The present invention relates to a synergistic composition comprising two plant substrates, active against many diseases of mammals, particularly humans.
Plants Lippia sidoides and Myracrodruon urundeuva are known in Brazilian folk medicine, traditionally used for treating bleeding gums and many other inflammatory diseases. They are found in the prior art references to the plant Myracrodruon urundeuva (Engl.), popularly known as “aroeira do sertao”, such as those mentioned below, typically concerning anti-inflammatory activity:
Teas: cuts and bruises, helping in healing;
Infusion for oral administration: inflammation of the liver and uterus;
Infusion: utero-vaginal douche for vaginal inflammation;
Postpartum seat bath;
Bark extract gargle: throat infections;
Stem bark powder: snake bite.
Lippia sidoides Cham. (Verbenaceae), popularly known as “alecrim pimenta” is largely grown in Northeastern Brazil. The hydro-alcoholic extract of this plant is largely used for the treatment of skin wounds, as mouth antiseptic, and in liquid soap preparations to treat and prevent general fungal infections of the body. Other uses mentioned below are typically related to antimicrobial activity: antiseptic, cleansing wounds, acne treatment, cold sore scab, white cloth, impinges, dandruff, foul smell of feet, armpits and groin, among others.
Surprisingly, it was found that compositions containing small amounts of these two combined substrates exhibit strong curative activity for various diseases, beyond what could be expected of antimicrobial and anti-inflammatory individual effects.
The thesis defended by Botelho, M. A. “The study of the effect of the gel of Alecrim-pimenta (Lippia sidoides) and Aroeira-do-sertao (Myracroduon urundeuva) and their isolated active principles in experimental periodontal disease”, Federal University of Ceará. Fortaleza 2007, Brazil, evaluated the effects of (a) individual extracts of each plant and their mixture and (b) gels with individual active ingredients contained in the two extracts, and the mixture of active ingredients with observed synergistic results upon microbial activity (bacteria and fungi) and rate of bone loss.
However, it was found that, unpredictably, the synergistic composition of that document is not in any way limited to just the disclosed applications.
Surprisingly, the effectiveness of combinations of such extracts or active principles contained therein also proved to be present in treating other diseases, injuries and traumas, without any relation to each other, providing new and strong evidence in all cases tested by topical application.
The substrates are respectively the extracts of the aroeira plant (Myracroduon urundeuva) and of the rosemary-pepper plant (Lippia sidoides) popularly known as “alecrim-pimenta”. As used herein, mention to these substrates also refer to the main active ingredients contained in such plants.
Without limiting the invention to scientific explanations, this composition has an effect on the immune system of the patient in order to provide, as a whole, results that extend beyond the contribution of each individual component.
As the sense used herein, “topical treatment” includes any application upon skin or mucosa with transdermal or transmucosal action. Still according to the sense used herein, “disorders” includes diseases, trauma and injury to the mammalian body.
The effectiveness of the combination of the extracts or the active principles contained therein also proved to be effective in treating other diseases, injuries and traumas, among which are:
a. various treatments
B. other applications
It is important to note that, unlike a purely additive effect of a substrate with antibacterial capacity and another substrate with anti-inflammatory capacity, it was found a synergistic effect, with performance and results above the mere addition of the individual effects. Additionally, this effect was repeatedly seen in use in many other conditions, diseases, injuries and traumas.
Thus, the present invention of multi-active synergistic composition for topical treatment of disorders in mammals, is characterized by comprising the combination of an extract of the aroeira plant (or isolated compounds found in extracts of the aroeira plant), a plant extract of alecrim-pimenta (or compounds isolated from plant extracts found in alecrim-pimenta), and one or more pharmaceutically acceptable excipients.
The “Aroeira” is a plant also known by the names of aroeira do campo, aroeira do sertão, aroeira da serra, urundeúva, uriunduba e aroeira preta, corresponding to the botanical classification M. urundeuva all Br (previous designations being Astronium juglandifolium and Astronium urundeuva).
The “Alecrim-pimenta” is a plant also known by the names of alecrim-grande, estrepa-cavalo, alecrim-bravo, alecrim do nordeste and lipia, corresponding to the botanical classification Lippia sidoides Cham.
The “extract of the aroeira plant” refers in general to extracts containing chalcones, tannins, flavonoids and alkaloids, of fractions or extracts containing mixtures thereof, for example, glycolic, butanolic, ethanolic extracts or fluid extract. It also refers to one or more of the dimeric chalcones urundeuvine A, B or C, regardless of their origin in this plant.
The “extract of the alecrim-pimenta plant” refers generally to extracts containing predominantly carvacrol and thymol, or extract fractions enriched in thymol and/or carvacrol, the thymol compound per se, the carvacrol compound per se, or mixtures thereof, regardless of its origin is the alecrim-pimenta plant. Example of a suitable extract is the essential oil obtained from the leaves of this plant.
The compositions of the invention may be formulated in any appropriate physical form, for example: powder, mud, gel, ointment, solutions, dispersions, emulsions, soaps, douches, patches, stickers, etc. A person skilled in the art knows how to formulate such compositions containing pharmaceutically acceptable excipients, for example, selected from among those cited in the following literature: Remington's Pharmaceutical Sciences, Mack Publishing, the European or the Brazilian Pharmacopeias.
In a particular embodiment, the invention encompasses the use of a carrier in the form of micro or nanogel.
Besides the mentioned synergistic mixture, the compositions of the invention may contain active ingredients and other ingredients, aimed to provide specific effects. A purely exemplary and non-limiting list includes one or more actives among healing agents, antibiotics, analgesics, hormones, haemostatic, antiseptic agents, antioxidants, antifungal, anti-inflammatory, anti-allergic.
The following examples are particular embodiment of the inventions, given only for illustrative purposes, without imposing limitations beyond those contained in the claims presented farther on.
Prepare mixture of glycolic extract of aroeira, antimicrobial solution sweetener, add to earlier stage phases and mix in a roller mill.
The gel of example 1 was applied to a patient twice a day over one week.
A faster and more effective improvement was found when compared to other medications commonly indicated for the treatment of such pathology (benzoyl peroxide, retinoic acid, azelaic acid).
Treatment of cold sores (herpes simplex).
The gel from example 1 was applied 3 times a day. A significant improvement was found, including the decrease of the pain and the course of the disease.
Hot vegetable oil skin Burn.
The gel of Example 1 was applied to the injured site at the foot of a patient, over a week, three times a day.
Oral aphthae (oral canker).
The gel of example 1 was applied to the tongue of a patient, twice a day during 48 hours.
Shaving ANTI haemostatic and anti-irritating.
The gel of example 1 was applied to the shaved area of a patient, just once after shaving.
Cut healing.
The gel of example 1 was applied to a superciliary cut of a patient, 3 times a day over 72 hours.
With the information and examples herein a person skilled in the art is able to carry out equivalent forms of the invention, not expressly described here, but with functions and results of the same nature as the ones described, therefore within the scope of the appended claims.