium hydroxide (50%) 0.26benzyl alcohol 0.30fragrance 0.20Compound A 2.00Compound C 2.00deionized water balance to 100.00______________________________________
EXAMPLE XVIII
A lotion formulation is prepared according to the procedure of Example XVII and consists of the following ingredients:
______________________________________Ingredients % by wt.______________________________________Carbopol 934 0.30propylene glycol 4.00isopropyl palmitate 1.00dimethicone, 50 cs. 1.00oleic acid 1.25stearoxymethylsilane 1.00sorbitan stearate 0.80cetyl alcohol 0.50stearyl alcohol 0.50synthetic beeswax 0.50glyceryl monostearate 1.25stearic acid 1.25polysorbate 61 1.20myristyl myristate 1.50butylparaben 0.05propylparaben 0.10methylparaben 0.15BHT 0.02sodium hydroxide (50%) 0.26benzyl alcohol 0.30fragrance 0.20Padimate O 4.00Compound C 3.00deionized water balance to 100.00______________________________________
The resulting composition is a thick, white lotion.
EXAMPLE XIX
A lotion formulation is prepared according to the procedure of Example XVII and consists of the following ingredients:
______________________________________Ingredients % by wt.______________________________________Carbopol 934 0.30propylene glycol 4.00isopropyl palmitate 1.00dimethicone, 50 cs. 1.00oleic acid 1.25stearoxymethylsilane 1.00sorbitan stearate 0.80cetyl alcohol 0.50stearyl alcohol 0.50synthetic beeswax 0.50glyceryl monostearate 1.25stearic acid 1.25polysorbate 61 1.20myristyl myristate 1.50butylparaben 0.05propylparaben 0.10methylparaben 0.15BHT 0.02sodium hydroxide (50%) 0.26benzyl alcohol 0.30fragrance 0.20octyl salicylate 2.00Compound E 2.00deionized water balance to 100.00______________________________________
The resulting composition is a thick, white lotion.
EXAMPLE XX
A lotion formulation is prepared according to the procedure of Example XVII and consists of the following ingredients:
______________________________________Ingredients % by wt.______________________________________Carbopol 934 0.30propylene glycol 4.00isopropyl palmitate 1.00dimethicone, 50 cs. 1.00oleic acid 1.25stearoxymethylsilane 1.00sorbitan stearate 0.80cetyl alcohol 0.50stearyl alcohol 0.50synthetic beeswax 0.50glyceryl monostearate 1.25stearic acid 1.25polysorbate 61 1.20butylparaben 0.05propylparaben 0.10methylparaben 0.15BHT 0.02sodium hydroxide (50%) 0.26benzyl alcohol 0.30fragrance 0.20Compound O 4.00deionized water balance to 100.00______________________________________
The resulting composition is a thick, white lotion.
EXAMPLE XXI
A lotion formulation is prepared according to the procedure of Example XVII and consists of the following ingredients:
______________________________________Ingredients % by wt.______________________________________Carbopol 934 0.30propylene glycol 4.00isopropyl palmitate 1.00dimethicone, 50 cs. 1.00oleic acid 1.25stearoxymethylsilane 1.00sorbitan stearate 0.80cetyl alcohol 0.50stearyl alcohol 0.50synthetic beeswax 0.50glyceryl monostearate 1.25stearic acid 1.25polysorbate 61 1.20butylparaben 0.05propylparaben 0.10methylparaben 0.15BHT 0.02sodium hydroxide (50%) 0.26benzyl alcohol 0.30fragrance 0.20Compound I 2.00Compound DD 2.00deionized water balance to 100.00______________________________________
The resulting composition is a thick, white lotion.
EXAMPLE XXII
A hand cream composition is prepared according to the following procedure. In a suitable beaker 367.4 g mineral oil, 55.0 g lanolin, 80.0 g white wax, 45.7 g paraffin, 70.0 g synthetic beeswax, 10.0 g glyceryl monostearate and 68.5 g white ceresine wax are melted and kept at a temperature of 70.degree. C. In a second beaker 241.8 g of deionized water, 9.0 g powdered borax and 1.0 g propylparaben are heated to 70.degree. C. and the contents of the first beaker are added to the second beaker and 30 g of Compound A and 20.0 g of Compound C are added thereto. The mixture is cooled to 55.degree. C. and 1.6 g of fragrance are added and the cooling continued to 45.degree. C. and the resulting composition filled in a suitable container and cooled to room temperature.
The resulting composition has the following formulation:
______________________________________Ingredients % by wt.______________________________________mineral oil 36.74lanolin, anhydrous cosmetic grade 5.50white wax, USP 8.00paraffin 4.57synthetic beeswax 7.00glyceryl monostearate 1.00white ceresine wax 6.85powdered borax 0.90fragrance 0.16propylparaben 0.10Compound A 3.00Compound C 2.00deionized water balance to 100.00______________________________________
EXAMPLE XXIII
A hand cream formulation is prepared according to the procedure of Example XXII and consists of the following ingredients:
______________________________________Ingredients % by wt.______________________________________mineral oil 36.74lanolin, anhydrous cosmetic grade 5.50white wax, USP 8.00paraffin 4.57synthetic beeswax 7.00glyceryl monostearate 1.00white ceresine wax 6.85powdered borax 0.90fragrance 0.16propylparaben 0.10Compound AA 3.00deionized water balance to 100.00______________________________________
EXAMPLE XIV
A hand cream formulation is prepared according to the procedure of Example XXII and consists of the following ingredients:
______________________________________Ingredients % by wt.______________________________________mineral oil 36.74lanolin, anhydrous cosmetic grade 5.50white wax, USP 8.00paraffin 4.57synthetic beeswax 7.00glyceryl monostearate 1.00white ceresine wax 6.85powdered borax 0.90fragrance 0.16propylparaben 0.10Compound O 3.00deionized water balance to 100.00______________________________________
EXAMPLE XXV
A hand cream formulation is prepared according to the procedure of Example XXII and consists of the following ingredients:
______________________________________Ingredients % by wt.______________________________________mineral oil 36.74lanolin, anhydrous cosmetic grade 5.50white wax, USP 8.00paraffin 4.57synthetic beeswax 7.00glyceryl monostearate 1.00white ceresine wax 6.85powdered borax 0.90fragrance 0.16propylparaben 0.10octyl salicylate 4.00Compound R 3.00deionized water balance to 100.00______________________________________
EXAMPLE XXVI
A hand cream formulation is prepared according to the procedure of Example XXII and consists of the following ingredients:
______________________________________Ingredients % by wt.______________________________________mineral oil 36.74lanolin, anhydrous cosmetic grade 5.50white wax, USP 8.00paraffin 4.57synthetic beeswax 7.00glyceryl monostearate 1.00white ceresine wax 6.85powdered borax 0.90fragrance 0.16propylparaben 0.10Compound JJ 2.00deionized water balance to 100.00______________________________________
EXAMPLE XXVII
A dry skin composition is prepared in accordance with the following procedure. In a suitable beaker 450.0 g petrolatum, 30.0 g polyethylene and 20.0 g silicon dioxide are melted at 80.degree. C. and homogenized. To this mixture, 338.0 g cyclomethicone, 100.0 g dimethicone, 10.0 g mineral oil, 1.0 g propylparaben, 1.0 g sorbic acid and 50.0 g Compound Q are added and the resultant mixture is cooled to 35.degree. C.
The resulting composition has the following formulation:
______________________________________Ingredients % by wt.______________________________________petrolatum, white USP 45.0polyethylene 3.0silicon dioxide 2.0cyclomethicone 33.8dimethicone, 50 cs. 10.0mineral oil 1.0propylparaben 0.1sorbic acid 0.1Compound O 5.0 100.0______________________________________
EXAMPLE XVIII
A dry skin formulation is prepared according to the procedure of Example XXVII and consists of the following ingredients:
______________________________________Ingredients % by wt.______________________________________petrolatum, white USP 49.0polyethylene 3.0silicon dioxide 2.0cyclomethicone 33.8dimethicone, 50 cs. 10.0mineral oil 1.0propylparaben 0.1sorbic acid 0.1Compound MM 5.0 100.0______________________________________
EXAMPLE XXIX
A dry skin formulation is prepared according to the procedure of Example XXVII and consists of the following ingredients:
______________________________________Ingredients % by wt.______________________________________petrolatum, white USP 45.0polyethylene 3.0silicon dioxide 2.0cyclomethicone 33.8dimethicone, 50 cs. 10.0mineral oil, J & J Special 1.0propylparaben 0.1sorbic acid 0.1Padimate O 3.0Compound C 2.0 100.0______________________________________
EXAMPLE XXX
A dry skin formulation is prepared according to the procedure of Example XXVII and consists of the following ingredients:
______________________________________Ingredients % by wt.______________________________________petrolatum, white USP 45.0polyethylene 3.0silicon dioxide 2.0cyclomethicone 33.8dimethicone, 50 cs. 10.0mineral oil 1.0propylparaben 0.1sorbic acid 0.1oxybenzone 2.0Compound B 3.0 100.0______________________________________
EXAMPLE XXXI
A lip balm composition is prepared according to the following procedure. In a suitable beaker 72.0 g petrolatum, 8.0 g Syncrowax HRC, 8.0 g Syncrowax ERL-C, 8.0 g Syncrowax HGL-C, 2.0 g Compound B and 2.0 g oxybenzone are added. The mixture is melted and cast into sticks at a temperature of 60.degree. C.
The resulting composition has the following formulation:
______________________________________Ingredients % by wt.______________________________________petrolatum, white USP 72.0Syncrowax HRC (Croda's tradename for 8.0glyceryl tribehenate)Syncrowax ERL-C (Croda's tradename for 8.0C.sub.18 -C.sub.36 wax fatty acid-ethylene glycol ester)Syncrowax HGL-C (Croda's tradename for 8.0C.sub.18 -C.sub.36 wax fatty acid triglyceride)Compound B 2.0oxybenzone 2.0 100.0______________________________________
EXAMPLE XXXII
A lip balm composition is prepared according to the procedure of Example XXXI and consists of the following ingredients:
______________________________________Ingredients % by wt.______________________________________petrolatum, white USP 69.0Syncrowax HRC 8.0Syncrowax ERL-C 8.0Syncrowax HGL-C 8.0Compound A 4.0Compound C 3.0 100.0______________________________________
EXAMPLE XXXIII
A lip balm composition is prepared according to the procedure of Example XXXI and consists of the following ingredients:
______________________________________Ingredients % by wt.______________________________________petrolatum, white USP 70.0Syncrowax HRC 8.0Syncrowax ERL-C 8.0Syncrowax HGL-C 8.0Compound M 2.0Padimate O 4.0 100.0______________________________________
EXAMPLE XXXIV
A lip balm composition is prepared according to the procedure of Example XXXI and consists of the following ingredients:
______________________________________Ingredients % by wt.______________________________________petrolatum, white USP 74.0Syncrowax HRC 8.0Syncrowax ERL-C 8.0Syncrowax HGL-C 8.0octyl salicylate 1.0Compound HH 1.0 100.0______________________________________

Number	Name	Date
3816611	Eberhardt et al.	Jun 1974
4042646	Edamura et al.	Aug 1977
4178449	Dusza et al.	Dec 1979

Sunscreen compositions

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