Surveillance genome sequencing to detect SARS-CoV-2 virus variants in Montana

Information

  • Research Project
  • 10381357
  • ApplicationId
    10381357
  • Core Project Number
    P20GM103546
  • Full Project Number
    3P20GM103546-10S1
  • Serial Number
    103546
  • FOA Number
    PA-18-935
  • Sub Project Id
  • Project Start Date
    9/1/2011 - 13 years ago
  • Project End Date
    7/31/2022 - 2 years ago
  • Program Officer Name
    CALDWELL, SHEILA
  • Budget Start Date
    6/1/2021 - 3 years ago
  • Budget End Date
    7/31/2022 - 2 years ago
  • Fiscal Year
    2021
  • Support Year
    10
  • Suffix
    S1
  • Award Notice Date
    6/15/2021 - 3 years ago
Organizations

Surveillance genome sequencing to detect SARS-CoV-2 virus variants in Montana

Project Summary Montana is a state with large rural and Tribal Nations populations. Both groups have been underrepresented in whole genome sequencing of SARS-CoV-2 variants and the state of Montana lags significantly behind the country as a whole in sequencing data available from patients infected with SARS-CoV-2. Given the emergence of dangerous SARS-CoV-2 variants with higher viral transmissibility and reduced response to monoclonal antibody therapy and vaccine efficacy, lack of sequencing data is a critical problem for the Montana state Department of Public Health and Human Services (DPHHS) in mounting an appropriate response to the pandemic. Furthermore, sequencing data will be particularly important for understanding viral transmission in Tribal Nations, which have been disproportionately affected by the pandemic. This supplement to the Center for Biomolecular Structure and Dynamics COBRE grant will allow whole genome sequencing and analysis of >3000 SARS-CoV-2 viruses isolated from patients in the state of Montana, including those living in rural and Tribal communities. General sequencing results will be made publicly available, except Tribal samples unless Tribal approval is given, through GenBank and GISAID to facilitate broader analysis of the emergence of variants of concern (VOC) and variants of interest (VOI) in the United States and will be communicated directly to the Montana DPHHS and participating Tribal Nations so that they can adjust their responses to the pandemic. We take advantage of the CLIA-certified SARS-CoV-2 testing facility on the University of Montana campus, our expertise in whole genome sequencing and our established relationships with Tribal Nations in Montana to accomplish the goals of this SARS-CoV-2 sequencing supplement. The analysis of these data will focus on three specific aims: ? Specific Aim 1: What is the genetic structure of SARS-CoV-2 variants across Montana communities and how does this variation compare to regional, national, and global SARS-CoV-2 diversity? ? Specific Aim 2: Does the genetic composition of circulating SARS-CoV-2 variants differ between rural versus metropolitan and Tribal versus non-Tribal communities in Montana? ? Specific Aim 3: Are specific outbreaks associated with known or putative novel variants of interest and/or concern? Overall, the project will provide critical new insight into how more dangerous variants of SARS-CoV-2 arise and spread in a rural state and among the disproportionately-effected Tribal Nations in Montana that will allow for better response to the pandemic for these groups.

IC Name
NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES
  • Activity
    P20
  • Administering IC
    GM
  • Application Type
    3
  • Direct Cost Amount
    477868
  • Indirect Cost Amount
    226606
  • Total Cost
    704474
  • Sub Project Total Cost
  • ARRA Funded
    False
  • CFDA Code
    859
  • Ed Inst. Type
    ORGANIZED RESEARCH UNITS
  • Funding ICs
    NIGMS:704474\
  • Funding Mechanism
    RESEARCH CENTERS
  • Study Section
  • Study Section Name
  • Organization Name
    UNIVERSITY OF MONTANA
  • Organization Department
    NONE
  • Organization DUNS
    010379790
  • Organization City
    MISSOULA
  • Organization State
    MT
  • Organization Country
    UNITED STATES
  • Organization Zip Code
    598124104
  • Organization District
    UNITED STATES