Claims
- 1. An adduct support, comprising: a chemically reactive support having azlactone-functionality at surfaces of the support and a ligand comprising a nucleophilic reagent reacted with the azlactone-functionality, wherein the chemically reactive support comprises a porous pre-existing support having surfaces and azlactone-functional moieties contacting only the surfaces and modifying reactivity of only such surfaces while retaining useful porosity of the pre-existing support;
- wherein said contacting is selected from the group consisting of chemically grafting the azlactone-functional moieties to the surfaces, crosslinking the azlactone-functional moieties in a coating over the surfaces, and forming crosslinked particles of the azlactone-functional moieties in contact with the surfaces.
- 2. The adduct support according to claim 1, wherein the azlactone-functional moieties comprise oxazolinone moieties of the formula: ##STR4## wherein R.sup.1 and R.sup.2 independently can be an alkyl group having 1 to 14 carbon atoms, a cycloalkyl group having 3 to 14 carbon atoms, an aryl group having 5 to 12 ring atoms, an arenyl group having 6 to 26 carbon atoms and 0 to 3 S, N, and nonperoxidic O heteroatoms, or R.sup.1 and R.sup.2 taken together with the carbon to which they are joined can form a carbocyclic ring containing 4 to 12 ring atoms, and
- n is an integer 0 or 1.
- 3. The adduct support according to claim 1, wherein the pre-existing support is a ceramic, glassy, metallic, or polymeric material.
- 4. The adduct support according to claim 3, wherein the pre-existing support is a polymeric material.
- 5. The adduct support according to claim 4, wherein the porous, polymeric material is a woven web, a nonwoven web, a microporous fiber, or a microporous membrane.
- 6. The adduct support according to claim 1, wherein the nucleophilic reagent comprises biologically active materials, acids, bases, chelators, hydrophiles, lipophiles, hydrophobes, zwitterions, detergents, or combinations thereof.
- 7. The adduct support according to claim 6, wherein biologically active material comprises substances which are biologically, immunochemically, physiologically, or pharmaceutically active.
- 8. The adduct support according to claim 7, wherein the biologically active material comprises proteins, peptides, polypeptides, antibodies, antigenic substances, enzymes, cofactors, inhibitors, lectins, hormones, receptors, coagulation factors, amino acids, histones, vitamins, drugs, cell surface markers, substances which interact with them, or combinations thereof.
- 9. The adduct support according to claim 6, wherein the adduct support is an adsorbant, complexing agent, catalyst, or chromatographic article.
- 10. The adduct support according to claim 6, wherein the adduct support is a mammalian body implant and wherein the nucleophilic reagent is an anticoagulant.
Parent Case Info
This is a division of application Ser. No. 07/896,107 filed Jun. 9, 1992 now U.S. Pat. No. 5,344,701.
US Referenced Citations (41)
Foreign Referenced Citations (2)
Number |
Date |
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3261568 |
Jul 1969 |
AUX |
0264804 |
Apr 1988 |
EPX |
Divisions (1)
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Number |
Date |
Country |
Parent |
896107 |
Jun 1992 |
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