Patent Application
20070264226
It has been discovered that the disinfecting solutions of the present invention containing combinations of sodium chlorite and myristamidopropyl dimethylamine (MAPD) or MAPD and polyhexamethylene biguanide (PHMB) are very effective against microbes. Additionally, the combinations of the present invention act synergistically to effect antimicrobial and bactericidal activity against acanthamoeba cysts and trophozoites at a much lower concentration of each individual antimicrobial agent than as has been previously used in conventional disinfecting solutions. Further, the combinations of the present invention act synergistically to effectuate an enhanced antiviral and antifungal activity.
In one embodiment of the present invention the disinfecting solution contains sodium chlorite and MAPD, the concentration range of sodium chlorite is from about 10 ppm to about 5000 ppm and the concentration range of MAPD is from about 0.05 ppm to about 500 ppm. A preferred embodiment includes sodium chlorite from about 10 ppm to about 1500 ppm and MAPD from about 0.05 ppm to about 50 ppm. A specific embodiment includes 400 ppm of sodium chlorite and 5 ppm of MAPD. This embodiment of the invention preferably has a pH range of about 5.5 to about 8.5, and has an even more highly preferred pH range of about 6.5 to about 7.5. One embodiment of this invention for use in ophthalmic preparations preferably has a tonicity in the range of about 200 mOsm to about 340 mOsm. Another embodiment of this invention for use in dermatological formulations preferably has a tonicity in the range of about 50 mOsm to about 5000 mOsm.
Another embodiment of the present invention envisions a disinfecting solution containing MAPD and PHMB, wherein MAPD is present from about 0.05 ppm to about 500 ppm and PHMB is present from about 0.01 ppm to about 100 ppm. A preferred embodiment includes MAPD from about 0.05 ppm to about 50 ppm and PHMB from about 0.01 ppm to about 10 ppm. A specific embodiment includes 5 ppm of MAPD and 0.5 ppm of PHMB. In this embodiment of the invention, a preferable pH range for the composition is about 5.0 to about 9.0, with a more highly preferred pH range of about 6.5 to about 7.5. One embodiment of this invention for use in ophthalmic preparations preferably has a tonicity in the range of about 200 mOsm to about 340 mOsm. Another embodiment of this invention for use in dermatological formulations preferably has a tonicity in the range of about 50 mOsm to about 5000 mOsm.
Either of the above synergistic combinations of disinfecting solutions may utilize myristamidopropyldimethylamine dimethicone copolyol phosphate in place of MAPD without any harmful adverse effects.
The antimicrobial activities of the synergistic disinfecting solutions are further enhanced by the addition of sequestering agents, such as disodium edatate (EDTA). The sequestering agents serve to reduce calcium ions and also help remove proteins. Furthermore, the addition of non-toxic and non-ionic surfactants, such as poloxamer and poloxamine, will further add to the synergistic effect of the disinfection capabilities of the present invention.
To improve contact lens wearer's comfort and acceptability, lubricating agents, tonicity agents, buffering agents, viscosity agents, and protein removing agents can be added into the present invention of the synergistic combination of antimicrobial agents for effective disinfecting solutions.
To improve skin disinfection comfort and acceptability, lubricating agents, tonicity agents, buffering agents, viscosity agents, and high molecular weight polymeric agents like sodium hyaluronate, hydroxypropylmethyl cellulose or carboxymethyl celluloses can be added into the present invention of the synergistic combination of antimicrobial agents for effective skin disinfecting solutions.
One embodiment of the present invention envisions a multipurpose disinfection composition having the following formula:
This embodiment has the preferred following formula:
Alternatively, this embodiment may have the following formula:
The preferred formulation of this embodiment is as follows:
Another embodiment of the present invention envisions a multipurpose disinfection composition having the following formula:
This embodiment has the preferred following formula:
Alternatively, this embodiment may have the following formula:
This embodiment has the preferred following formula:
In addition, the present invention can be equally effectively used for the purpose of other disinfecting requirements such as in foods, cosmetics, medical devices, as well as dermatological pharmaceutical preparations. The present invention may also be utilized as a multipurpose hard surface disinfectant solution useful, for example, in disinfecting countertops, tables, floors, walls, sinks, and other hard surfaces that may be contaminated with bacteria, viruses, and/or fungi.
The above description is given by way of example, and not limitation. Further, the various features of the embodiments disclosed herein can be used alone, or in varying combinations with each other and are not intended to be limited to the specific combination described herein. Thus, the scope of the claims is not to be limited by the illustrated embodiments.
This application claims the benefit of U.S. Provisional Application No. 60/799,380, filed on May 10, 2006, as well as U.S. Provisional Application No. 60/830,251, filed on Jul. 12, 2006, the teachings of both are herein expressly incorporated by reference.
| Number | Date | Country | |
|---|---|---|---|
| 60799380 | May 2006 | US | |
| 60830251 | Jul 2006 | US |
