SUPPORT SYSTEM FOR SUBCUTANEOUS INSULIN DELIVERY BY PUMP

Information

  • Research Project
  • 6524467
  • ApplicationId
    6524467
  • Core Project Number
    R01DK057210
  • Full Project Number
    5R01DK057210-03
  • Serial Number
    57210
  • FOA Number
    PAR-99-009
  • Sub Project Id
  • Project Start Date
    9/20/2000 - 21 years ago
  • Project End Date
    8/31/2003 - 18 years ago
  • Program Officer Name
    ARREAZA-RUBIN, GUILLERMO
  • Budget Start Date
    9/1/2002 - 19 years ago
  • Budget End Date
    8/31/2003 - 18 years ago
  • Fiscal Year
    2002
  • Support Year
    3
  • Suffix
  • Award Notice Date
    9/2/2002 - 19 years ago
Organizations

SUPPORT SYSTEM FOR SUBCUTANEOUS INSULIN DELIVERY BY PUMP

DESCRIPTION (Adapted from the application: Control of the blood glucose concentration in diabetes mellitus is crucial to avoiding complications of this disease. However, optimal glucose control is difficult, if not impossible for most patients with insulin-dependent diabetes to achieve with currently available therapy. This consists of either multiple daily insulin injections or use of an insulin pump, with dosage adjustment based on finger stick blood glucose readings one or more times each day. This revised application proposes to develop a feedback-controlled insulin delivery system consisting of an implantable glucose sensor linked to an insulin pump. This closed-loop system will be under the control of an algorithm that mimics the function of normal pancreatic beta cells. This algorithm will also be developed and tested in the proposed studies. Experiments will be performed in normal and diabetic dogs, as well as in human subjects with diabetes. In the first specific aim, the glucose sensor and insulin pump will be linked with a feedback algorithm and tested first in normal and then in diabetic dogs under various conditions designed to reflect clinical situations. In the second specific aim, the closed loop system and control algorithms will be tested in humans, with close attention to the sensor response to hypoglycemic challenge. In the third specific aim, the control algorithm will be refined and validated in diabetic humans with varying degrees of insulin sensitivity. In the fourth specific aim, the efficacy and safety of the closed-loop system will be tested for its ability to control blood glucose in diabetic humans. The overall goal is the same: to implement a working closed-loop insulin delivery system for Type I diabetic patients within three years.

IC Name
NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES
  • Activity
    R01
  • Administering IC
    DK
  • Application Type
    5
  • Direct Cost Amount
  • Indirect Cost Amount
  • Total Cost
    312363
  • Sub Project Total Cost
  • ARRA Funded
  • CFDA Code
    847
  • Ed Inst. Type
  • Funding ICs
    NIDDK:312363\
  • Funding Mechanism
  • Study Section
    ZRG1
  • Study Section Name
    Special Emphasis Panel
  • Organization Name
    MEDTRONIC MINIMED
  • Organization Department
  • Organization DUNS
  • Organization City
    NORTHRIDGE
  • Organization State
    CA
  • Organization Country
    UNITED STATES
  • Organization Zip Code
    91325
  • Organization District
    UNITED STATES