The present disclosure relates to particle accelerators, and, in particular, it is related to a superconducting electromagnet component and an isochronous cyclotron including the same.
Neutron capture therapy (NCT) is a type of radiation therapy that is carried out by delivering an element with better neutron absorption to a specific location, then performing a selective treatment by using the difference in the degree of neutron absorption of different elements, thereby precisely destroying cancer cells without destroying other healthy tissues.
Specifically, the existing isochronous cyclotron can accelerate a hydrogen ion (H−) beam and use a telescopic device including a carbon foil to strip off the double electrons of the H− for defining the energy of the proton beam. However, stripping off the double electrons of the H− will increase the temperature of the carbon foil and the telescopic device. Waiting for the telescopic device and the carbon foil to cool limits the current of the output proton beam. On the other hand, when the current of H− is too large, the service life of the carbon foil will be shortened accordingly. In other words, the existing design is only suitable for producing isotopes but not for generating proton beams with fixed energy and large current, and is therefore difficult to apply in the field of boron neutron capture therapy (BNCT). Therefore, it is necessary to develop an isochronous cyclotron that can stably supply a proton beam with a large current to facilitate the development and application of neutron capture therapy.
In some embodiments, a superconducting electromagnet component is provided. The superconducting electromagnet component includes a superconducting main coil, a superconducting trim coil group, and a superconducting focusing coil group. The superconducting main coil is disposed around the central axis, wherein the superconducting main coil includes an upper main coil and a lower main coil, and there is a median plane between the upper main coil and the lower main coil for accelerating a particle beam. The superconducting trim coil group is disposed in the superconducting main coil around the central axis. The superconducting trim coil group includes an upper trim coil group and a lower trim coil group, and the median plane is located between the upper trim coil group and the lower trim coil group. The superconducting focusing coil group is disposed on a side of the superconducting trim coil group away from the median plane. The superconducting focusing coil group includes an upper focusing coil group and a lower focusing coil group, and the median plane is located between the upper focusing coil group and the lower focusing coil group. The upper focusing coil group and the lower focusing coil group each include a plurality of first focusing coils and a plurality of second focusing coils. Each of the first focusing coils has a first fan-shaped structure, and they are disposed side by side around the central axis, wherein the current directions of two adjacent first focusing coils are opposite. Each of the second focusing coils has a second fan-shaped structure and is correspondingly disposed in the first focusing coils, wherein the current directions of two adjacent second focusing coils are opposite.
In some embodiments, an isochronous cyclotron is provided. The isochronous cyclotron includes a generator, an injection tube, a cavity, an inflector, the superconducting electromagnet component as described above, an accelerating device, an outlet, and a plurality of air extraction devices. The generator is configured to generate a positively charged particle source. The injection tube is in communicate with the generator and is configured to extract, bunch, and focus the positively charged particle source to form a positively charged particle beam. The cavity is in communication with the injection tube. The inflector is disposed in the cavity and configured to bend the traveling direction of the positively charged particle beam entering the cavity. The superconducting electromagnet component is disposed in the cavity, wherein the median plane of the superconducting electromagnet component accommodates the bent positively charged particle beam. The direction of the positively charged particle beam is bent from the direction where the injection tube enters to the cavity to the central region of the median plane, and the traveling direction of the positively charged particle beam is located in the median plane. The accelerating device is disposed in the cavity and configured to resonantly accelerate the positively charged particle beam on the median plane. The outlet is provided on the cavity and is configured to spontaneously extract the resonantly accelerated positively charged particle beam from the median plane to the outside of the cavity. A plurality of air extraction devices are in communication with the injection tube and the cavity to maintain the vacuum degree.
The superconducting electromagnet component and isochronous cyclotron of the present disclosure may be applied to various types of neutron capture therapy equipment. In order to make the features and advantages of the present disclosure more comprehensible, various embodiments are specially cited below, together with the accompanying drawings, to be described in detail as follows.
Aspects of the present disclosure are best understood from the following detailed description when read with the accompanying figures. It should be noted that, in accordance with the standard practice in the industry, various features are not drawn to scale. In fact, the dimensions of the various features may be arbitrarily increased or reduced for clarity of discussion.
The following disclosure provides many different embodiments, or examples, for implementing the provided superconducting electromagnet component and the isochronous cyclotron including the same. Specific examples of features and arrangements are described below to simplify the present disclosure. These are, of course, merely examples and are not intended to be limiting. For example, the formation of a first feature over or on a second feature in the description that follows may include embodiments in which the first and second features are formed in direct contact, and may also include embodiments in which additional features may be formed between the first and second features, such that the first and second features may not be in direct contact. In addition, the present disclosure may repeat reference numerals and/or letters in the various examples. This repetition is for the purpose of simplicity and clarity and does not in itself dictate a relationship between the various embodiments and/or configurations discussed.
The directional terms mentioned herein, such as “up”, “down”, “left”, “right” and similar terms refer to the directions in the drawings. Accordingly, the directional terms used herein are to illustrate, not to limit, the present disclosure.
In some embodiments of the present disclosure, terms about disposing and connecting, such as “disposing”, “connecting” and similar terms, unless otherwise specified, may refer to two features are in direct contact with each other, or may also refer to two features are not in direct contact with each other, wherein there is an additional connect feature between the two features. The terms about disposing and connecting may also include the case where both features are movable, or both features are fixed.
In addition, ordinal numbers such as “first”, “second”, and the like used in the specification and claims are configured to modify different features or to distinguish different embodiments or ranges, rather than to limit the number, the upper or lower limits of features, and are not intended to limit the order of manufacture or arrangement of features.
The terms “about”, “substantially”, or the like used herein generally means within 10%, within 5%, within 3%, within 2%, within 1%, or within 0.5% of a given value or a given range. The value given herein is an approximate value, that is, the meaning of “about” may still be implied without the specific description of “about” or “substantially”.
Unless otherwise defined, all terms including technical and scientific terms used herein have the same meaning as commonly understood by a person of ordinary skills in the art. It should be understood that these terms, such as those defined in commonly used dictionaries, should be interpreted as having meanings consistent with the relevant art and the background or context of the present disclosure, and should not be interpreted in an idealized or overly formal manner, unless otherwise defined in the embodiments of the present disclosure.
In some existing isochronous cyclotrons, hydrogen ions (H−) are usually used as charged particle beams, and the charged particle beams are resonantly accelerated on the median plane of the electromagnet component by an accelerating device. When the charged particle beam is accelerated to a specific energy, the two electrons of H− may be stripped off by the carbon foil placed on the path of H− to form hydrogen ions (H+). In this way, when the electrical property of the charged particle beam changes (from H− to H+), the charged particle beam will be pulled by the magnetic field (from clockwise (or counterclockwise) gyration to counterclockwise (or clockwise) gyration), and thus be taken out of the cyclotron as expected path.
However, the impact by the charged particle beam with high current will rapidly heat up the carbon foil, resulting in a short service life of the carbon foil. On the other hand, when the energy (e.g., kinetic energy) of the charged particle beam is higher, the temperature of the carbon foil will be further increased, which results in a shorter service life of the carbon foil. For neutron capture therapy equipment that requires large currents, the short-life carbon foil increases the times of regular replacements of the carbon foil, thereby increasing the inconvenience and increasing the risk of damage caused by disassembly and assembly of the carbon foil. In addition, if only a lower current is used to operate the device, the development and application of the device will be limited, and the treatment time with a lower current to operate the neutron capture therapy will be longer than the treatment time with a higher current to operate the neutron capture therapy. This will not only reduce the patient's comfort during treatment but also increase the probability of accidents due to longer treatment time.
In order to solve the above problems, the present disclosure provides a superconducting electromagnet component for an isochronous cyclotron and an isochronous cyclotron including the same. Specifically, the electromagnet component consists of three types of superconducting coil without iron cores and is configured to cause the charged particle beam (for example, H+) entering therein to perform an isochronous gyration motion and be spontaneously extracted under a specific kinetic energy. In this way, compared with existing cyclotrons, the isochronous cyclotron of the present disclosure (including the above-mentioned superconducting electromagnet component) does not need to control the path of the charged particle beam by a carbon foil, and it may stably generate high-current proton beams, thereby being more effectively used in neutron capture therapy equipment. On the other hand, since the superconducting coil of the present disclosure does not include iron cores, it may also have a significant lightweight effect. In some embodiments, the material of the superconducting coil without an iron core may be or may include NbTi, Nb3Sn, MgB2, Bi-2212, Bi-2223 (BiSrCaCuO), YBCO, combinations thereof, or other suitable materials, but the present disclosure is not limited thereto.
It should be noted that although it is mentioned above that the isochronous cyclotron of the present disclosure may be applied in neutron capture therapy equipment, the application of the present disclosure is not limited thereto. For example, the isochronous cyclotron of the present disclosure may also be applied to equipment that requires the use of proton beams with large currents, such as isotope production equipment. In order to make the present disclosure clearer and easier to understand, each component of the present disclosure will be explained in detail below.
In some embodiments, the superconducting main coil 10 is disposed around the central axis A and forms an accommodation space S inside. The accommodation space S is used to accommodate the superconducting trim coil group 20 and the superconducting focusing coil group 30. In some embodiments, the superconducting main coil 10 may be a hollow annular wall without an iron core (i.e., coreless), and the hollow annular wall extends vertically along the central axis A. The superconducting main coil 10 includes an upper main coil 10A and a lower main coil 10B, and the upper main coil 10A and the lower main coil 10B are disposed symmetrically with each other. There is a median plane P between the upper main coil 10A and the lower main coil 10B. In some embodiments, the superconducting main coil 10 is configured to generate a primary magnetic field that is used for horizontal focusing, isochronism, cyclotron motion of the charged particle beam, and self-extraction at specific kinetic energy. The main horizontal focusing magnetic field may cause the charged particle beam to be horizontally focused vertically to the traveling direction when moving on the median plane P.
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In some embodiments, the height h1 of the upper main coil 10A or the lower main coil 10B is between 200 mm and 500 mm, but the present disclosure is not limited thereto. For example, the height h1 of the upper main coil 10A or the lower main coil 10B may be 200 mm, 300 mm, 320 mm, 340 mm, 360 mm, 380 mm, 400 mm, 500 mm, or any value or range of values between the above values. As shown in
In some embodiments, the superconducting trim coil group 20 is disposed in the accommodation space S of the superconducting main coil 10 around the central axis A. In some embodiments, similar to the superconducting main coil 10, the superconducting trim coil group 20 may be a hollow annular pillar without an iron core (coreless), and the hollow annular pillar is surrounded by the inner wall of the superconducting main coil 10. As shown in
In some embodiments, the superconducting trim coil group 20 includes an upper trim coil group 20A and a lower trim coil group 20B, and the upper trim coil group 20A and the lower trim coil group 20B are disposed symmetrically with each other. The median plane P is located between the upper trim coil group 20A and the lower trim coil group 20B. In some embodiments, the superconducting trim coil group 20 is configured to generate the required magnetic field for finely tuned isochronous property and spontaneous extraction at specific kinetic energy. The magnetic field of the trim coil that is used for fine-tuning, in conjunction with the main coil magnetic field, enables the charged particle beam to be accelerated to a specific kinetic energy on the median plane P more stably and spontaneously extracted. As shown in
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In some embodiments, the superconducting focusing coil group 30 is disposed on a side of the superconducting trim coil group 20 away from the median plane P. The superconducting focusing coil group 30 includes an upper focusing coil group 30A and a lower focusing coil group 30B, and the upper focusing coil group 30A and the lower focusing coil group 30B are disposed symmetrically with each other. The median plane P is located between the upper focusing coil group 30A and the lower focusing coil group 30B. In some embodiments, the superconducting focusing coil group 30 is configured to generate a vertical focusing magnetic field that vertically focuses the charged particle beam on the median plane P. As shown in
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In addition, each second focusing coil 32A has a second fan-shaped structure. The size of the first fan-shaped structure of the first focusing coil 31A is larger than the size of the second fan-shaped structure of the second focusing coil 32A. In some embodiments, each second focusing coil 32A is disposed correspondingly in each first focusing coil 31A, wherein the current directions of two adjacent second focusing coils 32A are opposite. In other words, the magnetic fields formed by two adjacent second focusing coils 32A have different magnetic field intensities.
In some embodiments, each first focusing coil 31A and the second focusing coil 32A therein are configured to provide a vertical focusing magnetic field near the outer region and a vertical focusing magnetic field near the inner region, respectively. It should be noted that the current directions of each group of first focusing coils 31A and the second focusing coil 32A therein are the same, and the current directions of each group of first focusing coils 31A and the second focusing coils 32A therein are different from the current direction of another adjacent group of first focusing coils 31A and the second focusing coil 32A therein. In some embodiments, the area with high magnetic field intensity on the median plane P corresponding to the first focusing coil 31A and the second focusing coil 32A therein may be referred to as a hill H, and the area with low magnetic field intensity on the median plane P corresponding to the first focusing coil 31A and the second focusing coil 32A therein may be referred to as a valley V. In some embodiments, the difference in magnetic field intensity between the hill value and the valley value on the median plane P is between 0.1 T and 5.4 T, but the present disclosure is not limited thereto. For example, the magnetic field intensity difference may be 0.1 T, 0.5 T, 1.0 T, 1.5 T, 2.0 T, 2.7 T, 5.4 T, or any value or range of values between the above values.
Similar to the upper focusing coil group 30A, the lower focusing coil group 30B also includes a plurality of first focusing coils 31B and a plurality of second focusing coils 32B. The structure and arrangement of the first focusing coil 31B are similar to the first focusing coil 31A, and the structure and arrangement of the second focusing coil 32B are similar to the second focusing coil 32A, therefore the descriptions are omitted here. In some embodiments, the focusing coil group 30 only consists of the first focusing coils 31A, 31B and the second focusing coils 32A, 32B, and does not include other groups of focusing coils. By arranging two sets of focusing coils with fan-shaped structures of different sizes and closely disposed side by side, the charged particle beam may be vertically focused on the median plane P more stably and accurately.
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As mentioned above, the present disclosure effectively enables the charged particle beam on the median plane P to have isochronous and spontaneous extraction effects by providing a superconducting electromagnet component having the above components. In some embodiments, the average magnetic field intensity experienced by the charged particle beam on the median plane P is about 1.4 T to 2.7 T, but the present disclosure is not limited thereto. For example, the average magnetic field intensity experienced by the charged particle beam on the median plane P may be about 1.4 T, 1.8 T, 2.2 T, 2.7 T, or any value or range of values between the above values. In some embodiments, the extracted kinetic energy of the charged particle beam on the median plane P is between 5 MeV and 35 MeV, but the present disclosure is not limited thereto. For example, the extracted kinetic energy of the charged particle beam on the median plane P may be 5 MeV, 10 MeV, 20 MeV, 35 MeV, or any value or range of values between the above values. In some embodiments, the extraction kinetic energy of the charged particle beam on the median plane P may be 30 MeV, so that it may be preferably used in neutron capture therapy equipment. It should be noted that in the present disclosure, the charged particles are all H+.
The cavity 4 is in communication with the injection tube 3 and is used to accommodate the inflector 5, the superconducting electromagnet component 1, and the accelerating device 6. The inflector 5 is disposed in the cavity 4 and is configured to bend the traveling direction of the positively charged particle beam entering the cavity 4 to make the positively charged particle beam enter the median plane P in the electromagnet component 1. The electromagnet component 1 is disposed in the cavity 4, wherein the median plane P of the electromagnet component 1 accommodates the bent positively charged particle beam. Detailed features of the electromagnet component 1 may be referred to above and the descriptions thereof are omitted. The accelerating device 6 is disposed in the cavity and is configured to resonantly accelerate the positively charged particle beam on the median plane P (for example, using radio frequency (RF)). The outlet 7 is disposed on the cavity 4 and is configured to extract the resonantly accelerated positively charged particle beam from the median plane P to the outside of the cavity. The air extraction devices 8 are in fluid communication with the injection tube 3 and the cavity 4 and are configured to maintain the vacuum inside the cavity 4. Compared with existing devices, the isochronous cyclotron C of the present disclosure does not use as the charged particle beam, and therefore does not need to provide a carbon foil for stripping electrons on the path of the charged particle beam. In this way, without stripping electrons by the carbon foil to change the path of charged particles, the cyclotron of the present disclosure is not limited by the lifetime limit of the carbon foil, and thus can achieve the effect of outputting a proton beam with high energy at a large current.
As shown in Table 2 below, it is the current parameters of each component of the superconducting electromagnet component 1 of the example.
As shown in Table 3 below, it is the test results of the example.
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The foregoing outlines features of several embodiments so that those skilled in the art may better understand the aspects of the present disclosure. Those skilled in the art should appreciate that they may readily use the present disclosure as a basis for designing or modifying other processes and structures for carrying out the same purposes and/or achieving the same advantages of the embodiments introduced herein. Those skilled in the art should also realize that such equivalent constructions do not depart from the spirit and scope of the present disclosure, and that they may make various changes, substitutions, and alterations herein without departing from the spirit and scope of the present disclosure.
This application claims the benefit of U.S. Provisional Application No. 63/413,790, filed 06, October 2022, the entirety of which is incorporated by reference herein.
Number | Date | Country | |
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63413790 | Oct 2022 | US |