Super resolution and color motion artifact correction in a pulsed color imaging system

Information

  • Patent Grant
  • 10205877
  • Patent Number
    10,205,877
  • Date Filed
    Monday, May 1, 2017
    7 years ago
  • Date Issued
    Tuesday, February 12, 2019
    5 years ago
Abstract
The disclosure extends to methods, systems, and computer program products for producing an image in light deficient environments and associated structures, methods and features. The features of the systems and methods described herein may include providing improved resolution and color reproduction.
Description
STATEMENT REGARDING FEDERALLY SPONSORED RESEARCH OR DEVELOPMENT

Not Applicable.


BACKGROUND

Advances in technology have provided advances in imaging capabilities for medical use. One area that has enjoyed some of the most beneficial advances is that of endoscopic surgical procedures because of the advances in the components that make up an endoscope.


The disclosure relates generally to electromagnetic sensing and sensors. The disclosure also relates generally to increasing the resolution and color accuracy of a video stream. The features and advantages of the disclosure will be set forth in the description which follows, and in part will be apparent from the description, or may be learned by the practice of the disclosure without undue experimentation. The features and advantages of the disclosure may be realized and obtained by means of the instruments and combinations particularly pointed out in the appended claims.





BRIEF DESCRIPTION OF THE DRAWINGS

Non-limiting and non-exhaustive implementations of the disclosure are described with reference to the following figures, wherein like reference numerals refer to like parts throughout the various views unless otherwise specified. Advantages of the disclosure will become better understood with regard to the following description and accompanying drawings where:



FIG. 1 illustrates a flow chart of a method and system for producing an image in a light deficient environment made in accordance with the principles and teachings of the disclosure;



FIG. 2 is an illustration of a schematic of a pixel array configured in an x and y plane;



FIG. 3 is an illustration of a schematic of a pixel array configured in an x and y plane in accordance with the principles and teachings of the disclosure;



FIG. 4 is a graphical representation of an imaged object's motion through time in accordance with the principles and teachings of the disclosure;



FIG. 5 illustrates a schematic of supporting and enabling hardware in accordance with the principles and teachings of the disclosure;



FIGS. 6A and 6B illustrate a perspective view and a side view, respectively, of an implementation of a monolithic sensor having a plurality of pixel arrays for producing a three dimensional image in accordance with the teachings and principles of the disclosure;



FIGS. 7A and 7B illustrate a perspective view and a side view, respectively, of an implementation of an imaging sensor built on a plurality of substrates, wherein a plurality of pixel columns forming the pixel array are located on the first substrate and a plurality of circuit columns are located on a second substrate and showing an electrical connection and communication between one column of pixels to its associated or corresponding column of circuitry; and



FIGS. 8A and 8B illustrate a perspective view and a side view, respectively, of an implementation of an imaging sensor having a plurality of pixel arrays for producing a three dimensional image, wherein the plurality of pixel arrays and the image sensor are built on a plurality of substrates.





DETAILED DESCRIPTION

The disclosure extends to methods, systems, and computer based products for digital imaging that may be primarily suited to medical applications. In the following description of the disclosure, reference is made to the accompanying drawings, which form a part hereof, and in which is shown by way of illustration specific implementations in which the disclosure may be practiced. It is understood that other implementations may be utilized and structural changes may be made without departing from the scope of the disclosure.


For any digital imaging system, the final quality of video depends fundamentally on the engineering details of the front-end image electronic capture process. Broadly speaking, perceived image quality is dependent on the following properties:


Signal to noise ratio (SNR)


Dynamic range (DR)


Spatial resolution


Perception of visible unnatural artifacts


Perception of spatial distortion


Color fidelity and appeal


In general, manufacturers of cameras for many common purposes face continuous pressure toward greater miniaturization and lower cost. Both factors may have a detrimental effect however, on their ability to deliver high quality images.


More expensive cameras often use three monochrome sensors, precisely coupled to an elaborate arrangement of prisms and filters, since that provides for the best spatial resolution and color separation. Color cameras based on a single sensor generally have individual pixel-sized color filters fabricated onto the sensor in a mosaic arrangement. The most popular mosaic is the Bayer pattern, which exploits the fact that spatial resolution is more important for green data than for red or blue. While much cheaper to fabricate, Bayer based cameras cannot achieve the image quality realized by three-sensor solutions because of the spacing of the pattern. Sophisticated interpolation (demosaic) algorithms, such as that proposed by Malvar, He and Cutlar at Microsoft Research, help to reduce the resolution loss, but it can never be fully recovered. Another undesirable side-effect comes in the form of artifacts introduced by the color segmentation pattern, which are especially egregious around black and white edges. This can be addressed by lowering the optical MTF, but that may further degrade the final camera resolution.


If pixel count is a valued trait, that may necessitate smaller pixels in order to make a marketable product. Smaller pixels naturally have lower signal capacity which may reduce the dynamic range. Lower signal capacity also means the maximum possible signal to noise ratio is reduced, since photon shot noise scales as the square root of the signal charge. Lowering the pixel area also reduces the sensitivity, not only in proportion with the capture area, but quite likely at an even greater rate than that. This is because it becomes harder to direct photons into the light sensitive structure and thus to maintain quantum efficiency. Loss of sensitivity may be compensated by lowering the F-number, however, that may reduce the depth of focus (which impacts the resolution), and may lead to greater spatial distortion. Smaller pixels are also harder to manufacture consistently, which may result in greater defect rates, etc.


Rather than making the pixels smaller, it is thus desirable to seek other ways to bolster the resolution. This disclosure concerns an approach in which a monochrome sensor is employed. The color information is produced by illuminating different frames with alternating single wavelengths (i.e. red, green and blue) or combinations thereof. This allows the full pixel count to be exploited and Bayer artifacts to be avoided, as in three-sensor cameras. One issue with the frame-wise color switching arises from motion occurring within the scene, from frame to frame. Since different frames supply different color components, unnatural, colored effects may be visible, particularly in the vicinity of significant edges. Implementations may involve a full custom sensor capable of captured frame rates as high as e.g. 240 fps. Having access to such high rates allows for high progressive video rates (e.g. 60 P or higher), post-color reconstruction. While the high capture rate limits the impact of color motion artifacts, they may still be visible depending on the incident angular rate of motion of the scene, or of any object within it, relative to the sensor.


An implementation may employ an approach to colored frame pulsing in which the red, green and blue monochromatic sources are pulsed in combination. For every second frame, their relative energies are set in proportion to the standard luminance (Y) coefficients, so as to provide direct luminance information. On the alternate frames, the chrominance (Cb and Cr) information is provided by making a linear sum of the standard luminance and chrominance coefficients in order to bring the corresponding individual pulse energies to zero or positive values. The chrominance frames themselves alternate between Cb and Cr. This is referred to herein as the Y-Cb-Y-Cr sequence. This approach offers an advantage in terms of perceived resolution, compared with pure red, green and blue (R-G-B-G) pulsing, since all of the Y information per resulting output frame is derived from a single captured frame. With R-G-B-G pulsing, data is combined from three adjacent frames to provide the luminance. Therefore any motion will impact the resultant image sharpness.


A system designed for small diameter endoscopes with the image sensor placed at the distal end may be realized, which may preserve HD resolution, high inherent dynamic range and high sensitivity at the same time. The basis of this is a specially designed monochrome sensor which has fewer pixels than, e.g., a 1280×720 Bayer sensor, but which has superior spatial resolution by virtue of being monochrome. Maintaining a relatively large pixel at the expense of pixel count has multiple advantages for image quality, as discussed earlier.


In this disclosure, a method is described to further enhance the perceived resolution by applying the principal of super-resolution (SR) and to correct for the color artifacts resulting from the frame-wise modulation of color (CMAC), by making use of the motion information that is extracted by the SR algorithm.


Before the structure, systems and methods for producing an image in a light deficient environment are disclosed and described, it is to be understood that this disclosure is not limited to the particular structures, configurations, process steps, and materials disclosed herein as such structures, configurations, process steps, and materials may vary somewhat. It is also to be understood that the terminology employed herein is used for the purpose of describing particular embodiments only and is not intended to be limiting since the scope of the disclosure will be limited only by the appended claims and equivalents thereof.


In describing and claiming the subject matter of the disclosure, the following terminology will be used in accordance with the definitions set out below.


It must be noted that, as used in this specification and the appended claims, the singular forms “a,” “an,” and “the” include plural referents unless the context clearly dictates otherwise.


As used herein, the terms “comprising,” “including,” “containing,” “characterized by,” and grammatical equivalents thereof are inclusive or open-ended terms that do not exclude additional, unrecited elements or method steps.


As used herein, the phrase “consisting of” and grammatical equivalents thereof exclude any element or step not specified in the claim.


As used herein, the phrase “consisting essentially of” and grammatical equivalents thereof limit the scope of a claim to the specified materials or steps and those that do not materially affect the basic and novel characteristic or characteristics of the claimed disclosure.


As used herein, the term “proximal” shall refer broadly to the concept of a portion nearest an origin.


As used herein, the term “distal” shall generally refer to the opposite of proximal, and thus to the concept of a portion farther from an origin, or a furthest portion, depending upon the context.


As used herein, color sensors or multi spectrum sensors are those sensors known to have a color filter array (CFA) thereon so as to filter the incoming electromagnetic radiation into its separate components. In the visual range of the electromagnetic spectrum, such a CFA may be built on a Bayer pattern or modification thereon in order to separate green, red and blue spectrum components of the light.


In super resolution (SR), data from multiple, adjacent frames are combined to produce individual frames with higher spatial resolution. This depends upon accurate motion detection within local regions of the scene. Since the luminance plane is the most critical for spatial resolution, this is done for luminance frames only (or for green frames in the case of R-G-B-G light pulsing).


The systems and methods disclosed herein will be described in the context of the Y-Cb-Cr light pulsing scheme. However, the systems and methods of the disclosure are not limited or restricted to that particular pulsing scheme and are also applicable to the R-G-B-G image sequence scenario, with G taking the place of Y, and R and B taking the place of Cr and Cb.


There are four types of captured frames. Thus, for example, imagine f is a continuously rotating frame index which repeatedly counts from 0 to 3 during active video capture.


Then:


If (f mod 4)=0 or (f mod 4)=2 it is a Y frame, containing pure luminance information.


If (f mod 4)=1, it is a ‘Cb’ frame, containing a linear sum of Y and Cb data (Cb+Y).


If (f mod 4)=3, it is a ‘Cr’ frame, containing a linear sum of Y and Cr data (Cr+Y).


During frame reconstruction (color fusion), there may be one full color frame (in YCbCr space) generated for each luminance frame at the input. The luminance data may be combined with the chrominance data from the frame prior to and the frame following the Y frame. Note that given this pulsing sequence, the position of the Cb frame with respect to the Y frame ping-pongs between the before and after slots for alternate Y cases, as does its complementary Cr component. Therefore, the data from each captured Cb or Cr (i.e., C) frame may actually be utilized in two resultant full-color images. The minimum frame latency may be provided by performing the color fusion process during C frame capture.



FIG. 1 illustrates a flow chart of a method and system 100 for producing an image, image stream, or video in a light deficient environment made in accordance with the principles and teachings of the disclosure. It will be appreciated that the super resolution (SR) and color motion artifact correction (CMAC) processes 106 may take place within the camera ISP on raw, captured sensor data 102, right after all the digital sensor correction processes 104 and prior to fusion into linear RGB or YCbCr space color images. FIG. 1 illustrates placement of super resolution (SR) and color motion artifact correction (CMAC) within a camera ISP chain designed for frame-wise color modulation with Y-Cb-Y-Cr sequencing.


Two frame FIFOs are constructed, one for Y frames 110 in arrival order, the other for Cb plus Cr frames 108. The number of frames to use for the super resolution (SR) process is an optional variable. The Y FIFO depth would normally be odd in an actual embodiment, and its size would be determined by the available processing, memory or memory-bandwidth, or by motion detection precision or acceptable latency considerations. CMAC can in principle be performed with the minimum FIFO depth of 3 frames for Y and 2 for C. For the super resolution (SR) aspect, the use of 5 ‘Y’ frames may result in better resolution. On Y frames, the current object frame may be the central frame in the Y FIFO. On chrominance frames, the two C frames that flank the central Y frame may be adjusted in order to line up their motion to the central Y frame.


The motion detection method described here may be based upon the block matching approach which provides x and y motion vectors for small, independent blocks of pixels of configurable dimensions. There are other motion detection algorithms that could also be used in principle. Block matching offers advantages for simplicity of implementation, particularly for real time processing in hardware. A 2-stage match process is described which provides for a super resolved frame with double the pixel count in x and y. Further stages could be added to increase the pixel count further, however many more buffered frames and computation would be required to make it worthwhile.


In addition to the raw, buffered, Y object frame sitting in the middle of the Y FIFO (referred to as RY), three×2 up-scaled versions of it may be created. The first may be up-scaled using bilinear interpolation (referred to as buffer BL), the second using bicubic interpolation (buffer BC) and the third with no interpolation, just zeros where the empty pixels are (called NI). BL may be used in the block matching method, NI forms the baseline for the super-resolved frame and BC is the fallback pixel source for unfilled pixels within the super-resolved frame.


Referring to FIG. 2, there is illustrated a schematic of a pixel array 201 configured in an x and y plane. For each Y frame in the buffer, except for RY, the array may be segmented into square blocks 206 of some dimension, (e.g., 4×4). Each block 206 of pixels 202 may be shifted around, one pixel at a time, in both x and y, within some defined range of shifts in both + and − directions (e.g., +/−3 pixels). For each location it may be compared to the equivalent block 208 of pixels 204 sitting in that location with the object frame, RY. The x and y shifts encountered for the best match position become the recorded Cartesian motion co-ordinates for all pixels within the block. There may be various ways to make the comparison and a relatively convenient metric. One implementation may be to take the modulus of the pixel differences, (i.e., between the stationary pixel 204 in RY and the corresponding pixel in the block 206 under study), summed over all pixels in the block. The best match may be taken as the minimum of this value. It can also be recorded for each block as a matching quality metric, which may be used to arbitrate between competing pixels during the super resolution (SR) process. In an implementation, the minimum sum of squared differences may be used as the matching metric, for example.


Referring now to FIG. 3, at this stage, each pixel 302 within non-RY, Y-frames, has a motion estimate that is quantized at the captured resolution. This may not provide a feature or use for super resolution (SR), but it can nevertheless be used for the CMAC, if no super resolution (SR) is desired. If ×2 super resolution is sought, the next stage involves, for block of pixels 306 within the non-RY frames 302, comparing to the BL buffer instead of the RY buffer. Starting from the best shifted position (according to the recorded motion vectors), shifts are performed by + and −1 half-pixel, giving a total of 9 possible positions as illustrated best in FIG. 3. A half-pixel in the Y frame under study is one whole pixel with respect to BL. Of those 9 possible pixel positions, the best match is again determined and the recorded motion vector is adjusted accordingly. If the motion vector at this stage has a half integer component (with ˜75% probability), then it has the potential to enhance the final resolution.


Motion vectors for the two Y frames flanking RY, may be saved for the CMAC process, which occurs during the C frames.


The super resolution (SR) process itself may involve combining data from multiple Y frames into a central super-resolved frame, which is stationary with respect to the RY buffer. For each of the non-central Y buffers, a ×2 up-scaled version may be produced, in which the individual blocks have been shifted according to their (x,y) motion vectors. Any pixels at the ×2 resolution that are not filled after shifting are left blank.


The basis of the super-resolved frame is the NI buffer, which is the up-scaled version of RY with no interpolation. Three out of every four pixels in NI may be initially blank, and the primary objective is to fill the pixels with data from the up-scaled & shifted Y buffers. One approach may be to scan through the pixels looking for the first match for each empty pixel. At the end, any pixels that are still blank may be filled in from the BC buffer, which is the bicubic interpolated version of the central Y frame. Another approach to filling blank pixels may be to assess all possible candidates and choose the best one, based on some parameter that has been logged as a motion estimate quality metric. An example of such a metric may be the minimum sum of absolute differences for the originating block of pixels, or some derivative thereof. This requires at least one additional frame buffer per Y frame. Alternatively, all candidates can be combined in some way, e.g., as an average, which can be, e.g., weighted according to a quality parameter. In this case, even the non-zero pixels in NI can be substituted as well. The benefit may be that in addition to enhancing the resolution, the net signal to noise ratio is improved. Candidates with notably poor quality values can also be rejected altogether.



FIG. 4 illustrates the issue of significant motion from frame to frame with frame-wise color modulation. In the figure, the ball 402 is illustrated as moving on a trajectory across the scene during capture, resulting in different positions for the Y, Cb and Cr components. The color motion artifact correction may utilize the relative motion estimate for adjacent Y frames, to predict the motion that occurred for the intermediate C frames relative to the Y frame, to which they become associated during color fusion. One implementation may be to take the motion vectors and divide them by 2. In this implementation, there is an assumption that any motion that has occurred from Y frame to Y frame is linear. In an implementation, if motion estimation is available for 3 or more Y frames in addition to the object frame (RY), then bicubic interpolation may be employed for a more precise interpolation.


The pixel shifting can take place either at the original or the doubled resolution, following a bicubic upscale. Either way, after shifting there are many void locations with various random shapes and sizes to be filled in.


The application of the motion information is a little different for CMAC compared with super resolution (SR). Super resolution (SR) has the bicubic up-scaled version of RY as its default, so the worst case is that a pixel void is filled by interpolation using its sixteen closest neighbors in the correct motion frame. For CMAC there may be no predicting the distance of the nearest filled neighbors, all is known is that it is limited to the original block search distance divided by two (in the case of linear interpolation). Some means of interpolation is thus required to fill in the holes. One implementation to do this is for each missing pixel, find the distance to the closest filled pixel in +x, −x, +y and −y, then fill with an average level that has been weighted according to the reciprocal of each distance.


It should be noted that as used herein the term “light” is both a particle and a wavelength, and is intended to denote electromagnetic radiation that is detectable by a pixel array, and may be include wavelengths from the visible and non-visible spectrums of electromagnetic radiation. The term “partition” is used herein to mean a predetermined range of wavelengths of the electromagnetic spectrum that is less than the entire spectrum, or in other words, wavelengths that make up some portion of the electromagnetic spectrum. An emitter may be a light source that is controllable as to the portion of the electromagnetic spectrum that is emitted, the intensity of the emissions, or the duration of the emission, or all three. An emitter may emit light in any dithered, diffused, or columnated emission and may be controlled digitally or through analog methods or systems.


A pixel array of an image sensor may be paired with an emitter electronically, such that they are synced during operation for both receiving the emissions and for the adjustments made within the system. An emitter may be tuned to emit electromagnetic radiation, which may be pulsed in order to illuminate an object. It will be appreciated that the emitter may be in the form of a laser, which may be pulsed in order to illuminate an object. The emitter may pulse at an interval that corresponds to the operation and functionality of a pixel array. The emitter may pulse light in a plurality of electromagnetic partitions, such that the pixel array receives electromagnetic energy and produces a data set that corresponds (in time) with each specific electromagnetic partition.


A system may comprise a monochromatic pixel array (black and white), which is simply sensitive to electromagnetic radiation of any wavelength. The light emitter illustrated in the figure may be a laser emitter that is capable of emitting a green electromagnetic partition, a blue electromagnetic partition, and a red electromagnetic partition in any desired sequence. It will be appreciated that other light emitters may be used without departing from the scope of the disclosure, such as digital or analog based emitters.


During operation, the data created by the monochromatic sensor for any individual pulse may be assigned a specific color partition, wherein the assignment may be based on the timing of the pulsed color partition from the emitter. Even though the pixels are not color dedicated they can be assigned a color for any given data set based on timing. In one embodiment, three data sets representing RED, GREEN and BLUE pulses may then be combined to form a single image frame. It will be appreciated that the disclosure is not limited to any particular color combination or any particular electromagnetic partition, and that any color combination or any electromagnetic partition may be used in place of RED, GREEN and BLUE, such as Cyan, Magenta and Yellow, Ultraviolet, infra-red, or any other color combination, including all visible and non-visible wavelengths, without departing from the scope of the disclosure. The object to be imaged contains a red portion, green portion and a blue portion. As illustrated in the figure, the reflected light from the electromagnetic pulses only contains the data for the portion of the object having the specific color that corresponds to the pulsed color partition. Those separate color (or color interval) data sets can then be used to reconstruct the image by combining the data sets.


Implementations of the disclosure may comprise or utilize a special purpose or general-purpose computer including computer hardware, such as, for example, one or more processors and system memory, as discussed in greater detail below. Implementations within the scope of the disclosure may also include physical and other computer-readable media for carrying or storing computer-executable instructions and/or data structures. Such computer-readable media can be any available media that can be accessed by a general purpose or special purpose computer system. Computer-readable media that store computer-executable instructions are computer storage media (devices). Computer-readable media that carry computer-executable instructions are transmission media. Thus, by way of example, and not limitation, implementations of the disclosure can comprise at least two distinctly different kinds of computer-readable media: computer storage media (devices) and transmission media.


Computer storage media (devices) includes RAM, ROM, EEPROM, CD-ROM, solid state drives (“SSDs”) (e.g., based on RAM), Flash memory, phase-change memory (“PCM”), other types of memory, other optical disk storage, magnetic disk storage or other magnetic storage devices, or any other medium which can be used to store desired program code means in the form of computer-executable instructions or data structures and which can be accessed by a general purpose or special purpose computer.


A “network” is defined as one or more data links that enable the transport of electronic data between computer systems and/or modules and/or other electronic devices. In an implementation, a sensor and camera control unit may be networked in order to communicate with each other, and other components, connected over the network to which they are connected. When information is transferred or provided over a network or another communications connection (either hardwired, wireless, or a combination of hardwired or wireless) to a computer, the computer properly views the connection as a transmission medium. Transmissions media can include a network and/or data links which can be used to carry desired program code means in the form of computer-executable instructions or data structures and which can be accessed by a general purpose or special purpose computer. Combinations of the above should also be included within the scope of computer-readable media.


Further, upon reaching various computer system components, program code means in the form of computer-executable instructions or data structures that can be transferred automatically from transmission media to computer storage media (devices) (or vice versa). For example, computer-executable instructions or data structures received over a network or data link can be buffered in RAM within a network interface module (e.g., a “NIC”), and then eventually transferred to computer system RAM and/or to less volatile computer storage media (devices) at a computer system. RAM can also include solid state drives (SSDs or PCIx based real time memory tiered Storage, such as FusionIO). Thus, it should be understood that computer storage media (devices) can be included in computer system components that also (or even primarily) utilize transmission media.


Computer-executable instructions comprise, for example, instructions and data which, when executed at a processor, cause a general purpose computer, special purpose computer, or special purpose processing device to perform a certain function or group of functions. The computer executable instructions may be, for example, binaries, intermediate format instructions such as assembly language, or even source code. Although the subject matter has been described in language specific to structural features and/or methodological acts, it is to be understood that the subject matter defined in the appended claims is not necessarily limited to the described features or acts described above. Rather, the described features and acts are disclosed as example forms of implementing the claims.


Those skilled in the art will appreciate that the disclosure may be practiced in network computing environments with many types of computer system configurations, including, personal computers, desktop computers, laptop computers, message processors, control units, camera control units, hand-held devices, hand pieces, multi-processor systems, microprocessor-based or programmable consumer electronics, network PCs, minicomputers, mainframe computers, mobile telephones, PDAs, tablets, pagers, routers, switches, various storage devices, and the like. It should be noted that any of the above mentioned computing devices may be provided by or located within a brick and mortar location. The disclosure may also be practiced in distributed system environments where local and remote computer systems, which are linked (either by hardwired data links, wireless data links, or by a combination of hardwired and wireless data links) through a network, both perform tasks. In a distributed system environment, program modules may be located in both local and remote memory storage devices.


Further, where appropriate, functions described herein can be performed in one or more of: hardware, software, firmware, digital components, or analog components. For example, one or more application specific integrated circuits (ASICs) or field programmable gate arrays can be programmed to carry out one or more of the systems and procedures described herein. Certain terms are used throughout the following description and claims to refer to particular system components. As one skilled in the art will appreciate, components may be referred to by different names. This document does not intend to distinguish between components that differ in name, but not function.



FIG. 5 is a block diagram illustrating an example computing device 500. Computing device 500 may be used to perform various procedures, such as those discussed herein. Computing device 500 can function as a server, a client, or any other computing entity. Computing device can perform various monitoring functions as discussed herein, and can execute one or more application programs, such as the application programs described herein. Computing device 500 can be any of a wide variety of computing devices, such as a desktop computer, a notebook computer, a server computer, a handheld computer, camera control unit, tablet computer and the like.


Computing device 500 includes one or more processor(s) 502, one or more memory device(s) 504, one or more interface(s) 506, one or more mass storage device(s) 508, one or more Input/Output (I/O) device(s) 510, and a display device 530 all of which are coupled to a bus 512. Processor(s) 502 include one or more processors or controllers that execute instructions stored in memory device(s) 504 and/or mass storage device(s) 508. Processor(s) 502 may also include various types of computer-readable media, such as cache memory.


Memory device(s) 504 include various computer-readable media, such as volatile memory (e.g., random access memory (RAM) 514) and/or nonvolatile memory (e.g., read-only memory (ROM) 516). Memory device(s) 504 may also include rewritable ROM, such as Flash memory.


Mass storage device(s) 508 include various computer readable media, such as magnetic tapes, magnetic disks, optical disks, solid-state memory (e.g., Flash memory), and so forth. As shown in FIG. 5, a particular mass storage device is a hard disk drive 524. Various drives may also be included in mass storage device(s) 508 to enable reading from and/or writing to the various computer readable media. Mass storage device(s) 508 include removable media 526 and/or non-removable media.


I/O device(s) 510 include various devices that allow data and/or other information to be input to or retrieved from computing device 500. Example I/O device(s) 510 include digital imaging devices, electromagnetic sensors and emitters, cursor control devices, keyboards, keypads, microphones, monitors or other display devices, speakers, printers, network interface cards, modems, lenses, CCDs or other image capture devices, and the like.


Display device 530 includes any type of device capable of displaying information to one or more users of computing device 500. Examples of display device 530 include a monitor, display terminal, video projection device, and the like.


Interface(s) 106 include various interfaces that allow computing device 500 to interact with other systems, devices, or computing environments. Example interface(s) 506 may include any number of different network interfaces 520, such as interfaces to local area networks (LANs), wide area networks (WANs), wireless networks, and the Internet. Other interface(s) include user interface 518 and peripheral device interface 522. The interface(s) 506 may also include one or more user interface elements 518. The interface(s) 506 may also include one or more peripheral interfaces such as interfaces for printers, pointing devices (mice, track pad, etc.), keyboards, and the like.


Bus 512 allows processor(s) 502, memory device(s) 504, interface(s) 506, mass storage device(s) 508, and I/O device(s) 510 to communicate with one another, as well as other devices or components coupled to bus 512. Bus 512 represents one or more of several types of bus structures, such as a system bus, PCI bus, IEEE 1394 bus, USB bus, and so forth.


For purposes of illustration, programs and other executable program components are shown herein as discrete blocks, although it is understood that such programs and components may reside at various times in different storage components of computing device 500, and are executed by processor(s) 502. Alternatively, the systems and procedures described herein can be implemented in hardware, or a combination of hardware, software, and/or firmware. For example, one or more application specific integrated circuits (ASICs) can be programmed to carry out one or more of the systems and procedures described herein.


Referring now to FIGS. 6A and 6B, the figures illustrate a perspective view and a side view, respectively, of an implementation of a monolithic sensor 600 having a plurality of pixel arrays for producing a three dimensional image in accordance with the teachings and principles of the disclosure. Such an implementation may be desirable for three dimensional image capture, wherein the two pixel arrays 602 and 604 may be offset during use. In another implementation, a first pixel array 602 and a second pixel array 604 may be dedicated to receiving a predetermined range of wave lengths of electromagnetic radiation, wherein the first pixel array 602 is dedicated to a different range of wave length electromagnetic radiation than the second pixel array 604.



FIGS. 7A and 7B illustrate a perspective view and a side view, respectively, of an implementation of an imaging sensor 700 built on a plurality of substrates. As illustrated, a plurality of pixel columns 704 forming the pixel array are located on the first substrate 702 and a plurality of circuit columns 708 are located on a second substrate 706. Also illustrated in the figure are the electrical connection and communication between one column of pixels to its associated or corresponding column of circuitry. In one implementation, an image sensor, which might otherwise be manufactured with its pixel array and supporting circuitry on a single, monolithic substrate/chip, may have the pixel array separated from all or a majority of the supporting circuitry. The disclosure may use at least two substrates/chips, which will be stacked together using three-dimensional stacking technology. The first 702 of the two substrates/chips may be processed using an image CMOS process. The first substrate/chip 702 may be comprised either of a pixel array exclusively or a pixel array surrounded by limited circuitry. The second or subsequent substrate/chip 706 may be processed using any process, and does not have to be from an image CMOS process. The second substrate/chip 706 may be, but is not limited to, a highly dense digital process in order to integrate a variety and number of functions in a very limited space or area on the substrate/chip, or a mixed-mode or analog process in order to integrate for example precise analog functions, or a RF process in order to implement wireless capability, or MEMS (Micro-Electro-Mechanical Systems) in order to integrate MEMS devices. The image CMOS substrate/chip 702 may be stacked with the second or subsequent substrate/chip 706 using any three-dimensional technique. The second substrate/chip 706 may support most, or a majority, of the circuitry that would have otherwise been implemented in the first image CMOS chip 702 (if implemented on a monolithic substrate/chip) as peripheral circuits and therefore have increased the overall system area while keeping the pixel array size constant and optimized to the fullest extent possible. The electrical connection between the two substrates/chips may be done through interconnects 703 and 705, which may be wirebonds, bump and/or TSV (Through Silicon Via).



FIGS. 8A and 8B illustrate a perspective view and a side view, respectively, of an implementation of an imaging sensor 800 having a plurality of pixel arrays for producing a three dimensional image. The three dimensional image sensor may be built on a plurality of substrates and may comprise the plurality of pixel arrays and other associated circuitry, wherein a plurality of pixel columns 804a forming the first pixel array and a plurality of pixel columns 804b forming a second pixel array are located on respective substrates 802a and 802b, respectively, and a plurality of circuit columns 808a and 808b are located on a separate substrate 806. Also illustrated are the electrical connections and communications between columns of pixels to associated or corresponding column of circuitry.


It will be appreciated that the teachings and principles of the disclosure may be used in a reusable device platform, a limited use device platform, a re-posable use device platform, or a single-use/disposable device platform without departing from the scope of the disclosure. It will be appreciated that in a re-usable device platform an end-user is responsible for cleaning and sterilization of the device. In a limited use device platform the device can be used for some specified amount of times before becoming inoperable. Typical new device is delivered sterile with additional uses requiring the end-user to clean and sterilize before additional uses. In a re-posable use device platform a third-party may reprocess the device (e.g., cleans, packages and sterilizes) a single-use device for additional uses at a lower cost than a new unit. In a single-use/disposable device platform a device is provided sterile to the operating room and used only once before being disposed of.


Additionally, the teachings and principles of the disclosure may include any and all wavelengths of electromagnetic energy, including the visible and non-visible spectrums, such as infrared (IR), ultraviolet (UV), and X-ray.


It will be appreciated that various features disclosed herein provide significant advantages and advancements in the art. The following embodiments are exemplary of some of those features.


In the foregoing Detailed Description of the Disclosure, various features of the disclosure are grouped together in a single embodiment for the purpose of streamlining the disclosure. This method of disclosure is not to be interpreted as reflecting an intention that the claimed disclosure requires more features than are expressly recited in each claim. Rather, inventive aspects lie in less than all features of a single foregoing disclosed embodiment.


It is to be understood that the above-described arrangements are only illustrative of the application of the principles of the disclosure. Numerous modifications and alternative arrangements may be devised by those skilled in the art without departing from the spirit and scope of the disclosure and the appended claims are intended to cover such modifications and arrangements.


Thus, while the disclosure has been shown in the drawings and described above with particularity and detail, it will be apparent to those of ordinary skill in the art that numerous modifications, including, but not limited to, variations in size, materials, shape, form, function and manner of operation, assembly and use may be made without departing from the principles and concepts set forth herein.


The foregoing description has been presented for the purposes of illustration and description. It is not intended to be exhaustive or to limit the disclosure to the precise form disclosed. Many modifications and variations are possible in light of the above teaching. Further, it should be noted that any or all of the aforementioned alternate implementations may be used in any combination desired to form additional hybrid implementations of the disclosure.


Further, although specific implementations of the disclosure have been described and illustrated, the disclosure is not to be limited to the specific forms or arrangements of parts so described and illustrated. The scope of the disclosure is to be defined by the claims appended hereto, any future claims submitted here and in different applications, and their equivalents.

Claims
  • 1. A digital imaging method for use with an endoscope in ambient light deficient environments comprising: actuating an emitter to emit a pulse of a wavelength of electromagnetic radiation to cause illumination within the light deficient environment;wherein said pulse is within a first wavelength range that comprises a first portion of electromagnetic spectrum;pulsing said emitter at a predetermined interval;sensing reflected electromagnetic radiation from said pulse with a pixel array;wherein said pixel array is actuated at a sensing interval that corresponds to the pulse interval of said emitter;detecting motion of objects being imaged;increasing resolution for the pixel array by compensating for the detected motion by: sensing luminescence of a plurality of neighboring pixels to gather luminance data,bilinear interpolating the luminance data into a first upscaled data set,bicubic interpolating the luminance data into a second upscaled data set, andcreating a baseline with no interpolation of the luminance data into a third upscaled data set; andcreating a stream of images by combining a plurality of sensed reflected electromagnetic energies into a frame.
  • 2. The method of claim 1, wherein said sensing process comprises sensing luminance and linear sums of luminance plus chrominance in adjacent images in a stream of images forming a video stream.
  • 3. The method of claim 2, further comprising indexing frames within the video stream with a rotating frame index.
  • 4. The method of claim 3, wherein the rotating frame index comprises four counts.
  • 5. The method of claim 4, further comprising reconstructing the video stream by combining luminance and chrominance data from a prior indexed frame.
  • 6. The method of claim 4, further comprising reconstructing the video stream by combining luminance and chrominance data from a prior indexed frame and following indexed frame.
  • 7. The method of claim 4, further comprising reconstructing a frame for luminance and two frames for chrominance.
  • 8. The method of claim 4, further comprising reconstructing the video stream by combining luminance and chrominance data from a plurality of prior indexed frames and a plurality of latter indexed frames for increased resolution and accuracy.
  • 9. The method of claim 1, wherein the first upscaled data set is used for block matching.
  • 10. The method of claim 1, wherein the second upscaled data set is used for fall back pixel data.
  • 11. The method of claim 1, wherein the third upscaled data set forms the baseline for the resolution-enhanced data set.
  • 12. The method of claim 1, further comprising segmenting data created by the pixel array into segments of pixels and nearest neighbors.
  • 13. The method of claim 12, further comprising shifting each segment of pixels in the x direction and comparing with a neighboring frame at the same resolution, in order to determine motion of an object being imaged in the x direction.
  • 14. The method of claim 13, further comprising shifting each segment of pixels in the x direction in sub-pixel increments and comparing to the first up-scaled data set for greater precision of motion detection in the x direction.
  • 15. The method of claim 13, further comprising shifting each segment of pixels in the y direction and comparing with a neighboring frame at the same resolution, in order to determine motion of an object being imaged in the y direction.
  • 16. The method of claim 15, further comprising shifting each segment of pixels in the y direction in sub-pixel increments and comparing to the first up-scaled data set for greater precision of motion detection in the y direction.
  • 17. The method of claim 15, further comprising determining the vector of the motion of the object by combining the x and y motion of the of the object being imaged.
  • 18. The method of claim 17, further comprising estimating motion to combine data from multiple luminance frames into a single, higher resolution luminance frame.
  • 19. The method of claim 18, wherein said process is repeated for every frame containing luminance data in a continuous sequence.
CROSS-REFERENCE TO RELATED APPLICATIONS

This application is a continuation of U.S. application Ser. No. 14/214,311, filed Mar. 14, 2014 (now U.S. Pat. No. 9,641,815, issued May 2, 2017) and which claims the benefit of (1) U.S. Provisional Application No. 61/791,473, filed Mar. 15, 2013; (2) U.S. Provisional Application No. 61/790,487, filed Mar. 15, 2013; and (3) U.S. Provisional Application No. 61/790,804, filed Mar. 15, 2013; all of which are incorporated herein by reference in their entireties, including but not limited to those portions that specifically appear hereinafter, the incorporation by reference being made with the following exception: In the event that any portion of any of the above-referenced applications are inconsistent with this application, this application supersedes said above-referenced provisional applications.

US Referenced Citations (407)
Number Name Date Kind
3666885 Hemsley et al. May 1972 A
4011403 Epstein et al. Mar 1977 A
4363963 Ando Dec 1982 A
4433675 Konoshima Feb 1984 A
4436095 Kruger Mar 1984 A
4473839 Noda Sep 1984 A
4644403 Sakai et al. Feb 1987 A
4651226 Motoori et al. Mar 1987 A
4692606 Sakai et al. Sep 1987 A
4740837 Yanagisawa et al. Apr 1988 A
4741327 Yabe May 1988 A
4742388 Cooper et al. May 1988 A
4745471 Takamura et al. May 1988 A
4773396 Okazaki Sep 1988 A
4782386 Ams et al. Nov 1988 A
4786965 Yabe Nov 1988 A
4832003 Yabe May 1989 A
4845555 Yabe et al. Jul 1989 A
4853772 Kikuchi Aug 1989 A
4853773 Hibino et al. Aug 1989 A
4866526 Ams et al. Sep 1989 A
4884133 Kanno et al. Nov 1989 A
4884134 Tsuji et al. Nov 1989 A
4918521 Yabe et al. Apr 1990 A
4924856 Noguchi May 1990 A
4938205 Nudelman Jul 1990 A
4942473 Zeevi et al. Jul 1990 A
4947246 Kikuchi Aug 1990 A
4953539 Nakamura et al. Sep 1990 A
4959710 Uehara et al. Sep 1990 A
5016975 Sasaki et al. May 1991 A
5021888 Kondou et al. Jun 1991 A
5047846 Uchiyama et al. Sep 1991 A
RE33854 Adair Mar 1992 E
5103497 Hicks Apr 1992 A
5111804 Funakoshi May 1992 A
5133035 Hicks Jul 1992 A
5187572 Nakamura et al. Feb 1993 A
5188094 Adair Feb 1993 A
5196938 Blessinger Mar 1993 A
5200838 Nudelman et al. Apr 1993 A
5220198 Tsuji Jun 1993 A
5228430 Sakamoto Jul 1993 A
5233416 Inoue Aug 1993 A
5241170 Field, Jr. et al. Aug 1993 A
5264925 Shipp et al. Nov 1993 A
5313306 Kuban et al. May 1994 A
5325847 Matsuno Jul 1994 A
5402768 Adair Apr 1995 A
5408268 Shipp Apr 1995 A
5411020 Ito May 1995 A
5427087 Ito et al. Jun 1995 A
5454366 Ito et al. Oct 1995 A
5494483 Adair Feb 1996 A
5523786 Parulski Jun 1996 A
5550595 Hannah Aug 1996 A
5594497 Ahern et al. Jan 1997 A
5665959 Fossum et al. Sep 1997 A
5704836 Norton et al. Jan 1998 A
5730702 Tanaka et al. Mar 1998 A
5734418 Danna Mar 1998 A
5748234 Lippincott May 1998 A
5749830 Kaneko et al. May 1998 A
5754313 Pelchy et al. May 1998 A
5783909 Hochstein Jul 1998 A
5784099 Lippincott Jul 1998 A
5857963 Pelchy et al. Jan 1999 A
5887049 Fossum Mar 1999 A
5929901 Adair et al. Jul 1999 A
5949483 Fossum et al. Sep 1999 A
5986693 Adair et al. Nov 1999 A
6023315 Harrold et al. Feb 2000 A
6038067 George Mar 2000 A
6043839 Adair et al. Mar 2000 A
6139489 Wampler et al. Oct 2000 A
6142930 Ito et al. Nov 2000 A
6166768 Fossum et al. Dec 2000 A
6184922 Saito et al. Feb 2001 B1
6184940 Sano Feb 2001 B1
6215517 Takahashi et al. Mar 2001 B1
6222175 Krymski Apr 2001 B1
6239456 Berezin et al. May 2001 B1
6272269 Naum Aug 2001 B1
6275255 Adair et al. Aug 2001 B1
6292220 Ogawa et al. Sep 2001 B1
6294775 Seibel et al. Sep 2001 B1
6310642 Adair et al. Oct 2001 B1
6320331 Iida et al. Nov 2001 B1
6331156 Haefele et al. Dec 2001 B1
6389205 Muckner et al. May 2002 B1
6416463 Tsuzuki et al. Jul 2002 B1
6429953 Feng Aug 2002 B1
6444970 Barbato Sep 2002 B1
6445022 Barna et al. Sep 2002 B1
6445139 Marshall et al. Sep 2002 B1
6464633 Hosoda et al. Oct 2002 B1
6466618 Messing et al. Oct 2002 B1
6485414 Neuberger Nov 2002 B1
6512280 Chen et al. Jan 2003 B2
6627474 Barna et al. Sep 2003 B2
6631230 Campbell Oct 2003 B1
6659940 Adler Dec 2003 B2
6665013 Fossum et al. Dec 2003 B1
6677992 Matsumoto et al. Jan 2004 B1
6690466 Miller et al. Feb 2004 B2
6692431 Kazakevich Feb 2004 B2
6707499 Kung et al. Mar 2004 B1
6772181 Fu et al. Aug 2004 B1
6773392 Kikuchi et al. Aug 2004 B2
6791739 Ramanujan et al. Sep 2004 B2
6796939 Hirata et al. Sep 2004 B1
6799065 Niemeyer Sep 2004 B1
6809358 Hsieh et al. Oct 2004 B2
6838653 Campbell et al. Jan 2005 B2
6841947 Berg-johansen Jan 2005 B2
6847399 Ang Jan 2005 B1
6856712 Fauver et al. Feb 2005 B2
6873363 Barna et al. Mar 2005 B1
6879340 Chevallier Apr 2005 B1
6899675 Cline et al. May 2005 B2
6900829 Orzawa et al. May 2005 B1
6906745 Fossum et al. Jun 2005 B1
6921920 Kazakevich Jul 2005 B2
6933974 Lee Aug 2005 B2
6947090 Komoro et al. Sep 2005 B2
6961461 MacKinnon et al. Nov 2005 B2
6970195 Bidermann et al. Nov 2005 B1
6977733 Denk et al. Dec 2005 B2
6982740 Adair et al. Jan 2006 B2
6999118 Suzuki Feb 2006 B2
7009634 Iddan et al. Mar 2006 B2
7009648 Lauxtermann et al. Mar 2006 B2
7030904 Adair et al. Apr 2006 B2
7037259 Hakamata et al. May 2006 B2
7068878 Crossman-Bosworth et al. Jun 2006 B2
7071979 Ohtani et al. Jul 2006 B1
7079178 Hynecek Jul 2006 B2
7102682 Baer Sep 2006 B2
7105371 Fossum et al. Sep 2006 B2
7106377 Bean et al. Sep 2006 B2
7119839 Mansoorian Oct 2006 B1
7151568 Kawachi et al. Dec 2006 B2
7159782 Johnston et al. Jan 2007 B2
7184084 Glenn Feb 2007 B2
7189226 Auld et al. Mar 2007 B2
7189961 Johnston et al. Mar 2007 B2
7208983 Imaizumi et al. Apr 2007 B2
7252236 Johnston et al. Aug 2007 B2
7258663 Doguchi et al. Aug 2007 B2
7261687 Yang Aug 2007 B2
7280139 Pahr et al. Oct 2007 B2
7298938 Johnston Nov 2007 B2
7312879 Johnston Dec 2007 B2
7319478 Dolt et al. Jan 2008 B2
7355155 Wang Apr 2008 B2
7356198 Chauville et al. Apr 2008 B2
7365768 Ono et al. Apr 2008 B1
7369140 King et al. May 2008 B1
7369176 Sonnenschein et al. May 2008 B2
7455638 Ogawa et al. Nov 2008 B2
7470229 Ogawa et al. Dec 2008 B2
7476197 Wiklof et al. Jan 2009 B2
7532760 Kaplinsky et al. May 2009 B2
7540645 Choi May 2009 B2
7544163 MacKinnon et al. Jun 2009 B2
7545434 Bean et al. Jun 2009 B2
7564935 Suzuki Jul 2009 B2
7567291 Bechtel et al. Jul 2009 B2
7573516 Krymski et al. Aug 2009 B2
7573519 Phan et al. Aug 2009 B2
7583872 Seibel et al. Sep 2009 B2
7630008 Sarwari Dec 2009 B2
7744528 Wallace et al. Jun 2010 B2
7783133 Dunki-Jacobs et al. Aug 2010 B2
7784697 Johnston et al. Aug 2010 B2
7791009 Johnston et al. Sep 2010 B2
7792378 Liege et al. Sep 2010 B2
7794394 Frangioni Sep 2010 B2
7813538 Carroll et al. Oct 2010 B2
7914447 Kanai Mar 2011 B2
7916193 Fossum Mar 2011 B2
7935050 Luanava et al. May 2011 B2
7944566 Xie May 2011 B2
7969097 Van De Ven Jun 2011 B2
7995123 Lee et al. Aug 2011 B2
8040394 Fossum et al. Oct 2011 B2
8054339 Fossum et al. Nov 2011 B2
8059174 Mann et al. Nov 2011 B2
8100826 MacKinnon et al. Jan 2012 B2
8159584 Iwabuchi et al. Apr 2012 B2
8193542 Machara Jun 2012 B2
8212884 Seibel et al. Jul 2012 B2
8231522 Endo et al. Jul 2012 B2
8300111 Iwane Oct 2012 B2
8372003 St. George et al. Feb 2013 B2
8382662 Soper et al. Feb 2013 B2
8396535 Wang et al. Mar 2013 B2
8423110 Barbato et al. Apr 2013 B2
8471938 Altice, Jr. et al. Jun 2013 B2
8476575 Mokhuatyuk Jul 2013 B2
8482833 Cheng Jul 2013 B2
8493474 Richardson Jul 2013 B2
8493564 Brukilacchio et al. Jul 2013 B2
8523367 Ogura Sep 2013 B2
8537203 Seibel et al. Sep 2013 B2
8559743 Liege et al. Oct 2013 B2
8582011 Dosluoglu Nov 2013 B2
8602971 Farr Dec 2013 B2
8605177 Rossi et al. Dec 2013 B2
8610808 Prescher et al. Dec 2013 B2
8614754 Fossum Dec 2013 B2
8625016 Fossum et al. Jan 2014 B2
8638847 Wang Jan 2014 B2
8648287 Fossum Feb 2014 B1
8649848 Crane et al. Feb 2014 B2
8668339 Kabuki et al. Mar 2014 B2
8675125 Cossairt et al. Mar 2014 B2
8698887 Makino et al. Apr 2014 B2
8836834 Hashimoto et al. Sep 2014 B2
8848063 Jo et al. Sep 2014 B2
8858425 Farr et al. Oct 2014 B2
8885034 Adair et al. Nov 2014 B2
9516239 Blanquart et al. Dec 2016 B2
20010017649 Yaron Aug 2001 A1
20010030744 Chang Oct 2001 A1
20010055462 Seibel Dec 2001 A1
20020054219 Jaspers May 2002 A1
20020064341 Fauver et al. May 2002 A1
20020080248 Adair et al. Jun 2002 A1
20020080359 Denk et al. Jun 2002 A1
20020140844 Kurokawa et al. Oct 2002 A1
20020158986 Baer Oct 2002 A1
20030007087 Hakamata et al. Jan 2003 A1
20030007686 Roever Jan 2003 A1
20030107664 Suzuki Jun 2003 A1
20030189663 Dolt et al. Oct 2003 A1
20040082833 Adler et al. Apr 2004 A1
20040170712 Sadek El Mogy Sep 2004 A1
20050009982 Inagaki et al. Jan 2005 A1
20050027164 Barbato et al. Feb 2005 A1
20050038322 Banik Feb 2005 A1
20050113641 Bala May 2005 A1
20050122530 Denk et al. Jun 2005 A1
20050151866 Ando et al. Jul 2005 A1
20050200291 Naugler, Jr. et al. Sep 2005 A1
20050234302 MacKinnon et al. Oct 2005 A1
20050237384 Jess Oct 2005 A1
20050261552 Mori et al. Nov 2005 A1
20050288546 Sonnenschein et al. Dec 2005 A1
20060069314 Farr Mar 2006 A1
20060087841 Chern et al. Apr 2006 A1
20060197664 Zhang et al. Sep 2006 A1
20060202036 Wang et al. Sep 2006 A1
20060221250 Rossbach et al. Oct 2006 A1
20060226231 Johnston et al. Oct 2006 A1
20060264734 Kimoto et al. Nov 2006 A1
20060274335 Wittenstein Dec 2006 A1
20070010712 Negishi Jan 2007 A1
20070041448 Miller et al. Feb 2007 A1
20070083085 Birnkrant et al. Apr 2007 A1
20070129601 Johnston et al. Jun 2007 A1
20070147033 Ogawa et al. Jun 2007 A1
20070244364 Luanava et al. Oct 2007 A1
20070244365 Wiklof Oct 2007 A1
20070276187 Wiklof et al. Nov 2007 A1
20070279486 Bayer et al. Dec 2007 A1
20070285526 Mann et al. Dec 2007 A1
20080045800 Farr Feb 2008 A2
20080088719 Jacob et al. Apr 2008 A1
20080107333 Mazinani et al. May 2008 A1
20080136953 Barnea et al. Jun 2008 A1
20080158348 Karpen et al. Jul 2008 A1
20080165360 Johnston Jul 2008 A1
20080192131 Kim et al. Aug 2008 A1
20080218598 Harada et al. Sep 2008 A1
20080218615 Huang et al. Sep 2008 A1
20080218824 Johnston et al. Sep 2008 A1
20080249369 Seibel et al. Oct 2008 A1
20090012361 MacKinnon et al. Jan 2009 A1
20090012368 Banik Jan 2009 A1
20090021588 Border et al. Jan 2009 A1
20090024000 Chen Jan 2009 A1
20090028465 Pan Jan 2009 A1
20090074265 Huang et al. Mar 2009 A1
20090091645 Trimeche et al. Apr 2009 A1
20090137893 Seibel et al. May 2009 A1
20090147077 Tani et al. Jun 2009 A1
20090154886 Lewis et al. Jun 2009 A1
20090160976 Chen et al. Jun 2009 A1
20090189530 Ashdown et al. Jul 2009 A1
20090208143 Yoon et al. Aug 2009 A1
20090227847 Tepper et al. Sep 2009 A1
20090232213 Jia Sep 2009 A1
20090259102 Koninckx et al. Oct 2009 A1
20090268063 Ellis-Monaghan et al. Oct 2009 A1
20090292168 Farr Nov 2009 A1
20090309500 Reisch Dec 2009 A1
20090316116 Melville et al. Dec 2009 A1
20090322912 Blanquart Dec 2009 A1
20100026722 Kondo Feb 2010 A1
20100049180 Wells et al. Feb 2010 A1
20100069713 Endo et al. Mar 2010 A1
20100102199 Negley et al. Apr 2010 A1
20100121142 OuYang et al. May 2010 A1
20100121143 Sugimoto et al. May 2010 A1
20100123775 Shibasaki May 2010 A1
20100134608 Shibasaki Jun 2010 A1
20100134662 Bub Jun 2010 A1
20100135398 Wittmann Jun 2010 A1
20100137684 Shibasaki et al. Jun 2010 A1
20100149421 Lin et al. Jun 2010 A1
20100157037 Iketani et al. Jun 2010 A1
20100157039 Sugai Jun 2010 A1
20100165087 Corso et al. Jul 2010 A1
20100171429 Garcia et al. Jul 2010 A1
20100182446 Matsubayashi Jul 2010 A1
20100198009 Farr et al. Aug 2010 A1
20100198134 Eckhouse et al. Aug 2010 A1
20100201797 Shizukuishi et al. Aug 2010 A1
20100228089 Hoffman et al. Sep 2010 A1
20100261961 Scott et al. Oct 2010 A1
20100274082 Iguchi et al. Oct 2010 A1
20100274090 Ozaki et al. Oct 2010 A1
20100305406 Braun et al. Dec 2010 A1
20100309333 Smith et al. Dec 2010 A1
20110028790 Farr et al. Feb 2011 A1
20110063483 Rossi et al. Mar 2011 A1
20110122301 Yamura et al. May 2011 A1
20110149358 Cheng Jun 2011 A1
20110181709 Wright et al. Jul 2011 A1
20110181840 Cobb Jul 2011 A1
20110184239 Wright et al. Jul 2011 A1
20110184243 Wright et al. Jul 2011 A1
20110208004 Feingold et al. Aug 2011 A1
20110212649 Stokoe et al. Sep 2011 A1
20110237882 Saito Sep 2011 A1
20110237884 Saito Sep 2011 A1
20110245605 Jacobsen et al. Oct 2011 A1
20110245616 Kobayashi Oct 2011 A1
20110255844 Wu et al. Oct 2011 A1
20110274175 Sumitomo Nov 2011 A1
20110279679 Samuel et al. Nov 2011 A1
20110288374 Hadani et al. Nov 2011 A1
20110292258 Adler et al. Dec 2011 A1
20110295061 Haramaty et al. Dec 2011 A1
20120004508 McDowall et al. Jan 2012 A1
20120014563 Bendall Jan 2012 A1
20120029279 Kucklick Feb 2012 A1
20120033118 Lee et al. Feb 2012 A1
20120041267 Benning et al. Feb 2012 A1
20120041534 Clerc et al. Feb 2012 A1
20120050592 Oguma Mar 2012 A1
20120078052 Cheng Mar 2012 A1
20120098933 Robinson et al. Apr 2012 A1
20120104230 Eismann et al. May 2012 A1
20120113506 Gmitro et al. May 2012 A1
20120120282 Goris May 2012 A1
20120140302 Xie et al. Jun 2012 A1
20120155761 Matsuoka Jun 2012 A1
20120157774 Kaku Jun 2012 A1
20120194686 Liu et al. Aug 2012 A1
20120197080 Murayama Aug 2012 A1
20120242975 Min et al. Sep 2012 A1
20120262621 Sato et al. Oct 2012 A1
20120281111 Jo et al. Nov 2012 A1
20130018256 Kislev et al. Jan 2013 A1
20130035545 Ono Feb 2013 A1
20130053642 Mizuyoshi et al. Feb 2013 A1
20130070071 Peltie et al. Mar 2013 A1
20130126708 Blanquart May 2013 A1
20130127934 Chiang May 2013 A1
20130135589 Curtis et al. May 2013 A1
20130144120 Yamazaki Jun 2013 A1
20130155215 Shimada et al. Jun 2013 A1
20130155305 Shintani Jun 2013 A1
20130158346 Soper et al. Jun 2013 A1
20130184524 Shimada et al. Jul 2013 A1
20130211217 Yamaguchi et al. Aug 2013 A1
20130242069 Kobayashi Sep 2013 A1
20130244453 Sakamoto Sep 2013 A1
20130274597 Byrne et al. Oct 2013 A1
20130296652 Farr Nov 2013 A1
20130300837 DiCarlo et al. Nov 2013 A1
20130342690 Williams Dec 2013 A1
20140022365 Yoshino Jan 2014 A1
20140031623 Kagaya Jan 2014 A1
20140005532 Choi et al. Feb 2014 A1
20140052004 D'Alfonso et al. Feb 2014 A1
20140073852 Banik et al. Mar 2014 A1
20140073853 Swisher et al. Mar 2014 A1
20140078278 Lei Mar 2014 A1
20140088363 Sakai et al. Mar 2014 A1
20140104466 Fossum Apr 2014 A1
20140160318 Blanquart et al. Jun 2014 A1
20140163319 Blanquart et al. Jun 2014 A1
20140203084 Wang Jul 2014 A1
20140267655 Richardson et al. Sep 2014 A1
20140267851 Rhoads Sep 2014 A1
20140268860 Talbert et al. Sep 2014 A1
20140288365 Henley et al. Sep 2014 A1
20140300698 Wany Oct 2014 A1
20140316199 Kucklick Oct 2014 A1
20140354788 Yano Dec 2014 A1
20140364689 Adair et al. Dec 2014 A1
20150271370 Henley et al. Sep 2015 A1
20160183775 Blanquart et al. Jun 2016 A1
20170086853 Fogarty et al. Mar 2017 A1
Foreign Referenced Citations (15)
Number Date Country
1520696 Aug 2004 CN
101079966 Nov 2007 CN
101449575 Jun 2009 CN
101755448 Jun 2010 CN
102469932 May 2012 CN
0660616 Jun 1995 EP
1079255 Feb 2001 EP
1637062 Mar 2006 EP
1712177 Oct 2006 EP
1819151 Aug 2007 EP
2359739 Aug 2011 EP
2371268 Aug 2011 EP
1996005693 Feb 1996 WO
2009120228 Oct 2009 WO
2012043771 Apr 2012 WO
Non-Patent Literature Citations (1)
Entry
Blumenfeld, et al. Three-dimensional image registration of MR proximal femur images for the analysis of trabecular bone parameters. Oct. 2008. [retrieved on Jul. 30, 2014] Retrieved from the internet: <URL: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2673590/>.
Related Publications (1)
Number Date Country
20170230574 A1 Aug 2017 US
Provisional Applications (3)
Number Date Country
61791473 Mar 2013 US
61790804 Mar 2013 US
61790487 Mar 2013 US
Continuations (1)
Number Date Country
Parent 14214311 Mar 2014 US
Child 15583893 US