Claims
- 1. Process for the preparation of a compound of the formula:
- 2. The process according to claim 1, in which step c is directly followed by the additional step c′) consisting in the opening of the lactone to yield the corresponding D- or L-4-X-3-(N—Y)-aminobutyric acid, where X is a leaving group and in which step c′) is followed by steps f)-h).
- 3. The process according to claim 1, in which step f) is followed by an additional step i) comprising in hydrolysis of the ester and deprotecting the 3-amino group to yield R or S aminocarnitine or phosphonium aminocarnitine directly.
- 4. The process according to claim 1, in which group Y is tosyl.
- 5. The process according to claim 1, in which steps l)-n) allow the preparation of a chiral synthon.
- 6. The process of claim 5, in which R or S 3,4-diaminobutyric acid is prepared.
- 7. The process according to claim 1 in which the leaving group is iodine.
- 8. The process according to claim 1, in which said process is conducted without purification of the intermediate products.
Priority Claims (1)
Number |
Date |
Country |
Kind |
RM99A000418 |
Jun 1999 |
IT |
|
Parent Case Info
[0001] This application is a continuation-in-part of Ser. No. 10/018,794 filed Dec. 21, 2001, now U.S. Pat. No. ______ which is a 35 USC §371 of PCT/IT00/00258 filed Jun. 23, 2000.
Continuation in Parts (1)
|
Number |
Date |
Country |
Parent |
10018794 |
Dec 2001 |
US |
Child |
10338045 |
Jan 2003 |
US |