Synthesis and Applications of functional Macromolecules

Information

  • Research Project
  • 7336332
  • ApplicationId
    7336332
  • Core Project Number
    R01GM067866
  • Full Project Number
    5R01GM067866-06
  • Serial Number
    67866
  • FOA Number
  • Sub Project Id
  • Project Start Date
    1/1/2004 - 20 years ago
  • Project End Date
    12/31/2009 - 14 years ago
  • Program Officer Name
    FABIAN, MILES
  • Budget Start Date
    1/1/2008 - 16 years ago
  • Budget End Date
    12/31/2009 - 14 years ago
  • Fiscal Year
    2008
  • Support Year
    6
  • Suffix
  • Award Notice Date
    9/16/2008 - 16 years ago
Organizations

Synthesis and Applications of functional Macromolecules

[unreadable] DESCRIPTION (provided by applicant): Nature relies on structured macromolecules in the form of proteins and catalytic RNA's that fold into specific three-dimensional structures and present reactive functionality in precise constellations in order to carry out the chemical processes of life. The structured nature of these molecules and what we have learned from proteins about structure/function relationships suggests that given the ability to construct macromolecules and control their three-dimensional structures, we could develop macromolecules with biomimetic capabilities and with entirely new chemical functions. Our goal is to develop a novel, basic technology for synthesizing macromolecules with designed three-dimensional shapes and capable of presenting multiple chemically reactive groups in controlled ways to perform new functions. Our approach is to synthesize small, rigid molecular building blocks (bis-amino acids) and couple them through pairs of amide bonds to create ladder oligomers. Each monomer contains multiple stereocenters that are set in the building block synthesis. The bis-amino acids are assembled on solid support, or in solution, in specific sequences to form constitutionally precise macromolecules with specific structures. We propose the following specific goals. 1) We will utilize our prototype monomer to synthesize several scaffolds with interesting structures and determine their structures. 2) We will measure the flexibility of linear and bow-shaped scaffolds. 3) We will develop syntheses of additional monomers. 4) We will synthesize macromolecules that display cavities with dimensions comparable to those of protein active sites and determine their structures. 5) We will discover peptides that selectively bind these cavitand scaffolds and characterize the interaction through structure determination and measurement of binding free energies. 6) We will develop syntheses for bis-amino acids that display an additional functional group akin to the side chain of an amino acid. 7) We will develop a general approach to the design of complex functional group arrays that are capable of biomimetic function and could be used for the development of nanoscale molecular devices. [unreadable] [unreadable]

IC Name
NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES
  • Activity
    R01
  • Administering IC
    GM
  • Application Type
    5
  • Direct Cost Amount
  • Indirect Cost Amount
  • Total Cost
    252849
  • Sub Project Total Cost
  • ARRA Funded
  • CFDA Code
    859
  • Ed Inst. Type
    SCHOOLS OF ARTS AND SCIENCES
  • Funding ICs
    NIGMS:252849\
  • Funding Mechanism
  • Study Section
    MCHA
  • Study Section Name
    Medicinal Chemistry Study Section
  • Organization Name
    TEMPLE UNIVERSITY
  • Organization Department
    CHEMISTRY
  • Organization DUNS
  • Organization City
    PHILADELPHIA
  • Organization State
    PA
  • Organization Country
    UNITED STATES
  • Organization Zip Code
    19122
  • Organization District
    UNITED STATES