SYNTHESIS OF ANATOXIN-A

Information

• Research Project
• 3438678

• ApplicationId

  3438678

• Core Project Number

  R15GM040080

• Full Project Number

  1R15GM040080-01

• Serial Number

  40080

• FOA Number

• Sub Project Id

• Project Start Date

  6/1/1988 - 36 years ago

• Project End Date

  8/31/1990 - 34 years ago

• Program Officer Name

• Budget Start Date

  6/1/1988 - 36 years ago

• Budget End Date

  8/31/1990 - 34 years ago

• Fiscal Year

  1988

• Support Year

  1

• Suffix

• Award Notice Date

  5/11/1988 - 36 years ago

Organizations

• Bucknell University

The major long-term objective of this project is the synthesis of anatoxin-a using chemistry which will allow large quantities to be prepared as well as numerous analogs. Initially, the carbocyclic analog will be prepared starting with the Diels-Alder adduct of cyclopentadiene and maleic anhydride. Reaction with dimethylcuprate, a Hunsdiecker reaction and loss of hydrogen bromide gives acetylnorbornene. Cycloaddition with acetylene or 1,2-dichloroethylene should give a bicyclo(4.2.1)dienone which can be reduced to the desired analog of anatoxin-a. The alkaloid itself will be prepared using similar chemistry starting from pyrrole.

IC Name

• Activity

  R15

• Administering IC

  GM

• Application Type

  1

• Direct Cost Amount

• Indirect Cost Amount

• Total Cost

• Sub Project Total Cost

• ARRA Funded

• CFDA Code

  863

• Ed Inst. Type

  SCHOOLS OF ARTS AND SCIENCES

• Funding ICs

• Funding Mechanism

• Study Section

  MCHA

• Study Section Name

  Medicinal Chemistry Study Section

• Organization Name

  BUCKNELL UNIVERSITY

• Organization Department

• Organization DUNS

• Organization City

  LEWISBURG

• Organization State

  PA

• Organization Country

  UNITED STATES

• Organization Zip Code

  17837

• Organization District

  UNITED STATES