SYNTHESIS OF COMPLEX MOLECULES

Information

• Research Project
• 3280818

• ApplicationId

  3280818

• Core Project Number

  R01GM032192

• Full Project Number

  7R01GM032192-07

• Serial Number

  32192

• FOA Number

• Sub Project Id

• Project Start Date

  9/1/1989 - 35 years ago

• Project End Date

  12/31/1991 - 33 years ago

• Program Officer Name

• Budget Start Date

  9/1/1989 - 35 years ago

• Budget End Date

  12/31/1989 - 35 years ago

• Fiscal Year

  1989

• Support Year

  7

• Suffix

• Award Notice Date

  9/8/1989 - 35 years ago

Organizations

• SCRIPPS CLINIC AND RESEARCH FOUNDATION, A CA CORP

This proposal deseribes a program directed towards the total synthesis of aurodox (1) and application of the methodology to be developed to the synthesis of other natural and unnatural members of the elfamycin family. The proposed methodology includes (a) a stereocontrolled approach from carbohydrate precursors and (b) an asymmetric approach from achiral precursors designed also with high stereo control as a prime objective. Since aurodox (1) and its relatives exhibit potent antibiotic properties by inhibiting protein biosynthesis as well as ionophoric and growth-promoting activites, this program should contribute significantly to human and animal medicine as well as result in useful biological tools and new synthetic methodology.

IC Name

• Activity

  R01

• Administering IC

  GM

• Application Type

  7

• Direct Cost Amount

• Indirect Cost Amount

• Total Cost

• Sub Project Total Cost

• ARRA Funded

• CFDA Code

  859

• Ed Inst. Type

• Funding ICs

• Funding Mechanism

• Study Section

  MCHA

• Study Section Name

  Medicinal Chemistry Study Section

• Organization Name

  SCRIPPS CLINIC AND RESEARCH FOUNDATION

• Organization Department

• Organization DUNS

• Organization City

  SAN DIEGO

• Organization State

  CA

• Organization Country

  UNITED STATES

• Organization Zip Code

  92037

• Organization District

  UNITED STATES