Claims
- 1. A method for prolonging allograft survival in a mammal bearing an allograft, the method comprising administering a compound having the structure:
- 2. The method according to claim 1, wherein the immunosuppressive drug is selected from the group consisting of cyclosporine A, rapamycin and FK506.
- 3. The method according to claim 1, wherein R1 is selected from the group consisting of C1-C6 alkyl.
- 4. The method according to claim 3, wherein R1 is isopropyl.
- 5. The method according to claim 1, wherein R2 is selected from the group consisting of ethyl, n-propyl, n-butyl and iso-butyl.
- 6. The method according to claim 1, wherein R2 is n-propyl.
- 7. The method according to claim 1 wherein compound (I) is injected subcutaneously.
- 8. The method according to claim 1 wherein compound (I) is injected intravenously.
- 9. The method according to claim 8, wherein compound (I) is administered at a dose of about 0.025 to about 1 mg/kg.
- 10. A method for prolonging allograft survival in a mammal bearing an allograft, the method comprising administering a compound having the structure:
- 11. The method according to claim 10 wherein compound (II) is injected subcutaneously.
- 12. The method according to claim 10 wherein compound (II) is injected intravenously.
- 13. The method according to claim 12, wherein compound (II) is administered at a dose of about 0.025 to about 1 mg/kg.
CROSS-REFERENCE TO RELATED APPLICATIONS
[0001] This application claims priority from U.S. Provisional Patent Application Serial No. 60/281,088, filed on Apr. 3, 2001, and U.S. Provisional Patent Application Serial No. 60/282,535, filed on Apr. 9, 2001, the contents of which are hereby incorporated by reference in their entirety.
Provisional Applications (2)
|
Number |
Date |
Country |
|
60281088 |
Apr 2001 |
US |
|
60282535 |
Apr 2001 |
US |