Claims
- 1. A surgical implant comprising:
(a) an implant body; and (b) an osseo-stimulative surface, applied to said implant body, said surface including a calcium sulfate (“CS”) compound which is a member selected of the group consisting of CS dihydrate, CS hemihydrate, anhydrous CS and mixtures thereof.
- 2. The implant as recited in claim 1 in which said surface further comprises a stabilizer component.
- 3. The implant as recited in claim 2 in which said stabilizer component is a member selected from the group consisting of alkali metal fluorides, alkaline earth fluorides and combinations thereof.
- 4. The implant as recited in claim 2 in which said surface further comprises a viscosity modifier.
- 5. The implant as recited in claim 4 in which said viscosity modifier is a member selected from the group consisting of glycogen, maltose, polyethylene glycol, hyaluronic acid, nonfibrillar collagen, succinylated collagen, and mixtures thereof.
- 6. The implant as recited in claim 2 in which said surface further comprises a pH modifier.
- 7. The implant as recited in claim 6 in which said pH modifier is selected for decreasing pH.
- 8. The implant as recited in claim 7 in which said pH modifier is a member selected from the group consisting of sodium dihydrogen citrate, disodium hydrogen citrate, ammonium dihydrogen citrate, diammonium hydrogen citrate, potassium dihydrogen citrate, dipotassium hydrogen citrate and mixtures thereof.
- 9. The implant as recited in claim 6 in which said pH modifier is selected for increasing pH.
- 10. The implant as recited in claim 9 in which said pH modifier is a member selected from the group consisting of NaOH, KOH, NHOH ammonium citrate, sodium phosphate, disodium hydrogen phosphate, potassium phosphate, dipotassium hydrogen phosphate and mixtures thereof.
- 11. The implant as recited in claim 2 in which said implant body further comprises as osseo-stimulative microgeometry.
- 12. The implant as recited in claim 2 in which said CS compound comprises a molarity in a range of 0.5 to 20×10−2 M.
- 13. The dental implant as recited in claim 4 in which said CS compound comprises a molarity in a range of 0.5 to 20×10−2 M.
- 14. The implant as recited in claim 6 in which said CS compound comprises a molarity in a range of 0.5 to 20×10−2 M.
- 15. The implant as recited in claim 2 in which said surface is a member selected from the group consisting of a physically adhered layer, a powder, granules, paste, gel, grout, cement, gauze and combinations thereof.
- 16. The implant as recited in claim 15 in which properties of rate of bio-resorption of said CS compound of said surface is substantially matched to a surgical healing environment within which said implant is to be used in situ.
- 17. The implant as recited in claim 16 in which said surface defines a first layer.
- 18. The implant as recited in claim 17 in which said implant further comprises:
a second layer of said CS compound defining a barrier between osseous tissue in contact with said first layer and non-osseous tissue, said barrier having a slower rate of in situ bio-resorption than that of said CS compound of said first layer.
- 19. The implant as recited in claim 18 in which said second layer is a member selected from the group consisting of a physically adhered layer, a powder, granules, paste, gel, grout, gauze and combinations thereof.
- 20. The implant as recited in claim 19 in which properties of rate of bio-resorption of said CS compounds of either or both of said layers is substantially matched to a surgical healing environment within which said implant is to be used in situ.
- 21. A kit of dental implant materials for bone augmentation and bone defect reparation comprising:
(a) an implant body; and (b) an osseo-stimulative surface, applied to said implant body, said surface including a calcium sulfate (“CS”) compound which is a member selected from the group consisting of CS dihydrate, CS hemihydrate, anhydrous CS and mixtures thereof; and (c) a standalone quantity CS compound for in situ application to said implant body, in which said CS compound is a member selected from the group consisting of CS dihydrate, CS hemihydrate, anhydrous CS and mixtures thereof.
- 22. The kit as recited in claim 21 in which said surface further comprises a setting agent.
- 23. The kit as recited in claim 22 in which said setting agent is an alkaline metal salt solution.
- 24. The Kit as recited in claim 23 in which said setting agent is a potassium salt solution.
- 25. The kit as recited in claim 22 in which said surface further comprises a viscosity modifier.
- 26. The kit as recited in claim 25 in which said viscosity modifier is a member selected from the group consisting of glycogen, maltose, polyethylene glycol, hyaluronic acid, nonfibrillar collagen, succinylated collagen, and mixtures thereof.
- 27. The kit as recited in claim 22 in which said surface further comprises a pH modifier.
- 28. The kit as recited in claim 21 in which said standalone quantity of CS is a member consisting of a physically adhered layer, a powder, granules, paste, gel, grout, cement, gauze and combinations thereof.
- 29. The kit as recited in claim 28 in which said surface in which said surface comprises a matrix including particles of a resorbable agent for aiding in situ bio-resorption of said CS compound at a rate substantially matched to a process of bone healing.
- 30. The kit as recited in claim 28 in which said standalone CS quantity includes particles of a resorbable agent for aiding in situ bio-resorption of said CS compound at a rate substantially matched to a process of bone healing.
- 31. The kit as recited in claim 29 in which said resorbable agent is a member selected from the group consisting of aliphatic polyesters of an alpha-hydroxy acid derivative, a hydrophilic polymer, an amino derived polymer, poly-vinyl alcohols, polylactides, polyglycolides, polydioxanides, poly-episilon-caprolactones, polymeric salicylates and mixtures thereof.
- 32. The kit as recited in claim 30 in which said resorbable agent is a member selected from the group consisting of aliphatic polyesters of alpha-hydroxy acid derivative, a hydrophobic polymer, an amino derived polymer, poly-vinyl alcohols, polylactides, polyglycolides, polydioxanides, poly-episilon-caprolactones, polymeric salicylates and mixtures thereof.
- 33. A system of bone augmentation comprising:
(a) a surgical implant positioned within an osseotomy site; and (b) an osseo-stimulative surface positioned in situ about said surgical implant, said surface comprising a calcium sulfate(“CS”) compound which is a member selected from the group consisting of CS dihydrate, CS hemihydrate, anhydrous CS and mixtures thereof.
- 34. The system as recited in claim 33 in which said coating further comprises a stabilizer component.
- 35. The system as recited in claim 34 in which said stabilizer component is a member selected from the group consisting of alkali metal fluorides, alkaline earth fluorides and combinations thereof.
- 36. The system as recited in claim 34 in which said surface is a member selected from the group of a physically associated layer, the group consisting of a powder, granules, paste, gel, grout, gauze and combinations thereof.
REFERENCE TO RELATED APPLICATION
[0001] This case is a continuation-in-part of application Ser. No. 09/187,584, filed Nov. 6, 1998 by Ricci, et al, entitled Implantation of Surgical Implants with Calcium Sulfate, the subject matter of which is incorporated herein by reference.
Continuation in Parts (1)
|
Number |
Date |
Country |
Parent |
09187584 |
Nov 1998 |
US |
Child |
09766064 |
Jan 2001 |
US |