Claims
- 1. Nitrophenol resins on a support selected from compounds of the following formula:
- 2. The nitrophenol resin according to claim 1 wherein the solid support is selected from the group consisting of polystyrene, Tantagel, polyethylene glycol dimethacrylamide copolymers, macroporous resins, and silica gel.
- 3. A method for synthesizing nitrophenol resins comprising forming amide bonds between hydroxynitrobenzoic acids and an amino-alkyl polymer support.
- 4. The method according to claim 3 wherein the coupling scheme is 1,3-diisopropylcarbodiimide-1-hydroxybenzotriazole and 1-hydroxybenxotriazole.
- 5. The method according to claim 3 wherein the coupling occurs in a solvent selected from the group consisting of N,N-dimethyl formamide, 1-methyl-2pyrrolidinome tetrahydrofurene, and methylene chloride.
- 6. A method for synthesizing nitrophenol resins comprising hydrolyzing chlorobenzene.
- 7. The method according to claim 6 wherein an alkylamino resin is coupled with 4-chloro-3-nitrobenzoic acid.
- 8. A method for preparing carboxyl ester resins comprising reacting an acyl halide with a nitrophenol resin on a support selected from compounds of the following formula:
- 9. A method for preparing sulfonyl ester resins comprising reacting a sulfonyl halide with a nitrophenol resin on a support selected from compounds of the following formula:
- 10. A method for preparing amides comprising reacting an amine with a carboxyl ester resin produced according to claim 8.
- 11. The method according to claim 10 wherein the amine is selected from the group consisting of 1-cyclohexylpiperazine, 1-(2-pyridyl)piperazine, dimethylamine, 6-amino-l-hexanol, (S)-(+)-leucinol, n-butylamine.
CROSS REFERENCE TO RELATED APPLICATION
[0001] The present application claims priority from provisional application 60/421,568, filed Oct. 28, 2002, the entire contents of which are hereby incorporated by reference.
Provisional Applications (1)
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Number |
Date |
Country |
|
60421568 |
Oct 2002 |
US |