The present disclosure relates to a surgical apparatus, e.g., a surgical stapling apparatus. More particularly, the present disclosure relates to a surgical stapling apparatus including a detachable surgical buttress and/or an endoscopic surgical stapling apparatus that includes a detachable surgical buttress for a loading unit, e.g., a single use loading unit (“SULU”) or disposable loading unit (“DLU”). For simplicity, hereinafter, SULU or DLU will be referred to as “DLU”, but it should be understood to include either or both a DLU or SULU.
Surgical devices wherein tissue is first grasped or clamped between opposing jaw structure and then joined by surgical fasteners are well known in the art. In some instruments a knife is provided to cut the tissue which has been joined by the fasteners. The fasteners are typically in the form of surgical staples but two part polymeric fasteners can also be utilized.
Instruments for this purpose can include two elongated jaw members which are respectively used to capture or clamp tissue. Typically, one of the jaw members carries a staple cartridge which houses a plurality of staples arranged in at least two lateral rows while the other jaw member has an anvil that defines a surface for forming the staple legs as the staples are driven from the staple cartridge. Generally, the stapling operation is effected by cam members that travel longitudinally through the staple cartridge, with the cam members acting upon staple pushers to sequentially eject the staples from the staple cartridge. A knife can travel between the staple rows to longitudinally cut and/or open the stapled tissue between the rows of staples. Such instruments are disclosed, for example, in U.S. Pat. Nos. 3,079,606 and 3,490,675.
A later stapler disclosed in U.S. Pat. No. 3,499,591 also applies a double row of staples on each side of the incision. This patent discloses a surgical stapler that has a disposable loading unit in which a cam member moves through an elongate guide path between two sets of staggered staple carrying grooves. Staple drive members are located within the grooves and are positioned in such a manner so as to be contacted by the longitudinally moving cam member to effect ejection of the staples from the staple cartridge of the disposable loading unit. Other examples of such staplers are disclosed in U.S. Pat. Nos. 4,429,695 and 5,065,929.
Each of the instruments described above is designed for use in conventional surgical procedures wherein surgeons have direct manual access to the operative site. However, in endoscopic or laparoscopic procedures, surgery is performed through a small incision or through a narrow cannula inserted through small entrance wounds in the skin. In order to address the specific needs of endoscopic and/or laparoscopic surgical procedures, endoscopic surgical stapling devices have been developed and are disclosed in, for example, U.S. Pat. No. 5,040,715 (Green, et al.); U.S. Pat. No. 5,307,976 (Olson, et al.); U.S. Pat. No. 5,312,023 (Green, et al.); U.S. Pat. No. 5,318,221 (Green, et al.); U.S. Pat. No. 5,326,013 (Green, et al.); U.S. Pat. No. 5,332,142 (Robinson, et al.); and U.S. Pat. No. 6,241,139 (Milliman et al.), the entire contents of each of which are incorporated herein by reference.
Tyco Healthcare Group, LP, the assignee of the present application, has manufactured and marketed endoscopic stapling instruments, such as the Multifire ENDO GIA™. 30 and Multifire ENDO GIA™. 60 instruments, for a number of years. These instruments include a surgical stapling apparatus and a DLU. Typically, the DLU is attached to the apparatus immediately prior to surgery. After use, the DLU can be removed from the apparatus and a new DLU can be fastened to the apparatus to perform additional stapling and/or cutting operations. These instruments have provided significant clinical benefits. Nonetheless, improvements to these instruments are still possible.
It would be desirable to provide a surgical buttress selectively connected to at least one of the tissue contacting surfaces of the cartridge half-section and the anvil half-section of the surgical stapling apparatus.
It would also be desirable to provide a system for removing the surgical buttress from the tissue contacting surface of the cartridge half-section and/or the tissue contacting surface of the anvil half-section during a firing of the surgical stapling apparatus.
Accordingly, it is an object of this disclosure to meet the aforementioned desires.
In accordance with the present disclosure a surgical stapling apparatus is provided including a housing; a handle supported by the housing; an elongated body extending distally from the housing and having a distal end adapted to releasably engage a loading unit; and a loading unit supportable on a distal end of the housing. The loading unit includes a tool assembly having a cartridge assembly configured and adapted to releasably support a staple cartridge having a plurality of surgical fasteners therein, and an anvil assembly movably secured in relation to the cartridge assembly, wherein the anvil assembly is configured and adapted to support an anvil plate and, wherein each of the anvil plate and the staple cartridge define an elongate longitudinal slot. The loading unit further includes a surgical buttress releasably secured to a tissue contacting surface of at least one of the anvil plate and the staple cartridge, wherein each surgical buttress is secured to the at least one of the anvil assembly and the cartridge assembly by at least one anchor. The loading unit still further includes a drive assembly slidably supported in the tool assembly, the drive assembly including a knife blade slidably disposed within each elongate longitudinal slot, wherein movement of the drive assembly from a proximal position to a distal position results in the knife blade thereof cutting the at least one anchor and freeing each surgical buttress from the respective at least one anvil assembly and cartridge assembly.
The anvil assembly may include a proximal suture securing the surgical buttress thereto and/or a distal anchor securing the surgical buttress thereto. The cartridge assembly may include a proximal anchor securing the surgical buttress thereto and/or a distal anchor securing the surgical buttress thereto. Each anchor of the anvil assembly and the cartridge assembly may extend across the respective longitudinal slot of the anvil plate and the staple cartridge.
The anvil assembly may include a knife blade slidably or rotatably supported therein and defining a knife edge. The knife blade of the anvil assembly may cut at least one of the proximal and distal anchors of the anvil assembly upon actuation thereof. The knife blade of the anvil assembly may have a first position located substantially proximal of the distal anchor of the anvil assembly and a second position located substantially distal of the distal anchor of the anvil assembly, thereby cutting the distal anchor of the anvil assembly. The drive assembly may move the knife blade of the anvil assembly from the first position to the second position upon distal actuation of the drive assembly.
The cartridge assembly may include a knife blade slidably or rotatably supported therein and defining a knife edge, wherein the knife blade of the cartridge assembly cuts at least one of the proximal and distal anchors of the cartridge assembly upon actuation thereof. The knife blade of the cartridge assembly may have a first position located substantially proximal of the distal anchor of the cartridge assembly and a second position located substantially distal of the distal anchor of the cartridge assembly, thereby cutting the distal anchor of the cartridge assembly. The drive assembly may move the knife blade of the cartridge assembly from the first position to the second position upon distal actuation of the drive assembly.
According to another aspect of the present disclosure, a loading unit for use with a surgical stapling apparatus is provided. The loading unit includes a tool assembly having a cartridge assembly configured and adapted to releasably support a staple cartridge having a plurality of surgical fasteners therein, and an anvil assembly movably secured in relation to the cartridge assembly, wherein the anvil assembly is configured and adapted to support an anvil plate and, wherein each of the anvil plate and the staple cartridge define an elongate longitudinal slot. The loading unit also includes a surgical buttress releasably secured to a tissue contacting surface of at least one of the anvil plate and the staple cartridge, wherein each surgical buttress is secured to the at least one of the anvil assembly and the cartridge assembly by at least one anchor. The loading unit further includes a drive assembly slidably supported in the tool assembly, the drive assembly including a knife blade slidably disposed within each elongate longitudinal slot, wherein movement of the drive assembly from a proximal position to a distal position results in the knife blade thereof cutting the at least one anchor and freeing each surgical buttress from the respective at least one anvil assembly and cartridge assembly.
According to yet another aspect of the present disclosure, a loading unit for selective use with a surgical stapling apparatus is provided. The loading unit includes a tool assembly having a cartridge assembly configured and adapted to releasably support a staple cartridge having a plurality of surgical fasteners therein, and an anvil assembly movably secured in relation to the cartridge assembly, wherein the anvil assembly is configured and adapted to support an anvil plate and, wherein each of the anvil plate and the staple cartridge define an elongate longitudinal slot. The loading unit further includes a surgical buttress releasably secured to a tissue contacting surface of each of the anvil plate and the staple cartridge; and anchors securing the surgical buttress to each of the anvil plate and the staple cartridge, wherein an anchor is located near a proximal end and a distal end of each of the anvil assembly and the cartridge assembly. The loading unit also includes a knife blade operatively disposed in the anvil assembly, wherein the knife blade of the anvil assembly has a first position located proximal of a distal anchor of the anvil assembly and a second position located distal of the distal anchor of the anvil assembly, thereby cutting the distal anchor of the anvil assembly. The loading unit still further includes a knife blade operatively disposed in the cartridge assembly, wherein the knife blade of the cartridge assembly has a first position located proximal of a distal anchor of the cartridge assembly and a second position located distal of the distal anchor of the cartridge assembly, thereby cutting the distal anchor of the cartridge assembly. The loading unit also includes a drive assembly slidably supported in the tool assembly, the drive assembly including a knife blade slidably disposed within each elongate longitudinal slot, wherein movement of the drive assembly from a proximal position to a distal position results in the knife blade thereof cutting a proximal anchor of each of the anvil assembly and the cartridge assembly and freeing a proximal end of each surgical buttress from the respective at least one anvil assembly and cartridge assembly, and wherein movement of the drive assembly from the proximal position to the distal position moves the knife blade of the anvil assembly and the knife blade of the cartridge assembly from their respective first positions to their respective second positions, thereby cutting a respective distal anchor of the anvil assembly and the cartridge assembly and freeing a distal end of each surgical buttress from the respective at least one anvil assembly and cartridge assembly.
According to a further aspect of the present disclosure, a surgical stapling apparatus is provided. The surgical stapling apparatus includes a cartridge assembly defining a tissue contacting surface; an anvil assembly defining a tissue contacting surface; and a surgical buttress releasably secured to at least one of the tissue contacting surface of the cartridge assembly and the tissue contacting surface of the anvil assembly by at least one anchor.
An anchor may be placed near at least one of a proximal end and a distal end of each surgical buttress. Each anchor may extend transverse to a longitudinal axis of a respective one of the cartridge assembly and the anvil assembly.
The anchor may be selected from the group consisting of sutures, threads, tethers, straps, bands, lines, wires, cables, tacks, anchors, and fasteners.
At least a proximal anchor may extend across a respective longitudinal knife slot formed in each of the cartridge assembly and the anvil assembly and/or at least a distal anchor may extend across a respective longitudinal knife slot formed in each of the cartridge assembly and the anvil assembly.
The anchor may release a respective surgical buttress upon firing of the surgical stapling apparatus. Each anchor may be severed to release the surgical buttress upon a firing of the surgical stapling apparatus.
The surgical stapling apparatus may include a knife blade configured and dimensioned for slidable reciprocation through a respective longitudinal knife slot formed in each of the cartridge assembly and the anvil assembly, wherein the knife blade severs an anchor upon distal advancement thereof.
The surgical stapling apparatus may further include a drive assembly slidably supported for axial displacement along the cartridge assembly and the anvil assembly, wherein movement of the drive assembly from a proximal position to a distal position results in the separation of the surgical buttress from a respective one of the cartridge assembly and the anvil assembly.
An anchor may be placed near at least one of a proximal end and a distal end of each surgical buttress. The drive assembly may either directly cut each anchor or may cause each anchor to be cut in order to release the surgical buttress from the respective cartridge assembly and anvil assembly.
Additional advantages will become apparent from the description which follows, taken in conjunction with the accompanying drawings.
The present disclosure will be further described with reference to the accompanying drawings, wherein like reference numerals refer to like parts in the several views, and wherein:
Embodiments of the presently disclosed surgical stapling apparatus and DLU will now be described in detail with reference to the drawings, in which like reference numerals designate identical or corresponding elements in each of the several views.
In the drawings and in the description that follows, the term “proximal”, as is traditional, will refer to the end of the stapling apparatus which is closest to the operator, while the term “distal” will refer to the end of the apparatus which is furthest from the operator.
Surgical stapling apparatus 10 is an endoscopic apparatus and includes a handle assembly 12 and an elongated body 14 extending from handle assembly 12. A DLU 16 is releasably secured to the distal end of elongated body 14. While this disclosure relates to the use of a DLU with surgical stapling apparatus 10, it is understood and within the scope of the present disclosure that a single use loading unit (SULU) or other end effector and/or tool assembly can equally be used in cooperation with surgical stapling apparatus 10.
DLU 16 includes a tool assembly 17 having a cartridge assembly 18 housing a plurality of surgical fasteners or staples 84 (see
A rotatable member 28 is mounted on the forward end of barrel portion 26 to facilitate rotation of elongated body 14 and attached DLU 16 with respect to handle assembly 12. An articulation lever 30 is also mounted on the forward end of barrel portion 26 adjacent rotatable member 28 to facilitate articulation of tool assembly 17. Preferably, a pair of knobs 32 are movably positioned along barrel portion 26. Knobs 32 are advanced distally to approximate or close cartridge and/or anvil assembly 18, 20, and retracted proximally to unapproximate or open cartridge and/or anvil assembly 18, 20.
DLU 16 is desirably selectively removably couplable to elongated body 14. DLU 16 includes a housing portion 36 having a proximal end adapted to releasably engage the distal end of elongated body 14. A mounting assembly 38 is pivotally secured at “P” to the distal end of housing portion 36, and is configured to receive the proximal end of tool assembly 17 such that pivotal movement of tool assembly 17 about an axis at “P”, perpendicular to the longitudinal axis of housing portion 36, effects articulation of tool assembly 17.
With general reference to
An axial drive assembly 50 is operatively associated with and slidably disposed between cartridge and/or anvil assembly 18, 20. With reference to
Proximal end 56 of drive beam 52 of drive assembly 50 includes a pair of resilient engagement fingers which are dimensioned and configured to mountingly engage a drive member, e.g., a drive rod or control rod (not shown) when the proximal end of DLU 16 is engaged with elongated body 14 of surgical stapling apparatus 10. The control rod functions to impart axial movement of drive assembly 50 from handle assembly 12.
Distal end 54 of drive beam 52 of drive assembly 50 is configured and adapted to support an I-Beam 60. I-beam 60 includes a central wall portion 62 and an upper and lower rail portion 64a, 64b, respectively. A distal edge of central wall portion 62 defines a knife blade or the like 66.
As seen in
In operation, an upper surface of anvil plate 70 defines a camming surface 70c against which upper rail portion 64a of I-beam 60 engages to cam, urge and clamp anvil assembly 20 against the tissue as drive assembly 50 advances I-beam 60 through longitudinal slot 70b.
With continued reference to
As used herein the term anchor is understood to include and is not limited to suture, thread, tether, strap, band, line, wire, cable, fastener, tack, anchor or any other material suitable for the intended purpose disclosed herein.
Anvil assembly 20 further includes a knife blade 74 defining a distally oriented knife edge 74a and being operatively interposed within the cavity defined between anvil plate 70 and cover plate 72. Knife blade 74 has an initial or first condition positioned proximal of the distal pair of recesses 70e and a final or second condition positioned distal of the distal pair of recesses 70e. Knife blade 74 includes an engaging element 74b, e.g., a recess, formed in a surface thereof for selectively engaging a complementary engaging element, e.g., nub, (not shown) projecting from a surface of cover plate 72, or a distal cap 76 of anvil assembly 20. The engaging elements inter-engage with one another to maintain or hold knife blade 74 stationary and in the initial or first condition.
In an embodiment distal cap 76 includes a pair of opposed recesses 76a formed in opposed side edges thereof which align with the distal pair of recesses 70e formed in anvil plate 70 when cover plate 72 is assembled with anvil plate 70. Additionally, cover plate 72 defines a pair of opposed recesses 72a formed therein which align with the proximal pair of recesses 70d formed in anvil plate 70 when cover plate 72 is assembled with anvil plate 70.
Anvil assembly 20 further includes a surgical buttress “B”, pledget or the like operatively secured to a lower surface of anvil plate 70, by anchor “S”, to overlie at least some of anvil pockets 70a and/or at least a portion of a length of longitudinal slot 70b. In particular, an anchor “S” is threaded through a distal portion of the anvil buttress “B” and each of the distal pair of recesses 70e, and an anchor “S” is threaded through a proximal portion of anvil buttress “B” and each of the proximal pair of recesses 70d.
In one particular embodiment, a first end of a anchor “S” includes a knot, stop or the like (not shown) sized so as to not pass through one recess of the proximal pair of recesses 70d while a second end of anchor “S” passes through, and transversely across, anvil buttress “B”, at least once, and back through the other recess of the proximal pair of recesses 70d. For example, the second end of anchor “S” may be pinched or cinched in the other recess of the proximal pair of recesses 70d so as to anchor the second end of the anchor “S” and secure the anvil buttress “B” against the lower surface of anvil plate 70. Similarly, an anchor “S” is used to extend transversely across anvil buttress “B” and into engagement with the distal pair of recesses 70e.
In operation, as will be discussed in greater detail below, with anvil buttress “B” secured against the lower surface of anvil plate 70, during firing of surgical stapling apparatus 10, as drive assembly 50 is advanced (i.e., moved from a proximal-most position to a distal-most position), knife blade 66 slices through a central section of the proximal anchor “S”, thereby freeing the proximal end of the anvil buttress “B” from anvil assembly 20. As drive assembly 50 approaches the distal end of anvil plate 70, upper rail 64a of I-beam 60 abuts against and urges knife blade 74 distally. As knife blade 74 is moved distally, from the initial or first condition positioned proximal of the distal pair of recesses 70e to the final or second condition positioned distal of the distal pair of recesses 70e, knife edge 74a thereof slices or cuts through distal anchor “S”, thereby freeing the distal end of the anvil buttress “B” from anvil assembly 20. Knife blade 74 cuts through the distal anchor “S” extending through both recesses of the distal pair of recesses 70e.
As seen in
A central longitudinal slot 82c is formed in and extends along the length of staple cartridge 82 to facilitate passage of central wall portion 62 of I-beam 60 therethrough. During operation of surgical stapler 10, actuation sled 90 translates through longitudinal slots 82b of staple cartridge 82 to advance cam wedges 90a into sequential contact with pushers 92, to cause pushers 92 to translate vertically within retention slots 82a and urge fasteners 84 (e.g., staples) from slots 82a into the staple forming cavities 70a of anvil plate 70 of anvil assembly 20.
With continued reference to
Cartridge assembly 18 further includes a knife blade 94 defining a distally oriented knife edge 94a (see
Knife blade 94 may include an engaging element (not shown) formed in a surface thereof for selectively engaging a complementary engaging element (not shown) projecting from a surface of staple cartridge 82 of cartridge assembly 18. The engaging elements inter-engage with one another to maintain or hold knife blade 94 stationary and in the initial or first condition.
Cartridge assembly 18 further includes a surgical buttress “B”, pledget or the like operatively secured to an upper surface of staple cartridge 82, by anchors “S”, to overlie at least some of staple pockets 82a and/or at least a portion of a length of longitudinal slot 82c. In particular, an anchor “S” is threaded through a distal portion of the cartridge buttress “B” and each of the distal pair of recesses 82f, and an anchor “S” is threaded through a proximal portion of cartridge buttress “B” and each of the proximal pair of recesses 82e.
In one particular embodiment, a first end of each anchor “S” includes a knot, stop or the like (not shown) sized so as to not pass through one recess of the proximal pair of recesses 82e and a second end of each anchor “S” passes through, and transversely across, cartridge buttress “B”, at least once, and back through the other recess of the proximal pair of recesses 82e. For example, the second end of each anchor “S” may be pinched or cinched in the other recess of the proximal pair of recesses 82e so as to anchor the second end of the anchor “S” and secure the cartridge buttress “B” against the tissue contacting surface of staple cartridge 82. Similarly, an anchor “S” is used to extend transversely across cartridge buttress “B” and into engagement with the distal pair of recesses 82f.
In operation, as will be discussed in greater detail below, with cartridge buttress “B” secured against the tissue contacting surface of staple cartridge 82, during firing of surgical stapling apparatus 10, as drive assembly 50 is advanced (i.e., moved from a proximal-most position to a distal-most position), knife blade 66 slices through a central section of the proximal anchor “S”, thereby freeing the proximal end of the cartridge buttress “B” from cartridge assembly 18. As seen in
As drive assembly 50 is advanced from a proximal-most position to a distal-most position, knife blade 66 thereof slices or cuts longitudinally through both anvil buttress “B” and cartridge buttress “B”, thereby dividing the buttresses “B” substantially in half. Additionally, as drive assembly 50 is advanced from a proximal-most position to a distal-most position, upstanding cam wedges 90a of actuation sled 90 actuates pushers 92, to cause pushers 92 to translate vertically within retention slots 82a and urge fasteners 84 from slots 82a. As fasteners 84 (e.g., staples) are urged from slots 82a of staple cartridge 82, legs of fasteners 84 penetrate and pass through both anvil buttress “B” and cartridge buttress “B”, through any tissue (not shown) interposed between anvil buttress “B” and cartridge buttress “B”, and are formed against or within staple forming cavities 70a of anvil plate 70 of anvil assembly 20.
According to the present disclosure, anvil buttress “B” and/or cartridge buttress “B” is pre-loaded (i.e., from the manufacturer) onto anvil assembly 20 or cartridge assembly 18, respectively, of DLU 17. Additional or replacement buttresses “B” for anvil assembly 20 and/or cartridge assembly 18 may be secured to either anvil assembly 20 or cartridge assembly 18 as needed or desired.
In operation, with DLU 17 coupled to a distal end of elongated body 14 of surgical stapling apparatus 10, and with anvil buttress “B” and cartridge buttress “B” pre-loaded onto anvil assembly 20 and cartridge assembly 18, respectively, surgical stapling apparatus 10 is used in accordance with methods known by those skilled in the art. Once anvil assembly 20 and cartridge assembly 18 are clamped onto tissue, surgical stapling apparatus 10 is fired. In firing surgical stapling apparatus 10, drive assembly 50 is advanced from a proximal-most position to a distal-most position. In so doing, knife blade 66 of drive assembly 50 substantially simultaneously slices or cuts through a central section of the proximal anchor “S” of anvil assembly 20 and cartridge assembly 18, thereby respectively freeing the proximal end of anvil buttress “B” and cartridge buttress “B” therefrom.
As drive assembly 50 approaches the distal-most position, upper rail 64a of I-beam 60 abuts against and urges knife blade 74 distally while, substantially simultaneously or concomitantly therewith, shoulder 90c of central upstanding wedge or wall 90b of actuation sled 90 abuts against and urges knife blade 94 distally. As knife blade 74 is moved distally, from the initial position to the final position, knife edge 74a thereof slices or cuts through distal anchor “S” of anvil assembly 20, thereby freeing the distal end of the anvil buttress “B” from anvil assembly 20. As knife blade 94 is moved distally, from the initial position to the final position, knife edges 94a thereof slice or cut through distal anchor “S” of cartridge assembly 18, thereby freeing the distal end of the cartridge buttress “B” from cartridge assembly 18.
Also, knife blade 66 of drive assembly 50 substantially simultaneously slices or cuts longitudinally through both anvil buttress “B” and cartridge buttress “B”, thereby dividing the buttresses “B” substantially in half.
Turning now to
As seen in
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In an embodiment, as seen in
Staple cartridge 82 defines a distal recess 82g formed therein for selectively receiving a knife blade insert 83 therein. As seen in
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Turning now to
As best seen in
Knife blade 194 includes an arm 194a having a distal end secured near a distal end of carrier 80 or staple cartridge 82, and a proximal end extending substantially toward handle assembly 12 of surgical stapling apparatus 10. Knife blade 194 includes a knife edge 194b extending from proximal end of arm 194a in a direction substantially parallel with longitudinal slot 82c of staple cartridge 82. Knife edge 194b of knife blade 194 is substantially aligned between the distal pair of recesses 82f of staple cartridge 82, such that knife edge 194b is in juxtaposed alignment with an anchor “S” extending between the distal pair of recesses 82f of staple cartridge 82. Arm 194a of knife blade 194 has an initial condition wherein knife edge 194b is spaced away from anchor “S” extending between the distal pair of recesses 82f of staple cartridge 82.
In operation, as drive assembly 50 is advanced distally, actuation sled 90 (e.g., central upstanding wedge 90b) engages against the proximal end of arm 194a of knife blade 194 thereby biasing and camming the proximal end of arm 194a of knife blade 194 towards anchor “S” extending between the distal pair of recesses 82f of staple cartridge 82 such that knife edge 194b thereof severs or otherwise cuts through anchor “S” to free surgical buttress “B” from staple cartridge 82.
Knife edge 194b is retracted into staple cartridge 82 as a result of the spring force created by arm 194a in returning to the un-biased or initial condition. Alternatively, as seen in
Exemplary surgical buttresses “B” for use with the surgical stapling devices disclosed herein are shown and described in commonly assigned U.S. Pat. Nos. 5,542,594; 5,908,427; 5,964,774; and 6,045,560, and commonly assigned U.S. Application Serial Nos. 2006/0085034, filed on Apr. 20, 2006; and 2006/0135992, filed on Jun. 22, 2006, the entire contents of each of which is incorporated herein by reference.
As seen throughout the figures, and in particular
Turning now to
As seen in
In particular, with continued reference to
Knife blade 274 defines a camming edge 274c extending across longitudinal slot 270b of anvil plate 270, and a knife edge 274d extending transverse to camming edge 274c. Knife blade 274 is configured and dimensioned such that a portion of camming edge 274c and/or a portion of knife edge 274d extend across anchor “S”.
As seen in
As seen in
In operation, during firing of surgical stapling apparatus 10, as drive assembly 50 (see
Turning now to
As seen in
In particular, with continued reference to
Knife blade 294 defines a back or camming edge 294c extending across longitudinal slot 282c of staple cartridge 282, and a knife edge 294d extending parallel to camming edge 294c. Knife blade 294 is configured and dimensioned such that camming edge 294c and knife edge 294d are located proximal of anchor “S”.
As seen in
As seen in
In operation, during firing of surgical stapling apparatus 10, as drive assembly 50 (see
Turning now to
As seen in
In particular, with continued reference to
Knife blade 374 defines a camming edge 374c extending across longitudinal slot 370b of anvil plate 370, and a knife edge 374d extending transverse to camming edge 374c. Knife blade 374 is configured and dimensioned such that camming edge 374c is disposed proximally of anchor “S” and a portion of knife edge 374d extends across anchor “S”.
As seen in
As seen in
In operation, during firing of surgical stapling apparatus 10, as drive assembly 50 (see
Turning now to
As seen in
In particular, with continued reference to
Knife blade 394 defines a back or camming edge 394c extending across longitudinal slot 382c of staple cartridge 382, and a knife edge 394d extending parallel to camming edge 394c. Knife blade 394 is configured and dimensioned such that camming edge 394c and knife edge 394d are located proximal of anchor “S”.
As seen in
As seen in
In operation, during firing of surgical stapling apparatus 10, as drive assembly 50 (see
Turning now to
As seen in
In particular, with continued reference to
Knife blade 474 defines a camming edge 474c extending across longitudinal slot 470b of anvil plate 470, and a knife edge 474d extending transverse to camming edge 474c. Knife blade 474 is configured and dimensioned such that camming edge 474c is disposed proximally of the anchor (not shown) and a portion of knife edge 474d extends across anchor.
As seen in
Turning now to
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Proximal end 1152b of drive beam 1152 is formed as a pair of resilient engagement fingers which are dimensioned and configured to mountingly engage a drive or control rod (not shown) when the proximal end of end effector 1000 is connected to the handle assembly.
Distal end 1152a of drive beam 1152 is configured as an I-beam including an upper and lower rail portion 1154a, 1154b, respectively, extending transversely therefrom. A distal edge of a central beam of drive beam 1152 defines a knife blade 1156.
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With reference to
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Cartridge assembly 1200 includes a knife blade housing 1246 supported in staple cartridge 1220 at a location associated with the distal pair of recesses 1238. As seen in
As seen in
A first end of each suture “S1, S2” is anchored or fixed in a respective one recesses of the proximal and distal pair of recesses 1236, 1238 while a second end of each suture “S1, S2” passes transversely across respective distal and proximal tongues “B1b, B1a” of cartridge buttress “B1” and is anchored or fixed in a respective other recess of the proximal and distal pair of recesses 1236, 1238.
As seen in
As seen in
In operation, an upper surface of anvil plate 1310 defines a camming surface 1310a against which upper rail portion 1154a of drive beam 1152 engages to cam, urge and clamp anvil assembly 1300 against the tissue as drive assembly 1150 advances drive beam 1152 through longitudinal slot 1314.
With continued reference to
As seen in
As seen in
Anvil assembly 1300 further includes a surgical anvil buttress “B2” operatively secured to a lower surface of anvil plate 1310, by sutures “S”, to overlie at least some of anvil pockets 1312a and/or at least a portion of a length of longitudinal slot 1314. Surgical anvil buttress “B2” includes a proximal end portion in the form of tongue “B2a” having a transverse width dimension which is less than a transverse width dimension of surgical anvil buttress “B2”, and a distal end portion in the form of tongue “B2b” having a transverse width dimension which is less than the transverse width dimension of surgical anvil buttress “B2”. A first suture “S3” is threaded through each of the distal pair of recesses 1318, and a second suture “S4” is threaded through each of the proximal pair of recesses 1316.
A first end of suture “S3” is anchored or fixed in a recess of the distal pair of recesses 1318 and a second end of suture “S3” passes around/over distal tongue “B2b” of anvil buttress “B2”, transversely thereacross anvil buttress “B2”, so as to be anchored or fixed in the other recess of the distal pair of recesses 1318.
A first end of suture “S4” is anchored or fixed in a recess of the proximal pair of recesses 1316 while a second end of suture “S4” passes around/over proximal tongue “B2a” of anvil buttress “B2” and is anchored or fixed in the other recess of the proximal and pair of recesses 1316.
As seen in
In operation, as seen in
Concomitantly therewith, in operation, as seen in
As drive assembly 1150 approaches the distal end of staple cartridge 1220, shoulder 1228c of central upstanding wedge or wall 1228a of actuation sled 1228 abuts against and urges knife blade 1240 to rotate distally. As knife blade 1240 is rotated distally, knife edge 1242 is rotated from the initial or first condition positioned proximal of one of the distal pair of recesses 1238 to the final or second condition positioned distal of the one of the distal pair of recesses 1238. In so doing, knife edge 1242 slices or cuts through distal suture “S1”, thereby freeing the distal end of the cartridge buttress “B1” from cartridge assembly 1200.
As drive assembly 1150 is advanced from a proximal-most position to a distal-most position, knife blade 1156 thereof slices or cuts longitudinally through both cartridge buttress “B1” and anvil buttress “B”, thereby dividing the buttresses “B1, B2” substantially in half. Additionally, as drive assembly 1150 is advanced from a proximal-most position to a distal-most position, upstanding cam wedges 1228b of actuation sled 1228 actuates pushers 1226, to cause pushers 1226 to translate vertically within retention slots 1222 and urge staples 1224 from slots 1222. As staples 1224 are urged from slots 1222 of staple cartridge 1220, legs of staples 1224 penetrate and pass through both cartridge buttress “B1” and anvil buttress “B2”, through any tissue (not shown) interposed between cartridge buttress “B1” and anvil buttress “B2”, and are formed against or within staple deforming pockets 1312 of anvil plate 1310 of anvil assembly 1300.
Surgical buttresses “B1, B2” are each fabricated from a suitable biocompatible and bioabsorbable material. Surgical buttresses “B1, B2” are each fabricated from a non-absorbent material which does not retain fluid. Surgical buttresses “B1, B2” are each fabricated from “BIOSYN” made from GLYCOMER 631 (a block copolymer), a synthetic polyester composed of glycolide, dioxanone and trimethylene carbonate.
One block of the resulting copolymer contains randomly combined units derived from p-dioxanone (1,4-dioxan-2-one) and trimethylene carbonate (1,3-dioxan-2-one). The second block of the copolymer contains randomly combined units derived from glycolide and p-dioxanone. The resulting polyester is an ABA triblock terpolymer possessing about 60% glycolide, about 14% dioxanone, and about 26% trimethylene carbonate.
End effector 1000 is shown in
While the above-described embodiments surgical staplers incorporating the use of movable knife blades to sever and release surgical buttresses from the tissue contacting surfaces of the anvil assembly and the cartridge assembly have been shown and described in relation to endoscopic surgical staplers, it is envisioned and within the scope of the present disclosure that any of the above-embodiments may be incorporated into any type of surgical stapler, including and not limited to open surgical staplers, such as, for example, linear surgical staplers; arcuate or annular surgical staplers; and transverse surgical staplers.
It will be understood that various modifications may be made to the embodiments disclosed herein. For example, the stapling apparatus need not apply staples but rather may apply two part fasteners as is known in the art. Further, the length of the linear row of staples or fasteners may be modified to meet the requirements of a particular surgical procedure. Thus, the length of a single stroke of the actuation shaft and/or the length of the linear row of staples and/or fasteners within a disposable loading unit may be varied accordingly. Therefore, the above description should not be construed as limiting, but merely as exemplifications of preferred embodiments. Those skilled in the art will envision other modifications within the scope and spirit of the claims appended thereto.
This application is a continuation application of U.S. patent application Ser. No. 16/170,377, filed Oct. 25, 2018, which is a continuation application of U.S. patent application Ser. No. 14/934,192, filed Nov. 6, 2015, now U.S. Pat. No. 10,111,659, which is a continuation of U.S. patent application Ser. No. 13/799,357, filed Mar. 13, 2013, now U.S. Pat. No. 9,192,380, which is a continuation of U.S. patent application Ser. No. 12/528,526, filed Aug. 25, 2009, now U.S. Pat. No. 8,413,871, which is a National Stage Application of PCT/US2008/002981, filed Mar. 5, 2008, under 35 U.S.C. § 371 (a), which claims priority to U.S. Provisional Patent Application Ser. No. 60/905,566 filed Mar. 6, 2007, the disclosures of each of the above-identified applications are hereby incorporated by reference in their entirety.
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Extended European Search Report corresponding to EP 17 17 8528.0 dated Oct. 13, 2017. |
Australian Examination Report No. 1 corresponding to AU 2013234420 dated Oct. 24, 2017. |
Japanese Office Action corresponding to JP 2013-175379 dated Oct. 20, 2017. |
Japanese Office Action corresponding to JP 2013-147701 dated Oct. 27, 2017. |
Extended European Search Report corresponding to EP 17 17 5656.2 dated Nov. 7, 2017. |
Japanese Office Action corresponding to JP 2014-009738 dated Nov. 14, 2017. |
European Office Action corresponding to EP 13 17 3986.4 dated Nov. 29, 2017. |
Japanese Office Action corresponding to JP 2017-075975 dated Dec. 4, 2017. |
European Office Action corresponding to EP 13 19 7958.5 dated Dec. 11, 2017. |
European Office Action corresponding to counterpart European Patent Appln. No. EP 16 16 6367.9 dated Dec. 11, 2017. |
European Examination Report Communication, dated Dec. 11, 2017, corresponding to European Application No. 16 166 367.9; 4 pages. |
Japanese Notice of Allowance with English Summary form, dated May 14, 2018, corresponding to Japanese Application No. 2017-075975; 5 total pages. |
Australian Patent Examination Report No. 1, dated Sep. 7, 2015, corresponding to Australian Patent Application No. 2013237692; 5 pages. |
Extended European Search Report corresponding to EP 14 18 1125.7, completed Oct. 16, 2014 and dated Oct. 24, 2014; (7 pp). |
Extended European Search Report corresponding to EP 14 18 1127.3, completed Oct. 16, 2014 and dated Nov. 10, 2014; (8 pp). |
Extended European Search Report corresponding to EP 14 19 0419.3, completed Mar. 24, 2015 and dated Mar. 30, 2015; (6 pp). |
European Office Action corresponding to EP 12 198 776.2 dated Apr. 7, 2015. |
European Office Action corresponding to EP 13 156 297.7 dated Apr. 10, 2015. |
Australian Examination Report No. 1 corresponding to AU 2011250822 dated May 18, 2015. |
European Office Action corresponding to EP 12 186 175.1 dated Jun. 1, 2015. |
Chinese Office Action corresponding to CN 201010517292.8 dated Jun. 2, 2015. |
Extended European Search Report corresponding to EP 14 17 4814.5 dated Jun. 9, 2015. |
Australian Examination Report No. 1 corresponding to AU 2014200584 dated Jun. 15, 2015. |
European Office Action corresponding to EP 13 180 881.8 dated Jun. 19, 2015. |
European Office Action corresponding to EP 14 157 195.0 dated Jul. 2, 2015. |
Extended European Search Report corresponding to EP 12 19 6902.6 dated Aug. 6, 2015. |
Extended European Search Report corresponding to EP 14 15 2060.1 dated Aug. 14, 2015. |
Chinese Office Action corresponding to CN 201210129787.2 dated Aug. 24, 2015. |
Canadian Office Action corresponding to CA 2,696,419 dated Jan. 14, 2016. |
Japanese Office Action (No English translation available), dated Feb. 3, 2016, corresponding to Japanese Application No. 2014-252703; 1 page. |
Chinese First Office Action corresponding to counterpart Int'l Appln. No. JP 201410449019.4, dated Mar. 30, 2016. |
European Office Action, dated Apr. 20, 2016, corresponding to counterpart European Application No. 11 183 256.4; 5 pages. |
Chinese Notification of Reexamination corresponding to CN 201010517292.8 dated Jun. 2, 2015. |
Japanese Office Action corresponding to JP 2014-216989 dated Sep. 11, 2015. |
Canadian First Office Action corresponding to CA 2,686,105 dated Sep. 17, 2015. |
Japanese Office Action corresponding to JP 2012-040188 dated Oct. 21, 2015. |
European Communication corresponding to EP 13 17 6895.4 dated Nov. 5, 2015. |
Chinese First Office Action corresponding to CN 201210544552 dated Nov. 23, 2015. |
Chinese First Office Action corresponding to CN 201210545228 dated Nov. 30, 2015. |
Extended European Search Report corresponding to EP 15 18 0491.1 dated Dec. 9, 2015. |
Extended European Search Report corresponding to EP 15 18 3819.0 dated Dec. 11, 2015. |
Canadian Office Action corresponding to CA 2,697,819 dated Jan. 6, 2016. |
European Office Action corresponding to EP 12 19 8776.2 dated Jan. 19, 2016. |
Extended European Search Report corresponding to EP 15 17 4146.9 dated Jan. 20, 2016. |
Chinese First Office Action corresponding to CN 201310353628.5 dated Jan. 25, 2016. |
Extended European Search Report corresponding to EP 12 19 6912.5 dated Feb. 1, 2016. |
Japanese Office Action corresponding to JP 2012-098903 dated Feb. 22, 2016. |
Extended European Search Report corresponding to EP 12 19 8753.1 dated Feb. 24, 2016. |
Chinese First Office Action corresponding to CN 201410449019.4 dated Mar. 30, 2016. |
Extended European Search Report corresponding to EP 16 15 0232.3 dated Apr. 12, 2016. |
Australian Examination Report No. 1 corresponding to AU 2012244169 dated May 10, 2016. |
European Office Action corresponding to EP 10 25 0715.9 dated May 12, 2016. |
Chinese First Office Action corresponding to CN 201410778512.0 dated May 13, 2016. |
Australian Examination Report No. 1 corresponding to AU 2012227358 dated May 16, 2016. |
Japanese Office Action corresponding to JP 2012-040188 dated May 17, 2016. |
Australian Examination Report No. 1 corresponding to AU 2012244380 dated May 20, 2016. |
Australian Examination Report No. 1 corresponding to AU 2014227480 dated May 21, 2016. |
Australian Examination Report No. 1 corresponding to AU 2012254977 dated May 30, 2016. |
Extended European Search Report corresponding to EP 16 15 3647.9 dated Jun. 3, 2016. |
Japanese Office Action (with English translation), dated Sep. 26, 2016, corresponding to Japanese Application No. 2014-252703; 7 total pages. |
Chinese First Office Action corresponding to CN 2013107068710 dated Dec. 16, 2016. |
Chinese First Office Action corresponding to CN 201310646606.8 dated Dec. 23, 2016. |
International Search Report from application EP 06016962.0 dated Jan. 3, 2007. |
International Search Report from application PCT/US05/36740 dated Mar. 23, 2007. |
International Search Report from Application No. PCT/US2008/002981 dated Jun. 26, 2008. |
International Search Report from Application No. EP 08 25 1779 dated Jul. 23, 2008. |
International Search Report corresponding to European Application No. EP 12 15 2229.6, completed on Feb. 23, 2012 and dated Mar. 1, 2012; 4 pages. |
International Search Report corresponding to European Application No. EP 12 15 0511.9, completed on Apr. 16, 2012 and dated Apr. 24, 2012; 7 pages. |
International Search Report corresponding to European Application No. EP 12 15 2541.4, completed on Apr. 23, 2012 and dated May 3, 2012; 10 pages. |
International Search Report corresponding to European Application No. EP 12 16 5609.4, completed on Jul. 5, 2012 and dated Jul. 13, 2012; 8 pages. |
International Search Report corresponding to European Application No. EP 12 15 8861.0, completed on Jul. 17, 2012 and dated Jul. 24, 2012; 9 pages. |
International Search Report corresponding to European Application No. EP 12 16 5878.5, completed on Jul. 24, 2012 and dated Aug. 6, 2012; 8 pages. |
International Search Report corresponding to European Application No. EP 11 18 8309.6, completed on Dec. 15, 2011 and dated Jan. 12, 2012;3 pages. |
International Search Report corresponding to European Application No. EP 06 00 4598, completed on Jun. 22, 2006; 2 pages. |
International Search Report corresponding to European Application No. EP 06 01 6962.0, completed on Jan. 3, 2007 and dated Jan. 11, 2007; 10 pages. |
International Search Report corresponding to International Application No. PCT/US05/36740, completed on Feb. 20, 2007 and dated Mar. 23, 2007; 8 pages. |
International Search Report corresponding to International Application No. PCT/US2008/002981, completed on Jun. 9, 2008 and dated Jun. 26, 2008; 2 pages. |
International Search Report corresponding to European Application No. EP 08 25 1779, completed on Jul. 14, 2008 and dated Jul. 23, 2008; 5 pages. |
International Search Report corresponding to European Application No. EP 08 25 1989.3, completed on Mar. 11, 2010 and dated Mar. 24, 2010; 3 pages. |
International Search Report corresponding to European Application No. EP 10 25 0715.9, completed on Jun. 30, 2010 and dated Jul. 20, 2010; 3 pages. |
International Search Report corresponding to European Application No. EP 05 80 4382.9, completed on Oct. 5, 2010 and dated Oct. 12, 2010; 3 pages. |
International Search Report corresponding to European Application No. EP 10 25 1437.9, completed on Nov. 22, 2010 and dated Dec. 16, 2010; 3 pages. |
International Search Report corresponding to European Application No. EP 09 25 2897.5, completed on Feb. 7, 2011 and dated Feb. 15, 2011; 3 pages. |
International Search Report corresponding to European Application No. EP 10 25 0642.5, completed on Mar. 25, 2011 and dated Apr. 4, 2011; 4 pages. |
Extended European Search Report corresponding to EP No. 12 19 1035.0, completed Jan. 11, 2013 and dated Jan. 18, 2013; 7 pages. |
Extended European Search Report corresponding to EP No. 12 18 6175.1, completed Jan. 15, 2013 and dated Jan. 23, 2013; 7 pages. |
Extended European Search Report corresponding to EP No. 12 19 1114.3, completed Jan. 23, 2013 and dated Jan. 31, 2013; 10 pages. |
Extended European Search Report corresponding to EP No. 12 19 2224.9, completed Mar. 14, 2013 and dated Mar. 26, 2013; 8 pages. |
Extended European Search Report corresponding to EP No. 12 19 6911.7, completed Apr. 18, 2013 and dated Apr. 24, 2013; 8 pages. |
Extended European Search Report corresponding to EP 12 19 1035.0, completed Jan. 11, 2013 and dated Jan. 18, 2013; 7 pages. |
Extended European Search Report corresponding to EP 12 19 6904.2, completed Mar. 28, 2013 and dated Jul. 26, 2013; 8 pages. |
Extended European Search Report corresponding to EP 12 19 8749.9, completed May 21, 2013 and dated May 31, 2013; 8 pages. |
Extended European Search Report corresponding to EP 07 00 5842.5, completed May 13, 2013 and dated May 29, 2013; 7 pages. |
Extended European Search Report corresponding to EP 12 19 8776.2, completed May 16, 2013 and dated May 27, 2013; 8 pages. |
Extended European Search Report corresponding to EP 13 15 6297.7, completed Jun. 4, 2013 and dated Jun. 13, 2013; 7 pages. |
Extended European Search Report corresponding to EP 13 17 3985.6, completed Aug. 19, 2013 and dated Aug. 28, 2013; 6 pages. |
Extended European Search Report corresponding to EP 13 17 3986.4, completed Aug. 20, 2013 and dated Aug. 29, 2013; 7 pages. |
Extended European Search Report corresponding to EP 13 17 7437.4, completed Sep. 11, 2013 and dated Sep. 19, 2013; (6 pp). |
International Search Report corresponding to European Application No. EP 05 02 2585.3, completed on Jan. 25, 2006 and dated Feb. 3, 2006; 4 pages. |
International Search Report corresponding to International Application No. PCT/US2007/022713, completed on Apr. 21, 2008 and dated May 15, 2008; 1 page. |
International Search Report corresponding to European Application No. EP 08 25 1989.3, completed on Mar. 11, 2010 and dated Mar. 24, 2010; 6 pages. |
International Search Report corresponding to European Application No. EP 10 25 0639.1, completed on Jun. 17, 2010 and dated Jun. 28, 2010; 7 pages. |
Extended European Search Report corresponding to EP 13 19 2123.1, completed Jan. 30, 2014 and dated Feb. 10, 2014; (8 pp). |
European Office Action corresponding to counterpart Int'l Appln No. EP 12 198 776.2 dated Apr. 7, 2015. |
European Office Action corresponding to counterpart Int'l Appln No. EP 13 156 297.7 dated Apr. 10, 2015. |
Australian Examination Report No. 1 corresponding to counterpart Int'l Appln No. AU 2011250822 dated May 18, 2015. |
European Office Action corresponding to counterpart Int'l Appln No. EP 12 186 175.1 dated Jun. 1, 2015. |
Chinese Office Action corresponding to counterpart Int'l Appln No. CN 201010517292.8 dated Jun. 2, 2015. |
Extended European Search Report corresponding to counterpart Int'l Appln No. EP 14 17 4814.5 dated Jun. 9, 2015. |
Australian Examination Report No. 1 corresponding to counterpart Int'l Appln No. AU 2014200584 dated Jun. 15, 2015. |
European Office Action corresponding to counterpart Int'l Appln No. EP 13 180 881.8 dated Jun. 19, 2015. |
European Office Action corresponding to counterpart Int'l Appln No. EP 14 157 195.0 dated Jul. 2, 2015. |
Extended European Search Report corresponding to counterpart Int'l Appln No. EP 12 19 6902.6 dated Aug. 6, 2015. |
Extended European Search Report corresponding to counterpart Int'l Appln No. EP 14 15 2060.1 dated Aug. 14, 2015. |
Chinese Office Action corresponding to counterpart Int'l Appln No. CN 201210129787.2 dated Aug. 24, 2015. |
European Office Action corresponding to counterpart Int'l Appln. No. EP 12 19 8776.2 dated Jan. 19, 2016. |
Extended European Search Report corresponding to counterpart Int'l Appln. No. EP 16150232.3, dated Apr. 12, 2016. |
Chinese Notification of Reexamination corresponding to counterpart Int'l Appln. No. CN 201010517292.8 dated Jun. 2, 2015. |
Canadian First Office Action corresponding to counterpart Int'l Appln. No. CA 2,686,105 dated Sep. 17, 2015. |
Chinese First Office Action corresponding to counterpart Int'l Appln. No. CN 201210544552 dated Nov. 23, 2015. |
Chinese First Office Action corresponding to counterpart Int'l Appln. No. CN 201210545228 dated Nov. 30, 2015. |
Extended European Search Report corresponding to counterpart Int'l Appln. No. EP 15 18 0491.1 dated Dec. 9, 2015. |
Extended European Search Report corresponding to counterpart Int'l Appln. No. EP 15 18 3819.0 dated Dec. 11, 2015. |
Canadian Office Action corresponding to counterpart Int'l Appln. No. CA 2,697,819 dated Jan. 6, 2016. |
Canadian Office Action corresponding to counterpart Int'l Appln. No. CA 2,696,419 dated Jan. 14, 2016. |
Extended European Search Report corresponding to counterpart Int'l Appln. No. EP 15 17 4146.9 dated Jan. 20, 2016. |
Chinese First Office Action corresponding to counterpart Int'l Appln. No. CN 201310353628.5 dated Jan. 25, 2016. |
Extended European Search Report corresponding to counterpart Int'l Appln. No. EP 12 19 6912.5 dated Feb. 1, 2016. |
Extended European Search Report corresponding to counterpart Int'l Appln. No. EP 12 19 8753.1 dated Feb. 24, 2016. |
Chinese First Office Action corresponding to counterpart Int'l Appln. No. CN 201410449019.4 dated Mar. 30, 2016. |
Australian Examination Report No. 1 corresponding to counterpart Int'l Appln. No. AU 2012244169 dated May 10, 2016. |
European Office Action corresponding to counterpart Int'l Appln. No. EP 10 25 0715.9 dated May 12, 2016. |
Chinese First Office Action corresponding to counterpart Int'l Appln. No. CN 201410778512.0 dated May 13, 2016. |
Australian Examination Report No. 1 corresponding to counterpart Int'l Appln. No. AU 2012227358 dated May 16, 2016. |
International Search Report corresponding to EP 10 25 0642, completed on Mar. 25, 2011 and dated Apr. 4, 2011; 4 pages. |
International Search Report corresponding to EP 11 18 8309, completed on Dec. 15, 2011 and dated Jan. 12, 2012; 3 pages. |
International Search Report corresponding to EP 12 15 2229, completed on Feb. 23, 2012 and dated Mar. 1, 2012; 4 pages. |
International Search Report corresponding to EP 12 15 0511, completed on Apr. 16, 2012 and dated Apr. 24, 2012; 7 pages. |
International Search Report corresponding to EP 12 15 2541, completed on Apr. 23, 2012 and dated May 3, 2012; 10 pages. |
International Search Report corresponding to EP 12 16 5609, completed on Jul. 5, 2012 and dated Jul. 13, 2012; 8 pages. |
International Search Report corresponding to EP 12 15 8861, completed on Jul. 17, 2012 and dated Jul. 24, 2012; 9 pages. |
International Search Report corresponding to EP 12 16 5878, completed on Jul. 24, 2012 and dated Aug. 6, 2012; 8 pages. |
Extended European Search Report corresponding to EP 11 19 0763.0, completed Jun. 18, 2015 and dated Jun. 25, 2015; (8 pp). |
Extended European Search Report, dated Jan. 16, 2017, corresponding to counterpart European Appinication No. EP 16 16 6367.9; 9 pages. |
Eurpean Communication corresponding to counterpart Int'l Appln. No. EP 13 17 6895.4 dated Nov. 5, 2015. |
International Search Report corresponding to EP 05 02 2585, completed on Jan. 25, 2006 and dated Feb. 3, 2006; 4 pages. |
International Search Report corresponding to EP 06 01 6962, completed on Jan. 3, 2007 and dated Jan. 11, 2007; 10 pages. |
International Search Report corresponding to PCT/US2005/036740, completed on Feb. 20, 2007 and dated Mar. 23, 2007; 8 pages. |
International Search Report corresponding to PCT/US2007/022713, completed on Apr. 21, 2008 and dated May 15, 2008; 1 page. |
International Search Report corresponding to PCT/US2008/002981, completed on Jun. 9, 2008 and dated Jun. 26, 2008; 2 pages. |
International Search Report corresponding to EP 08 25 1779, completed on Jul. 14, 2008 and dated Jul. 23, 2008; 5 pages. |
International Search Report corresponding to EP 08 25 1989, completed on Mar. 11, 2010 and dated Mar. 24, 2010; 6 pages. |
International Search Report corresponding to EP 10 25 0639, completed on Jun. 17, 2010 and dated Jun. 28, 2010; 7 pages. |
International Search Report corresponding to EP 10 25 0715, completed on Jun. 30, 2010 and dated Jul. 20, 2010; 3 pages. |
International Search Report corresponding to EP 05 80 4382, completed on Oct. 5, 2010 and dated Oct. 12, 2010; 3 pages. |
International Search Report corresponding to EP 10 25 1437, completed on Nov. 22, 2010 and dated Dec. 16, 2010; 3 pages. |
International Search Report corresponding to EP 09 25 2897, completed on Feb. 7, 2011 and dated Feb. 15, 2011; 3 pages. |
International Search Report corresponding to EP 10 25 0642, completed on Mar. 2011 and dated Apr. 4, 2011; 4 pages. |
European Search Report issued by the European Patent Office dated Dec. 20, 2018 in corresponding European Patent Application No. 18192317.8. |
European Search Report corresponding to EP 06 00 4598, completed Jun. 22, 2006; (2 pp). |
European Search Report corresponding to EP 06 01 6962.0, completed Jan. 3, 2007 and dated Jan. 11, 2007; (10 pp). |
International Search Report corresponding to International Application No. PCT/US2005/036740, completed Feb. 20, 2007 and dated Mar. 23, 2007; (8 pp). |
International Search Report corresponding to International Application No. PCT/US2007/022713, completed Apr. 21, 2008 and dated May 15, 2008; (1 p). |
International Search Report corresponding to International Application No. PCT/US2008/002981, completed Jun. 9, 2008 and dated Jun. 26, 2008; (2 pp). |
Japanese Office Action corresponding to counterpart Int'l Appln. No. JP 2012-040188 dated Oct. 21, 2015. |
European Office Action corresponding to counterpart European Appln. No. EP 15 17 4146.9 dated May 15, 2017. |
Japanese Office Action corresponding to counterpart Japanese Appln. No. JP 2013-154561 dated May 23, 2017. |
European Office Action corresponding to counterpart European Appln. No. EP 12 19 4784.0 dated May 29, 2017. |
Japanese Office Action corresponding to counterpart Japanese Appln. No. JP 2013-169083 dated May 31, 2017. |
Australian Examination Report No. 1 corresponding to counterpart Australian Appln. No. AU 2013213767 dated Jun. 29, 2017. |
Australian Examination Report No. 2 corresponding to counterpart Australian Appln. No. AU 2012261752 dated Jul. 7, 2017. |
Australian Examination Report No. 1 corresponding to counterpart Australian Appln. No. AU 2013266989 dated Jul. 10, 2017. |
Extended European Search Report corresponding to counterpart European Appln. No. EP 14 15 3609.4 dated Jul. 14, 2017. |
Australian Examination Report No. 1 corresponding to counterpart Australian Appln. No. AU 2013234418 dated Jul. 14, 2017. |
Extended European Search Report corresponding to counterpart European Appln. No. EP 14 15 3610.2 dated Jul. 17, 2017. |
Australian Examination Report No. 1 corresponding to counterpart Australian Appln. No. AU 2014200109 dated Jul. 20, 2017. |
Australian Examination Report No. 1 corresponding to counterpart Australian Appln. No. AU 2014200074 dated Jul. 20, 2017. |
Japanese Office Action corresponding to counterpart Japanese Appln. No. JP 2013-250857 dated Aug. 17, 2017. |
Japanese Office Action corresponding to counterpart Japanese Appln. No. JP 2013-229471 dated Aug. 17, 2017. |
Australian Examination Report No. 1 corresponding to counterpart Australian Appln. No. AU 2014200793 dated Sep. 2, 2017. |
Extended European Search Report corresponding to counterpart European Appln. No. EP 17 17 8528.0 dated Oct. 13, 2017. |
Australian Examination Report No. 1 corresponding to counterpart Australian Appln. No. AU 2013234420 dated Oct. 24, 2017. |
Japanese Office Action corresponding to counterpart Japanese Appln. No. JP 2013-175379 dated Oct. 20, 2017. |
Japanese Office Action corresponding to counterpart Japanese Appln. No. JP 2013-147701 dated Oct. 27, 2017. |
Extended European Search Report corresponding to counterpart European Appln. No. EP 17 17 5656.2 dated Nov. 7, 2017. |
Japanese Office Action corresponding to counterpart Japanese Appln. No. JP 2014-009738 dated Nov. 14, 2017. |
European Office Action corresponding to counterpart European Appln. No. EP 13 17 3986.4 dated Nov. 29, 2017. |
Japanese Office Action corresponding to counterpart Japanese Appln. No. JP 2017-075975 dated Dec. 4, 2017. |
European Office Action corresponding to counterpart European Appln. No. EP 13 19 7958.5 dated Dec. 11, 2017. |
International Search Report for PCT/US2008/002981 date of completion is Jun. 9, 2008 (2 pages). |
European Search Report for EP 09252897.5-2310 date of completion is Feb. 7, 2011 (3 pages). |
European Search Report for EP 11183254.9-2310 date of completion is Nov. 6, 2012 (6 pages). |
European Search Report for EP 11183256.4-2310 date of completion is Nov. 7, 2012 (6 pages). |
Canadian Office Action with Examination Report, dated Oct. 6, 2015, corresponding to Canadian Application No. 2,688,171; 3 total pages. |
International Search Report corresponding to EP 06 00 4598, completed on Jun. 22, 2006; 2 pages. |
Australian Examination Report No. 1 corresponding to counterpart Int'l Appln. No AU 2012244380 dated May 20, 2016. |
Australian Examination Report No. 1 corresponding to counterpart Int'l Appln. No AU 2014227480 dated May 21, 2016. |
Australian Examination Report No. 1 corresponding to counterpart Int'l Appln. No AU 2012254977 dated May 30, 2016. |
Extended European Search Report corresponding to counterpart Int'l Appln. No. EP 16 15 3647.9 dated Jun. 3, 2016. |
Chinese First Office Action corresponding to counterpart Int'l Appln. No. CN 2013107068710 dated Dec. 16, 2016. |
Chinese First Office Action corresponding to counterpart Int'l Appln. No. CN 201310646606.8 dated Dec. 23, 2016. |
Japanese Office Action corresponding to counterpart Int'l Appln. No. JP 2013-000321 dated Jan. 4, 2017. |
Extended European Search Report corresponding to counterpart Int'l Appln. No. EP 16 16 6367.9 dated Jan. 16, 2017. |
Australian Examination Report No. 1 corresponding to counterpart Int'l Appln. No. AU 2013206777 dated Feb. 1, 2017. |
Chinese Second Office Action corresponding to counterpart Int'l Appln. No. CN 2013103036903 dated Feb. 23, 2017. |
Japanese Office Action corresponding to counterpart Int'l Appln. No. JP 2013-175379 dated Mar. 1, 2017. |
Chinese First Office Action corresponding to counterpart Int'l Appln. No. CN 201410028462.4 dated Mar. 2, 2017. |
Chinese First Office Action corresponding to counterpart Int'l Appln. No. CN 201410084070 dated Mar. 13, 2017. |
Extended European Search Report corresponding to counterpart Int'l Appln. No. EP 16 19 6549.6 dated Mar. 17, 2017. |
Japanese Office Action corresponding to counterpart Int'l Appln. No. JP 2013-147701 dated Mar. 21, 2017. |
Australian Examination Report No. 1 corresponding to counterpart Int'l Appln. No. AU 2013206804 dated Mar. 21, 2017. |
Australian Examination Report No. 1 corresponding to counterpart Int'l Appln. No. AU 2013211499 dated May 4, 2017. |
Australian Examination Report No. 1 corresponding to counterpart Int'l Appln. No. AU 2014201008 dated May 23, 2017. |
Japanese Office Action corresponding to counterpart Int'l Appln. No. JP 2014-216989 dated Sep. 11, 2015. |
Japanese Office Action corresponding to counterpart Int'l Appln. No. JP 2012-098903 dated Feb. 22, 2016. |
Japanese Office Action corresponding to counterpart Int'l Appln. No. JP 2012-040188 dated May 17, 2016. |
Number | Date | Country | |
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20210045739 A1 | Feb 2021 | US |
Number | Date | Country | |
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60905566 | Mar 2007 | US |
Number | Date | Country | |
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Parent | 16170377 | Oct 2018 | US |
Child | 17086600 | US | |
Parent | 14934192 | Nov 2015 | US |
Child | 16170377 | US | |
Parent | 13799357 | Mar 2013 | US |
Child | 14934192 | US | |
Parent | 12528526 | US | |
Child | 13799357 | US |