SYNTHESIS OF SCA-TM PROTEINS WITH HUMAN IGM SPECIFICITY

Information

• Research Project
• 3498457

• ApplicationId

  3498457

• Core Project Number

  R43GM043696

• Full Project Number

  1R43GM043696-01

• Serial Number

  43696

• FOA Number

• Sub Project Id

• Project Start Date

  2/1/1990 - 34 years ago

• Project End Date

  8/31/1990 - 33 years ago

• Program Officer Name

• Budget Start Date

  2/1/1990 - 34 years ago

• Budget End Date

  8/31/1990 - 33 years ago

• Fiscal Year

  1990

• Support Year

  1

• Suffix

• Award Notice Date

  1/19/1990 - 34 years ago

Organizations

• GENEX CORPORATION

DESCRIPTION: (Adapted from Investigator's Abstract) A Single-Chain Antibody protein with specificity for human IgM will be prepared. The SCA protein will be designed from a variable of the anti-human IgM monoclonal antibody, DA4.4. A gene to synthesize this protein will be constructed and the protein expressed in E. coli. The protein will be folded, purified, and assayed for its binding to human IgM. This protein will be used as a reagent for the purification of human IgM monoclonal antibodies, as a diagnostic reagent for antigen specific IgM, and as a therapeutic in extra corporeal blood filtration for diseases, e.g., cancer, and AIDS. The immobilizations necessary for this protein to perform in these reactions will be developed during Phase II.

IC Name

• Activity

  R43

• Administering IC

  GM

• Application Type

  1

• Direct Cost Amount

• Indirect Cost Amount

• Total Cost

• Sub Project Total Cost

• ARRA Funded

• CFDA Code

  821

• Ed Inst. Type

• Funding ICs

• Funding Mechanism

• Study Section

  SSS

• Study Section Name

• Organization Name

  GENEX CORPORATION

• Organization Department

• Organization DUNS

• Organization City

  GAITHERSBURG

• Organization State

  MD

• Organization Country

  UNITED STATES

• Organization Zip Code

  20877

• Organization District

  UNITED STATES