Claims
- 1. An improved pharmaceutical depot adapted for implantation in a human or non-human animal for the prolonged release therewithin of at least one biologically active substance, said depot comprising a silicone carrier and incorporated therein said biologically active substance, the improvement wherein said depot is coated with a biologically active and biocompatible glass, glass-ceramic or ceramic material comprising at least about 40 weight percent silicon dioxide, said glass coating being capable of forming a bond to soft tissue upon implantation.
- 2. The depot of claim 1 wherein said biologically active and biocompatible glass, glass-ceramic or ceramic has the following weight percentage composition:WeightCompositionPercentageSiO240-52CaO10-50NaO210-35P2O52-8CaF2 0-25B2O3 0-10.
- 3. The depot of claim 1 wherein said coating of said biologically active and biocompatible glass, glass-ceramic or ceramic has a thickness of from about 0.02 mm to about 1.0 mm.
- 4. The depot of claim 1 wherein said biologically active substance is a steroid, hormone, antibiotic, chemotherapeutical agent, prostaglandin, vitamin, contraceptive or behavior modification agent.
BACKGROUND OF THE INVENTION
1. Related Application
Reference is hereby made to provisional patent application Ser. No. 60/105,982 filed Oct. 28, 1998, upon which the claim of domestic priority is based herein.
US Referenced Citations (13)
Provisional Applications (1)
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Number |
Date |
Country |
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60/105982 |
Oct 1998 |
US |