Claims
- 1. A composition comprising, as a first component, a fraction derived from hops; and as a second component, at least one member selected from the group consisting of rosemary, an extract derived from rosemary, a compound derived from rosemary, a triterpene species, a diterpene lactone species, and tryptanthrin.
- 2. The composition of claim 1, wherein the fraction derived from hops is extracted with CO2.
- 3. The composition of claim 1, wherein the fraction derived from hops is selected from the group consisting of isoalpha acids, reduced isoalpha acids, tetra-hydroisoalpha acids, hexa-hydroisoalpha acids, and spent hops.
- 4. The composition of claim 1, wherein the fraction derived from hops comprises a compound of a supragenus having the formula:
- 5. The composition of claim 1, wherein the fraction derived from hops comprises a compound of Genus A having the formula:
- 6. The composition of claim 1, wherein the fraction derived from hops comprises a compound of Genus B having the formula:
- 7. The composition of claim 1, wherein the fraction derived from hops comprises a compound selected from the group consisting of cohumulone, adhumulone, isohumulone, isocohumulone, isoadhumulone, dihydro-isohumulone, dihydro-isocohumulone, dihydro-adhumulone, tetrahydro-isohumulone, tetrahydro-isocohumulone, tetrahydro-adhumulone, hexahydro-isohumulone, hexahydro-isocohumulone, and hexahydro-adhumulone.
- 8. The composition of claim 1, wherein the second component is a compound derived from rosemary that is selected from the group consisting of 1,8-cineole, 19-alpha-hydroxyursolic acid, 2-β-hydroxyoleanolic acid, 3-O-acetyloleanolic acid, 3-O-acetylursolic acid, 6-methoxy-luteolin-7-glucoside, 6-methoxyluteolin, 6-methoxyluteolin-7-glucoside, methoxyluteolin-7-methylether, 7-ethoxy-rosmanol, 7-methoxy-rosmanol, alpha-amyrin, alpha-humulene, alpha-hydroxyhydrocaffeic acid, alpha-pinene, alpha-terpinene, alpha-terpinenyl acetate, alpha-terpineol, alpha-thujone, apigenin, apigenin-7-glucoside, curcumene, benzyl-alcohol, β-amyrenone, β-amyrin, β-elemene, β-pinene, betulin, betulinic acid, borneol, bornyl-acetate, caffeic acid, camphene, camphor, carnosic acid, carnosol, carvacrol, carvone, caryophyllene, caryophyllene-oxide, chlorogenic acid, diosmetin, gamma-terpinene, hesperidin, isoborneol, limonene, luteolin, luteolin-3′-O-(3″-O-acetyl)-β-D-glucuronide, luteolin-3′-O-(4″-O-acetyl)-β-D-glucuronide, luteolin-3′-O-β-D-glucuronide, luteolin-7-glucoside, methyl-eugenol, myrcene, neo-chlorogenic acid, nepetin, octanoic acid, oleanolic acid, p-cymene, piperitenone, rosmanol, rosmaric acid, rosmaricine, rosmaridiphenol, rosemarinic acid, rosmarinol, rosmariquinone, sabinene, sabinyl acetate, salicylates, salicylic acid-2-β-D-glucoside, squalene, terpinen-4-ol, terpinolene, thymol, trans-anethole, trans-carveol, ursolic acid, verbenone, and zingiberene.
- 9. The composition of claim 8, wherein the second component is a compound derived from rosemary that is selected from the group consisting of betulin, betulinic acid, carnosic acid, carnosol, carvacrol, chlorogenic acid, diosmetin, limonene, and luteolin.
- 10. The composition of claim 1, wherein the second component is a triterpene species that is selected from the group consisting of 18-a-glycyrrhetinic acid, 18-β-glycyrrhetinic acid, 2-a-3-a-dihydrooxyurs-12-3n-28-onic acid, 3-a-hydroxyursolic acid, 3-oxo-ursolic acid, betulin, betulinic acid, celastrol, eburicoic acid, friedelin, glycyrrhizin, gypsogenin, oleanolic acid, oleanolic acid-3-acetate, pachymic acid, pinicolic acid, sophoradiol, soyasapogenol A, soyasapogenol B, tripterin, triptophenolide, tumulosic acid, ursolic acid, ursolic acid-3-acetate, uvaol, and β-sitosterol.
- 11. The composition of claim 10, wherein the second component is a triterpene species that is selected from the group consisting of 18-a-glycyrrhetinic acid, 18-β-glycyrrhetinic acid, 2-a-3-a-dihydrooxyurs-12-3n-28-onic acid, 3-a-hydroxyursolic acid, 3-oxo-ursolic acid, betulin, betulinic acid, celastrol, friedelin, oleanolic acid, tripterin, triptophenolide, ursolic acid, and uvaol.
- 12. The composition of claim 1, wherein the second component is tryptanthrin, a triterpene species, or a diterpene lactone species that is conjugated to a member selected from the group consisting of mono- or di-saccharides, amino acids, sulfates, succinate, acetate, and glutathione.
- 13. The composition of claim 1, wherein the composition comprises about 0.5 to 10000 mg of the fraction isolated or derived from hops.
- 14. The composition of claim 13, wherein the composition comprises about 50 to 7500 mg of the fraction isolated or derived from hops.
- 15. The composition of claim 1, wherein the composition comprises about 0.035 to 3500 mg of tryptanthrin, wherein the second component is tryptanthrin.
- 16. The composition of claim 15, wherein the composition comprises about 0.7 to 700 mg of tryptanthrin, wherein the second component is tryptanthrin.
- 17. The composition of claim 1, wherein the composition comprises about 0.5 to 5000 mg of the second component, wherein the second component is selected from the group consisting of rosemary, extract derived from rosemary, and a compound derived from rosemary.
- 18. The composition of claim 17, wherein the composition comprises about 5 to 2000 mg of the second component, wherein the second component is selected from the group consisting of rosemary, extract derived from rosemary, and a compound derived from rosemary.
- 19. The composition of claim 1, wherein the composition comprises about 0.035 to 3500 mg of a triterpene species, wherein the second component is a triterpene species.
- 20. The composition of claim 19, wherein the composition comprises about 0.7 to 700 mg of a triterpene species, wherein the second component is a triterpene species.
- 21. The composition of claim 1, wherein the composition comprises about 0.001 to 10 weight percent of the first component.
- 22. The composition of claim 21, wherein the composition comprises about 0.1 to 1 weight percent of the first component.
- 23. The composition of claim 1, wherein the composition comprises about 0.001 to 10 weight percent of the second component.
- 24. The composition of claim 23, wherein the composition comprises about 0.1 to 1 weight percent of the second component.
- 25. The composition of claim 1, wherein a ratio of the first component to the second component is in the range of about 100:1 to about 1:100.
- 26. The composition of claim 25, wherein the ratio of the first component to the second component is in the range of about 50:1 to about 1:50.
- 27. The composition of claim 1, wherein the composition further comprises a pharmaceutically acceptable carrier.
- 28. A composition comprising as a first component, a fraction isolated or derived from hops; and as a second component, at least one member selected from the group consisting of rosemary, an extract derived from rosemary, a compound derived from rosemary, and tryptanthrin.
- 29. The composition of claim 28, wherein the fraction isolated or derived from hops is extracted with CO2.
- 30. The composition of claim 28, wherein the fraction isolated or derived from hops is selected from the group consisting of alpha acids, isoalpha acids, reduced isoalpha acids, tetra-hydroisoalpha acids, hexa-hydroisoalpha acids, beta acids, and spent hops.
- 31. The composition of claim 28, wherein the fraction isolated or derived from hops comprises a compound of a supragenus having the formula:
- 32. The composition of claim 28, wherein the fraction isolated or derived from hops comprises a compound of Genus A having the formula:
- 33. The composition of claim 28, wherein the fraction isolated or derived from hops comprises a compound of Genus B having the formula:
- 34. The composition of claim 28, wherein the fraction isolated or derived from hops comprises a compound selected from the group consisting of humulone, cohumulone, adhumulone, isohumulone, isocohumulone, isoadhumulone, dihydro-isohumulone, dihydro-isocohumulone, dihydro-adhumulone, tetrahydro-isohumulone, tetrahydro-isocohumulone, tetrahydro-adhumulone, hexahydro-isohumulone, hexahydro-isocohumulone, and hexahydro-adhumulone.
- 35. The composition of claim 28, wherein the second component is a compound derived from rosemary that is selected from the group consisting of 1,8-cineole, 19-alpha-hydroxyursolic acid, 2-β-hydroxyoleanolic acid, 3-O-acetyloleanolic acid, 3-O-acetylursolic acid, 6-methoxy-luteolin-7-glucoside, 6-methoxyluteolin, 6-methoxyluteolin-7-glucoside, methoxyluteolin-7-methylether, 7-ethoxy-rosmanol, 7-methoxy-rosmanol, alpha-amyrin, alpha-humulene, alpha-hydroxyhydrocaffeic acid, alpha-pinene, alpha-terpinene, alpha-terpinenyl acetate, alpha-terpineol, alpha-thujone, apigenin, apigenin-7-glucoside, curcumene, benzyl-alcohol, β-amyrenone, β-amyrin, β-elemene, β-pinene, betulin, betulinic acid, borneol, bornyl-acetate, caffeic acid, camphene, camphor, carnosic acid, carnosol, carvacrol, carvone, caryophyllene, caryophyllene-oxide, chlorogenic acid, diosmetin, gamma-terpinene, hesperidin, isoborneol, limonene, luteolin, luteolin-3′-O-(3″-O-acetyl)-β-D-glucuronide, luteolin-3′-O-(4″-O-acetyl)-β-D-glucuronide, luteolin-3′-O-β-D-glucuronide, luteolin-7-glucoside, methyl-eugenol, myrcene, neo-chlorogenic acid, nepetin, octanoic acid, oleanolic acid, p-cymene, piperitenone, rosmanol, rosmaric acid, rosmaricine, rosmaridiphenol, rosemarinic acid, rosmarinol, rosmariquinone, sabinene, sabinyl acetate, salicylates, salicylic acid-2-β-D-glucoside, squalene, terpinen-4-ol, terpinolene, thymol, trans-anethole, trans-carveol, ursolic acid, verbenone, and zingiberene.
- 36. The composition of claim 35, wherein the second component is a compound derived from rosemary that is selected from the group consisting of betulin, betulinic acid, carnosic acid, carnosol, carvacrol, chlorogenic acid, diosmetin, limonene, and luteolin.
- 37. The composition of claim 28, wherein the second component is tryptanthrin that is conjugated to a member selected from the group consisting of mono- or di-saccharides, amino acids, sulfates, succinate, acetate, and glutathione.
- 38. The composition of claim 28, wherein the composition comprises about 0.5 to 10000 mg of the fraction isolated or derived from hops.
- 39. The composition of claim 38, wherein the composition comprises about 50 to 7500 mg of the fraction isolated or derived from hops.
- 40. The composition of claim 28, wherein the composition comprises about 0.35 to 3500 mg of tryptanthrin, wherein the second component is tryptanthrin.
- 41. The composition of claim 40, wherein the composition comprises about 0.7 to 700 mg of tryptanthrin, wherein the second component is tryptanthrin.
- 42. The composition of claim 28, wherein the composition comprises about 0.5 to 5000 mg of the second component, wherein the second component is selected from the group consisting of rosemary, extract derived from rosemary, and a compound derived from rosemary.
- 43. The composition of claim 42, wherein the composition comprises about 5 to 2000 mg of the second component, wherein the second component is selected from the group consisting of rosemary, extract derived from rosemary, and a compound derived from rosemary.
- 44. The composition of claim 28, wherein the composition comprises about 0.001 to 10 weight percent of the first component.
- 45. The composition of claim 44, wherein the composition comprises about 0.1 to 1 weight percent of the first component.
- 46. The composition of claim 28, wherein the composition comprises about 0.001 to 10 weight percent of the second component.
- 47. The composition of claim 46, wherein the composition comprises about 0.1 to 1 weight percent of the second component.
- 48. The composition of claim 28, wherein a ratio of the first component to the second component is in the range of about 100:1 to about 1:100.
- 49. The composition of claim 48, wherein the ratio of the first component to the second component is in the range of about 50:1 to about 1:50.
- 50. The composition of claim 28, wherein the composition further comprises a pharmaceutically acceptable carrier.
- 51. A method of modulating inflammatory response in cells, the method comprising contacting the cells with a composition comprising a fraction isolated or derived from hops and a second component selected from the group consisting of rosemary, an extract derived from rosemary, a compound derived from rosemary, a triterpene species, a diterpene lactone species, and tryptanthrin.
- 52. A method of treating or inhibiting a pathological condition in a mammal associated with tissue-specific activation of inflammation, the method comprising administering to the mammal a composition comprising a fraction isolated or derived from hops and a second component selected from the group consisting of rosemary, an extract derived from rosemary, a compound derived from rosemary, a triterpene species, a diterpene lactone species, and tryptanthrin.
- 53. The method of claim 52, wherein the fraction isolated or derived from hops is selected from the group consisting of alpha acids, isoalpha acids, reduced isoalpha acids, tetra-hydroisoalpha acids, hexa-hydroisoalpha acids, beta acids, and spent hops.
- 54. The method of claim 52, wherein the fraction isolated or derived from hops comprises a compound of a supragenus having the formula:
- 55. The method of claim 52, wherein the fraction isolated or derived from hops comprises a compound of Genus A having the formula:
- 56. The method of claim 52, wherein the fraction isolated or derived from hops comprises a compound of Genus B having the formula:
- 57. The method of claim 52, wherein the fraction isolated or derived from hops comprises a compound selected from the group consisting of humulone, cohumulone, adhumulone, isohumulone, isocohumulone, isoadhumulone, dihydro-isohumulone, dihydro-isocohumulone, dihydro-adhumulone, tetrahydro-isohumulone, tetrahydro-isocohumulone, tetrahydro-adhumulone, hexahydro-isohumulone, hexahydro-isocohumulone, and hexahydro-adhumulone.
- 58. The method of claim 52, wherein the composition comprises about 0.5 to 10000 mg of the fraction isolated or derived from hops.
- 59. The method of claim 58, wherein the composition comprises about 50 to 7500 mg of the fraction isolated or derived from hops.
- 60. The method of claim 52, wherein the composition comprises about 0.001 to 10 weight percent of the fraction isolated or derived from hops.
- 61. The method of claim 60, wherein the composition comprises about 0.1 to 1 weight percent of the fraction isolated or derived from hops.
- 62. The method of claim 52, wherein the second component is rosemary.
- 63. The method of claim 52, wherein the second component is an extract derived from rosemary.
- 64. The method of claim 52, wherein the second component is a triterpene species.
- 65. The method of claim 52, wherein the composition further comprises a third component different from the second component, said third component is selected from the group consisting of rosemary, an extract derived from rosemary, a compound derived from rosemary, a triterpene species, a diterpene lactone species, and tryptanthrin.
- 66. The method of claim 65, wherein the second and third components are an extract derived from rosemary and tryptanthrin, respectively.
- 67. The method of claim 52, wherein the second component is a compound derived from rosemary that is selected from the group consisting of 1,8-cineole, 19-alpha-hydroxyursolic acid, 2-β-hydroxyoleanolic acid, 3-O-acetyloleanolic acid, 3-O-acetylursolic acid, 6-methoxy-luteolin-7-glucoside, 6-methoxyluteolin, 6-methoxyluteolin-7-glucoside, methoxyluteolin-7-methylether, 7-ethoxy-rosmanol, 7-methoxy-rosmanol, alpha-amyrin, alpha-humulene, alpha-hydroxyhydrocaffeic acid, alpha-pinene, alpha-terpinene, alpha-terpinenyl acetate, alpha-terpineol, alpha-thujone, apigenin, apigenin-7-glucoside, curcumene, benzyl-alcohol, β-amyrenone, β-amyrin, β-elemene, β-pinene, betulin, betulinic acid, borneol, bornyl-acetate, caffeic acid, camphene, camphor, carnosic acid, carnosol, carvacrol, carvone, caryophyllene, caryophyllene-oxide, chlorogenic acid, diosmetin, gamma-terpinene, hesperidin, isoborneol, limonene, luteolin, luteolin-3′-O-(3″-O-acetyl)-β-D-glucuronide, luteolin-3′-O-(4″-O-acetyl)-β-D-glucuronide, luteolin-3′-O-β-D-glucuronide, luteolin-7-glucoside, methyl-eugenol, myrcene, neo-chlorogenic acid, nepetin, octanoic acid, oleanolic acid, p-cymene, piperitenone, rosmanol, rosmaric acid, rosmaricine, rosmaridiphenol, rosemarinic acid, rosmarinol, rosmariquinone, sabinene, sabinyl acetate, salicylates, salicylic acid-2-β-D-glucoside, squalene, terpinen-4-ol, terpinolene, thymol, trans-anethole, trans-carveol, ursolic acid, verbenone, and zingiberene.
- 68. The method of claim 67, wherein the second component is a compound derived from rosemary that is selected from the group consisting of betulin, betulinic acid, carnosic acid, carnosol, carvacrol, chlorogenic acid, diosmetin, limonene, and luteolin.
- 69. The method of claim 52, wherein the composition comprises about 0.5 to 5000 mg of the second component, wherein the second component is selected from the group consisting of rosemary, extract derived from rosemary, and a compound derived from rosemary.
- 70. The method of claim 69, wherein the composition comprises about 5 to 2000 mg of the second component, wherein the second component is selected from the group consisting of rosemary, extract derived from rosemary, and a compound derived from rosemary.
- 71. The method of claim 52, wherein the second component is a triterpene species or a diterpene lactone species that is conjugated to a member selected from the group consisting of mono- or di-saccharides, amino acids, sulfates, succinate, acetate, and glutathione.
- 72. The method of claim 52, wherein the second component is a triterpene species that is selected from the group consisting of 18-a-glycyrrhetinic acid, 18-β-glycyrrhetinic acid, 2-a-3-a-dihydrooxyurs-12-3n-28-onic acid, 3-a-hydroxyursolic acid, 3-oxo-ursolic acid, betulin, betulinic acid, celastrol, eburicoic acid, friedelin, glycyrrhizin, gypsogenin, oleanolic acid, oleanolic acid-3-acetate, pachymic acid, pinicolic acid, sophoradiol, soyasapogenol A, soyasapogenol B, tripterin, triptophenolide, tumulosic acid, ursolic acid, ursolic acid-3-acetate, uvaol, and β-sitosterol.
- 73. The method of claim 72, wherein the second component is a triterpene species that is selected from the group consisting of 18-a-glycyrrhetinic acid, 18-β-glycyrrhetinic acid, 2-a-3-a-dihydrooxyurs-12-3n-28-onic acid, 3-a-hydroxyursolic acid, 3-oxo-ursolic acid, betulin, betulinic acid, celastrol, friedelin, oleanolic acid, tripterin, triptophenolide, ursolic acid, and uvaol.
- 74. The method of claim 52, wherein the composition comprises about 0.035 to 3500 mg of a triterpene species, wherein the second component is a triterpene species.
- 75. The method of claim 74, wherein the composition comprises about 0.7 to 700 mg of a triterpene species, wherein the second component is a triterpene species.
- 76. The method of claim 52, wherein the second component is tryptanthrin that is conjugated to a member selected from the group consisting of mono- or di-saccharides, amino acids, sulfates, succinate, acetate, and glutathione.
- 77. The method of claim 52, wherein the composition comprises about 0.035 to 3500 mg of tryptanthrin, wherein the second component is tryptanthrin.
- 78. The method of claim 77, wherein the composition comprises about 0.7 to 700 mg of tryptanthrin, wherein the second component is tryptanthrin.
- 79. The method of claim 52, wherein the composition comprises about 0.001 to 10 weight percent of the second component.
- 80. The method of claim 79, wherein the composition comprises about 0.1 to 1 weight percent of the second component.
- 81. The method of claim 52, wherein a ratio of the first component to the second component is in the range of about 100:1 to about 1:100.
- 82. The method of claim 81, wherein the ratio of the first component to the second component is in the range of about 50:1 to about 1:50.
- 83. The method of claim 52, wherein the pathological condition is selected from the group consisting of autoimmune diseases, inflammatory diseases, neurological diseases, and cancer.
- 84. The method of claim 52, wherein the pathological condition is selected from the group consisting of inflammation, inflammation-associated disorders, arthritis, asthma, bronchitis, menstrual cramps, tendonitis, bursitis, skin-related conditions, gastrointestinal conditions, cancer, ophthalmic diseases, pulmonary inflammation, nervous system disorders, allergic rhinitis, respiratory distress syndrome, endotoxin shock syndrome, atherosclerosis, and central nervous damage.
- 85. The method of claim 52, wherein the composition further comprises a pharmaceutically acceptable carrier.
- 86. The method of claim 52 wherein the composition is administered orally, topically, parenterally, or rectally.
- 87. A method of modulating the amount of cyclooxygenase-2 (COX-2) activity in target cells without substantially modulating COX-2 activity in non-target cells, the method comprising contacting the cells with a composition comprising a fraction isolated or derived from hops and a second component selected from the group consisting of rosemary, an extract derived from rosemary, a compound derived from rosemary, a triterpene species, a diterpene lactone species, and tryptanthrin.
- 88. The method of claim 87, wherein the non-target cells are also contacted with said fraction isolated or derived from hops.
- 89. The method of claim 87, wherein the contacting step is in vivo.
- 90. The method of claim 86, wherein the COX-2 activity is modulated by inhibition of COX-2 gene.
- 91. A method of treating or inhibiting a pathological condition in a mammal involving inhibiting inducibility or activity of cyclooxygenase-2 (COX-2), the method comprising administering to the mammal a composition comprising a fraction isolated or derived from hops and a second component selected from the group consisting of rosemary, an extract derived from rosemary, a compound derived from rosemary, a triterpene species, a diterpene lactone, and tryptanthrin.
- 92. The method of claim 91, wherein the fraction isolated or derived from hops is selected from the group consisting of alpha acids, isoalpha acids, reduced isoalpha acids, tetra-hydroisoalpha acids, hexa-hydroisoalpha acids, beta acids, and spent hops.
- 93. The method of claim 91, wherein the fraction isolated or derived from hops comprises a compound of a supragenus having the formula:
- 94. The method of claim 91, wherein the fraction isolated or derived from hops comprises a compound of Genus A having the formula:
- 95. The method of claim 91, wherein the fraction isolated or derived from hops comprises a compound of Genus B having the formula:
- 96. The method of claim 91, wherein the fraction isolated or derived from hops comprises a compound selected from the group consisting of humulone, cohumulone, adhumulone, isohumulone, isocohumulone, isoadhumulone, dihydro-isohumulone, dihydro-isocohumulone, dihydro-adhumulone, tetrahydro-isohumulone, tetrahydro-isocohumulone, tetrahydro-adhumulone, hexahydro-isohumulone, hexahydro-isocohumulone, and hexahydro-adhumulone.
- 97. The method of claim 91, wherein the second component is an extract derived from rosemary.
- 98. The method of claim 91, wherein the second component is a triterpene species.
- 99. The method of claim 91, wherein the composition further comprises a third component different from the second component, the third component is selected from the group consisting of rosemary, an extract derived from rosemary, a compound derived from rosemary, a triterpene species, a diterpene lactone, and tryptanthrin.
- 100. The method of claim 99, wherein the second and third components are an extract derived from rosemary and tryptanthrin, respectively.
- 101. The method of claim 91, wherein the second component is a compound derived from rosemary that is selected from the group consisting of 1,8-cineole, 19-alpha-hydroxyursolic acid, 2-β-hydroxyoleanolic acid, 3-O-acetyloleanolic acid, 3-0-acetylursolic acid, 6-methoxy-luteolin-7-glucoside, 6-methoxyluteolin, 6-methoxyluteolin-7-glucoside, methoxyluteolin-7-methylether, 7-ethoxy-rosmanol, 7-methoxy-rosmanol, alpha-amyrin, alpha-humulene, alpha-hydroxyhydrocaffeic acid, alpha-pinene, alpha-terpinene, alpha-terpinenyl acetate, alpha-terpineol, alpha-thujone, apigenin, apigenin-7-glucoside, curcumene, benzyl-alcohol, β-amyrenone, β-amyrin, β-elemene, β-pinene, betulin, betulinic acid, borneol, bornyl-acetate, caffeic acid, camphene, camphor, carnosic acid, carnosol, carvacrol, carvone, caryophyllene, caryophyllene-oxide, chlorogenic acid, diosmetin, gamma-terpinene, hesperidin, isoborneol, limonene, luteolin, luteolin-3′-O-(3″-O-acetyl)-β-D-glucuronide, luteolin-3′-O-(4″-O-acetyl)-β-D-glucuronide, luteolin-3′-O-β-D-glucuronide, luteolin-7-glucoside, methyl-eugenol, myrcene, neo-chlorogenic acid, nepetin, octanoic acid, oleanolic acid, p-cymene, piperitenone, rosmanol, rosmaric acid, rosmaricine, rosmaridiphenol, rosemarinic acid, rosmarinol, rosmariquinone, sabinene, sabinyl acetate, salicylates, salicylic acid-2-β-D-glucoside, squalene, terpinen-4-ol, terpinolene, thymol, trans-anethole, trans-carveol, ursolic acid, verbenone, and zingiberene.
- 102. The method of claim 101, wherein the second component is a triterpene species or a diterpene lactone species that is conjugated to a member selected from the group consisting of mono- or di-saccharides, amino acids, sulfates, succinate, acetate, and glutathione.
- 103. The method of claim 91, wherein the second component is a triterpene species that is selected from the group consisting of 18-a-glycyrrhetinic acid, 18-β-glycyrrhetinic acid, 2-a-3-a-dihydrooxyurs-12-3n-28-onic acid, 3-a-hydroxyursolic acid, 3-oxo-ursolic acid, betulin, betulinic acid, celastrol, eburicoic acid, friedelin, glycyrrhizin, gypsogenin, oleanolic acid, oleanolic acid-3-acetate, pachymic acid, pinicolic acid, sophoradiol, soyasapogenol A, soyasapogenol B, tripterin, triptophenolide, tumulosic acid, ursolic acid, ursolic acid-3-acetate, uvaol, and β-sitosterol.
- 104. The method of claim 91, wherein the second component is tryptanthrin that is conjugated to a member selected from the group consisting of mono- or di-saccharides, amino acids, sulfates, succinate, acetate, and glutathione.
- 105. The method of claim 91, wherein a ratio of the first component to the second component is in the range of about 100:1 to about 1:100.
- 106. The method of claim 105, wherein the ratio of the first component to the second component is in the range of about 50:1 to about 1:50.
- 107. The method of claim 91, wherein the pathological condition is selected from the group consisting of inflammation, inflammation-associated disorders, arthritis, asthma, bronchitis, menstrual cramps, tendonitis, bursitis, skin-related conditions, gastrointestinal conditions, cancer, ophthalmic diseases, pulmonary inflammation, nervous system disorders, allergic rhinitis, respiratory distress syndrome, endotoxin shock syndrome, atherosclerosis, and central nervous damage.
- 108. The method of claim 91, wherein the composition further comprises a pharmaceutically acceptable carrier.
- 109. The method of claim 91, wherein the composition is administered orally, topically, parenterally, or rectally.
- 110. A method of inhibiting prostaglandin synthesis selectively in target cells, the method comprising contacting the cells with a fraction isolated or derived from hops and a second component selected from the group consisting of rosemary, an extract derived from rosemary, a compound derived from rosemary, a triterpene species, a diterpene lactone, and tryptanthrin.
- 111. The method of claim 110, wherein the fraction isolated or derived from hops is selected from the group consisting of alpha acids, isoalpha acids, reduced isoalpha acids, tetra-hydroisoalpha acids, hexa-hydroisoalpha acids, beta acids, and spent hops.
- 112. The method of claim 110, wherein the fraction isolated or derived from hops comprises a compound of a supragenus having the formula:
- 113. The method of claim 110, wherein the fraction isolated or derived from hops comprises a compound of Genus A having the formula:
- 114. The method of claim 110, wherein the fraction isolated or derived from hops comprises a compound of Genus B having the formula:
- 115. The method of claim 110, wherein the fraction isolated or derived from hops comprises a compound selected from the group consisting of humulone, cohumulone, adhumulone, isohumulone, isocohumulone, isoadhumulone, dihydro-isohumulone, dihydro-isocohumulone, dihydro-adhumulone, tetrahydro-isohumulone, tetrahydro-isocohumulone, tetrahydro-adhumulone, hexahydro-isohumulone, hexahydro-isocohumulone, and hexahydro-adhumulone.
CROSS-REFERENCE TO RELATED APPLICATIONS
[0001] This patent application is a continuation-in-part of U.S. application Ser. No. 10/400,293, filed Mar. 26, 2003, and a continuation-in-part of U.S. application Ser. No. 10/401,283, filed Mar. 26, 2003, both of which claim the benefit under 35 U.S.C. § 119(e) to provisional application No. 60/450,237, filed on Feb. 25, 2003, and provisional application No. 60/420,383, filed on Oct. 21, 2002. The contents of each of these earlier applications are hereby incorporated by reference as if recited herein in their entirety.
Provisional Applications (2)
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Number |
Date |
Country |
|
60450237 |
Feb 2003 |
US |
|
60420383 |
Oct 2002 |
US |
Continuation in Parts (2)
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Number |
Date |
Country |
Parent |
10400293 |
Mar 2003 |
US |
Child |
10464410 |
Jun 2003 |
US |
Parent |
10401283 |
Mar 2003 |
US |
Child |
10400293 |
Mar 2003 |
US |