Claims
- 1. A sustained-release preparation which comprises indomethacin or a salt thereof as an active ingredient and collagen as carrier, said preparation being prepared by a process which comprises:
- a. mixing indomethacin or a salt thereof and collagen to form a liquid mixture; and
- b. drying without heat treatment of the resultant mixture.
- 2. The preparation according to claim 1, wherein indomethacin or a salt thereof is contained in an amount of 0.5 to 500 mg per dosage unit.
- 3. The preparation according to claim 1, wherein the preparation consists essentially of indomethacin or a salt thereof and collagen.
- 4. The preparation according to claim 3, wherein a small amount of gelatin is also incorporated as the carrier.
- 5. A sustained-release preparation which comprises indomethacin or a salt thereof as an active ingredient and collagen as a carrier, said preparation being in the form of powder particles suspended in a viscous solvent suitable for injection, or being in the form of a shaped preparation suitable for use as an injection in a solid state or for implanting into a body, said preparation being prepared by a process which comprises:
- a. mixing indometachin or a salt thereof and collagen to form a liquid mixture; and
- b. drying without heat treatment of the resultant mixture.
- 6. The preparation according to claim 5, wherein the form of the shaped preparation is needle-like or fine bar-like having a diameter of about 0.5 mm to 1.5 mm and a length of about 5 mm to 15 mm.
- 7. The preparation according to claim 5, wherein the shaped preparation is in the form of a pellet, sphere, hemisphere, button, grain or powder.
- 8. The preparation according to claim 5, which further comprises a viscous solvent.
- 9. A method for the preparation of a sustained-release preparation of indomethacin or a salt thereof, which comprises mixing indomethacin or a salt thereof and collagen to form a liquid mixture and drying without heat treatment of the resultant mixture.
- 10. The method according to claim 9, wherein the mixing step is conducted at a temperature of about 5.degree. C. to 30.degree. C.
- 11. The method according to claim 9, wherein the drying step is effected by lyophilization at a temperature of -50.degree. C. to 0.degree. C.
- 12. The method according to claim 9, wherein the dried mixture is pulverized to produce the powder particles.
- 13. The method according to claim 9, wherein the preparation is shaped by compressing the dried mixture or by allowing the dried mixture to stand in a mold until formed.
Priority Claims (2)
Number |
Date |
Country |
Kind |
58-193064 |
Oct 1983 |
JPX |
|
58-206226 |
Nov 1983 |
JPX |
|
Parent Case Info
This application is a divisional of copending application Ser. No. 06/855,387, filed on Apr. 24, 1986, now U.S. Pat. No. 4,855,134 which is a continuation-in-part application of U.S. Ser. No. 660,045 filed on Oct. 12, 1984 now abandoned.
US Referenced Citations (16)
Foreign Referenced Citations (12)
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Mar 1980 |
BEX |
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Nov 1983 |
EPX |
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EPX |
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Mar 1985 |
EPX |
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JPX |
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Sep 1981 |
JPX |
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WOX |
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Non-Patent Literature Citations (1)
Entry |
Merck Index, Eleventh Edition, pp. 786-787, #4874 Indomethaein. |
Divisions (1)
|
Number |
Date |
Country |
Parent |
855387 |
Apr 1986 |
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Continuation in Parts (1)
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Number |
Date |
Country |
Parent |
660045 |
Oct 1984 |
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