Claims
- 1. Process for the preparation of compounds with the formula:
- 2. Process according to claim 1, in which step c is directly followed by step c′) consisting in the opening of the lactone to yield the corresponding D- or L-4-X-3-(N—Y)-aminobutyric acid, where X is a leaving group and Y is as defined above, and in which step c′) is followed steps f)-h) as in claim 1.
- 3. Process according to claim 1, in which step f) is followed by step i) consisting in hydrolysis of the ester and deprotection of the 3-amino group to yield R or S aminocamitine or phosphonium aminocarnitine directly.
- 4. Process according to claim 1, in which group Y is tosyl.
- 5. Process according to claim 1 in which steps l)-n) allow the preparation of a chiral synthon such as R or S 3,4 diaminobutyric acid.
- 6. Process according to claim 1 in which the leaving group is iodine.
- 7. Process according to claim 1, in which said process is conducted without purification of the intermediate products.
- 8. Compound 8b as potential CPT inhibitor with antiketotic and antidiabetic activity and as useful intermediate for the synthesis of pharmaceutically active compounds.
Priority Claims (1)
Number |
Date |
Country |
Kind |
RM99A000418 |
Jun 1999 |
IT |
|
Parent Case Info
[0001] This application is a continuation-in-part of application Ser. No. 10/338,045 filed Jan. 8, 2003, which is a continuation-in-part of Ser. No. 10/018,794 filed Dec. 21, 2001, now U.S. ______ which is a 35 USC §371 of PCT/IT00/00258 filed Jun. 23, 2000.
Continuation in Parts (2)
|
Number |
Date |
Country |
Parent |
10338045 |
Jan 2003 |
US |
Child |
10372627 |
Feb 2003 |
US |
Parent |
10018794 |
Dec 2001 |
US |
Child |
10338045 |
Jan 2003 |
US |